JP2010531304A - 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー - Google Patents
抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー Download PDFInfo
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| MX358640B (es) | 2008-01-04 | 2018-08-29 | Intellikine Llc | Isoquinolin-1 (2h) -onas y tieno [2,3-d]pirimidin-4(3h) -onas substituidas, y metodos de uso de las mismas. |
| HRP20140754T2 (hr) | 2009-06-29 | 2015-07-17 | Incyte Corporation | Pirimidinoni kao inhibitori pi3k |
| CA2793835C (en) | 2009-10-21 | 2021-07-20 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011050211A2 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| AR079529A1 (es) * | 2009-12-18 | 2012-02-01 | Incyte Corp | Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k |
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| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
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| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
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| US9233946B2 (en) | 2010-09-17 | 2016-01-12 | Kancera Ab | Sulfonamide compounds |
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| TWI546305B (zh) | 2011-01-10 | 2016-08-21 | 英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| GB201103762D0 (en) | 2011-03-07 | 2011-04-20 | Vib Vzw | Means and methods for the treatment of neurodegenerative disorders |
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| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| US9492418B2 (en) | 2011-05-10 | 2016-11-15 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibitors of PFKFB3 for cancer therapy |
| RU2477723C2 (ru) | 2011-06-16 | 2013-03-20 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
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| LT3196202T (lt) | 2011-09-02 | 2019-07-10 | Incyte Holdings Corporation | Heterociklilaminai, kaip pi3k slopikliai |
| CN104168958B (zh) | 2011-12-22 | 2017-12-01 | 坎塞拉有限公司 | 可用于治疗炎症和癌症的二芳基磺酰胺 |
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| CN105102000B (zh) | 2012-11-01 | 2021-10-22 | 无限药品公司 | 使用pi3激酶亚型调节剂的癌症疗法 |
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| DK2925757T3 (en) | 2012-11-19 | 2018-01-15 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| RS59911B1 (sr) | 2013-10-14 | 2020-03-31 | Eisai R&D Man Co Ltd | Selektivno supstituisana jedinjenja hinolina |
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| CN117736209A (zh) | 2015-02-27 | 2024-03-22 | 因赛特控股公司 | Pi3k抑制剂的盐及其制备方法 |
| EP3285769A4 (en) | 2015-04-24 | 2019-01-09 | University Of Louisville Research Foundation, Inc. | SELECTIVE PFKFB4 INHIBITORS FOR THE TREATMENT OF CANCER |
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2008
- 2008-06-18 EP EP08768587.1A patent/EP2167058B1/en not_active Not-in-force
- 2008-06-18 US US12/141,751 patent/US8088385B2/en not_active Expired - Fee Related
