JP2010528039A - 被覆されたヒアルロン酸粒子 - Google Patents

被覆されたヒアルロン酸粒子 Download PDF

Info

Publication number
JP2010528039A
JP2010528039A JP2010509527A JP2010509527A JP2010528039A JP 2010528039 A JP2010528039 A JP 2010528039A JP 2010509527 A JP2010509527 A JP 2010509527A JP 2010509527 A JP2010509527 A JP 2010509527A JP 2010528039 A JP2010528039 A JP 2010528039A
Authority
JP
Japan
Prior art keywords
hyaluronic acid
coated
particles
composition
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010509527A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010528039A5 (enExample
Inventor
ジュリー・エイ・チャンピオン
サミール・ミトラゴトリ
アーメト・テゼル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2010528039A publication Critical patent/JP2010528039A/ja
Publication of JP2010528039A5 publication Critical patent/JP2010528039A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
JP2010509527A 2007-05-23 2008-05-21 被覆されたヒアルロン酸粒子 Pending JP2010528039A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93965907P 2007-05-23 2007-05-23
PCT/US2008/064378 WO2008147817A2 (en) 2007-05-23 2008-05-21 Coated hyaluronic acid particles

Publications (2)

Publication Number Publication Date
JP2010528039A true JP2010528039A (ja) 2010-08-19
JP2010528039A5 JP2010528039A5 (enExample) 2011-07-07

Family

ID=39645603

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010509527A Pending JP2010528039A (ja) 2007-05-23 2008-05-21 被覆されたヒアルロン酸粒子

Country Status (7)

Country Link
US (2) US20090022808A1 (enExample)
EP (1) EP2162158A2 (enExample)
JP (1) JP2010528039A (enExample)
AU (1) AU2008256864A1 (enExample)
BR (1) BRPI0811777A2 (enExample)
CA (1) CA2687983A1 (enExample)
WO (1) WO2008147817A2 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017502972A (ja) * 2013-12-31 2017-01-26 ペベエベ・エスア 身体再建及び身体成形における使用のための制御放出脂肪酸組成物
KR101769739B1 (ko) * 2017-01-18 2017-08-21 구태훈 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법
KR101781288B1 (ko) * 2016-01-26 2017-09-26 서울과학기술대학교 산학협력단 친수성 고분자 및 소수성 고분자를 포함하는 하이드로젤 입자 및 그의 제조방법
KR20180067197A (ko) * 2016-12-12 2018-06-20 구태훈 구형 입자를 갖는 연조직용 필러 및, 그 제조방법
KR20180085341A (ko) * 2017-01-18 2018-07-26 구태훈 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법
JP2021522938A (ja) * 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ 細胞及び組織の送達のためのナノファイバー−ハイドロゲル複合体
JP2021522926A (ja) * 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ 軟組織の補填及び再生の増強のためのナノファイバー−ハイドロゲル複合体
US11684700B2 (en) 2014-08-15 2023-06-27 The Johns Hopkins University Composite material for tissue restoration

