JP2010530435A - 局所的に投与される低用量のコルチコステロイド - Google Patents

局所的に投与される低用量のコルチコステロイド Download PDF

Info

Publication number
JP2010530435A
JP2010530435A JP2010513319A JP2010513319A JP2010530435A JP 2010530435 A JP2010530435 A JP 2010530435A JP 2010513319 A JP2010513319 A JP 2010513319A JP 2010513319 A JP2010513319 A JP 2010513319A JP 2010530435 A JP2010530435 A JP 2010530435A
Authority
JP
Japan
Prior art keywords
day
poly
hydrocortisone
pain
prednisolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010513319A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010530435A5 (enExample
Inventor
マッケイ,ウィリアム・エフ
ザネラ,ジョン・マイヤーズ
ホボット,クリストファー・エム
Original Assignee
ウォーソー・オーソペディック・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウォーソー・オーソペディック・インコーポレーテッド filed Critical ウォーソー・オーソペディック・インコーポレーテッド
Publication of JP2010530435A publication Critical patent/JP2010530435A/ja
Publication of JP2010530435A5 publication Critical patent/JP2010530435A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2010513319A 2007-06-19 2008-06-05 局所的に投与される低用量のコルチコステロイド Pending JP2010530435A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/765,040 US20080317805A1 (en) 2007-06-19 2007-06-19 Locally administrated low doses of corticosteroids
PCT/US2008/065869 WO2008157057A2 (en) 2007-06-19 2008-06-05 Locally administrated low doses of corticosteroids

Publications (2)

Publication Number Publication Date
JP2010530435A true JP2010530435A (ja) 2010-09-09
JP2010530435A5 JP2010530435A5 (enExample) 2011-02-17

Family

ID=39739800

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010513319A Pending JP2010530435A (ja) 2007-06-19 2008-06-05 局所的に投与される低用量のコルチコステロイド

Country Status (5)

Country Link
US (2) US20080317805A1 (enExample)
EP (1) EP2170271A2 (enExample)
JP (1) JP2010530435A (enExample)
CN (1) CN101765422A (enExample)
WO (1) WO2008157057A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516910A (ja) * 2015-06-02 2018-06-28 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 神経外傷を制限するための処方物および方法
JP2023107784A (ja) * 2015-12-07 2023-08-03 プロキシマジェン,リミティド ライアビリティ カンパニー 疼痛の治療のためのvap-1阻害剤

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090324678A1 (en) * 2004-07-16 2009-12-31 Spinal Restoration, Inc. Methods and kits for treating joints and soft tissues
US20090197780A1 (en) * 2008-02-01 2009-08-06 Weaver Jimmie D Ultrafine Grinding of Soft Materials
EP2234619A4 (en) * 2008-04-18 2010-10-27 Medtronic Inc COMPOSITIONS AND METHODS FOR TREATING HERNIES DISCALES
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US8883768B2 (en) * 2008-04-18 2014-11-11 Warsaw Orthopedic, Inc. Fluocinolone implants to protect against undesirable bone and cartilage destruction
US7993666B2 (en) * 2008-04-18 2011-08-09 Warsaw Orthopedic, Inc. Methods and compositions for treating pain comprising a statin
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
US9289409B2 (en) 2008-04-18 2016-03-22 Warsaw Orthopedic, Inc. Sulindac formulations in a biodegradable material
US8524267B2 (en) 2008-04-18 2013-09-03 Warsaw Orthopedic, Inc. Dexamethasone formulations in a biodegradable material
US9492375B2 (en) 2008-07-23 2016-11-15 Warsaw Orthopedic, Inc. Foam carrier for bone grafting
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
US20100228097A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Methods and compositions to diagnose pain
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
US20110027331A1 (en) * 2009-07-29 2011-02-03 Warsaw Orthopedic, Inc. An implantable drug depot having a reversible phase transition material for treatment of pain and/or inflammation
US8653029B2 (en) 2009-07-30 2014-02-18 Warsaw Orthopedic, Inc. Flowable paste and putty bone void filler
US8597192B2 (en) 2009-10-30 2013-12-03 Warsaw Orthopedic, Inc. Ultrasonic devices and methods to diagnose pain generators
US8758791B2 (en) * 2010-01-26 2014-06-24 Warsaw Orthopedic, Inc. Highly compression resistant matrix with porous skeleton
US8475824B2 (en) * 2010-01-26 2013-07-02 Warsaw Orthopedic, Inc. Resorbable matrix having elongated particles
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
AU2015268647B2 (en) * 2010-08-04 2017-08-24 Flexion Therapeutics, Inc. Corticosteroids for the Treatment of Joint Pain
US9717779B2 (en) 2011-01-31 2017-08-01 Warsaw Orthopedic, Inc. Implantable matrix having optimum ligand concentrations
EP3281631A1 (en) 2011-08-04 2018-02-14 Flexion Therapeutics, Inc. Corticosteroids for the treatment of joint pain
ES2598753T3 (es) * 2012-11-27 2017-01-30 Eduardo Cos Alfonso Composición farmacéutica para el tratamiento de la tendinitis calcificada y/o bursitis calcificada
TWI624262B (zh) 2013-01-23 2018-05-21 桑紐爾製藥公司 醫藥配方
US20140271770A1 (en) * 2013-03-15 2014-09-18 Warsaw Orthopedic, Inc. Methods And Compositions For Treating Post-Operative Pain Comprising Clonidine
IL287731B2 (en) * 2013-03-21 2025-05-01 Eupraxia Pharmaceuticals USA LLC A sustained-release preparation for injection for the treatment of arthritis and resulting pain
TWI674899B (zh) 2015-01-21 2019-10-21 美商桑紐爾製藥公司 醫藥配方
ES2672993T3 (es) 2015-10-27 2018-06-19 Eupraxia Pharmaceuticals Inc. Formulaciones de liberación sostenida de anestésicos locales
SG11201809490YA (en) * 2016-04-29 2018-11-29 Enceladus Pharmaceuticals B V Liposomal corticosteroids for topical injection in inflamed lesions or areas
CN106983733A (zh) * 2017-03-08 2017-07-28 江苏富泽药业有限公司 曲安奈德plga缓释微球注射剂、其制备方法及其在制备治疗骨关节炎疼痛药物中的应用
BR102020010923A2 (pt) * 2020-05-29 2021-12-14 Luiz Peracchi Edson Implante subcutâneo reabsorvível de longa duração com liberação prolongada de substância farmacologicamente ativa pré-concentrada em polímero para tratamento da insuficiência adrenal crônica ou hipocortisolismo

