CN101636385B - 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 - Google Patents

作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 Download PDF

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Publication number
CN101636385B
CN101636385B CN2008800089997A CN200880008999A CN101636385B CN 101636385 B CN101636385 B CN 101636385B CN 2008800089997 A CN2008800089997 A CN 2008800089997A CN 200880008999 A CN200880008999 A CN 200880008999A CN 101636385 B CN101636385 B CN 101636385B
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dihydro
oxo
carbonyl
amino
cyclopropyl
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CN2008800089997A
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Chinese (zh)
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CN101636385A (zh
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J·伯奇
J·法兰德
韩永新
C·斯图里诺
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Merck Canada Inc
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Merck Frosst Canada Ltd
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
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CN2008800089997A 2007-03-26 2008-03-25 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 Expired - Fee Related CN101636385B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92001807P 2007-03-26 2007-03-26
US60/920,018 2007-03-26
PCT/CA2008/000561 WO2008116304A1 (en) 2007-03-26 2008-03-25 Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists

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CN101636385A CN101636385A (zh) 2010-01-27
CN101636385B true CN101636385B (zh) 2012-09-05

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US (1) US8003661B2 (enExample)
EP (1) EP2125724B1 (enExample)
JP (1) JP2010522218A (enExample)
CN (1) CN101636385B (enExample)
AU (1) AU2008232265B2 (enExample)
CA (1) CA2681146A1 (enExample)
WO (1) WO2008116304A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011003166A (es) * 2008-09-25 2011-04-27 Merck Frosst Canada Ltd Derivados de sulfonilurea beta-carbolina como antagonistas del receptor ep4.
JPWO2010087425A1 (ja) 2009-01-30 2012-08-02 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
WO2014143591A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
WO2018210992A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
AU2018268311B2 (en) 2017-05-18 2022-02-10 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
WO2018210994A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Phenyl derivatives as pge2 receptor modulators
WO2022102731A1 (ja) 2020-11-13 2022-05-19 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608214A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
DE69635254T2 (de) 1995-07-07 2006-07-13 Astrazeneca Ab Ortho-substituierte aromatische Verbindungen, die drei (Het)aryl-Ringe enthalten, deren Herstellung und deren Verwendung als Prostaglandin-E2-(PGE2)-Antagonisten
HN2001000224A (es) * 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
GB0031302D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives
CA2482382A1 (en) * 2002-04-12 2003-10-23 Pfizer Inc. Pyrazole compounds as anti-inflammatory and analgesic agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608214A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

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EP2125724A1 (en) 2009-12-02
CN101636385A (zh) 2010-01-27
AU2008232265A1 (en) 2008-10-02
AU2008232265B2 (en) 2013-02-28
US20100105718A1 (en) 2010-04-29
WO2008116304A1 (en) 2008-10-02
EP2125724A4 (en) 2012-02-15
JP2010522218A (ja) 2010-07-01
CA2681146A1 (en) 2008-10-02
EP2125724B1 (en) 2014-12-03
US8003661B2 (en) 2011-08-23

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