JP2010530881A5 - - Google Patents
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- Publication number
- JP2010530881A5 JP2010530881A5 JP2010513416A JP2010513416A JP2010530881A5 JP 2010530881 A5 JP2010530881 A5 JP 2010530881A5 JP 2010513416 A JP2010513416 A JP 2010513416A JP 2010513416 A JP2010513416 A JP 2010513416A JP 2010530881 A5 JP2010530881 A5 JP 2010530881A5
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- Japan
- Prior art keywords
- substituted
- unsubstituted
- och
- compound according
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 13
- 239000011780 sodium chloride Substances 0.000 claims 13
- 239000012453 solvate Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- -1 4- (methoxy) phenyl Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 230000000813 microbial Effects 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 206010060945 Bacterial infection Diseases 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94529407P | 2007-06-20 | 2007-06-20 | |
US60/945,294 | 2007-06-20 | ||
US4117808P | 2008-03-31 | 2008-03-31 | |
US61/041,178 | 2008-03-31 | ||
PCT/US2008/067550 WO2008157726A1 (en) | 2007-06-20 | 2008-06-19 | Boron-containing small molecules |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014087397A Division JP2014148531A (ja) | 2007-06-20 | 2014-04-21 | ホウ素含有小分子 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010530881A JP2010530881A (ja) | 2010-09-16 |
JP2010530881A5 true JP2010530881A5 (US07794700-20100914-C00125.png) | 2011-08-04 |
JP5530923B2 JP5530923B2 (ja) | 2014-06-25 |
Family
ID=40156702
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010513416A Active JP5530923B2 (ja) | 2007-06-20 | 2008-06-19 | ホウ素含有小分子 |
JP2014087397A Pending JP2014148531A (ja) | 2007-06-20 | 2014-04-21 | ホウ素含有小分子 |
JP2015187239A Active JP6570391B2 (ja) | 2007-06-20 | 2015-09-24 | ホウ素含有小分子 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014087397A Pending JP2014148531A (ja) | 2007-06-20 | 2014-04-21 | ホウ素含有小分子 |
JP2015187239A Active JP6570391B2 (ja) | 2007-06-20 | 2015-09-24 | ホウ素含有小分子 |
Country Status (29)
Families Citing this family (67)
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PT3424932T (pt) | 2005-02-16 | 2021-05-19 | Anacor Pharmaceuticals Inc | Boronoftalidas para utilização terapêutica |
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DK2719388T3 (da) | 2006-02-16 | 2019-05-13 | Anacor Pharmaceuticals Inc | Borholdige små molekyler som antiinflammatoriske midler |
EP2015757A4 (en) | 2006-05-02 | 2011-01-26 | Anacor Pharmaceuticals Inc | HYDROLYSERESISTENT, BOROYED THERAPEUTIC USES |
JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
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WO2009140309A2 (en) * | 2008-05-12 | 2009-11-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
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WO2010045503A1 (en) * | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
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WO2011049971A1 (en) | 2009-10-20 | 2011-04-28 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
WO2011060199A1 (en) * | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
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WO2011116348A1 (en) | 2010-03-19 | 2011-09-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
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KR102152901B1 (ko) | 2010-09-07 | 2020-09-07 | 아나코르 파마슈티칼스 인코포레이티드 | 세균 감염을 치료하기 위한 벤족사보롤 유도체 |
WO2013025975A1 (en) * | 2011-08-17 | 2013-02-21 | Glaxosmithkline Llc | Combination treatments for hepatitis c |
WO2013049424A1 (en) | 2011-09-28 | 2013-04-04 | Wisconsin Alumni Research Foundation | Catalytic conversion of cellulose to fuels and chemicals using boronic acids |
AR088668A1 (es) | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Moleculas pequeñas que contienen boro |
AR088669A1 (es) | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos |
JP6031122B2 (ja) * | 2011-12-22 | 2016-11-24 | ミクウルク ファーマシューティカルズ,インコーポレイテッド | 抗微生物療法のための三環式ホウ素化合物 |
US20150080342A1 (en) * | 2012-04-14 | 2015-03-19 | Anacor Pharmaceuticals, Inc. | Benzoxaborole compounds and uses thereof |
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US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9598443B2 (en) | 2013-02-01 | 2017-03-21 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules as antiprotozoal agents |
AU2014202928B1 (en) * | 2013-06-05 | 2014-09-11 | Agrofresh Inc. | Compounds and compositions |
KR101636431B1 (ko) * | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
AU2014305792C1 (en) | 2013-08-09 | 2018-07-05 | Anacor Pharmaceuticals, LLC. | Tricyclic benzoxaborole compounds and uses thereof |