- 2008-06-18 AU AU2008266856A patent/AU2008266856A1/en not_active Abandoned
- 2008-06-18 JP JP2010513237A patent/JP2010531304A/ja active Pending
- 2008-06-18 WO PCT/US2008/007594 patent/WO2008156783A2/en not_active Ceased
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| WO2001046110A2 (en) * | 1999-12-23 | 2001-06-28 | The University Of Georgia Research Foundation, Inc. | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
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| JPN6013026052; ＲＯＢＩＮＳＯＮ， Ｔ． Ｐ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ａｒｏｍａｔｉｃ ｅｎｏｎｅｓ ｒｅｌａｔｅｄ ｔｏ ｃｕｒｃｕｍｉｎ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１３， Ｎｏ．１２, 2005, ｐ．４００７-４０１３ * |
| JPN6013026055; ＳＩＬＶＡ， Ｃ． Ｈ． Ｔ． Ｐ． ｅｔ ａｌ: 'Ｍｏｌｅｃｕｌａｒ ｄｙｎａｍｉｃｓ， ｄａｔａｂａｓｅ ｓｃｒｅｅｎｉｎｇ， ｄｅｎｓｉｔｙ ｆｕｎｃｔｉｏｎａｌ ａｎｄ ｄｏｃｋｉｎｇ ｓｔｕｄｉｅｓ ｏｆ ｎｏｖｅｌ ＲＡＲ ｌｉｇａｎｄｓ' ＢＩＯＰＨＹＳＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１１７， Ｎｏ．１, 2005, ｐ．７３-７７ * |
| JPN6013026059; ＫＡＴＲＩＴＺＫＹ， Ａ． Ｒ． ｅｔ ａｌ: 'ＱＳＡＲ ｍｏｄｅｌｉｎｇ ｏｆ ａｎｔｉ-ｉｎｖａｓｉｖｅ ａｃｔｉｖｉｔｙ ｏｆ ｏｒｇａｎｉｃ ｃｏｍｐｏｕｎｄｓ ｕｓｉｎｇ ｓｔｒｕｃｔｕｒａｌ ｄｅｓｃｒｉｐｔｏｒｓ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１４， Ｎｏ．２０, 2006, ｐ．６９３３-６９３９ * |
| JPN7013002017; ＴＥＬＡＮＧ，Ｓ． ｅｔ ａｌ: 'Ｒａｓ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｒｅｑｕｉｒｅｓ ｍｅｔａｂｏｌｉｃ ｃｏｎｔｒｏｌ ｂｙ ６-ｐｈｏｓｐｈｏｆｒｕｃｔｏ-２-ｋｉｎａｓｅ' Ｏｎｃｏｇｅｎｅ Ｖｏｌ．２５， Ｎｏ．５５, 2006, ｐ．７２２５-７２３４ * |
| JPN7013002018; ＹＡＲＲＯＷ， Ｊ． Ｃ． ｅｔ ａｌ: 'ＰＨＥＮＯＴＹＰＩＣ ＳＣＲＥＥＮＩＮＧ ＯＦ ＳＭＡＬＬ ＭＯＬＥＣＵＬＥ ＬＩＢＲＡＲＩＥＳ ＢＹ ＨＩＧＨ ＴＨＲＯＵＧＨＰＵＴ ＣＥＬＬ ＩＭＡＧＩＮＧ' ＣＯＭＢＩＮＡＴＯＲＩＡＬ ＣＨＥＭＩＳＴＲＹ ＆ ＨＩＧＨ ＴＨＲＯＵＧＨＰＵＴ ＳＣＲＥＥＮＩＮＧ Ｖｏｌ．６， Ｎｏ．４, 2003, ｐ．２７９-２８６ * |
| JPN7013002019; ＩＲＩＫＵＲＡ， Ｔ． ｅｔ ａｌ: 'ＡＮＴＩ ＴＵＭＯＲ ＡＣＴＩＶＩＴＹ ＯＦ ３ ＳＵＢＳＴＩＴＵＴＥＤ ＣＩＮＮＡＭＯＹＬ ＰＹＲＩＤＩＮＥ ＡＮＤ １ ＯＸＩＤＥ' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＳＯＣＩＥＴＹ ＯＦ ＪＡＰＡＮ Ｖｏｌ．１８， Ｎｏ．７, 1970, ｐ．１４０８-１４１３ * |
| JPN7013002020; ＨＡＧＧＡＲＴＹ， Ｓ． Ｊ． ｅｔ ａｌ: 'Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ Ｍｏｄｕｌａｔｉｏｎ ｏｆ ｔｈｅ Ｈｕｍａｎ Ｃｈｒｏｍａｔｉｄ Ｄｅｃａｔｅｎａｔｉｏｎ Ｃｈｅｃｋｐｏｉｎｔ' ＣＨＥＭＩＳＴＲＹ ＡＮＤ ＢＩＯＬＯＧＹ Ｖｏｌ．１０， Ｎｏ．１２, 2003, ｐ．１２６７-１２７９ * |
| JPN7013002021; ＫＡＵ， Ｔ． Ｒ． ｅｔ ａｌ: 'Ａ ＣＨＥＭＩＣＡＬ ＧＥＮＥＴＩＣ ＳＣＲＥＥＮ ＩＤＥＮＴＩＦＩＥＳ ＩＮＨＩＢＩＴＯＲＳ ＯＦ ＲＥＧＵＬＡＴＥＤ ＮＵＣＬＥＡＲ ＥＸＰＯＲＴ ＯＦ Ａ ＦＯＲＫＨＥＡＤ ＴＲＡＮＳＣＲＩＰＴ' ＣＡＮＣＥＲ ＣＥＬＬ Ｖｏｌ．４， Ｎｏ．６, 2003, ｐ．４６３-４７６ * |
| JPN7013002022; ＮＡＭ， Ｎ．-Ｈ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｃｙｔｏｔｏｘｉｃｉｔｙ ｏｆ ２，５-ｄｉｈｙｄｒｏｘｙｃｈａｌｃｏｎｅｓ ａｎｄ ｒｅｌａｔｅｄ ｃｏｍｐｏｕｎｄｓ' ＡＲＣＨＩＶＥＳ ＯＦ ＰＨＡＲＭＡＣＡＬ ＲＥＳＥＡＲＣＨ Ｖｏｌ．２７， Ｎｏ．６, 2004, ｐ．５８１-５８８ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015512398A (ja) * | 2012-03-29 | 2015-04-27 | アドヴァンスト キャンサー セラピューティクス エルエルシーＡｄｖａｎｃｅｄ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ | Ｐｆｋｆｂ２阻害剤および抗癌治療法としての使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2167058B1 (en) | 2015-08-12 |
| AU2008266856A2 (en) | 2010-02-11 |
| US20090074884A1 (en) | 2009-03-19 |
| AU2008266856A1 (en) | 2008-12-24 |
| US8088385B2 (en) | 2012-01-03 |
| WO2008156783A3 (en) | 2009-07-16 |
| EP2167058A2 (en) | 2010-03-31 |
| WO2008156783A2 (en) | 2008-12-24 |
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