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20060073208A1 (en) * 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
CA2687990A1 (en) * 2007-05-23 2008-12-04 Allergan, Inc. Cross-linked collagen and uses thereof
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
PT2818184T (pt) 2007-11-16 2019-01-28 Aclaris Therapeutics Inc Composições e métodos para o tratamento de púrpura
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
WO2009108760A2 (en) 2008-02-26 2009-09-03 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
CA2735173C (en) 2008-09-02 2017-01-10 Tautona Group Lp Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
JP4885245B2 (ja) * 2009-01-15 2012-02-29 日本航空電子工業株式会社 Rdコンバータ及び角度検出装置
US20120295914A1 (en) * 2009-05-29 2012-11-22 Galderma Research & Development Combination of adrenergic receptor agonist alpha-1 or alpha-2, preferably brimonidine with fillers, preferably hyaluronic acid
FR2948286B1 (fr) 2009-07-27 2011-08-26 Jean-Noel Thorel Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes
US20110172180A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US20110171310A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
FR2955258A1 (fr) 2010-01-20 2011-07-22 Biopharmex Holding Ltd Composition injectable
US8586562B2 (en) 2010-03-12 2013-11-19 Allergan Industrie, Sas Fluid compositions for improving skin conditions
EP4062950A1 (en) 2010-03-22 2022-09-28 Allergan, Inc. Syringe comprising dermal filler for soft tissue augmentation
EP2404993A1 (en) * 2010-07-09 2012-01-11 Merz Pharma GmbH & Co. KGaA Alginate filler including eukaryotic cells
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8946194B2 (en) 2010-10-08 2015-02-03 Board Of Regents, University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
US9095558B2 (en) 2010-10-08 2015-08-04 Board Of Regents, The University Of Texas System Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
RU2624239C2 (ru) 2011-06-03 2017-07-03 Аллерган, Инк. Составы кожного наполнителя, включая антиоксиданты
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20150252120A1 (en) 2012-10-09 2015-09-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Modified hyaluronic acid derivatives and use thereof
BR112015013774A2 (pt) 2012-12-11 2017-07-11 Univ Texas membrana de hidrogel para prevenção de adesão
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
US20160143943A1 (en) 2013-07-08 2016-05-26 Denka Company Limited Core-Shell Crosslinked Hyaluronic Acid Gel Particles, Production Method for Same, and Medical Material
WO2015018461A1 (fr) 2013-08-09 2015-02-12 Genbiotech Compositions therapeutiques comprenant d'acide hyaluronique
US20150209265A1 (en) * 2014-01-27 2015-07-30 Allergan Holdings France S.A.S. Spherical forms of cross-linked hyaluronic acid and methods of use thereof
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
RU2715234C2 (ru) 2015-02-13 2020-02-26 Аллерган Эндюстри, Сас Имплантаты для моделирования, увеличения или коррекции частей лица, например подбородка
WO2018102480A1 (en) * 2016-11-30 2018-06-07 Brown University Methods of fabricating hyper compliant polymer particles and methods of use and compositions
US11980700B2 (en) 2017-03-08 2024-05-14 Alafair Biosciences, Inc. Hydrogel medium for the storage and preservation of tissue
CN111770739B (zh) * 2018-02-18 2024-10-25 G&G生物技术有限公司 具有增强的壳粘附性的植入物
WO2019191405A1 (en) * 2018-03-29 2019-10-03 Ayyala Ramesh S Methods and compositions for delivery of a therapeutic agent
KR102955766B1 (ko) 2018-05-03 2026-04-22 콜플랜트 리미티드 진피 충전제 및 이의 적용
CN110575564B (zh) * 2019-09-30 2020-05-08 张勇 用于医学整形美容的填充物及其制备方法和应用
US20220362437A1 (en) * 2021-05-13 2022-11-17 Shanghai Qisheng Biological Preparation Co., Ltd. Hyaluronic Acid Compositions Containing Slowly Resorbable Polymers
EP4395796A4 (en) 2021-09-01 2024-12-25 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
EP4457266A4 (en) 2021-12-28 2025-10-22 Shanghai Qisheng Biological Preparation Co Ltd HYALURONIC ACID-COLLAGEN COPOLYMER COMPOSITIONS AND THEIR MEDICAL APPLICATIONS
CN115721615B (zh) * 2022-11-17 2024-08-30 华熙生物科技股份有限公司 一种透明质酸颗粒及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11507679A (ja) * 1995-06-06 1999-07-06 シー.アール.バード,インコーポレイティド 水溶性ポリマーの粒子の水性分散液の製造法および得られた粒子
JP2006504448A (ja) * 2002-07-02 2006-02-09 プロサイト コーポレイション ペプチド銅錯体および軟組織充填物を含有する組成物
WO2006125620A2 (en) * 2005-05-27 2006-11-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2128827A (en) * 1938-03-09 1938-08-30 Frank B Killian Method and apparatus for manufacturing thin rubber articles
US5643464A (en) * 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
EP0680525B1 (en) * 1993-01-20 1997-05-07 E.R. SQUIBB & SONS, INC. Fibres
US6214331B1 (en) * 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6007843A (en) * 1995-09-29 1999-12-28 Lam Pharmaceuticals Corp. Sustained release delivery system
US5935164A (en) * 1997-02-25 1999-08-10 Pmt Corporaton Laminated prosthesis and method of manufacture
FR2764514B1 (fr) * 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US6773723B1 (en) * 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
CA2424896A1 (en) * 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
JP2005513081A (ja) * 2000-12-13 2005-05-12 パーデュー・リサーチ・ファウンデイション 溶媒交換による薬剤のマイクロカプセル化
US6979440B2 (en) * 2001-01-29 2005-12-27 Salvona, Llc Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric
US6780366B2 (en) * 2002-08-15 2004-08-24 Mentor Corporation Drip retainer
KR100523953B1 (ko) * 2002-08-27 2005-10-25 주식회사 엘지생명과학 천연다당류와 히알루론산의 마이크로비드 및 이의 제조 방법
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
JP2008502690A (ja) * 2004-06-15 2008-01-31 アンドリュー シァン チェン, リン脂質組成物ならびにその調製方法および使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11507679A (ja) * 1995-06-06 1999-07-06 シー.アール.バード,インコーポレイティド 水溶性ポリマーの粒子の水性分散液の製造法および得られた粒子
JP2006504448A (ja) * 2002-07-02 2006-02-09 プロサイト コーポレイション ペプチド銅錯体および軟組織充填物を含有する組成物
WO2006125620A2 (en) * 2005-05-27 2006-11-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017502972A (ja) * 2013-12-31 2017-01-26 ペベエベ・エスア 身体再建及び身体成形における使用のための制御放出脂肪酸組成物
US11684700B2 (en) 2014-08-15 2023-06-27 The Johns Hopkins University Composite material for tissue restoration
KR101781288B1 (ko) * 2016-01-26 2017-09-26 서울과학기술대학교 산학협력단 친수성 고분자 및 소수성 고분자를 포함하는 하이드로젤 입자 및 그의 제조방법
KR20180067197A (ko) * 2016-12-12 2018-06-20 구태훈 구형 입자를 갖는 연조직용 필러 및, 그 제조방법
KR101879065B1 (ko) * 2016-12-12 2018-07-17 구태훈 구형 입자를 갖는 연조직용 필러 및, 그 제조방법
KR101769739B1 (ko) * 2017-01-18 2017-08-21 구태훈 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법
KR20180085341A (ko) * 2017-01-18 2018-07-26 구태훈 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법
KR102363007B1 (ko) * 2017-01-18 2022-02-14 구태훈 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법
JP2021522938A (ja) * 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ 細胞及び組織の送達のためのナノファイバー−ハイドロゲル複合体
JP2021522926A (ja) * 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ 軟組織の補填及び再生の増強のためのナノファイバー−ハイドロゲル複合体
US11771807B2 (en) 2018-05-09 2023-10-03 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
US12161781B2 (en) 2018-05-09 2024-12-10 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery

