JP2010524894A5 - - Google Patents

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Publication number
JP2010524894A5
JP2010524894A5 JP2010503511A JP2010503511A JP2010524894A5 JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5 JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5
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JP
Japan
Prior art keywords
alkyl
phenyl
optionally substituted
carbocyclyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010503511A
Other languages
English (en)
Japanese (ja)
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JP2010524894A (ja
JP5675341B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/054711 external-priority patent/WO2008128982A1/en
Publication of JP2010524894A publication Critical patent/JP2010524894A/ja
Publication of JP2010524894A5 publication Critical patent/JP2010524894A5/ja
Application granted granted Critical
Publication of JP5675341B2 publication Critical patent/JP5675341B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010503511A 2007-04-18 2008-04-18 グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体 Expired - Fee Related JP5675341B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91254007P 2007-04-18 2007-04-18
US60/912,540 2007-04-18
PCT/EP2008/054711 WO2008128982A1 (en) 2007-04-18 2008-04-18 Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors

Publications (3)

Publication Number Publication Date
JP2010524894A JP2010524894A (ja) 2010-07-22
JP2010524894A5 true JP2010524894A5 (https=) 2011-09-08
JP5675341B2 JP5675341B2 (ja) 2015-02-25

Family

ID=39684456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010503511A Expired - Fee Related JP5675341B2 (ja) 2007-04-18 2008-04-18 グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体

Country Status (6)

Country Link
US (1) US9034907B2 (https=)
EP (1) EP2160389B1 (https=)
JP (1) JP5675341B2 (https=)
DK (1) DK2160389T3 (https=)
ES (1) ES2478673T3 (https=)
WO (1) WO2008128982A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732162B2 (en) * 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
CA2696934A1 (en) * 2007-09-12 2010-02-16 Probiodrug Ag Transgenic mice
NZ586665A (en) * 2008-01-14 2011-12-22 Probiodrug Ag MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct)
EP2320942B1 (en) 2008-07-21 2018-03-14 Probiodrug AG Diagnostic antibody assay
WO2010114636A1 (en) * 2009-04-03 2010-10-07 Mount Sinai School Of Medicine Of New York University Compositions for treatment of alzheimer's disease
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011076854A1 (en) 2009-12-22 2011-06-30 Probiodrug Ag CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN
EP2537029A1 (en) 2010-02-18 2012-12-26 Probiodrug AG Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
US9868728B2 (en) 2010-10-29 2018-01-16 Emory University Quinazoline derivatives, compositions, and uses related thereto
BR112013023211B1 (pt) 2011-03-16 2022-11-08 Vivoryon Therapeutics N.V. Anticorpo monoclonal, seu uso, composição, linhagem celular, método diagnóstico in vitro e kit
WO2013181135A1 (en) * 2012-05-31 2013-12-05 Emory University Quinazoline derivatives, compositions, and uses related thereto
WO2016097305A1 (en) 2014-12-19 2016-06-23 Probiodrug Ag Novel method for the detection of pglu-abeta peptides
EP4006038A1 (en) 2015-12-09 2022-06-01 Cadent Therapeutics, Inc. Thienopyrimidinone nmda receptor modulators and uses thereof
SMT202000534T1 (it) 2015-12-09 2020-11-10 Cadent Therapeutics Inc Modulatori eteroaromatici del recettore nmda e loro usi
ES2975336T3 (es) 2016-12-22 2024-07-04 Novartis Ag Moduladores del receptor NMDA y usos de los mismos
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
BR112021001967A2 (pt) 2018-08-03 2021-04-27 Cadent Therapeutics, Inc. moduladores de receptor nmda heteroaromáticos e usos dos mesmos

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293500A1 (en) 1987-06-01 1988-12-07 American Cyanamid Company 3-heteroalkyl-2,4.quinzaoline-diones
US4684654A (en) 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
US6948038B2 (en) * 2001-07-24 2005-09-20 Microsoft Corporation System and method for backing up and restoring data
WO2003053958A1 (en) * 2001-12-20 2003-07-03 Celltech R & D Limited Quinazolinedione derivatives
KR20110059664A (ko) 2003-05-05 2011-06-02 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
US8338120B2 (en) 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
JP4806628B2 (ja) * 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
BRPI0415409A (pt) 2003-10-15 2006-12-05 Probiodrug Ag uso de efetuadores de ciclases de glutaminila e glutamato
US20050171112A1 (en) 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP2338490A3 (en) 2003-11-03 2012-06-06 Probiodrug AG Combinations useful for the treatment of neuronal disorders
US7667044B2 (en) 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
US7304086B2 (en) 2004-02-05 2007-12-04 Probiodrug Ag Inhibitors of glutaminyl cyclase
BRPI0718507A2 (pt) 2006-09-21 2013-11-12 Probiodrug Ag Genes relacionados à glutaminil ciclase
US8420684B2 (en) 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5599614B2 (ja) 2006-11-09 2014-10-01 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP2010516235A (ja) 2007-01-19 2010-05-20 プロビオドルグ エージー アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル
US7803810B2 (en) 2007-03-09 2010-09-28 Probiodrug Ag Inhibitors

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