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503695A (ja) * 1992-09-10 1996-04-23 チルドレンズ メディカル センター コーポレイション 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス
JPH11504634A (ja) * 1995-05-01 1999-04-27 チルドレンズ メディカル センター コーポレイション 局所麻酔薬とグルココルチコイドとの組み合わせによる延長された神経遮断
JPH11506450A (ja) * 1995-06-02 1999-06-08 オキュレックス ファーマシューティカルズ,インコーポレイティド 親水性及び疎水性薬剤の組合せによる薬剤の制御放出のための改良処方物
JP2000511941A (ja) * 1997-07-02 2000-09-12 ユーロ−セルティーク エス.エイ. 関節間隙および身体間隙における持効性麻酔
JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク,エス.エイ. 局所麻酔薬および使用法
WO2005110362A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Biodegradable ocular implants with long-term release characteristics
JP2006525953A (ja) * 2003-01-09 2006-11-16 アラーガン、インコーポレイテッド 生分解性眼用インプラント

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003510A1 (en) * 1989-08-28 1991-03-21 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
AU2001273623B2 (en) * 2000-06-22 2006-06-08 Spinal Restoration, Inc. Bioadhesive compositions and methods of preparation and use
EP2283845A1 (en) * 2001-04-26 2011-02-16 pSivida Inc. Sustained release drug delivery system containing codrugs
WO2003028660A2 (en) * 2001-10-04 2003-04-10 Case Western Reserve University Drug delivery devices and methods
JP5105697B2 (ja) * 2002-01-18 2012-12-26 シヴィダ・インコーポレイテッド コドラッグのコントロールデリバリ用ポリマー性ゲルシステム
DE10305811A1 (de) * 2003-02-12 2004-08-26 Ethicon Gmbh Chirurgisches Implantat
EP3173072A1 (en) * 2004-10-01 2017-05-31 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US20060253100A1 (en) * 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
US20070178138A1 (en) * 2006-02-01 2007-08-02 Allergan, Inc. Biodegradable non-opthalmic implants and related methods
US8673019B2 (en) * 2006-04-13 2014-03-18 Warsaw Orthopedic, Inc. Use of anti-inflammatory compounds with allograft tissue implantation
US7741273B2 (en) * 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503695A (ja) * 1992-09-10 1996-04-23 チルドレンズ メディカル センター コーポレイション 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス
JPH11504634A (ja) * 1995-05-01 1999-04-27 チルドレンズ メディカル センター コーポレイション 局所麻酔薬とグルココルチコイドとの組み合わせによる延長された神経遮断
JPH11506450A (ja) * 1995-06-02 1999-06-08 オキュレックス ファーマシューティカルズ,インコーポレイティド 親水性及び疎水性薬剤の組合せによる薬剤の制御放出のための改良処方物
JP2000511941A (ja) * 1997-07-02 2000-09-12 ユーロ−セルティーク エス.エイ. 関節間隙および身体間隙における持効性麻酔
JP2004521111A (ja) * 2001-01-25 2004-07-15 ユーロ−セルティーク,エス.エイ. 局所麻酔薬および使用法
JP2006525953A (ja) * 2003-01-09 2006-11-16 アラーガン、インコーポレイテッド 生分解性眼用インプラント
WO2005110362A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Biodegradable ocular implants with long-term release characteristics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012056437; Anesth Analg. Vol.56, No.6, 197712, p.862-863 *
JPN6012056439; J Bone Joint Surg Am. Vol.38, No.3, 1956, p.585-592 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018516910A (ja) * 2015-06-02 2018-06-28 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 神経外傷を制限するための処方物および方法
JP2023107784A (ja) * 2015-12-07 2023-08-03 プロキシマジェン,リミティド ライアビリティ カンパニー 疼痛の治療のためのvap-1阻害剤

Also Published As

Publication number Publication date
CN101765422A (zh) 2010-06-30
US20140336162A1 (en) 2014-11-13
WO2008157057A2 (en) 2008-12-24
US20080317805A1 (en) 2008-12-25
EP2170271A2 (en) 2010-04-07
WO2008157057A3 (en) 2010-01-28

Similar Documents

Publication Publication Date Title
JP2010530435A (ja) 局所的に投与される低用量のコルチコステロイド
US10624905B2 (en) Corticosteroids for the treatment of joint pain
JP2011518180A (ja) クロニジンを含んでなる、術後疼痛を治療するための方法及び組成物
JP6247720B2 (ja) 関節痛の治療のためのコルチコステロイド
AU2015268647B2 (en) Corticosteroids for the Treatment of Joint Pain

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101217

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121029

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130322