JP2010526091A - 癌の処置のための生物学的な標的基の改変 - Google Patents
癌の処置のための生物学的な標的基の改変 Download PDFInfo
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- JP2010526091A JP2010526091A JP2010506622A JP2010506622A JP2010526091A JP 2010526091 A JP2010526091 A JP 2010526091A JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010526091 A JP2010526091 A JP 2010526091A
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- Prior art keywords
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91507007P | 2007-04-30 | 2007-04-30 | |
PCT/US2008/062113 WO2008134761A2 (en) | 2007-04-30 | 2008-04-30 | Modification of biological targeting groups for the treatment of cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010526091A true JP2010526091A (ja) | 2010-07-29 |
JP2010526091A5 JP2010526091A5 (US07638558-20091229-C00407.png) | 2012-03-15 |
Family
ID=39820986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010506622A Pending JP2010526091A (ja) | 2007-04-30 | 2008-04-30 | 癌の処置のための生物学的な標的基の改変 |
Country Status (4)
Cited By (4)
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JP2020502051A (ja) * | 2016-11-09 | 2020-01-23 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
US11859019B2 (en) | 2016-11-22 | 2024-01-02 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
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CA2861601A1 (en) | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
US8216582B2 (en) * | 2006-06-23 | 2012-07-10 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
US8258190B2 (en) | 2007-04-30 | 2012-09-04 | Intezyne Technologies, Inc. | Encapsulated contrast agents |
GB0803076D0 (en) | 2008-02-20 | 2008-03-26 | Univ Ghent | Mucosal Membrane Receptor and uses thereof |
WO2009134405A2 (en) | 2008-04-30 | 2009-11-05 | Siemens Medical Solutions Usa, Inc. | Novel substrate based pet imaging agents |
MX336869B (es) | 2008-11-03 | 2016-02-04 | Alethia Biotherapeutics Inc | Anticuerpos que bloquean espicificamente la actividad biologica de un antigeno de tumor. |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
WO2010127271A1 (en) | 2009-04-30 | 2010-11-04 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
MX2011011730A (es) * | 2009-05-04 | 2011-12-08 | Intezyne Technologies Inc | Micelas polimericas que contienen sn-38 para el tratamiento de cancer. |
GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
WO2011060104A2 (en) * | 2009-11-10 | 2011-05-19 | Allegro Pharmaceuticals, Inc. | Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites |
US8765920B2 (en) | 2009-12-23 | 2014-07-01 | The Scripps Research Institute | Tyrosine bioconjugation through aqueous Ene-like reactions |
PL3173427T3 (pl) | 2011-03-31 | 2019-11-29 | Adc Therapeutics Sa | Przeciwciała przeciwko antygenowi związanemu z nerkami 1 i ich fragmenty wiążące antygen |
WO2012142659A1 (en) * | 2011-04-19 | 2012-10-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Site-selective modification of proteins |
EP2707036A4 (en) | 2011-05-09 | 2015-03-18 | Allegro Pharmaceuticals Inc | INTEGRIN RECEPTOR ANTAGONISTS AND METHOD FOR THEIR USE |
CN102335190B (zh) * | 2011-07-18 | 2013-01-23 | 华东师范大学 | 还原降解释药可控的巯嘌呤纳米胶束前药及其应用 |
PT2802351T (pt) | 2012-01-09 | 2019-06-27 | Adc Therapeutics Sa | Agentes para o tratamento de cancro da mama triplo negativo |
US20130296531A1 (en) | 2012-04-11 | 2013-11-07 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
EP2852664B1 (en) | 2012-05-18 | 2017-09-06 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase. |
SI2859017T1 (sl) | 2012-06-08 | 2019-05-31 | Sutro Biopharma, Inc. | Protitelesa, ki vsebujejo specifične nenaravne aminokislinske ostanke, postopki njihove priprave in postopki njihove uporabe |
