JP2010527980A5 - - Google Patents

Download PDF

Info

Publication number
JP2010527980A5
JP2010527980A5 JP2010508908A JP2010508908A JP2010527980A5 JP 2010527980 A5 JP2010527980 A5 JP 2010527980A5 JP 2010508908 A JP2010508908 A JP 2010508908A JP 2010508908 A JP2010508908 A JP 2010508908A JP 2010527980 A5 JP2010527980 A5 JP 2010527980A5
Authority
JP
Japan
Prior art keywords
alkyl
aryl
acceptable salt
pharmaceutically acceptable
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010508908A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010527980A (ja
Filing date
Publication date
Priority claimed from GB0709789A external-priority patent/GB0709789D0/en
Priority claimed from GB0800454A external-priority patent/GB0800454D0/en
Application filed filed Critical
Priority claimed from PCT/GB2008/050370 external-priority patent/WO2008142454A1/en
Publication of JP2010527980A publication Critical patent/JP2010527980A/ja
Publication of JP2010527980A5 publication Critical patent/JP2010527980A5/ja
Pending legal-status Critical Current

Links

JP2010508908A 2007-05-22 2008-05-22 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物 Pending JP2010527980A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0709789A GB0709789D0 (en) 2007-05-22 2007-05-22 Compounds
GB0800454A GB0800454D0 (en) 2008-01-11 2008-01-11 Compounds
PCT/GB2008/050370 WO2008142454A1 (en) 2007-05-22 2008-05-22 Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders

Publications (2)

Publication Number Publication Date
JP2010527980A JP2010527980A (ja) 2010-08-19
JP2010527980A5 true JP2010527980A5 (enExample) 2011-07-07

Family

ID=39643985

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010508908A Pending JP2010527980A (ja) 2007-05-22 2008-05-22 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物

Country Status (4)

Country Link
US (1) US8278442B2 (enExample)
EP (1) EP2152671A1 (enExample)
JP (1) JP2010527980A (enExample)
WO (1) WO2008142454A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010527980A (ja) 2007-05-22 2010-08-19 プロシディオン・リミテッド 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物
EP2197835A1 (en) * 2007-09-07 2010-06-23 Prosidion Limited Bicyclic aryl and heteroaryl receptor modulators
WO2012090177A2 (en) * 2010-12-30 2012-07-05 Lupin Limited Cannabinoid receptor modulators
IN2014MN00226A (enExample) * 2011-07-05 2015-09-25 Lupin Ltd
ES2660287T3 (es) * 2012-08-06 2018-03-21 Biogen Ma Inc. Compuestos que son agentes moduladores de s1p y/o agentes moduladores de atx
AU2014354085B2 (en) 2013-11-20 2018-04-26 Ube Corporation Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes
CN107001259B (zh) 2014-08-27 2019-12-06 豪夫迈·罗氏有限公司 作为taar配体的取代的氮杂环丁烷衍生物
WO2016185032A1 (en) * 2015-05-20 2016-11-24 Integrative Research Laboratories Sweden Ab Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission
CN105330616B (zh) * 2015-12-09 2017-09-26 苏州明锐医药科技有限公司 卡利拉嗪的制备方法
AU2017340403B2 (en) 2016-10-05 2022-03-17 The United States as Represented by the Department of Veterans Affairs Small molecule AMPK activators
CN106588842A (zh) * 2016-12-05 2017-04-26 天津羲泽润科技有限公司 一种合成7‑甲氧基‑1‑苯并呋喃‑4‑甲醛的方法
EP4027987A4 (en) 2019-09-10 2023-11-29 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods and materials for increasing level of phosphorylated ampk protein
WO2023165874A1 (en) * 2022-03-01 2023-09-07 Syngenta Crop Protection Ag Pyrimidinyl-oxy-quinoline based herbicidal compounds