Also Published As

Publication number Publication date
WO2008147817A2 (en) 2008-12-04
WO2008147817A3 (en) 2009-11-05
US20090022808A1 (en) 2009-01-22
EP2162158A2 (en) 2010-03-17
BRPI0811777A2 (pt) 2019-09-24
US20100217403A1 (en) 2010-08-26
AU2008256864A1 (en) 2008-12-04
CA2687983A1 (en) 2008-12-04

Similar Documents

Publication Publication Date Title
US20100217403A1 (en) Swellable hyaluronic acid particles
CN100582146C (zh) 生物相容性交联凝胶
EP2766056B1 (en) Threads of cross-linked hyaluronic acid and methods of use thereof
KR20170123099A (ko) 폴리카프로락톤 및 히알루론산을 포함하는 피부용 필러 조성물
JP6096844B2 (ja) 組織を分離する脂肪酸癒着障壁
US9744260B2 (en) Timing controlled in-situ cross-linking of halyuronic acid during injection
HU220257B (hu) Poliszacharid gélkészítmények
WO2013071216A1 (en) Injectable filler
JP5518288B2 (ja) 癒着阻止用医用材料
KR102385241B1 (ko) 가교 히알루론산과 plla 필러 결합체를 포함하는 필러 주사제제 및 이의 제조방법
US20150209265A1 (en) Spherical forms of cross-linked hyaluronic acid and methods of use thereof
CN110072921A (zh) 生物降解性高分子的多孔性微粒及包含其的高分子填充物
CN118434459A (zh) 使用可注射、中性pH可溶性胶原-糖胺聚糖组合物的软组织充填
US20130273115A1 (en) Injectable filler
Shen et al. Injectable amino-modified poly-L-lactic acid microspheres/hyaluronic acid-based hydrogel composites for soft tissue fillers
WO2014169299A1 (en) Temperature-release catalyst for cross-linking halyuronic acid during injection
US9220807B2 (en) Non-toxic cross-linker for hyaluronic acid
US20140329756A1 (en) Temperature-release catalyst for cross-linking halyuronic acid during injection
WO2014169300A1 (en) Non-toxic cross-linker for halyuronic acid
WO2021201150A1 (ja) 生体吸収性医療材料
WO1993013755A1 (fr) Composition injectable contenant des microcapsules de collagene
CN118987362A (zh) 一种仿生细胞外基质的复合填充剂及其制备方法
JP2009167136A (ja) 徐放性微粒子および徐放性微粒子の製造方法
KR100824726B1 (ko) 골조직 침투형 골유착 임플란트
HK40117985A (en) Hydrogel microparticle-based soft tissue fillers

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110523

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110523

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130305

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130307

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130730