CN101636385B - 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 - Google Patents

作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 Download PDF

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Publication number
CN101636385B
CN101636385B CN2008800089997A CN200880008999A CN101636385B CN 101636385 B CN101636385 B CN 101636385B CN 2008800089997 A CN2008800089997 A CN 2008800089997A CN 200880008999 A CN200880008999 A CN 200880008999A CN 101636385 B CN101636385 B CN 101636385B
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Prior art keywords
dihydro
oxo
carbonyl
amino
cyclopropyl
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CN2008800089997A
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Chinese (zh)
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CN101636385A (zh
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J·伯奇
J·法兰德
韩永新
C·斯图里诺
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Merck Canada Inc
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Merck Frosst Canada Ltd
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
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CN2008800089997A 2007-03-26 2008-03-25 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 Expired - Fee Related CN101636385B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92001807P 2007-03-26 2007-03-26
US60/920,018 2007-03-26
PCT/CA2008/000561 WO2008116304A1 (en) 2007-03-26 2008-03-25 Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists

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CN101636385A CN101636385A (zh) 2010-01-27
CN101636385B true CN101636385B (zh) 2012-09-05

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CN2008800089997A Expired - Fee Related CN101636385B (zh) 2007-03-26 2008-03-25 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物

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US (1) US8003661B2 (enExample)
EP (1) EP2125724B1 (enExample)
JP (1) JP2010522218A (enExample)
CN (1) CN101636385B (enExample)
AU (1) AU2008232265B2 (enExample)
CA (1) CA2681146A1 (enExample)
WO (1) WO2008116304A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011003166A (es) 2008-09-25 2011-04-27 Merck Frosst Canada Ltd Derivados de sulfonilurea beta-carbolina como antagonistas del receptor ep4.
WO2010087425A1 (ja) 2009-01-30 2010-08-05 国立大学法人京都大学 前立腺癌の進行抑制剤および進行抑制方法
WO2014143591A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
PE20191787A1 (es) 2017-05-18 2019-12-24 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituidos
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
AR111808A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
US11325899B2 (en) 2017-05-18 2022-05-10 Idorsia Pharmaceuticals Ltd Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
JP7816164B2 (ja) 2020-11-13 2026-02-18 小野薬品工業株式会社 Ｅｐ４拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608214A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
US5834468A (en) 1995-07-07 1998-11-10 Zeneca Limited Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists
HN2001000224A (es) * 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
GB0031302D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives
JP2005532291A (ja) * 2002-04-12 2005-10-27 ファイザー株式会社 抗炎症薬および鎮痛薬としてのピラゾール化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608214A1 (en) * 2005-05-19 2006-11-23 Merck Frosst Canada Ltd. Quinoline derivatives as ep4 antagonists

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AU2008232265B2 (en) 2013-02-28
US8003661B2 (en) 2011-08-23
CA2681146A1 (en) 2008-10-02
WO2008116304A1 (en) 2008-10-02
EP2125724A1 (en) 2009-12-02
EP2125724A4 (en) 2012-02-15
CN101636385A (zh) 2010-01-27
EP2125724B1 (en) 2014-12-03
AU2008232265A1 (en) 2008-10-02
US20100105718A1 (en) 2010-04-29
JP2010522218A (ja) 2010-07-01

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