JP2010524466A5 - - Google Patents

Download PDF

Info

Publication number
JP2010524466A5
JP2010524466A5 JP2010504124A JP2010504124A JP2010524466A5 JP 2010524466 A5 JP2010524466 A5 JP 2010524466A5 JP 2010504124 A JP2010504124 A JP 2010504124A JP 2010504124 A JP2010504124 A JP 2010504124A JP 2010524466 A5 JP2010524466 A5 JP 2010524466A5
Authority
JP
Japan
Prior art keywords
seq
sequence
cancer
antibody
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010504124A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010524466A (ja
JP5209702B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/005137 external-priority patent/WO2008130704A2/en
Publication of JP2010524466A publication Critical patent/JP2010524466A/ja
Publication of JP2010524466A5 publication Critical patent/JP2010524466A5/ja
Application granted granted Critical
Publication of JP5209702B2 publication Critical patent/JP5209702B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010504124A 2007-04-17 2008-04-17 ＰＤＧＦＲβ特異的インヒビター Expired - Fee Related JP5209702B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92397907P 2007-04-17 2007-04-17
US60/923,979 2007-04-17
PCT/US2008/005137 WO2008130704A2 (en) 2007-04-17 2008-04-17 PDGFRβ-SPECIFIC INHIBITORS

Publications (3)

Publication Number Publication Date
JP2010524466A JP2010524466A (ja) 2010-07-22
JP2010524466A5 true JP2010524466A5 (show.php) 2010-10-21
JP5209702B2 JP5209702B2 (ja) 2013-06-12

Family

ID=39837443

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504124A Expired - Fee Related JP5209702B2 (ja) 2007-04-17 2008-04-17 ＰＤＧＦＲβ特異的インヒビター

Country Status (14)

Country Link
US (3) US7740850B2 (show.php)
EP (1) EP2139921A2 (show.php)
JP (1) JP5209702B2 (show.php)
KR (1) KR101136262B1 (show.php)
CN (1) CN101707882A (show.php)
AU (1) AU2008242444B2 (show.php)
BR (1) BRPI0810374A2 (show.php)
CA (1) CA2682390A1 (show.php)
EA (1) EA019595B1 (show.php)
IL (1) IL200779A0 (show.php)
MX (1) MX2009011226A (show.php)
NZ (1) NZ579734A (show.php)
UA (1) UA99608C2 (show.php)
WO (1) WO2008130704A2 (show.php)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009228158B2 (en) 2008-03-27 2014-02-27 Zymogenetics, Inc. Compositions and methods for inhibiting PDGFRbeta and VEGF-A
US20120231537A1 (en) * 2008-04-30 2012-09-13 Gradalis, Inc. Highly Pure Plasmid DNA Preparations
WO2009135048A2 (en) * 2008-04-30 2009-11-05 Gradalis, Inc. Highly pure plasmid dna preparations and processes for preparing the same
US20110305672A1 (en) 2008-07-25 2011-12-15 University Of Georgia Research Foundation, Inc. COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME
ES2410579T5 (es) * 2008-12-16 2021-10-04 Novartis Ag Sistemas de despliegue de levaduras
TW201102068A (en) * 2009-06-02 2011-01-16 Novartis Ag Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
CA2775400A1 (en) * 2009-09-28 2011-03-31 Medizinische Universitat Wien New use of pdgfrbeta inhibitors
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
EP3798236B1 (en) 2011-03-15 2022-08-10 X-Body, Inc. Antibody screening methods
CN102250249A (zh) * 2011-06-18 2011-11-23 常州亚当生物技术有限公司 一种抗VEGF/PDGFRbeta双特异性抗体及其应用
JP2015527869A (ja) 2011-08-26 2015-09-24 メリマック ファーマシューティカルズ インコーポレーティッド タンデムＦｃ二重特異性抗体
CN104105708B (zh) 2011-12-05 2018-04-03 X博迪生物科学公司 PDGF受体β结合多肽
TWI613215B (zh) 2012-02-22 2018-02-01 再生元醫藥公司 抗－大－內皮素－１（ｂｉｇ－ｅｔ－１）抗體及其用途
JO3405B1 (ar) 2013-01-09 2019-10-20 Regeneron Pharma الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
WO2014138449A1 (en) 2013-03-06 2014-09-12 Merrimack Pharmaceuticals, Inc. Anti-c-met tandem fc bispecific antibodies
WO2015035342A2 (en) 2013-09-08 2015-03-12 Oligasis Llc Factor viii zwitterionic polymer conjugates
US9914769B2 (en) 2014-07-15 2018-03-13 Kymab Limited Precision medicine for cholesterol treatment
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
KR102127408B1 (ko) * 2014-01-29 2020-06-29 삼성전자주식회사 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
KR20210013299A (ko) 2014-10-17 2021-02-03 코디악 사이언시스 인코포레이티드 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트
CA2980385A1 (en) 2015-03-20 2016-09-29 Johann Wolfgang Goethe-Universitat Frankfurt Am Main Pericyte long non-coding rnas
WO2017106609A2 (en) * 2015-12-16 2017-06-22 Kadmon Corporation, Llc. Pdgfr beta antibody
MY200764A (en) 2015-12-16 2024-01-14 Regeneron Pharma Compositions and methods of manufacturing protein microparticles
NZ783685A (en) 2015-12-30 2025-09-26 Kodiak Sciences Inc Antibodies and conjugates thereof
BR112018076281A2 (pt) 2016-06-20 2019-03-26 Kymab Limited imunocitocina, uso de uma imunocitocina, método, composição farmacêutica, método para tratar uma doença proliferativa em um animal, ácido nucleico, vetor, hospedeiro e anticorpo ou fragmento do mesmo
EP3532100A4 (en) 2016-10-30 2020-11-25 Shanghai Henlius Biotech, Inc. ANTI-PD-L1 ANTIBODIES AND VARIANTS
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
WO2018169785A2 (en) * 2017-03-13 2018-09-20 The Government Of The United States Of America As Represented By The Secretary Of The Army Therapeutic antibodies to marburg virus
CN109021104B (zh) * 2017-06-12 2022-08-12 上海睿智化学研究有限公司 一种抗人血小板衍生生长因子β受体的抗体及其应用
WO2019165982A1 (en) 2018-02-28 2019-09-06 WuXi Biologics Ireland Limited Monoclonal antibody against human lag-3, method for preparing same, and use thereof
SG11202008242XA (en) 2018-03-02 2020-09-29 Kodiak Sciences Inc Il-6 antibodies and fusion constructs and conjugates thereof
DE102018204828A1 (de) 2018-03-29 2019-10-02 Ford Global Technologies, Llc Verhinderung von Glatteis durch Abwasser von Kraftfahrzeugen
US11773155B2 (en) 2018-08-09 2023-10-03 Beijing Wisdomab Biotechnology Co., Ltd Bispecific antibody against rabies virus, and application thereof
US12098206B2 (en) 2018-10-05 2024-09-24 Seoul National University R&Db Foundation PDGF receptor antibody and use thereof
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
KR20220140551A (ko) * 2020-02-07 2022-10-18 바이오리온 테크놀러지스 비.브이. 혈소판 유래 성장 인자 수용체(pdgfr) 항체, 이의 컨쥬게이트, 조성물 및 용도
UY40783A (es) 2023-06-12 2024-12-31 Amgen Inc Proteínas de unión a agonistas del receptor beta de linfotoxina
CN118440214B (zh) * 2024-04-02 2025-01-28 山东大学 一种靶向PDGFRβ的嵌合抗原受体、CAR-T细胞及应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1992013867A1 (en) 1991-01-31 1992-08-20 Cor Therapeutics, Inc. Domains of extracellular region of human platelet derived growth factor receptor polypeptides
US5817310A (en) * 1991-12-02 1998-10-06 Cor Therapeutics, Inc. Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
US20020009443A1 (en) * 1991-12-02 2002-01-24 Vanitha Ramakrishman Inhibitory immunoglobulin polypeptides to human pdgf beta receptor
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
US5976534A (en) 1993-02-25 1999-11-02 Zymogenetics, Inc. Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin
US5620687A (en) 1993-02-25 1997-04-15 Zymogenetics, Inc. Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors
US5840299A (en) 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
US6811779B2 (en) 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
US5882644A (en) 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US6259971B1 (en) * 1997-06-30 2001-07-10 Compaq Computer Corporation Portable fuel-cell-powered system with ultrasonic atomization of H2O by-product
US7740841B1 (en) * 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
EP1299419A2 (en) 2000-05-24 2003-04-09 Imclone Systems, Inc. Bispecific immunoglobulin-like antigen binding proteins and method of production
WO2002027848A2 (de) * 2000-09-22 2002-04-04 Siemens Aktiengesellschaft Verfahren zum überwachen des medienaustritts aus einer brennstoffzelle und brennstoffzellenanlage
EP1313161A1 (en) * 2001-11-15 2003-05-21 Ballard Power Systems AG Fuel cell system and method for operating the same
WO2005046602A2 (en) * 2003-11-10 2005-05-26 Greenville Hospital System Vegf receptor antagonists
WO2006020258A2 (en) 2004-07-17 2006-02-23 Imclone Systems Incorporated Novel tetravalent bispecific antibody
WO2008011216A2 (en) 2006-05-16 2008-01-24 Pro-Pharmaceuticals, Inc. Galactose-pronged polysaccharides in a formulation for antifibrotic therapies

