JP2010527939A5 - - Google Patents
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- Publication number
- JP2010527939A5 JP2010527939A5 JP2010508671A JP2010508671A JP2010527939A5 JP 2010527939 A5 JP2010527939 A5 JP 2010527939A5 JP 2010508671 A JP2010508671 A JP 2010508671A JP 2010508671 A JP2010508671 A JP 2010508671A JP 2010527939 A5 JP2010527939 A5 JP 2010527939A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- binding fragment
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 40
- 239000000427 antigen Substances 0.000 claims 24
- 102000036639 antigens Human genes 0.000 claims 24
- 108091007433 antigens Proteins 0.000 claims 24
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 8
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 7
- 102000046157 human CSF2 Human genes 0.000 claims 7
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 5
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241001529936 Murinae Species 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93140207P | 2007-05-23 | 2007-05-23 | |
| AU2007902751A AU2007902751A0 (en) | 2007-05-23 | Neutralizing antibodies | |
| PCT/AU2008/000728 WO2008141391A1 (en) | 2007-05-23 | 2008-05-23 | Neutralizing antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010527939A JP2010527939A (ja) | 2010-08-19 |
| JP2010527939A5 true JP2010527939A5 (cg-RX-API-DMAC7.html) | 2011-07-07 |
Family
ID=40031329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508671A Pending JP2010527939A (ja) | 2007-05-23 | 2008-05-23 | 中和抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110044996A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2160407A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010527939A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101687926A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008253608A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2687791A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008141391A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8398972B2 (en) | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
| WO2009062238A1 (en) * | 2007-11-12 | 2009-05-22 | Crc For Asthma And Airways Ltd | Epitope for neutralizing antibodies |
| KR101898982B1 (ko) * | 2008-12-22 | 2018-09-14 | 더 유니버시티 오브 멜버른 | 골관절염 치료 |
| JP5674677B2 (ja) | 2008-12-22 | 2015-02-25 | ザ ユニバーシティー オブ メルボルンＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｍｅｌｂｏｕｒｎｅ | 疼痛治療 |
| WO2011153592A1 (en) * | 2010-06-10 | 2011-12-15 | Crc For Asthma And Airways Ltd | Therapeutic molecules |
| US9567397B2 (en) * | 2010-11-18 | 2017-02-14 | Merck Serono S.A. | Antibody with specificity for GM-CSF (I) |
| AU2011331180B2 (en) * | 2010-11-18 | 2016-07-07 | Crc For Asthma & Airways | Antibody with specificity for GM-CSF (II) |
| BR112013033944A2 (pt) | 2011-07-06 | 2017-12-19 | Morphosys Ag | combinação sinérgica |
| GB201220242D0 (en) * | 2012-11-09 | 2012-12-26 | Fusion Antibodies Ltd | Antibody |
| JP6490419B2 (ja) * | 2014-12-24 | 2019-03-27 | 学校法人関西医科大学 | 制御性ｔ細胞分化誘導剤 |
| US10316078B2 (en) * | 2015-03-17 | 2019-06-11 | Agency For Science, Technology And Research | Serotype cross-reactive, dengue neutralizing antibody and uses thereof |
| NZ750976A (en) | 2016-09-19 | 2023-01-27 | I Mab Biopharma Hangzhou Co Ltd | Anti-gm-csf antibodies and uses thereof |
| CN107840885B (zh) * | 2016-09-19 | 2020-11-10 | 天境生物科技(上海)有限公司 | Gm-csf抗体及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2060741A1 (en) * | 1991-02-11 | 1992-08-12 | Robert S. Greenfield | Gm-csf inhibiting oligopeptides |
| US5874082A (en) * | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
| EP2351838A1 (en) * | 2000-10-20 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Crosslinking agonistic antibodies |
| ES2365606T3 (es) * | 2002-02-13 | 2011-10-07 | Ludwig Institute For Cancer Research Ltd. | Anticuerpos contra gm-csf quiméricos. |
| EP2468774A3 (en) * | 2005-04-18 | 2013-01-02 | Amgen Research (Munich) GmbH | Antibody neutralizers of human granulocyte macrophage colony stimulating factor |
| NZ564027A (en) * | 2005-05-18 | 2011-06-30 | Morphosys Ag | Anti-GM-CSF antibodies and uses therefor |
| JP4736037B2 (ja) * | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| WO2009062238A1 (en) * | 2007-11-12 | 2009-05-22 | Crc For Asthma And Airways Ltd | Epitope for neutralizing antibodies |
| ME01005B (me) * | 2007-11-13 | 2012-10-20 | Boehringer Ingelheim Int | MONOKLONSKA ANTITIJELA KOJA SE VEZUJU ZA HGM-CSF l MEDICINSKI PREPARATI KOJI IH SADRŽE |
-
2008
- 2008-05-23 CA CA002687791A patent/CA2687791A1/en not_active Abandoned
- 2008-05-23 JP JP2010508671A patent/JP2010527939A/ja active Pending
- 2008-05-23 AU AU2008253608A patent/AU2008253608A1/en not_active Abandoned
- 2008-05-23 CN CN200880023397A patent/CN101687926A/zh active Pending
- 2008-05-23 US US12/601,514 patent/US20110044996A1/en not_active Abandoned
- 2008-05-23 EP EP08747994A patent/EP2160407A4/en not_active Withdrawn
- 2008-05-23 WO PCT/AU2008/000728 patent/WO2008141391A1/en not_active Ceased