JP2010531304A - 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー - Google Patents
抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー Download PDFInfo
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| EP2525790B1 (en) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
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| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
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| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| AR084824A1 (es) | 2011-01-10 | 2013-06-26 | Intellikine Inc | Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas |
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| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
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| US9492418B2 (en) | 2011-05-10 | 2016-11-15 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Inhibitors of PFKFB3 for cancer therapy |
| RU2477723C2 (ru) | 2011-06-16 | 2013-03-20 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
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| EP2794009B1 (en) | 2011-12-22 | 2017-08-30 | Kancera AB | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| US10000449B2 (en) | 2011-12-22 | 2018-06-19 | Kancera Ab | Bisarylsulfonamides useful in the treatment of inflammation and cancer |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
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| HRP20181367T4 (hr) | 2012-11-01 | 2021-11-26 | Infinity Pharmaceuticals, Inc. | Liječenje raka korištenjem modulatora izoforme pi3 kinaze |
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| US10881654B2 (en) * | 2015-04-24 | 2021-01-05 | University Of Louisville Research Foundation, Inc. | Selective PFKFB4 inhibitors for the treatment of cancer |
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| US20180147198A1 (en) * | 2015-05-28 | 2018-05-31 | University Of Louisville Research Foundation, Inc. | Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer |
| WO2017208174A2 (en) * | 2016-05-31 | 2017-12-07 | The Regents Of The University Of California | Methods of treating disease with pfkfb3 inhibitors |
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| ES3008911T3 (en) | 2017-07-11 | 2025-03-25 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| US10774046B2 (en) | 2017-10-26 | 2020-09-15 | University Of Louisville Research Foundation, Inc. | Inhibitors for the treatment of cancer and related methods |
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| CN109535068B (zh) * | 2018-12-26 | 2022-07-29 | 中国药科大学 | 吡啶取代查尔酮类化合物或其可药用的盐及其制备方法和用途 |
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| PT4069691T (pt) | 2019-12-06 | 2024-12-18 | Vertex Pharma | Tetrahidrofuranos substituídos como moduladores dos canais de sódio |
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2008
- 2008-06-18 WO PCT/US2008/007594 patent/WO2008156783A2/en not_active Ceased
- 2008-06-18 US US12/141,751 patent/US8088385B2/en not_active Expired - Fee Related
- 2008-06-18 JP JP2010513237A patent/JP2010531304A/ja active Pending
