JP2010522711A5 - - Google Patents

Info

Publication number

JP2010522711A5

JP2010522711A5 JP2010500240A JP2010500240A JP2010522711A5 JP 2010522711 A5 JP2010522711 A5 JP 2010522711A5 JP 2010500240 A JP2010500240 A JP 2010500240A JP 2010500240 A JP2010500240 A JP 2010500240A JP 2010522711 A5 JP2010522711 A5 JP 2010522711A5

Authority

JP

Japan

Prior art keywords

methyl

compound

hydrogen

pharmaceutically acceptable

salt

Prior art date

2008-03-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 229910052739 hydrogen Inorganic materials 0.000 claims 17
• 239000001257 hydrogen Substances 0.000 claims 17
• 150000003839 salts Chemical class 0.000 claims 16
• 150000001875 compounds Chemical class 0.000 claims 12
• 150000002431 hydrogen Chemical class 0.000 claims 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
• 125000000217 alkyl group Chemical group 0.000 claims 7
• 125000005843 halogen group Chemical group 0.000 claims 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 5
• 229910052731 fluorine Inorganic materials 0.000 claims 5
• 239000011737 fluorine Substances 0.000 claims 5
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
• 229910052801 chlorine Inorganic materials 0.000 claims 4
• 239000000460 chlorine Substances 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
• 208000002193 Pain Diseases 0.000 claims 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 230000004770 neurodegeneration Effects 0.000 claims 3
• 208000015122 neurodegenerative disease Diseases 0.000 claims 3
• 230000036407 pain Effects 0.000 claims 3
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
• 206010012289 Dementia Diseases 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
• 229910052794 bromium Inorganic materials 0.000 claims 2
• 208000010877 cognitive disease Diseases 0.000 claims 2
• 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical class 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 208000027061 mild cognitive impairment Diseases 0.000 claims 2
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• 206010065390 Inflammatory pain Diseases 0.000 claims 1
• 208000009829 Lewy Body Disease Diseases 0.000 claims 1
• 201000002832 Lewy body dementia Diseases 0.000 claims 1
• 208000026072 Motor neurone disease Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
• 206010039966 Senile dementia Diseases 0.000 claims 1
• 201000004810 Vascular dementia Diseases 0.000 claims 1
• 230000032683 aging Effects 0.000 claims 1
• 125000000304 alkynyl group Chemical group 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 150000001721 carbon Chemical group 0.000 claims 1
• 206010008118 cerebral infarction Diseases 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 230000003412 degenerative effect Effects 0.000 claims 1
• 150000002222 fluorine compounds Chemical class 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 208000005264 motor neuron disease Diseases 0.000 claims 1
• QMMZOEZYJBOYMF-UHFFFAOYSA-N n-[(2,4-dichlorophenyl)methyl]-1-ethyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(CC)C1C(=O)NCC1=CC=C(Cl)C=C1Cl QMMZOEZYJBOYMF-UHFFFAOYSA-N 0.000 claims 1
• YEHSQGUPLMSNOY-UHFFFAOYSA-N n-[(2,4-dichlorophenyl)methyl]-1-methyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(C)C1C(=O)NCC1=CC=C(Cl)C=C1Cl YEHSQGUPLMSNOY-UHFFFAOYSA-N 0.000 claims 1
• CXJGALUKEJTMJA-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-ethyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(CC)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl CXJGALUKEJTMJA-UHFFFAOYSA-N 0.000 claims 1
• YGCMKVHDGGAEFD-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-6-oxopiperidine-2-carboxamide Chemical compound C1CCC(=O)N(C)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl YGCMKVHDGGAEFD-UHFFFAOYSA-N 0.000 claims 1
• 208000004296 neuralgia Diseases 0.000 claims 1
• 208000021722 neuropathic pain Diseases 0.000 claims 1
• -1 or R 9 Chemical compound 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 208000009935 visceral pain Diseases 0.000 claims 1