JP2010531304A - 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー - Google Patents
抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー Download PDFInfo
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| JP2015512398A (ja) * | 2012-03-29 | 2015-04-27 | アドヴァンスト キャンサー セラピューティクス エルエルシーＡｄｖａｎｃｅｄ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ | Ｐｆｋｆｂ２阻害剤および抗癌治療法としての使用方法 |
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| BRPI1015135B1 (pt) | 2009-06-29 | 2021-08-03 | Incyte Holdings Corporation | Pirimidinonas inibidoras de pi3k, composição compreendendo tais compostos, bem como usos dos mesmos |
| WO2011050211A2 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
| US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| US9403769B2 (en) | 2010-02-22 | 2016-08-02 | Advanced Cancer Therapeutics, Llc | Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CA2796311A1 (en) | 2010-04-14 | 2011-10-20 | Incyte Corporation | Fused derivatives as pi3k.delta. inhibitors |
| EP3045452A1 (en) | 2010-04-22 | 2016-07-20 | Vertex Pharmaceuticals Inc. | Process of producing cycloalkylcarboxamido-indole compounds |
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| WO2011161201A1 (en) | 2010-06-22 | 2011-12-29 | Kancera Ab | Bisarylsulfonamides useful as kinase inhibitors in the treatment of inflammation and cancer |
| WO2012035171A2 (en) | 2010-09-17 | 2012-03-22 | Kancera Ab | New compounds |
| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| NZ612909A (en) | 2011-01-10 | 2015-09-25 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| GB201103762D0 (en) | 2011-03-07 | 2011-04-20 | Vib Vzw | Means and methods for the treatment of neurodegenerative disorders |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| US9492418B2 (en) | 2011-05-10 | 2016-11-15 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibitors of PFKFB3 for cancer therapy |
| RU2477723C2 (ru) | 2011-06-16 | 2013-03-20 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
| GB201112145D0 (en) | 2011-07-15 | 2011-08-31 | Vib Vzw | Means and methods for the treatment of pathological angiogenesis |
| DK3513793T3 (da) | 2011-09-02 | 2021-04-26 | Incyte Holdings Corp | Heterocyclylaminer som pi3k-inhibitorer |
| JP6216326B2 (ja) | 2011-12-22 | 2017-10-18 | カンセラ・アクチエボラグ | 炎症および癌の処置において有用なビスアリールスルホンアミド |
| US10000449B2 (en) | 2011-12-22 | 2018-06-19 | Kancera Ab | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| MX386085B (es) | 2012-11-01 | 2025-03-18 | Infinity Pharmaceuticals Inc | Tratamiento de canceres utilizando moduladores de las isoformas de pi3 cinasa |
| US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| PL2925757T3 (pl) | 2012-11-19 | 2018-06-29 | Novartis Ag | Związki i kompozycje do leczenia chorób pasożytniczych |
