JP2010529080A5 - - Google Patents
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- Publication number
- JP2010529080A5 JP2010529080A5 JP2010510782A JP2010510782A JP2010529080A5 JP 2010529080 A5 JP2010529080 A5 JP 2010529080A5 JP 2010510782 A JP2010510782 A JP 2010510782A JP 2010510782 A JP2010510782 A JP 2010510782A JP 2010529080 A5 JP2010529080 A5 JP 2010529080A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- disorder
- stereoisomers
- difluorophenyl
- pyrrolidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- KVTILWXFURUWHL-UHFFFAOYSA-N 3-(3,4-difluorophenyl)pyrrolidine Chemical compound C1=C(F)C(F)=CC=C1C1CNCC1 KVTILWXFURUWHL-UHFFFAOYSA-N 0.000 claims 4
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000029364 generalized anxiety disease Diseases 0.000 claims 2
- 208000019906 panic disease Diseases 0.000 claims 2
- QSBSGFHTQBDWJV-UHFFFAOYSA-N 3-(2,4-difluorophenyl)pyrrolidine Chemical compound FC1=CC(F)=CC=C1C1CNCC1 QSBSGFHTQBDWJV-UHFFFAOYSA-N 0.000 claims 1
- BZRNHMNSDPKKHM-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)pyrrolidine Chemical compound C1=C(Cl)C(Cl)=CC=C1C1CNCC1 BZRNHMNSDPKKHM-UHFFFAOYSA-N 0.000 claims 1
- QDXUCQPDXXXLPM-UHFFFAOYSA-N 3-(3,4-difluorophenyl)-1-methylpyrrolidine Chemical compound C1N(C)CCC1C1=CC=C(F)C(F)=C1 QDXUCQPDXXXLPM-UHFFFAOYSA-N 0.000 claims 1
- NSNPKCDGEORKKV-UHFFFAOYSA-N 3-(3,5-difluorophenyl)pyrrolidine Chemical compound FC1=CC(F)=CC(C2CNCC2)=C1 NSNPKCDGEORKKV-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000012239 Developmental disease Diseases 0.000 claims 1
- 208000027534 Emotional disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 208000029560 autism spectrum disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 230000010249 dopaminergic function Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 201000001716 specific phobia Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 0 *c1cc(*)c(C2CN(*)CC2)cc1 Chemical compound *c1cc(*)c(C2CN(*)CC2)cc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94199307P | 2007-06-05 | 2007-06-05 | |
| SE0701386 | 2007-06-05 | ||
| PCT/EP2008/056912 WO2008148799A1 (en) | 2007-06-05 | 2008-06-04 | New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529080A JP2010529080A (ja) | 2010-08-26 |
| JP2010529080A5 true JP2010529080A5 (OSRAM) | 2011-07-21 |
Family
ID=39672106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510782A Pending JP2010529080A (ja) | 2007-06-05 | 2008-06-04 | 皮質カテコールアミン作動性神経伝達の調節因子としての新規な二置換フェニルピロリジン |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100197760A1 (OSRAM) |
| EP (1) | EP2155669B1 (OSRAM) |
| JP (1) | JP2010529080A (OSRAM) |
| CN (1) | CN101711234A (OSRAM) |
| AT (1) | ATE508110T1 (OSRAM) |
| AU (1) | AU2008258597A1 (OSRAM) |
| CA (1) | CA2689692A1 (OSRAM) |
| DE (1) | DE602008006720D1 (OSRAM) |
| MX (1) | MX2009012716A (OSRAM) |
| NZ (1) | NZ581363A (OSRAM) |
| WO (1) | WO2008148799A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2155671B8 (en) | 2007-06-05 | 2018-02-21 | Integrative Research Laboratories Sweden AB | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
| NZ592566A (en) | 2008-11-24 | 2013-03-28 | Nsab Af Neurosearch Sweden Ab | 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission |
| EP2367785B1 (en) | 2008-11-24 | 2014-10-15 | Integrative Research Laboratories Sweden AB | Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| KR101885190B1 (ko) * | 2011-03-31 | 2018-08-06 | 셰브런 유.에스.에이.인크. | 탈랍 촉매 안정성 및 윤활유 수율을 개선하기 위한 신규 방법 및 촉매 시스템 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US364414A (en) * | 1887-06-07 | Gael hollweg | ||
| US2878264A (en) * | 1959-03-17 | Substituted amino alcohols | ||
| US3118907A (en) * | 1961-08-14 | 1964-01-21 | Mead Johnson & Co | 3-substituted-3-pyrrolidinols |
| US3635982A (en) * | 1969-04-08 | 1972-01-18 | American Home Prod | Amino-substituted-quinoxalinyloxazolidines and -oxazines |
| CA2105666C (en) | 1991-04-17 | 2006-02-14 | Kjell Anders Ivan Svensson | New centrally acting substituted phenylazacycloalkanes |
| US5129962A (en) * | 1991-10-22 | 1992-07-14 | International Business Machines Corporation | Tacky, no-clean thermally dissipated soldering flux |
| US20020169155A1 (en) * | 1998-09-04 | 2002-11-14 | Millennium Pharmaceuticals, Inc. | Chemokine receptor anagonists and methods of use therefor |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| TWI308976B (en) * | 2003-02-14 | 2009-04-21 | Chunghwa Picture Tubes Ltd | Process and structure of linquid crystal panel with one drop fill |
| EA200701782A3 (ru) * | 2003-04-24 | 2008-04-28 | Инсайт Корпорейшн | Производные азаспироалканов в качестве ингибиторов металлопротеаз |
| JP4765627B2 (ja) * | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
| TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| KR100690854B1 (ko) * | 2005-11-08 | 2007-03-09 | 엘지전자 주식회사 | 멀티태스킹이 가능한 휴대용 단말기 및 그의 멀티태스킹처리방법 |
| EP1966164B1 (en) * | 2005-12-21 | 2013-03-06 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
| US20080070649A1 (en) * | 2006-09-06 | 2008-03-20 | Uchida Toshi K | Free Space Optical Interconnections in Cellular Telephone Handsets |
-
2008
- 2008-06-04 CA CA2689692A patent/CA2689692A1/en not_active Abandoned
- 2008-06-04 CN CN200880018786A patent/CN101711234A/zh active Pending
- 2008-06-04 AT AT08760493T patent/ATE508110T1/de not_active IP Right Cessation
- 2008-06-04 JP JP2010510782A patent/JP2010529080A/ja active Pending
- 2008-06-04 US US12/663,211 patent/US20100197760A1/en not_active Abandoned
- 2008-06-04 AU AU2008258597A patent/AU2008258597A1/en not_active Abandoned
- 2008-06-04 MX MX2009012716A patent/MX2009012716A/es active IP Right Grant
- 2008-06-04 WO PCT/EP2008/056912 patent/WO2008148799A1/en not_active Ceased
- 2008-06-04 NZ NZ581363A patent/NZ581363A/en unknown
- 2008-06-04 DE DE602008006720T patent/DE602008006720D1/de active Active
- 2008-06-04 EP EP08760493A patent/EP2155669B1/en not_active Not-in-force
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