JP2010522710A - Ｐ２ｘ７調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体 - Google Patents

Ｐ２ｘ７調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体 Download PDF

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Publication number
JP2010522710A
JP2010522710A JP2010500239A JP2010500239A JP2010522710A JP 2010522710 A JP2010522710 A JP 2010522710A JP 2010500239 A JP2010500239 A JP 2010500239A JP 2010500239 A JP2010500239 A JP 2010500239A JP 2010522710 A JP2010522710 A JP 2010522710A
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Prior art keywords
methyl
compound
fluorine
hydrogen
pain
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JP2010500239A
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English (en)
Japanese (ja)
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JP2010522710A5 (OSRAM
Inventor
ポール・ジョン・ベスウィック
ダリル・サイモン・ウォルター
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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority claimed from GB0706206A external-priority patent/GB0706206D0/en
Priority claimed from GB0805048A external-priority patent/GB0805048D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2010522710A publication Critical patent/JP2010522710A/ja
Publication of JP2010522710A5 publication Critical patent/JP2010522710A5/ja
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
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JP2010500239A 2007-03-29 2008-03-20 Ｐ２ｘ７調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体 Withdrawn JP2010522710A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0706206A GB0706206D0 (en) 2007-03-29 2007-03-29 Novel compounds
GB0805048A GB0805048D0 (en) 2008-03-18 2008-03-18 Niovel compounds
PCT/EP2008/053431 WO2008119685A2 (en) 2007-03-29 2008-03-20 Oxazolidine and morpholine carboxamide derivatives as p2x7 modulators

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Publication Number Publication Date
JP2010522710A true JP2010522710A (ja) 2010-07-08
JP2010522710A5 JP2010522710A5 (OSRAM) 2011-05-06

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JP2010500239A Withdrawn JP2010522710A (ja) 2007-03-29 2008-03-20 Ｐ２ｘ７調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体

Country Status (4)

Country Link
US (1) US20100144727A1 (OSRAM)
EP (1) EP2139875A2 (OSRAM)
JP (1) JP2010522710A (OSRAM)
WO (1) WO2008119685A2 (OSRAM)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2009542595A (ja) * 2006-07-06 2009-12-03 グラクソ グループ リミテッド Ｐ２ｘ７受容体アンタゴニストとしての置換ｎ−フェニルメチル−５−オキソ−プロリン−２−アミドおよびそれらの使用方法

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