JP2010522218A - Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 - Google Patents

Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 Download PDF

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Publication number
JP2010522218A
JP2010522218A JP2010500035A JP2010500035A JP2010522218A JP 2010522218 A JP2010522218 A JP 2010522218A JP 2010500035 A JP2010500035 A JP 2010500035A JP 2010500035 A JP2010500035 A JP 2010500035A JP 2010522218 A JP2010522218 A JP 2010522218A
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Prior art keywords
dihydro
oxo
carbonyl
amino
cyclopropyl
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JP2010500035A
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Japanese (ja)
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JP2010522218A5 (enExample
Inventor
バーチ，ジェイソン
ファラン，ジュリ
ハン，ヨンシン
スチューリノ，クラウディオ
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Merck Canada Inc
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Merck Canada Inc
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Publication of JP2010522218A publication Critical patent/JP2010522218A/ja
Publication of JP2010522218A5 publication Critical patent/JP2010522218A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Addiction (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
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  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
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JP2010500035A 2007-03-26 2008-03-25 Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 Pending JP2010522218A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92001807P 2007-03-26 2007-03-26
PCT/CA2008/000561 WO2008116304A1 (en) 2007-03-26 2008-03-25 Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists

Publications (2)

Publication Number Publication Date
JP2010522218A true JP2010522218A (ja) 2010-07-01
JP2010522218A5 JP2010522218A5 (enExample) 2011-05-06

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ID=39787996

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JP2010500035A Pending JP2010522218A (ja) 2007-03-26 2008-03-25 Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体

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US (1) US8003661B2 (enExample)
EP (1) EP2125724B1 (enExample)
JP (1) JP2010522218A (enExample)
CN (1) CN101636385B (enExample)
AU (1) AU2008232265B2 (enExample)
CA (1) CA2681146A1 (enExample)
WO (1) WO2008116304A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503605A (ja) * 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010087425A1 (ja) 2009-01-30 2010-08-05 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
WO2014143591A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
ES2896476T3 (es) 2017-05-18 2022-02-24 Idorsia Pharmaceuticals Ltd Derivados de pirimidina
HRP20211533T1 (hr) 2017-05-18 2022-01-07 Idorsia Pharmaceuticals Ltd Derivati fenila kao modulatori receptora pge2
TWI768043B (zh) 2017-05-18 2022-06-21 瑞士商愛杜西亞製藥有限公司 N-取代吲哚衍生物
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
KR20230107228A (ko) 2020-11-13 2023-07-14 오노 야꾸힝 고교 가부시키가이샤 Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517099A (ja) * 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
JP2004517054A (ja) * 2000-10-19 2004-06-10 ファイザー株式会社 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
WO2006122403A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
US5834468A (en) 1995-07-07 1998-11-10 Zeneca Limited Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517054A (ja) * 2000-10-19 2004-06-10 ファイザー株式会社 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物
JP2004517099A (ja) * 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
WO2006122403A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503605A (ja) * 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体

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AU2008232265A1 (en) 2008-10-02
EP2125724B1 (en) 2014-12-03
CN101636385A (zh) 2010-01-27
AU2008232265B2 (en) 2013-02-28
WO2008116304A1 (en) 2008-10-02
EP2125724A4 (en) 2012-02-15
EP2125724A1 (en) 2009-12-02
CA2681146A1 (en) 2008-10-02
US8003661B2 (en) 2011-08-23
CN101636385B (zh) 2012-09-05
US20100105718A1 (en) 2010-04-29

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