JP2010530435A - 局所的に投与される低用量のコルチコステロイド - Google Patents

局所的に投与される低用量のコルチコステロイド Download PDF

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Publication number
JP2010530435A
JP2010530435A JP2010513319A JP2010513319A JP2010530435A JP 2010530435 A JP2010530435 A JP 2010530435A JP 2010513319 A JP2010513319 A JP 2010513319A JP 2010513319 A JP2010513319 A JP 2010513319A JP 2010530435 A JP2010530435 A JP 2010530435A
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JP
Japan
Prior art keywords
day
poly
hydrocortisone
pain
prednisolone
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JP2010513319A
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Japanese (ja)
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JP2010530435A5 (enExample
Inventor
マッケイ,ウィリアム・エフ
ザネラ,ジョン・マイヤーズ
ホボット,クリストファー・エム
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ウォーソー・オーソペディック・インコーポレーテッド
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Publication of JP2010530435A publication Critical patent/JP2010530435A/ja
Publication of JP2010530435A5 publication Critical patent/JP2010530435A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2010513319A 2007-06-19 2008-06-05 局所的に投与される低用量のコルチコステロイド Pending JP2010530435A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/765,040 US20080317805A1 (en) 2007-06-19 2007-06-19 Locally administrated low doses of corticosteroids
PCT/US2008/065869 WO2008157057A2 (en) 2007-06-19 2008-06-05 Locally administrated low doses of corticosteroids

Publications (2)

Publication Number Publication Date
JP2010530435A true JP2010530435A (ja) 2010-09-09
JP2010530435A5 JP2010530435A5 (enExample) 2011-02-17

Family

ID=39739800

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010513319A Pending JP2010530435A (ja) 2007-06-19 2008-06-05 局所的に投与される低用量のコルチコステロイド

Country Status (5)

Country Link
US (2) US20080317805A1 (enExample)
EP (1) EP2170271A2 (enExample)
JP (1) JP2010530435A (enExample)
CN (1) CN101765422A (enExample)
WO (1) WO2008157057A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516910A (ja) * 2015-06-02 2018-06-28 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 神経外傷を制限するための処方物および方法
JP2023107784A (ja) * 2015-12-07 2023-08-03 プロキシマジェン,リミティド ライアビリティ カンパニー 疼痛の治療のためのvap-1阻害剤

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US20090324678A1 (en) * 2004-07-16 2009-12-31 Spinal Restoration, Inc. Methods and kits for treating joints and soft tissues
US20090197780A1 (en) * 2008-02-01 2009-08-06 Weaver Jimmie D Ultrafine Grinding of Soft Materials
US8883768B2 (en) * 2008-04-18 2014-11-11 Warsaw Orthopedic, Inc. Fluocinolone implants to protect against undesirable bone and cartilage destruction
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US7993666B2 (en) * 2008-04-18 2011-08-09 Warsaw Orthopedic, Inc. Methods and compositions for treating pain comprising a statin
US9289409B2 (en) * 2008-04-18 2016-03-22 Warsaw Orthopedic, Inc. Sulindac formulations in a biodegradable material
US8524267B2 (en) 2008-04-18 2013-09-03 Warsaw Orthopedic, Inc. Dexamethasone formulations in a biodegradable material
BRPI0905078A2 (pt) * 2008-04-18 2015-06-30 Medtronic Inc Métodos para tratar hérnia de disco intervertebral e para reduzir o tamanho de uma hérnia de disco intervertebral, e, depósito implantável de drogas
US9492375B2 (en) * 2008-07-23 2016-11-15 Warsaw Orthopedic, Inc. Foam carrier for bone grafting
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
US20100228097A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Methods and compositions to diagnose pain
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
US20110027331A1 (en) * 2009-07-29 2011-02-03 Warsaw Orthopedic, Inc. An implantable drug depot having a reversible phase transition material for treatment of pain and/or inflammation
US8653029B2 (en) 2009-07-30 2014-02-18 Warsaw Orthopedic, Inc. Flowable paste and putty bone void filler
US8597192B2 (en) 2009-10-30 2013-12-03 Warsaw Orthopedic, Inc. Ultrasonic devices and methods to diagnose pain generators
US8758791B2 (en) * 2010-01-26 2014-06-24 Warsaw Orthopedic, Inc. Highly compression resistant matrix with porous skeleton
US8475824B2 (en) * 2010-01-26 2013-07-02 Warsaw Orthopedic, Inc. Resorbable matrix having elongated particles
AU2015268647B2 (en) * 2010-08-04 2017-08-24 Flexion Therapeutics, Inc. Corticosteroids for the Treatment of Joint Pain
UA111162C2 (uk) * 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
US9717779B2 (en) 2011-01-31 2017-08-01 Warsaw Orthopedic, Inc. Implantable matrix having optimum ligand concentrations
WO2013019280A1 (en) 2011-08-04 2013-02-07 Flexion Therapeutics Corticosteroids for the treatment of joint pain
PT2735309T (pt) * 2012-11-27 2016-09-26 Cos Alfonso Eduardo Composição farmacêutica para o tratamento da tendinite calcificada e/ou da bursite calcificada
JP6215354B2 (ja) 2013-01-23 2017-10-18 セムヌール ファーマシューティカルズ, インコーポレイテッド 不溶性コルチコステロイドおよび可溶性コルチコステロイドを含む医薬処方物
US20140271770A1 (en) * 2013-03-15 2014-09-18 Warsaw Orthopedic, Inc. Methods And Compositions For Treating Post-Operative Pain Comprising Clonidine
WO2014153541A1 (en) 2013-03-21 2014-09-25 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
TWI772659B (zh) 2015-01-21 2022-08-01 美商桑紐爾製藥公司 醫藥配方
RU2018119121A (ru) 2015-10-27 2019-11-28 Юпраксия Фармасьютикалз Инк. Лекарственные формы местных анастетиков с замедленным высвобождением
EP3448359B1 (en) * 2016-04-29 2023-06-07 Laurentia Holding B.V. Liposomal corticosteroids for topical injection in inflamed lesions or areas
CN106983733A (zh) * 2017-03-08 2017-07-28 江苏富泽药业有限公司 曲安奈德plga缓释微球注射剂、其制备方法及其在制备治疗骨关节炎疼痛药物中的应用
BR102020010923A2 (pt) * 2020-05-29 2021-12-14 Luiz Peracchi Edson Implante subcutâneo reabsorvível de longa duração com liberação prolongada de substância farmacologicamente ativa pré-concentrada em polímero para tratamento da insuficiência adrenal crônica ou hipocortisolismo