Similar Documents

Publication Publication Date Title
JP2010524466A5 (show.php)
IL261585A (en) Antigen-binding human proteins that bind beta-klotho, fgf receptors and their complexes
JP2012505912A5 (show.php)
NZ610153A (en) Novel anti-dr5 antibody
AU2018256487A1 (en) Antibodies that bind to TL1A and their uses
JP2015522252A5 (show.php)
JP2020500538A5 (show.php)
PH12014500089A1 (en) Antibodies that bind to ox40 and their uses
RU2015129813A (ru) Антитела, которые связываются с лигандом запрограммированной клеточной смерти 1 (pd-l1)
WO2012045481A3 (en) Antibody targeting osteoclast-related protein siglec-15
MX2011008843A (es) Anticuerpos humanizados que se unen a cd19 y sus usos.
RU2015126533A (ru) Анти-cd47 антитела и способы их применения
NZ602621A (en) Antibodies against csf-1r
EA032189B9 (ru) Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их
JP2009106306A5 (ja) 抗PDGFRα抗体
RU2013140625A (ru) Антитела против ангиопоэтина-2 человека
RU2016119152A (ru) Стабильные и растворимые антитела, ингибирующие vegf
IL198379A (en) Human antibodies and antibodies that bind sphingosine-1-phosphate, their encoded nucleic acids, and their preparations and methods for treating the disease
JP2013529183A5 (show.php)
NZ709390A (en) Folate receptor 1 antibodies and immunoconjugates and uses thereof
NZ584726A (en) Heparin-binding epidermal growth factor-like growth factor antigen binding proteins
NZ630433A (en) Antibodies and uses thereof to detect folate receptor 1
JP2011219478A5 (show.php)
JP2016116527A5 (show.php)
JP2013535190A5 (show.php)