JP2010521458A5 - - Google Patents

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Publication number
JP2010521458A5
JP2010521458A5 JP2009553600A JP2009553600A JP2010521458A5 JP 2010521458 A5 JP2010521458 A5 JP 2010521458A5 JP 2009553600 A JP2009553600 A JP 2009553600A JP 2009553600 A JP2009553600 A JP 2009553600A JP 2010521458 A5 JP2010521458 A5 JP 2010521458A5
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JP
Japan
Prior art keywords
group
trifluoromethyl
ylamino
pyridin
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009553600A
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English (en)
Japanese (ja)
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JP2010521458A (ja
JP5569956B2 (ja
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Priority claimed from PCT/US2008/003205 external-priority patent/WO2008115369A2/en
Publication of JP2010521458A publication Critical patent/JP2010521458A/ja
Publication of JP2010521458A5 publication Critical patent/JP2010521458A5/ja
Application granted granted Critical
Publication of JP5569956B2 publication Critical patent/JP5569956B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009553600A 2007-03-16 2008-03-10 接着斑キナーゼのインヒビター Expired - Fee Related JP5569956B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US89537907P 2007-03-16 2007-03-16
US60/895,379 2007-03-16
US94663707P 2007-06-27 2007-06-27
US60/946,637 2007-06-27
US3002508P 2008-02-20 2008-02-20
US61/030,025 2008-02-20
PCT/US2008/003205 WO2008115369A2 (en) 2007-03-16 2008-03-10 Inhibitors of focal adhesion kinase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014104005A Division JP2014148542A (ja) 2007-03-16 2014-05-20 接着斑キナーゼのインヒビター

Publications (3)

Publication Number Publication Date
JP2010521458A JP2010521458A (ja) 2010-06-24
JP2010521458A5 true JP2010521458A5 (online.php) 2011-05-06
JP5569956B2 JP5569956B2 (ja) 2014-08-13

Family

ID=39628767

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009553600A Expired - Fee Related JP5569956B2 (ja) 2007-03-16 2008-03-10 接着斑キナーゼのインヒビター
JP2014104005A Pending JP2014148542A (ja) 2007-03-16 2014-05-20 接着斑キナーゼのインヒビター

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014104005A Pending JP2014148542A (ja) 2007-03-16 2014-05-20 接着斑キナーゼのインヒビター

Country Status (10)

Country Link
US (2) US8501763B2 (online.php)
EP (2) EP2134689B1 (online.php)
JP (2) JP5569956B2 (online.php)
CN (2) CN101679264A (online.php)
CA (1) CA2681015C (online.php)
DK (1) DK2134689T3 (online.php)
ES (1) ES2485040T3 (online.php)
PL (1) PL2134689T3 (online.php)
TW (2) TWI536991B (online.php)
WO (1) WO2008115369A2 (online.php)

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JP6027230B2 (ja) 2012-05-15 2016-11-16 キャンサー・リサーチ・テクノロジー・リミテッド ５−［［４−［［モルホリン−２−イル］メチルアミノ］−５−（トリフルオロメチル）−２−ピリジル］アミノ］ピラジン−２−カルボニトリルおよびその治療上の使用
JP2016501203A (ja) 2012-11-20 2016-01-18 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インドールアミン２，３−ジオキシゲナーゼの阻害剤として有用な化合物
WO2014177524A1 (en) * 2013-05-01 2014-11-06 F. Hoffmann-La Roche Ag C-linked heterocycloalkyl substituted pyrimidines and their uses
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WO2015054477A1 (en) 2013-10-09 2015-04-16 The General Hospital Corporation Methods of diagnosing and treating b cell acute lymphoblastic leukemia
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
IL256652B2 (en) 2015-06-29 2026-03-01 Verastem Inc Dapatinib in combination with an anti-PD1 antibody, anti-PDL1 antibody, or anti-PD1 ligand for use in the treatment of cancer
CA3002558A1 (en) 2015-10-29 2017-05-04 Effector Therapeutics, Inc. Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit mnk1 and mnk2
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PT3757097T (pt) 2015-11-26 2022-06-20 Novartis Ag Derivados de diamino piridina
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
MX394700B (es) 2017-02-14 2025-03-24 Effector Therapeutics Inc Inhibidores de mnk sustituidos con piperidina y métodos relacionados con los mismos.
KR102526964B1 (ko) 2018-02-26 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Hbv 복제 억제제로서의 치환된 피롤리진 화합물
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CN111233834B (zh) * 2020-03-09 2021-08-31 北京师范大学 一类靶向fak的化合物和其标记物、及它们的制备方法和应用
TW202204348A (zh) 2020-04-07 2022-02-01 美商西爾拉癌症醫學公司 Ｃｈｋ１抑制劑之合成方法
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WO2024251270A1 (zh) * 2023-06-08 2024-12-12 希格生科（深圳）有限公司 含氮芳环化合物及其医药用途

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BRPI0722383A2 (pt) * 2006-12-08 2012-06-05 Irm Llc compostos inibidores de proteìna quinase, composições contendo os mesmos bem como seus usos
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US20100317663A1 (en) 2008-02-19 2010-12-16 Jerry Leroy Adams Anilinopyridines as inhibitors of fak

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