JP2010522218A - Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 - Google Patents

Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 Download PDF

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Publication number
JP2010522218A
JP2010522218A JP2010500035A JP2010500035A JP2010522218A JP 2010522218 A JP2010522218 A JP 2010522218A JP 2010500035 A JP2010500035 A JP 2010500035A JP 2010500035 A JP2010500035 A JP 2010500035A JP 2010522218 A JP2010522218 A JP 2010522218A
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dihydro
oxo
carbonyl
amino
cyclopropyl
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JP2010500035A
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Japanese (ja)
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JP2010522218A5 (enExample
Inventor
バーチ，ジェイソン
ファラン，ジュリ
ハン，ヨンシン
スチューリノ，クラウディオ
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Merck Canada Inc
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Merck Canada Inc
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Publication of JP2010522218A publication Critical patent/JP2010522218A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
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  • Pain & Pain Management (AREA)
  • Obesity (AREA)
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JP2010500035A 2007-03-26 2008-03-25 Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体 Pending JP2010522218A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92001807P 2007-03-26 2007-03-26
PCT/CA2008/000561 WO2008116304A1 (en) 2007-03-26 2008-03-25 Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists

Publications (2)

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JP2010522218A true JP2010522218A (ja) 2010-07-01
JP2010522218A5 JP2010522218A5 (enExample) 2011-05-06

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ID=39787996

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JP2010500035A Pending JP2010522218A (ja) 2007-03-26 2008-03-25 Ｅｐ４受容体アンタゴニストとしてのナフタレン及びキノリンスルホニル尿素誘導体

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US (1) US8003661B2 (enExample)
EP (1) EP2125724B1 (enExample)
JP (1) JP2010522218A (enExample)
CN (1) CN101636385B (enExample)
AU (1) AU2008232265B2 (enExample)
CA (1) CA2681146A1 (enExample)
WO (1) WO2008116304A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503605A (ja) * 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010087425A1 (ja) 2009-01-30 2010-08-05 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
WO2014143591A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
PE20191787A1 (es) 2017-05-18 2019-12-24 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituidos
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
JP7816164B2 (ja) 2020-11-13 2026-02-18 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517054A (ja) * 2000-10-19 2004-06-10 ファイザー株式会社 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物
JP2004517099A (ja) * 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
WO2006122403A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

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Publication number Priority date Publication date Assignee Title
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
US5834468A (en) 1995-07-07 1998-11-10 Zeneca Limited Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004517054A (ja) * 2000-10-19 2004-06-10 ファイザー株式会社 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物
JP2004517099A (ja) * 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物
WO2006122403A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503605A (ja) * 2008-09-25 2012-02-09 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのベータ−カルボリンスルホニルウレア誘導体

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AU2008232265B2 (en) 2013-02-28
US8003661B2 (en) 2011-08-23
CA2681146A1 (en) 2008-10-02
WO2008116304A1 (en) 2008-10-02
EP2125724A1 (en) 2009-12-02
EP2125724A4 (en) 2012-02-15
CN101636385A (zh) 2010-01-27
EP2125724B1 (en) 2014-12-03
AU2008232265A1 (en) 2008-10-02
US20100105718A1 (en) 2010-04-29
CN101636385B (zh) 2012-09-05

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