JP2010531304A - 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー - Google Patents

抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー Download PDF

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JP2010531304A
JP2010531304A JP2010513237A JP2010513237A JP2010531304A JP 2010531304 A JP2010531304 A JP 2010531304A JP 2010513237 A JP2010513237 A JP 2010513237A JP 2010513237 A JP2010513237 A JP 2010513237A JP 2010531304 A JP2010531304 A JP 2010531304A
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hydrogen atom
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aralkyl
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JP2010531304A5 (enExample
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チェスニー ジェイソン
オー トレント ジョン
テラン スチェッタ
クレム ブライアン
メイアー ジェイソン
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University of Louisville Research Foundation ULRF
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010513237A 2007-06-18 2008-06-18 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー Pending JP2010531304A (ja)

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US93603007P 2007-06-18 2007-06-18
PCT/US2008/007594 WO2008156783A2 (en) 2007-06-18 2008-06-18 Family of pfkfb3 inhibitors with anti-neoplastic activities

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JP2010531304A true JP2010531304A (ja) 2010-09-24
JP2010531304A5 JP2010531304A5 (enExample) 2011-07-28

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US (1) US8088385B2 (enExample)
EP (1) EP2167058B1 (enExample)
JP (1) JP2010531304A (enExample)
AU (1) AU2008266856A1 (enExample)
WO (1) WO2008156783A2 (enExample)