EA038093B1 (ru) * | 2013-12-20 | 2021-07-05 | Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли |
US10040806B2 (en) * | 2014-02-17 | 2018-08-07 | Syngenta Participations Ag | Microbiocidally active benzoxaboroles |
JP6605513B2 (ja) * | 2014-07-01 | 2019-11-13 | 第一三共株式会社 | 抗菌剤としての三環式ベンゾオキサボロール |
EP3212196A4 (en) * | 2014-10-29 | 2018-07-11 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of hiv protease |
MA41495A (fr) * | 2015-02-12 | 2017-12-19 | Anacor Pharmaceuticals Inc | Composés benzoxaborole et leurs utilisations |
CN107872956B (zh) | 2015-04-09 | 2020-07-10 | 宾夕法尼亚州研究基金会 | 含有苯并氧杂硼戊环的协同性抗真菌组合物 |
US10160867B2 (en) * | 2015-08-06 | 2018-12-25 | The Penn State Research Foundation | Benzoxaborole-containing coating resistant to cellulose-supportable fungus |
WO2017151489A1 (en) | 2016-03-02 | 2017-09-08 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
CN113845536A (zh) | 2016-03-02 | 2021-12-28 | 比尔及梅琳达盖茨基金会 | 含硼小分子 |
US10874679B2 (en) | 2016-03-02 | 2020-12-29 | Bill & Melinda Gates Foundation | Boron-containing small molecules |
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HUE056320T2 (hu) | 2016-05-12 | 2022-02-28 | Anacor Pharmaceuticals Inc | L-valin amid benzoxaborol származékok parazita betegségek kezelésére |
US10961261B2 (en) | 2017-03-01 | 2021-03-30 | Anacor Pharmaceuticals, Inc. | Oxaborole analogs and uses thereof |
CN107090000B (zh) * | 2017-04-27 | 2019-07-12 | 上海交通大学 | 一种苯并硼唑7位脂肪酸的衍生物及其制备与用途 |
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DK2719388T3 (da) * | 2006-02-16 | 2019-05-13 | Anacor Pharmaceuticals Inc | Borholdige små molekyler som antiinflammatoriske midler |
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WO2009140309A2 (en) * | 2008-05-12 | 2009-11-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
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2008
- 2008-06-18 JO JOP/2008/0288A patent/JO3396B1/ar active
- 2008-06-19 BR BRPI0813450A patent/BRPI0813450B8/pt active IP Right Grant
- 2008-06-19 NZ NZ582706A patent/NZ582706A/en unknown
- 2008-06-19 MY MYPI20095460A patent/MY162692A/en unknown
- 2008-06-19 CN CN201410134063.6A patent/CN104017008A/zh active Pending
- 2008-06-19 KR KR1020167009966A patent/KR101685656B1/ko active IP Right Grant
- 2008-06-19 US US12/142,692 patent/US7816344B2/en active Active
- 2008-06-19 KR KR1020157021997A patent/KR20150100945A/ko not_active IP Right Cessation
- 2008-06-19 NO NO08825921A patent/NO2164331T3/no unknown
- 2008-06-19 EP EP08825921.3A patent/EP2164331B1/en active Active
- 2008-06-19 WO PCT/US2008/067550 patent/WO2008157726A1/en active Application Filing
- 2008-06-19 KR KR1020107001062A patent/KR101578351B1/ko active IP Right Grant
- 2008-06-19 JP JP2010513416A patent/JP5530923B2/ja active Active
- 2008-06-19 ES ES08825921.3T patent/ES2655299T3/es active Active
- 2008-06-19 CN CN200880101464.4A patent/CN101772302B/zh active Active
- 2008-06-19 AU AU2008265630A patent/AU2008265630B2/en active Active
- 2008-06-19 SG SG2012045712A patent/SG182219A1/en unknown
- 2008-06-19 CA CA2692135A patent/CA2692135C/en active Active
- 2008-06-19 EA EA200901617A patent/EA020530B1/ru not_active IP Right Cessation
- 2008-06-19 DK DK08825921.3T patent/DK2164331T3/da active
- 2008-06-19 MX MX2015007480A patent/MX347688B/es unknown
- 2008-06-20 UY UY31171A patent/UY31171A1/es unknown
- 2008-06-20 TW TW097123257A patent/TW200911822A/zh unknown
- 2008-06-20 PE PE2008001074A patent/PE20090840A1/es not_active Application Discontinuation
- 2008-06-20 AR ARP080102661A patent/AR067105A1/es active IP Right Grant
- 2008-06-20 CL CL2008001855A patent/CL2008001855A1/es unknown
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2009
- 2009-11-26 IL IL202379A patent/IL202379A/en active IP Right Grant
- 2009-12-11 DO DO2009000281A patent/DOP2009000281A/es unknown
- 2009-12-17 ZA ZA2009/09003A patent/ZA200909003B/en unknown
- 2009-12-18 CO CO09145296A patent/CO6251209A2/es not_active Application Discontinuation
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2010
- 2010-01-15 MA MA32517A patent/MA31675B1/fr unknown
- 2010-01-18 CR CR11224A patent/CR11224A/es unknown
- 2010-07-30 US US12/848,051 patent/US8895534B2/en active Active
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2011
- 2011-06-21 ZA ZA2011/04573A patent/ZA201104573B/en unknown
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2014
- 2014-04-21 JP JP2014087397A patent/JP2014148531A/ja active Pending
- 2014-11-07 US US14/536,483 patent/US9796735B2/en active Active
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2015
- 2015-09-24 JP JP2015187239A patent/JP6570391B2/ja active Active
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2017
- 2017-09-28 US US15/718,422 patent/US10533021B2/en active Active