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225080B1 (en) * 1992-03-23 2001-05-01 George R. Uhl Mu-subtype opioid receptor
US6235496B1 (en) 1993-03-08 2001-05-22 Advanced Research & Technology Institute Nucleic acid encoding mammalian mu opioid receptor
US5658783A (en) * 1993-11-08 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Mammalian methadone-specific opioid receptor gene and uses
US5821219A (en) 1995-08-11 1998-10-13 Oregon Health Sciences University Opioid antagonists and methods of their use
AU2003239389A1 (en) 2002-05-30 2003-12-19 Eli Lilly And Company Opioid receptor antagonists
PL212616B1 (pl) * 2002-09-19 2012-10-31 Lilly Co Eli Eter diarylowy i kompozycja farmaceutyczna zawierajaca ten eter
BRPI0407616A (pt) * 2003-03-07 2006-02-14 Lilly Co Eli composto, composição farmacêutica, método para bloquear uma combinação de receptor de mu, capa, delta (heterodìmero) deste em mamìferos, método para tratar ou prevenir obesidade e doenças relacionadas, uso de um composto, e método de suprimir o apetite em um paciente em necessidade deste"
WO2004080996A1 (en) 2003-03-07 2004-09-23 Eli Lilly And Company Opioid receptor antagonists
JP2007516256A (ja) 2003-12-12 2007-06-21 イーライ リリー アンド カンパニー オピオイド受容体拮抗物質
CN1894240A (zh) 2003-12-22 2007-01-10 伊莱利利公司 阿片受体拮抗剂
ATE399164T1 (de) 2004-03-12 2008-07-15 Lilly Co Eli Antagonisten des opioidrezeptors
US7381750B2 (en) 2004-03-12 2008-06-03 Eli Lilly And Company Amino-phenoxymethyl-benzamide opioid receptor antagonists
ES2318472T3 (es) 2004-03-15 2009-05-01 Eli Lilly And Company Derivados de 5-(5-(aminoetil)-indol-1-ilmetil)-benzamida y compuestos relacionados como antagonistas del receptor opioide para el tratamiento de la obesidad.
CA2557794A1 (en) 2004-03-15 2005-10-06 Eli Lilly And Company Opioid receptor antagonists
EP1943226A2 (en) 2005-10-13 2008-07-16 Smithkline Beecham Corporation Phenol ethers as modulators of the opioid receptors
JP5362565B2 (ja) 2006-08-09 2013-12-11 スミスクライン ビーチャム コーポレーション オピオイド受容体のアンタゴニストまたはインバースアゴニストである新規化合物
US20100222345A1 (en) 2006-08-09 2010-09-02 Caroline Jean Diaz Novel compounds as antagonists or inverse agonists for opioid receptors
KR20090051778A (ko) 2006-09-08 2009-05-22 화이자 프로덕츠 인코포레이티드 다이아릴 에터 유도체 및 이의 용도
KR20090064478A (ko) 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
JP2010527980A (ja) 2007-05-22 2010-08-19 プロシディオン・リミテッド 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物
US20100113512A1 (en) * 2008-10-30 2010-05-06 Diane Michele Ignar Method of treatment using novel antagonists or inverse agonists at opioid receptors

Similar Documents

Publication Publication Date Title
JP2010527980A5 (enExample)
JP2009533410A5 (enExample)
AU2014219283C1 (en) Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
JP2010514832A5 (enExample)
JP2010514831A5 (enExample)
JP2007508361A5 (enExample)
JP2011500658A5 (enExample)
JP2011500659A5 (enExample)
EA032028B1 (ru) СТИМУЛЯТОРЫ рГЦ
JP2018039825A (ja) Ｔｒｋ阻害化合物
CN103298799B (zh) 适用于治疗血脂异常的杂环化合物
JP2019532079A5 (enExample)
JP2007508360A5 (enExample)
JP2014508811A5 (enExample)
UA74066C2 (en) Derivatives of 4,5-dihydro-1n-pyrazole with antagonistic activity relative to receptors of canabis-1, a method for the preparation trhereof, a pharmaceutical composition and a method for treatment
JP2006522035A5 (enExample)
JP2007500720A5 (enExample)
TW201736334A (zh) 雌激素受體調節劑
EA200800430A1 (ru) Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов
JP2007514674A5 (enExample)
JP2011527333A5 (enExample)
JP2015502371A5 (enExample)
ATE450496T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
WO2006019886A3 (en) Pyrrolo(oxo)isoquinolines as 5ht ligands
TW200538098A (en) Therapeutic agents