CN101754767A - 移植物抗宿主疾病的治疗 - Google Patents

移植物抗宿主疾病的治疗 Download PDF

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Publication number
CN101754767A
CN101754767A CN200880100116A CN200880100116A CN101754767A CN 101754767 A CN101754767 A CN 101754767A CN 200880100116 A CN200880100116 A CN 200880100116A CN 200880100116 A CN200880100116 A CN 200880100116A CN 101754767 A CN101754767 A CN 101754767A
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Prior art keywords
bone marrow
cell
cells
stem cell
clone
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CN200880100116A
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Chinese (zh)
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宋淳旭
李文熙
金喆守
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Inha Industry Partnership Institute
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Inha Industry Partnership Institute
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880100116A 2007-05-25 2008-05-27 移植物抗宿主疾病的治疗 Pending CN101754767A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94034907P 2007-05-25 2007-05-25
US60/940,349 2007-05-25
KR10-2007-0053298 2007-05-31
KR1020070053298A KR20080105555A (ko) 2007-05-31 2007-05-31 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법
PCT/IB2008/003005 WO2009040666A2 (en) 2007-05-25 2008-05-27 Treatment of graft-versus-host disease

Publications (1)

Publication Number Publication Date
CN101754767A true CN101754767A (zh) 2010-06-23

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ID=40072607

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880100116A Pending CN101754767A (zh) 2007-05-25 2008-05-27 移植物抗宿主疾病的治疗

Country Status (7)

Country Link
US (2) US20080292601A1 (https=)
EP (1) EP2160100B8 (https=)
JP (1) JP5683264B2 (https=)
KR (1) KR20080105555A (https=)
CN (1) CN101754767A (https=)
ES (1) ES2628362T3 (https=)
WO (1) WO2009040666A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674818A (zh) * 2018-09-29 2019-04-26 南方医科大学南方医院 hAMSCs在制备治疗急性移植物抗宿主病药物中的用途
CN115361960A (zh) * 2020-02-19 2022-11-18 迈索布拉斯特国际有限公司 用于治疗慢性移植物抗宿主病的方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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KR20080105555A (ko) * 2007-05-31 2008-12-04 인하대학교 산학협력단 중간엽 골수세포를 이용한 이식편대숙주질환 치료제 및치료방법
US8545888B2 (en) * 2007-06-14 2013-10-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Tendon stem cells
KR20200011604A (ko) 2008-08-20 2020-02-03 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
EP2454363B1 (en) 2009-07-13 2020-07-22 Biogencell, Ltd. Method for using directing cells for specific stem/progenitor cell activation and differentiation
KR101694554B1 (ko) * 2011-08-30 2017-01-18 가톨릭대학교 산학협력단 자연살해세포 억제제 및 간엽줄기세포를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료를 위한 세포치료제 조성물
KR101705378B1 (ko) * 2011-09-23 2017-02-13 가톨릭대학교 산학협력단 간엽줄기세포 및 ⅰｌ-21 차단제를 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물
US8956870B2 (en) 2012-01-19 2015-02-17 Biogencell, Ltd. Method for using directing cells for specific stem/progenitor cell activation and differentiation
WO2016116507A1 (en) * 2015-01-20 2016-07-28 Ge Healthcare Bio-Sciences Corp Process simulation in cell a processing facility
EP3595683A1 (en) 2017-03-15 2020-01-22 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants
US12011460B2 (en) 2018-02-20 2024-06-18 Universite De Montreal Expansion of NK and DC cells in vivo mediating immune response
KR102096886B1 (ko) * 2018-06-04 2020-04-03 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 이식편대숙주 질환 예방 혹은 치료용 조성물
US20220387504A1 (en) * 2018-12-17 2022-12-08 Scm Lifescience Co., Ltd. Pharmaceutical composition comprising clonal stem cells for treating graft-versus-host disease
EP4132544A4 (en) * 2020-04-06 2024-10-23 Rxcell Inc. HYPOIMMUNOGENIC CELLS AND METHODS AND COMPOSITIONS FOR THEIR PRODUCTION
KR102880836B1 (ko) * 2024-03-11 2025-11-04 에스씨엠생명과학 주식회사 중간엽 줄기세포의 대량 배양 방법
KR102880848B1 (ko) * 2024-03-11 2025-11-04 에스씨엠생명과학 주식회사 중간엽 줄기세포의 신속 층분리 배양 방법
WO2025192960A1 (ko) * 2024-03-11 2025-09-18 에스씨엠생명과학 주식회사 중간엽 줄기세포의 신속 층분리 배양 방법

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WO1999047163A2 (en) * 1998-03-18 1999-09-23 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US20050142119A1 (en) * 2000-06-05 2005-06-30 Beerelli Seshi Human mesenchymal progenitor cell
US20060286669A1 (en) * 2005-06-17 2006-12-21 Song Sun U Isolation of multi-lineage stem cells
US20080292601A1 (en) * 2007-05-25 2008-11-27 Song Sun Uk Treatment of graft-versus-host disease with il-10 expressing cells

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US20050142119A1 (en) * 2000-06-05 2005-06-30 Beerelli Seshi Human mesenchymal progenitor cell
US20060286669A1 (en) * 2005-06-17 2006-12-21 Song Sun U Isolation of multi-lineage stem cells
US20080292601A1 (en) * 2007-05-25 2008-11-27 Song Sun Uk Treatment of graft-versus-host disease with il-10 expressing cells

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674818A (zh) * 2018-09-29 2019-04-26 南方医科大学南方医院 hAMSCs在制备治疗急性移植物抗宿主病药物中的用途
CN115361960A (zh) * 2020-02-19 2022-11-18 迈索布拉斯特国际有限公司 用于治疗慢性移植物抗宿主病的方法

Also Published As

Publication number Publication date
US20080292600A1 (en) 2008-11-27
EP2160100B8 (en) 2017-07-05
ES2628362T3 (es) 2017-08-02
EP2160100A4 (en) 2011-08-31
WO2009040666A2 (en) 2009-04-02
JP5683264B2 (ja) 2015-03-11
EP2160100B1 (en) 2017-03-15
WO2009040666A3 (en) 2009-12-30
US20080292601A1 (en) 2008-11-27
US20160166614A9 (en) 2016-06-16
EP2160100A2 (en) 2010-03-10
US9439929B2 (en) 2016-09-13
JP2010527988A (ja) 2010-08-19
KR20080105555A (ko) 2008-12-04

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