WO2014004639A1 (en) | 2012-06-26 | 2014-01-03 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
WO2014007632A1 (en) * | 2012-07-06 | 2014-01-09 | Stichting Het Nederlands Kanker Instituut | Cysteine protease capturing agents |
ES2907763T3 (es) * | 2012-08-31 | 2022-04-26 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
US10117946B2 (en) | 2012-12-24 | 2018-11-06 | Agency For Science, Technology And Research | Self-assembling ultrashort peptides modified with bioactive agents by click chemistry |
US20150104520A1 (en) * | 2013-04-05 | 2015-04-16 | Vuong Trieu | Nanoparticle Formulations in Biomarker Detection |
EP3019522B1 (en) | 2013-07-10 | 2017-12-13 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
US20170080093A1 (en) * | 2013-10-22 | 2017-03-23 | Tyme, Inc. | Tyrosine Derivatives And Compositions Comprising Them |
BR112016016153A2 (pt) | 2014-01-13 | 2017-12-12 | Berg Llc | composições de enolase 1 (eno1) e usos das mesmas |
GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
US9303069B2 (en) * | 2014-05-05 | 2016-04-05 | University Of Mississippi Medical Center | Peptides for treating cancer |
CN104177476B (zh) * | 2014-08-29 | 2016-10-05 | 国家纳米科学中心 | 一种靶向人癌细胞的多肽及其应用 |
SG11201806419RA (en) | 2016-01-27 | 2018-08-30 | Sutro Biopharma Inc | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
CN105859834B (zh) * | 2016-04-12 | 2019-07-19 | 北京大学 | 一种用于靶向治疗的多肽和核酸偶联化合物 |
CN111278847B (zh) * | 2017-07-10 | 2024-04-19 | 斯坦福国际研究院 | 分子导向系统肽及其用途 |
JP2020529427A (ja) | 2017-08-04 | 2020-10-08 | バイスクルテクス・リミテッド | Cd137に対して特異的な二環式ペプチドリガンド |
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WO2007016542A2 (en) * | 2005-08-01 | 2007-02-08 | President And Fellows Of Harvard College | Her-2 blocking bifunctional targeted peptides |
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US5650270A (en) * | 1982-02-01 | 1997-07-22 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
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US5622699A (en) * | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
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2008
- 2008-04-30 JP JP2010506622A patent/JP2010526091A/ja active Pending
- 2008-04-30 EP EP08747259A patent/EP2155177A2/en not_active Withdrawn
- 2008-04-30 US US12/113,101 patent/US20090110662A1/en not_active Abandoned
- 2008-04-30 WO PCT/US2008/062113 patent/WO2008134761A2/en active Application Filing
Patent Citations (1)
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WO2007016542A2 (en) * | 2005-08-01 | 2007-02-08 | President And Fellows Of Harvard College | Her-2 blocking bifunctional targeted peptides |
Non-Patent Citations (2)
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JPN6013014238; 新村出 編: 広辞苑 第五版 第五版, 19981111, p.622(き【基】の項), 岩波書店 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020502051A (ja) * | 2016-11-09 | 2020-01-23 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
JP7175887B2 (ja) | 2016-11-09 | 2022-11-21 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
JP2023025022A (ja) * | 2016-11-09 | 2023-02-21 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
US11878046B2 (en) | 2016-11-09 | 2024-01-23 | Ohio State Innovation Foundation | Di-sulfide containing cell penetrating peptides and methods of making and using thereof |
JP7490735B2 (ja) | 2016-11-09 | 2024-05-27 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
US11859019B2 (en) | 2016-11-22 | 2024-01-02 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
Also Published As
Publication number | Publication date |
---|---|
WO2008134761A3 (en) | 2009-03-05 |
WO2008134761A2 (en) | 2008-11-06 |
US20090110662A1 (en) | 2009-04-30 |
EP2155177A2 (en) | 2010-02-24 |
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