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WO2011103557A1 (en) * 2010-02-22 2011-08-25 Advanced Cancer Therapeutics, Llc Small molecule inhibitors of pfkfb3 and glycolytic flux and their methods of use as anti-cancer therapeutics
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EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
RU2745977C2 (ru) 2010-04-22 2021-04-05 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2011161201A1 (en) 2010-06-22 2011-12-29 Kancera Ab Bisarylsulfonamides useful as kinase inhibitors in the treatment of inflammation and cancer
EP2616450B1 (en) 2010-09-17 2018-05-02 Kancera AB Sulfonamide compounds
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
KR20180080358A (ko) 2011-01-10 2018-07-11 인피니티 파마슈티칼스, 인코포레이티드 이소퀴놀린온 및 이의 고체 형태의 제조 방법
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WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
US9492418B2 (en) 2011-05-10 2016-11-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Inhibitors of PFKFB3 for cancer therapy
RU2477723C2 (ru) 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
GB201112145D0 (en) 2011-07-15 2011-08-31 Vib Vzw Means and methods for the treatment of pathological angiogenesis
KR102030609B1 (ko) 2011-09-02 2019-10-11 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
US10000449B2 (en) 2011-12-22 2018-06-19 Kancera Ab Bisarylsulfonamides useful in the treatment of inflammation and cancer
MX348147B (es) 2011-12-22 2017-05-30 Kancera Ab Biarilsulfonamidas utiles en el tratamiento de la inflamacion y cancer.
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
IL291945B2 (en) 2012-11-01 2025-11-01 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
US8871754B2 (en) 2012-11-19 2014-10-28 Irm Llc Compounds and compositions for the treatment of parasitic diseases
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MY192489A (en) 2013-10-14 2022-08-23 Eisai R&D Man Co Ltd Selectively substituted quinoline compounds
EP3057948B1 (en) 2013-10-14 2018-03-14 Eisai R&D Management Co., Ltd. Selectively substituted quinoline derivatives
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WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
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US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
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WO2017208174A2 (en) * 2016-05-31 2017-12-07 The Regents Of The University Of California Methods of treating disease with pfkfb3 inhibitors
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CN119258070A (zh) 2018-06-01 2025-01-07 因赛特公司 治疗pi3k相关病症的给药方案
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CN109535068B (zh) * 2018-12-26 2022-07-29 中国药科大学 吡啶取代查尔酮类化合物或其可药用的盐及其制备方法和用途
US12441703B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
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DK4069691T3 (da) 2019-12-06 2024-10-28 Vertex Pharma Substituerede tetrahydrofuraner som modulatorer af natriumkanaler
MA64853B1 (fr) 2021-06-04 2025-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques
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JPN6013026052; ＲＯＢＩＮＳＯＮ，　Ｔ．　Ｐ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｂｉｏｌｏｇｉｃａｌ　ｅｖａｌｕａｔｉｏｎ　ｏｆ　ａｒｏｍａｔｉｃ　ｅｎｏｎｅｓ　ｒｅｌａｔｅｄ　ｔｏ　ｃｕｒｃｕｍｉｎ' ＢＩＯＯＲＧＡＮＩＣ　＆　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１３，　Ｎｏ．１２, 2005, ｐ．４００７-４０１３ *
JPN6013026055; ＳＩＬＶＡ，　Ｃ．　Ｈ．　Ｔ．　Ｐ．　ｅｔ　ａｌ: 'Ｍｏｌｅｃｕｌａｒ　ｄｙｎａｍｉｃｓ，　ｄａｔａｂａｓｅ　ｓｃｒｅｅｎｉｎｇ，　ｄｅｎｓｉｔｙ　ｆｕｎｃｔｉｏｎａｌ　ａｎｄ　ｄｏｃｋｉｎｇ　ｓｔｕｄｉｅｓ　ｏｆ　ｎｏｖｅｌ　ＲＡＲ　ｌｉｇａｎｄｓ' ＢＩＯＰＨＹＳＩＣＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１１７，　Ｎｏ．１, 2005, ｐ．７３-７７ *
JPN6013026059; ＫＡＴＲＩＴＺＫＹ，　Ａ．　Ｒ．　ｅｔ　ａｌ: 'ＱＳＡＲ　ｍｏｄｅｌｉｎｇ　ｏｆ　ａｎｔｉ-ｉｎｖａｓｉｖｅ　ａｃｔｉｖｉｔｙ　ｏｆ　ｏｒｇａｎｉｃ　ｃｏｍｐｏｕｎｄｓ　ｕｓｉｎｇ　ｓｔｒｕｃｔｕｒａｌ　ｄｅｓｃｒｉｐｔｏｒｓ' ＢＩＯＯＲＧＡＮＩＣ　＆　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１４，　Ｎｏ．２０, 2006, ｐ．６９３３-６９３９ *
JPN7013002017; ＴＥＬＡＮＧ，Ｓ．　ｅｔ　ａｌ: 'Ｒａｓ　ｔｒａｎｓｆｏｒｍａｔｉｏｎ　ｒｅｑｕｉｒｅｓ　ｍｅｔａｂｏｌｉｃ　ｃｏｎｔｒｏｌ　ｂｙ　６-ｐｈｏｓｐｈｏｆｒｕｃｔｏ-２-ｋｉｎａｓｅ' Ｏｎｃｏｇｅｎｅ Ｖｏｌ．２５，　Ｎｏ．５５, 2006, ｐ．７２２５-７２３４ *
JPN7013002018; ＹＡＲＲＯＷ，　Ｊ．　Ｃ．　ｅｔ　ａｌ: 'ＰＨＥＮＯＴＹＰＩＣ　ＳＣＲＥＥＮＩＮＧ　ＯＦ　ＳＭＡＬＬ　ＭＯＬＥＣＵＬＥ　ＬＩＢＲＡＲＩＥＳ　ＢＹ　ＨＩＧＨ　ＴＨＲＯＵＧＨＰＵＴ　ＣＥＬＬ　ＩＭＡＧＩＮＧ' ＣＯＭＢＩＮＡＴＯＲＩＡＬ　ＣＨＥＭＩＳＴＲＹ　＆　ＨＩＧＨ　ＴＨＲＯＵＧＨＰＵＴ　ＳＣＲＥＥＮＩＮＧ Ｖｏｌ．６，　Ｎｏ．４, 2003, ｐ．２７９-２８６ *
JPN7013002019; ＩＲＩＫＵＲＡ，　Ｔ．　ｅｔ　ａｌ: 'ＡＮＴＩ　ＴＵＭＯＲ　ＡＣＴＩＶＩＴＹ　ＯＦ　３　ＳＵＢＳＴＩＴＵＴＥＤ　ＣＩＮＮＡＭＯＹＬ　ＰＹＲＩＤＩＮＥ　ＡＮＤ　１　ＯＸＩＤＥ' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＳＯＣＩＥＴＹ　ＯＦ　ＪＡＰＡＮ Ｖｏｌ．１８，　Ｎｏ．７, 1970, ｐ．１４０８-１４１３ *
JPN7013002020; ＨＡＧＧＡＲＴＹ，　Ｓ．　Ｊ．　ｅｔ　ａｌ: 'Ｓｍａｌｌ　Ｍｏｌｅｃｕｌｅ　Ｍｏｄｕｌａｔｉｏｎ　ｏｆ　ｔｈｅ　Ｈｕｍａｎ　Ｃｈｒｏｍａｔｉｄ　Ｄｅｃａｔｅｎａｔｉｏｎ　Ｃｈｅｃｋｐｏｉｎｔ' ＣＨＥＭＩＳＴＲＹ　ＡＮＤ　ＢＩＯＬＯＧＹ Ｖｏｌ．１０，　Ｎｏ．１２, 2003, ｐ．１２６７-１２７９ *
JPN7013002021; ＫＡＵ，　Ｔ．　Ｒ．　ｅｔ　ａｌ: 'Ａ　ＣＨＥＭＩＣＡＬ　ＧＥＮＥＴＩＣ　ＳＣＲＥＥＮ　ＩＤＥＮＴＩＦＩＥＳ　ＩＮＨＩＢＩＴＯＲＳ　ＯＦ　ＲＥＧＵＬＡＴＥＤ　ＮＵＣＬＥＡＲ　ＥＸＰＯＲＴ　ＯＦ　Ａ　ＦＯＲＫＨＥＡＤ　ＴＲＡＮＳＣＲＩＰＴ' ＣＡＮＣＥＲ　ＣＥＬＬ Ｖｏｌ．４，　Ｎｏ．６, 2003, ｐ．４６３-４７６ *
JPN7013002022; ＮＡＭ，　Ｎ．-Ｈ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｃｙｔｏｔｏｘｉｃｉｔｙ　ｏｆ　２，５-ｄｉｈｙｄｒｏｘｙｃｈａｌｃｏｎｅｓ　ａｎｄ　ｒｅｌａｔｅｄ　ｃｏｍｐｏｕｎｄｓ' ＡＲＣＨＩＶＥＳ　ＯＦ　ＰＨＡＲＭＡＣＡＬ　ＲＥＳＥＡＲＣＨ Ｖｏｌ．２７，　Ｎｏ．６, 2004, ｐ．５８１-５８８ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015512398A (ja) * 2012-03-29 2015-04-27 アドヴァンスト キャンサー セラピューティクス エルエルシーＡｄｖａｎｃｅｄ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ Ｐｆｋｆｂ２阻害剤および抗癌治療法としての使用方法

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EP2167058A2 (en) 2010-03-31
AU2008266856A2 (en) 2010-02-11
US8088385B2 (en) 2012-01-03
WO2008156783A2 (en) 2008-12-24
AU2008266856A1 (en) 2008-12-24
US20090074884A1 (en) 2009-03-19
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EP2167058B1 (en) 2015-08-12

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