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503695A (ja) * 1992-09-10 1996-04-23 チルドレンズ メディカル センター コーポレイション 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス
JPH11504634A (ja) * 1995-05-01 1999-04-27 チルドレンズ メディカル センター コーポレイション 局所麻酔薬とグルココルチコイドとの組み合わせによる延長された神経遮断
JPH11506450A (ja) * 1995-06-02 1999-06-08 オキュレックス ファーマシューティカルズ,インコーポレイティド 親水性及び疎水性薬剤の組合せによる薬剤の制御放出のための改良処方物
JP2000511941A (ja) * 1997-07-02 2000-09-12 ユーロ−セルティーク エス.エイ. 関節間隙および身体間隙における持効性麻酔
JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク,エス.エイ. 局所麻酔薬および使用法
WO2005110362A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Biodegradable ocular implants with long-term release characteristics
JP2006525953A (ja) * 2003-01-09 2006-11-16 アラーガン、インコーポレイテッド 生分解性眼用インプラント

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JPH05502465A (ja) * 1989-08-28 1993-04-28 ファーマスーティカル デリバリー システムズ 治療薬剤の制御放出のために有用な生体内で分解し得るポリマー
WO2001097872A1 (en) * 2000-06-22 2001-12-27 Austin Sam L Bioadhesive compositions and methods of preparation and use
AU2002259045B2 (en) * 2001-04-26 2008-05-22 Psivida Us Inc. Sustained release drug delivery system containing codrugs
US20030118649A1 (en) * 2001-10-04 2003-06-26 Jinming Gao Drug delivery devices and methods
MXPA04006875A (es) * 2002-01-18 2004-12-06 Control Delivery Sys Inc Sistema de gel polimerico para suministro controlado de cofarmacos.
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WO2006039336A2 (en) * 2004-10-01 2006-04-13 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US20060253100A1 (en) * 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
US20070178138A1 (en) * 2006-02-01 2007-08-02 Allergan, Inc. Biodegradable non-opthalmic implants and related methods
US8673019B2 (en) * 2006-04-13 2014-03-18 Warsaw Orthopedic, Inc. Use of anti-inflammatory compounds with allograft tissue implantation
US7741273B2 (en) * 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs

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JPH08503695A (ja) * 1992-09-10 1996-04-23 チルドレンズ メディカル センター コーポレイション 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス
JPH11504634A (ja) * 1995-05-01 1999-04-27 チルドレンズ メディカル センター コーポレイション 局所麻酔薬とグルココルチコイドとの組み合わせによる延長された神経遮断
JPH11506450A (ja) * 1995-06-02 1999-06-08 オキュレックス ファーマシューティカルズ,インコーポレイティド 親水性及び疎水性薬剤の組合せによる薬剤の制御放出のための改良処方物
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JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク,エス.エイ. 局所麻酔薬および使用法
JP2006525953A (ja) * 2003-01-09 2006-11-16 アラーガン、インコーポレイテッド 生分解性眼用インプラント
WO2005110362A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Biodegradable ocular implants with long-term release characteristics

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516910A (ja) * 2015-06-02 2018-06-28 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 神経外傷を制限するための処方物および方法
JP2023107784A (ja) * 2015-12-07 2023-08-03 プロキシマジェン,リミティド ライアビリティ カンパニー 疼痛の治療のためのvap-1阻害剤

Also Published As

Publication number Publication date
US20080317805A1 (en) 2008-12-25
CN101765422A (zh) 2010-06-30
US20140336162A1 (en) 2014-11-13
EP2170271A2 (en) 2010-04-07
WO2008157057A3 (en) 2010-01-28
WO2008157057A2 (en) 2008-12-24

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