| PE20160608A1 (es) | 2013-10-14 | 2016-07-08 | Eisai Randd Man Co Ltd | Compuestos de quinolina selectivamente sustituida |
| AU2014334551B2 (en) | 2013-10-14 | 2018-05-10 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| PL3925607T3 (pl) | 2014-04-15 | 2023-10-30 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
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| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| MX373232B (es) | 2015-02-27 | 2020-05-08 | Incyte Holdings Corp | Sales del inhibidor fosfoinositida 3-cinasa (pi3k) y procesos para su preparación. |
| US10881654B2 (en) | 2015-04-24 | 2021-01-05 | University Of Louisville Research Foundation, Inc. | Selective PFKFB4 inhibitors for the treatment of cancer |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
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| US20180147198A1 (en) * | 2015-05-28 | 2018-05-31 | University Of Louisville Research Foundation, Inc. | Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer |
| WO2017208174A2 (en) * | 2016-05-31 | 2017-12-07 | The Regents Of The University Of California | Methods of treating disease with pfkfb3 inhibitors |
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| EP3651752B1 (en) | 2017-07-11 | 2024-11-20 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US10774046B2 (en) | 2017-10-26 | 2020-09-15 | University Of Louisville Research Foundation, Inc. | Inhibitors for the treatment of cancer and related methods |
| MA52761A (fr) | 2018-06-01 | 2021-04-14 | Incyte Corp | Schéma posologique destiné au traitement de troubles liés à la pi3k |
| EP3833345B1 (en) | 2018-08-07 | 2024-07-17 | Kemijski Institut | Small molecule-inhibitors of 6-phosphofructo-1-kinase for reducing lactate generation by cancer cells |
| CN109535068B (zh) * | 2018-12-26 | 2022-07-29 | 中国药科大学 | 吡啶取代查尔酮类化合物或其可药用的盐及其制备方法和用途 |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| FI4069691T3 (fi) | 2019-12-06 | 2024-11-13 | Vertex Pharma | Substituoituja tetrahydrofuraaneja natriumkanavien modulaattoreina |
| CR20230586A (es) | 2021-06-04 | 2024-05-07 | Vertex Pharma | N-(hydroxyalquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio |
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2008
- 2008-06-18 AU AU2008266856A patent/AU2008266856A1/en not_active Abandoned
- 2008-06-18 EP EP08768587.1A patent/EP2167058B1/en not_active Not-in-force
- 2008-06-18 WO PCT/US2008/007594 patent/WO2008156783A2/en not_active Ceased
- 2008-06-18 JP JP2010513237A patent/JP2010531304A/ja active Pending
- 2008-06-18 US US12/141,751 patent/US8088385B2/en not_active Expired - Fee Related
Patent Citations (3)
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| WO2001046110A2 (en) * | 1999-12-23 | 2001-06-28 | The University Of Georgia Research Foundation, Inc. | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