- 2008-06-18 EP EP08768587.1A patent/EP2167058B1/en not_active Not-in-force
- 2008-06-18 AU AU2008266856A patent/AU2008266856A1/en not_active Abandoned
Patent Citations (3)
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| WO2001046110A2 (en) * | 1999-12-23 | 2001-06-28 | The University Of Georgia Research Foundation, Inc. | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
| WO2006037761A1 (en) * | 2004-10-01 | 2006-04-13 | Dac S.R.L. | New histone deacetylases inhibitors |
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Non-Patent Citations (9)
| Title |
|---|
| JPN6013026052; ＲＯＢＩＮＳＯＮ， Ｔ． Ｐ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ａｒｏｍａｔｉｃ ｅｎｏｎｅｓ ｒｅｌａｔｅｄ ｔｏ ｃｕｒｃｕｍｉｎ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１３， Ｎｏ．１２, 2005, ｐ．４００７-４０１３ * |
| JPN6013026055; ＳＩＬＶＡ， Ｃ． Ｈ． Ｔ． Ｐ． ｅｔ ａｌ: 'Ｍｏｌｅｃｕｌａｒ ｄｙｎａｍｉｃｓ， ｄａｔａｂａｓｅ ｓｃｒｅｅｎｉｎｇ， ｄｅｎｓｉｔｙ ｆｕｎｃｔｉｏｎａｌ ａｎｄ ｄｏｃｋｉｎｇ ｓｔｕｄｉｅｓ ｏｆ ｎｏｖｅｌ ＲＡＲ ｌｉｇａｎｄｓ' ＢＩＯＰＨＹＳＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１１７， Ｎｏ．１, 2005, ｐ．７３-７７ * |
| JPN6013026059; ＫＡＴＲＩＴＺＫＹ， Ａ． Ｒ． ｅｔ ａｌ: 'ＱＳＡＲ ｍｏｄｅｌｉｎｇ ｏｆ ａｎｔｉ-ｉｎｖａｓｉｖｅ ａｃｔｉｖｉｔｙ ｏｆ ｏｒｇａｎｉｃ ｃｏｍｐｏｕｎｄｓ ｕｓｉｎｇ ｓｔｒｕｃｔｕｒａｌ ｄｅｓｃｒｉｐｔｏｒｓ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．１４， Ｎｏ．２０, 2006, ｐ．６９３３-６９３９ * |
| JPN7013002017; ＴＥＬＡＮＧ，Ｓ． ｅｔ ａｌ: 'Ｒａｓ ｔｒａｎｓｆｏｒｍａｔｉｏｎ ｒｅｑｕｉｒｅｓ ｍｅｔａｂｏｌｉｃ ｃｏｎｔｒｏｌ ｂｙ ６-ｐｈｏｓｐｈｏｆｒｕｃｔｏ-２-ｋｉｎａｓｅ' Ｏｎｃｏｇｅｎｅ Ｖｏｌ．２５， Ｎｏ．５５, 2006, ｐ．７２２５-７２３４ * |
| JPN7013002018; ＹＡＲＲＯＷ， Ｊ． Ｃ． ｅｔ ａｌ: 'ＰＨＥＮＯＴＹＰＩＣ ＳＣＲＥＥＮＩＮＧ ＯＦ ＳＭＡＬＬ ＭＯＬＥＣＵＬＥ ＬＩＢＲＡＲＩＥＳ ＢＹ ＨＩＧＨ ＴＨＲＯＵＧＨＰＵＴ ＣＥＬＬ ＩＭＡＧＩＮＧ' ＣＯＭＢＩＮＡＴＯＲＩＡＬ ＣＨＥＭＩＳＴＲＹ ＆ ＨＩＧＨ ＴＨＲＯＵＧＨＰＵＴ ＳＣＲＥＥＮＩＮＧ Ｖｏｌ．６， Ｎｏ．４, 2003, ｐ．２７９-２８６ * |
| JPN7013002019; ＩＲＩＫＵＲＡ， Ｔ． ｅｔ ａｌ: 'ＡＮＴＩ ＴＵＭＯＲ ＡＣＴＩＶＩＴＹ ＯＦ ３ ＳＵＢＳＴＩＴＵＴＥＤ ＣＩＮＮＡＭＯＹＬ ＰＹＲＩＤＩＮＥ ＡＮＤ １ ＯＸＩＤＥ' ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＳＯＣＩＥＴＹ ＯＦ ＪＡＰＡＮ Ｖｏｌ．１８， Ｎｏ．７, 1970, ｐ．１４０８-１４１３ * |
| JPN7013002020; ＨＡＧＧＡＲＴＹ， Ｓ． Ｊ． ｅｔ ａｌ: 'Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ Ｍｏｄｕｌａｔｉｏｎ ｏｆ ｔｈｅ Ｈｕｍａｎ Ｃｈｒｏｍａｔｉｄ Ｄｅｃａｔｅｎａｔｉｏｎ Ｃｈｅｃｋｐｏｉｎｔ' ＣＨＥＭＩＳＴＲＹ ＡＮＤ ＢＩＯＬＯＧＹ Ｖｏｌ．１０， Ｎｏ．１２, 2003, ｐ．１２６７-１２７９ * |
| JPN7013002021; ＫＡＵ， Ｔ． Ｒ． ｅｔ ａｌ: 'Ａ ＣＨＥＭＩＣＡＬ ＧＥＮＥＴＩＣ ＳＣＲＥＥＮ ＩＤＥＮＴＩＦＩＥＳ ＩＮＨＩＢＩＴＯＲＳ ＯＦ ＲＥＧＵＬＡＴＥＤ ＮＵＣＬＥＡＲ ＥＸＰＯＲＴ ＯＦ Ａ ＦＯＲＫＨＥＡＤ ＴＲＡＮＳＣＲＩＰＴ' ＣＡＮＣＥＲ ＣＥＬＬ Ｖｏｌ．４， Ｎｏ．６, 2003, ｐ．４６３-４７６ * |
| JPN7013002022; ＮＡＭ， Ｎ．-Ｈ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｃｙｔｏｔｏｘｉｃｉｔｙ ｏｆ ２，５-ｄｉｈｙｄｒｏｘｙｃｈａｌｃｏｎｅｓ ａｎｄ ｒｅｌａｔｅｄ ｃｏｍｐｏｕｎｄｓ' ＡＲＣＨＩＶＥＳ ＯＦ ＰＨＡＲＭＡＣＡＬ ＲＥＳＥＡＲＣＨ Ｖｏｌ．２７， Ｎｏ．６, 2004, ｐ．５８１-５８８ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015512398A (ja) * | 2012-03-29 | 2015-04-27 | アドヴァンスト キャンサー セラピューティクス エルエルシーＡｄｖａｎｃｅｄ Ｃａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ | Ｐｆｋｆｂ２阻害剤および抗癌治療法としての使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008156783A3 (en) | 2009-07-16 |
| US20090074884A1 (en) | 2009-03-19 |
| US8088385B2 (en) | 2012-01-03 |
| AU2008266856A2 (en) | 2010-02-11 |
| EP2167058A2 (en) | 2010-03-31 |
| AU2008266856A1 (en) | 2008-12-24 |
| WO2008156783A2 (en) | 2008-12-24 |
| EP2167058B1 (en) | 2015-08-12 |
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