JP2010527988A5 - - Google Patents
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- Publication number
- JP2010527988A5 JP2010527988A5 JP2010508932A JP2010508932A JP2010527988A5 JP 2010527988 A5 JP2010527988 A5 JP 2010527988A5 JP 2010508932 A JP2010508932 A JP 2010508932A JP 2010508932 A JP2010508932 A JP 2010508932A JP 2010527988 A5 JP2010527988 A5 JP 2010527988A5
- Authority
- JP
- Japan
- Prior art keywords
- surface antigen
- cell surface
- bone marrow
- cells
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710160107 Outer membrane protein A Proteins 0.000 claims 39
- 210000004027 cell Anatomy 0.000 claims 21
- 210000000130 stem cell Anatomy 0.000 claims 19
- 210000001185 bone marrow Anatomy 0.000 claims 18
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 230000000735 allogeneic effect Effects 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 10
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 8
- 208000024908 graft versus host disease Diseases 0.000 claims 8
- 208000024891 symptom Diseases 0.000 claims 8
- 102000003814 Interleukin-10 Human genes 0.000 claims 7
- 108090000174 Interleukin-10 Proteins 0.000 claims 7
- 229940076144 interleukin-10 Drugs 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 6
- 102000018866 Hyaluronan Receptors Human genes 0.000 claims 6
- 102100025304 Integrin beta-1 Human genes 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 239000006228 supernatant Substances 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000002798 bone marrow cell Anatomy 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 102000004008 5'-Nucleotidase Human genes 0.000 claims 3
- 102000012085 Endoglin Human genes 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
- 238000000432 density-gradient centrifugation Methods 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 108010039918 Polylysine Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 238000012136 culture method Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000016332 liver symptom Diseases 0.000 claims 2
- 229920000656 polylysine Polymers 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000024340 acute graft versus host disease Diseases 0.000 claims 1
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2007-0053298 | 2007-05-31 | ||
| KR1020070053298A KR20080105555A (ko) | 2007-05-31 | 2007-05-31 | 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 |
| PCT/IB2008/003005 WO2009040666A2 (en) | 2007-05-25 | 2008-05-27 | Treatment of graft-versus-host disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527988A JP2010527988A (ja) | 2010-08-19 |
| JP2010527988A5 true JP2010527988A5 (https=) | 2012-07-05 |
| JP5683264B2 JP5683264B2 (ja) | 2015-03-11 |
Family
ID=40072607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508932A Active JP5683264B2 (ja) | 2007-05-31 | 2008-05-27 | 移植片対宿主病の治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080292601A1 (https=) |
| EP (1) | EP2160100B8 (https=) |
| JP (1) | JP5683264B2 (https=) |
| KR (1) | KR20080105555A (https=) |
| CN (1) | CN101754767A (https=) |
| ES (1) | ES2628362T3 (https=) |
| WO (1) | WO2009040666A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080105555A (ko) * | 2007-05-31 | 2008-12-04 | 인하대학교 산학협력단 | 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 |
| US8545888B2 (en) * | 2007-06-14 | 2013-10-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tendon stem cells |
| KR20200011604A (ko) | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
| EP2454363B1 (en) | 2009-07-13 | 2020-07-22 | Biogencell, Ltd. | Method for using directing cells for specific stem/progenitor cell activation and differentiation |
| KR101694554B1 (ko) * | 2011-08-30 | 2017-01-18 | 가톨릭대학교 산학협력단 | 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물 |
| KR101705378B1 (ko) * | 2011-09-23 | 2017-02-13 | 가톨릭대학교 산학협력단 | 간엽줄기세포 및 ⅰｌ-21 차단제를 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물 |
| US8956870B2 (en) | 2012-01-19 | 2015-02-17 | Biogencell, Ltd. | Method for using directing cells for specific stem/progenitor cell activation and differentiation |
| WO2016116507A1 (en) * | 2015-01-20 | 2016-07-28 | Ge Healthcare Bio-Sciences Corp | Process simulation in cell a processing facility |
| EP3595683A1 (en) | 2017-03-15 | 2020-01-22 | Orca Biosystems, Inc. | Compositions and methods for hematopoietic stem cell transplants |
| US12011460B2 (en) | 2018-02-20 | 2024-06-18 | Universite De Montreal | Expansion of NK and DC cells in vivo mediating immune response |
| KR102096886B1 (ko) * | 2018-06-04 | 2020-04-03 | 이화여자대학교 산학협력단 | 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 이식편대숙주 질환 예방 혹은 치료용 조성물 |
| CN109674818A (zh) * | 2018-09-29 | 2019-04-26 | 南方医科大学南方医院 | hAMSCs在制备治疗急性移植物抗宿主病药物中的用途 |
| US20220387504A1 (en) * | 2018-12-17 | 2022-12-08 | Scm Lifescience Co., Ltd. | Pharmaceutical composition comprising clonal stem cells for treating graft-versus-host disease |
| CN115361960A (zh) * | 2020-02-19 | 2022-11-18 | 迈索布拉斯特国际有限公司 | 用于治疗慢性移植物抗宿主病的方法 |
| EP4132544A4 (en) * | 2020-04-06 | 2024-10-23 | Rxcell Inc. | HYPOIMMUNOGENIC CELLS AND METHODS AND COMPOSITIONS FOR THEIR PRODUCTION |
| KR102880836B1 (ko) * | 2024-03-11 | 2025-11-04 | 에스씨엠생명과학 주식회사 | 중간엽 줄기세포의 대량 배양 방법 |
| KR102880848B1 (ko) * | 2024-03-11 | 2025-11-04 | 에스씨엠생명과학 주식회사 | 중간엽 줄기세포의 신속 층분리 배양 방법 |
| WO2025192960A1 (ko) * | 2024-03-11 | 2025-09-18 | 에스씨엠생명과학 주식회사 | 중간엽 줄기세포의 신속 층분리 배양 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5426098A (en) * | 1993-09-02 | 1995-06-20 | Celtrix Pharmaceuticals, Inc. | Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor beta |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US6082364A (en) | 1997-12-15 | 2000-07-04 | Musculoskeletal Development Enterprises, Llc | Pluripotential bone marrow cell line and methods of using the same |
| AU755888B2 (en) | 1998-03-18 | 2003-01-02 | Mesoblast International Sarl | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US7303769B2 (en) | 2000-06-05 | 2007-12-04 | University Of South Florida | Method for purifying pluri-differentiated mesenchymal progenitor cells |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| EP2298864B1 (en) * | 2004-03-22 | 2017-10-11 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| US7781211B2 (en) * | 2005-06-17 | 2010-08-24 | Homeotherapy, Co. Ltd | Isolation of multi-lineage stem cells |
| KR20080105555A (ko) | 2007-05-31 | 2008-12-04 | 인하대학교 산학협력단 | 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법 |
-
2007
- 2007-05-31 KR KR1020070053298A patent/KR20080105555A/ko not_active Ceased
-
2008
- 2008-05-27 CN CN200880100116A patent/CN101754767A/zh active Pending
- 2008-05-27 ES ES08834068.2T patent/ES2628362T3/es active Active
- 2008-05-27 US US12/127,743 patent/US20080292601A1/en not_active Abandoned
- 2008-05-27 US US12/127,734 patent/US9439929B2/en active Active
- 2008-05-27 JP JP2010508932A patent/JP5683264B2/ja active Active
- 2008-05-27 EP EP08834068.2A patent/EP2160100B8/en active Active
- 2008-05-27 WO PCT/IB2008/003005 patent/WO2009040666A2/en not_active Ceased
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