| WO2006037761A1 (en) * | 2004-10-01 | 2006-04-13 | Dac S.R.L. | New histone deacetylases inhibitors |
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Non-Patent Citations (9)
| Title |
|---|
| JPN6013026052; ＲＯＢＩＮＳＯＮ， Ｔ． Ｐ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ａｒｏｍａｔｉｃ ｅｎｏｎｅｓ ｒｅｌａｔｅｄ ｔｏ ｃｕｒｃｕｍｉｎ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１３， Ｎｏ．１２, 2005, ｐ．４００７-４０１３ * |
| JPN6013026055; ＳＩＬＶＡ， Ｃ． Ｈ． Ｔ． Ｐ． ｅｔ ａｌ: 'Ｍｏｌｅｃｕｌａｒ ｄｙｎａｍｉｃｓ， ｄａｔａｂａｓｅ ｓｃｒｅｅｎｉｎｇ， ｄｅｎｓｉｔｙ ｆｕｎｃｔｉｏｎａｌ ａｎｄ ｄｏｃｋｉｎｇ ｓｔｕｄｉｅｓ ｏｆ ｎｏｖｅｌ ＲＡＲ ｌｉｇａｎｄｓ' ＢＩＯＰＨＹＳＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１１７， Ｎｏ．１, 2005, ｐ．７３-７７ * |
| JPN6013026059; ＫＡＴＲＩＴＺＫＹ， Ａ． Ｒ． ｅｔ ａｌ: 'ＱＳＡＲ ｍｏｄｅｌｉｎｇ ｏｆ ａｎｔｉ-ｉｎｖａｓｉｖｅ ａｃｔｉｖｉｔｙ ｏｆ ｏｒｇａｎｉｃ ｃｏｍｐｏｕｎｄｓ ｕｓｉｎｇ ｓｔｒｕｃｔｕｒａｌ ｄｅｓｃｒｉｐｔｏｒｓ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１４， Ｎｏ．２０, 2006, ｐ．６９３３-６９３９ * |
| JPN7013002017; ＴＥＬＡＮＧ，Ｓ． ｅｔ ａｌ: 'Ｒａｓ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｒｅｑｕｉｒｅｓ ｍｅｔａｂｏｌｉｃ ｃｏｎｔｒｏｌ ｂｙ ６-ｐｈｏｓｐｈｏｆｒｕｃｔｏ-２-ｋｉｎａｓｅ' Ｏｎｃｏｇｅｎｅ Ｖｏｌ．２５， Ｎｏ．５５, 2006, ｐ．７２２５-７２３４ * |
| JPN7013002018; ＹＡＲＲＯＷ， Ｊ． Ｃ． ｅｔ ａｌ: 'ＰＨＥＮＯＴＹＰＩＣ ＳＣＲＥＥＮＩＮＧ ＯＦ ＳＭＡＬＬ ＭＯＬＥＣＵＬＥ ＬＩＢＲＡＲＩＥＳ ＢＹ ＨＩＧＨ ＴＨＲＯＵＧＨＰＵＴ ＣＥＬＬ ＩＭＡＧＩＮＧ' ＣＯＭＢＩＮＡＴＯＲＩＡＬ ＣＨＥＭＩＳＴＲＹ ＆ ＨＩＧＨ ＴＨＲＯＵＧＨＰＵＴ ＳＣＲＥＥＮＩＮＧ Ｖｏｌ．６， Ｎｏ．４, 2003, ｐ．２７９-２８６ * |
| JPN7013002019; ＩＲＩＫＵＲＡ， Ｔ． ｅｔ ａｌ: 'ＡＮＴＩ ＴＵＭＯＲ ＡＣＴＩＶＩＴＹ ＯＦ ３ ＳＵＢＳＴＩＴＵＴＥＤ ＣＩＮＮＡＭＯＹＬ ＰＹＲＩＤＩＮＥ ＡＮＤ １ ＯＸＩＤＥ' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＳＯＣＩＥＴＹ ＯＦ ＪＡＰＡＮ Ｖｏｌ．１８， Ｎｏ．７, 1970, ｐ．１４０８-１４１３ * |
| JPN7013002020; ＨＡＧＧＡＲＴＹ， Ｓ． Ｊ． ｅｔ ａｌ: 'Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ Ｍｏｄｕｌａｔｉｏｎ ｏｆ ｔｈｅ Ｈｕｍａｎ Ｃｈｒｏｍａｔｉｄ Ｄｅｃａｔｅｎａｔｉｏｎ Ｃｈｅｃｋｐｏｉｎｔ' ＣＨＥＭＩＳＴＲＹ ＡＮＤ ＢＩＯＬＯＧＹ Ｖｏｌ．１０， Ｎｏ．１２, 2003, ｐ．１２６７-１２７９ * |
| JPN7013002021; ＫＡＵ， Ｔ． Ｒ． ｅｔ ａｌ: 'Ａ ＣＨＥＭＩＣＡＬ ＧＥＮＥＴＩＣ ＳＣＲＥＥＮ ＩＤＥＮＴＩＦＩＥＳ ＩＮＨＩＢＩＴＯＲＳ ＯＦ ＲＥＧＵＬＡＴＥＤ ＮＵＣＬＥＡＲ ＥＸＰＯＲＴ ＯＦ Ａ ＦＯＲＫＨＥＡＤ ＴＲＡＮＳＣＲＩＰＴ' ＣＡＮＣＥＲ ＣＥＬＬ Ｖｏｌ．４， Ｎｏ．６, 2003, ｐ．４６３-４７６ * |
| JPN7013002022; ＮＡＭ， Ｎ．-Ｈ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｃｙｔｏｔｏｘｉｃｉｔｙ ｏｆ ２，５-ｄｉｈｙｄｒｏｘｙｃｈａｌｃｏｎｅｓ ａｎｄ ｒｅｌａｔｅｄ ｃｏｍｐｏｕｎｄｓ' ＡＲＣＨＩＶＥＳ ＯＦ ＰＨＡＲＭＡＣＡＬ ＲＥＳＥＡＲＣＨ Ｖｏｌ．２７， Ｎｏ．６, 2004, ｐ．５８１-５８８ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015512398A (ja) * | 2012-03-29 | 2015-04-27 | アドヴァンスト キャンサー セラピューティクス エルエルシーＡｄｖａｎｃｅｄ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ | Ｐｆｋｆｂ２阻害剤および抗癌治療法としての使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2167058B1 (en) | 2015-08-12 |
| WO2008156783A3 (en) | 2009-07-16 |
| WO2008156783A2 (en) | 2008-12-24 |
| AU2008266856A2 (en) | 2010-02-11 |
| AU2008266856A1 (en) | 2008-12-24 |
| US8088385B2 (en) | 2012-01-03 |
| EP2167058A2 (en) | 2010-03-31 |
| US20090074884A1 (en) | 2009-03-19 |
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