JP2010521422A - 動物において肥満症を予防または治療するための組成物および方法 - Google Patents
動物において肥満症を予防または治療するための組成物および方法 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Landscapes
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- Chemical & Material Sciences (AREA)
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Abstract
【選択図】なし
Description
[0014] 本発明の他の特徴および利点は、以下の例の詳細な記述を参照することにより理解されるであろう。
[0018] 本明細書中で用いる用語”過体重”、”太った”、”肥満”、”肥満症”およびこれらに類する用語は、それの’理想体重’より多い動物の体重状態を表わす。たとえば、動物に適用した用語”太った”は、動物飼育の専門家その他の当業者に既知の技術および方法を用いて、過剰量の体脂肪組織をもつと判定されたいずれかの動物、または過剰量の体脂肪組織を発現する傾向にある動物を意味することができる。たとえば下記の場合、動物は”太っている”とみなされる:(1)その動物が25以上の肥満指数(BMI)をもつ場合(動物の状態を特性付けるある方法において”過体重”および”肥満”動物を含むとみなされる数値)、(2)動物飼育の専門家が判定して、または当業者に既知のとおり、動物の体重がそれの”理想体重”より15%以上多い場合、(3)DEXAにより測定して、動物の体脂肪率が27%以上である場合、あるいは(4)当業者が”Small Animal Clinical Nutrition”, 4th Edition, Chapter 13 (ISBN 0-945837-05-4)に記載された方法を用いて判定して1〜5の尺度で動物が3より大きい身体状態スコア(BCS)をもつ場合、または他のBCS法を用いてそれと同等のものをもつ場合。ある場合には、理想体重より20%以上多い動物が肥満とみなされる。本明細書中で本発明の方法および組成物に関して用いる用語”肥満症”は、当業者がその動物に理想的であるより多いとみなすいずれかの体重状態を含む。
約0〜約90重量%、好ましくは約5〜約45重量%の炭水化物;
約5〜約70重量%、好ましくは約10〜約60重量%のタンパク質;
約2〜約50重量%、好ましくは約5〜約40重量%の脂肪;
約0.1〜約20重量%、好ましくは約1〜約11重量%の総食物繊維;
約0〜約15重量%、好ましくは約2〜約8重量%のビタミンおよび無機質、酸化防止剤、ならびに動物の栄養要求を支持する他の栄養素;ならびに
約25〜約200ppm、好ましくは約50〜約125ppmのカプサイシン。
約0〜約90重量%、好ましくは約5〜約45重量%の炭水化物;
約5〜約70重量%、好ましくは約20〜約60重量%のタンパク質;
約2〜約50重量%、好ましくは約5〜約40重量%の脂肪;
約0.1〜約20重量%、好ましくは約1〜約11重量%の総食物繊維;
約0〜約15重量%、好ましくは約2〜約8重量%のビタミンおよび無機質、酸化防止剤、ならびに動物の栄養要求を支持する他の栄養素;ならびに
約25〜約200ppm、好ましくは約50〜約125ppmのカプサイシン。
インビトロでイヌ類の遺伝子の発現を改変しうる物質のデータベースの作成
[0043] 本発明者らは、イヌ類の細胞においてインビトロで種々のイヌ類遺伝子の発現を改変することが知られている物質のデータベースを、以下に示す先に記載された方法に従ってコンパイルした(たとえばU.S.2006−0200320 A1を参照)。
インビボでのイヌ類の摂取試験
[0049] 実施例1のインビトロデータに基づいて、カプサイシンを含む飼料を調べるインビボでのイヌ類の摂取試験を、以下に示すように実施する。
Claims (27)
- 動物において肥満症を予防または治療するのに有効な量のカプサイシノイドまたはその活性代謝産物を含む組成物。
- 組成物が動物においてエネルギー制限に関連する1以上の遺伝子の発現を改変することができる、請求項1の組成物。
- カプサイシノイドがカプサイシンまたはその活性代謝産物である、請求項1の組成物。
- カプサイシノイドがジヒドロカプサイシンまたはその活性代謝産物である、請求項1の組成物。
- 組成物がさらに可溶性繊維、メチオニン、EPAおよびDHAよりなる群から選択される物質を含む、請求項1〜4のいずれかの組成物。
- 組成物が湿潤ペットフードである、請求項1〜5のいずれかの組成物。
- 組成物が乾燥ペットフードである、請求項1〜5のいずれかの組成物。
- 動物がイヌ類である、請求項1〜7のいずれかの組成物。
- 動物がネコ類である、請求項1〜7のいずれかの組成物。
- 動物において肥満症を予防または治療するための方法であって、動物において肥満症を予防または治療するのに有効な量のカプサイシノイドまたはその活性代謝産物を含む組成物を動物に投与することを含む方法。
- 組成物が動物においてエネルギー制限に関連する1以上の遺伝子の発現を改変することができる、請求項10の方法。
- カプサイシノイドがカプサイシンまたはその活性代謝産物である、請求項10の方法。
- カプサイシノイドがジヒドロカプサイシンまたはその活性代謝産物である、請求項10の方法。
- 組成物がさらに可溶性繊維、メチオニン、EPAおよびDHAよりなる群から選択される物質を含む、請求項10〜13のいずれかの方法。
- 組成物が湿潤ペットフードである、請求項10〜14のいずれかの方法。
- 組成物が乾燥ペットフードである、請求項10〜14のいずれかの方法。
- 動物がイヌ類である、請求項10〜16のいずれかの方法。
- 動物がネコ類である、請求項10〜16のいずれかの方法。
- 動物において肥満症を予防または治療するための組成物の製造における、カプサイシノイドまたはその活性代謝産物の使用。
- 動物において食物摂取を自己調節させるための組成物の製造における、カプサイシノイドまたはその活性代謝産物の使用。
- カプサイシノイドがカプサイシンまたはその活性代謝産物である、請求項19〜20のいずれかの使用。
- カプサイシノイドがジヒドロカプサイシンまたはその活性代謝産物である、請求項19〜20のいずれかの使用。
- 動物において食物摂取を自己調節させるための方法であって、食物摂取を自己調節させるのに有効な量のカプサイシノイドまたはその活性代謝産物を含む組成物を動物に投与することを含む方法。
- 動物において食物摂取を自己調節させるのに有効な量のカプサイシノイドまたはその活性代謝産物を含む組成物。
- 食物摂取を自己調節させるのに有効な量の組成物を動物に投与することを含む、動物において食物摂取を自己調節させるための方法における、前記請求項のいずれかの組成物の使用。
- 動物において肥満症を予防または治療するのに有効な量の組成物を動物に投与することを含む、動物において肥満症を予防または治療するための方法における、前記請求項のいずれかの組成物の使用。
- 前記請求項のいずれかの組成物を含むキット。
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PCT/US2007/062714 WO2008103180A1 (en) | 2007-02-23 | 2007-02-23 | Compositions and methods for preventing or treating obesity in animals |
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US (1) | US20100048723A1 (ja) |
EP (1) | EP2124614A1 (ja) |
JP (1) | JP2010521422A (ja) |
CN (1) | CN101662948A (ja) |
AU (1) | AU2007347423B2 (ja) |
BR (1) | BRPI0721349A2 (ja) |
CA (1) | CA2678808C (ja) |
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Cited By (2)
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JP2015006200A (ja) * | 2010-12-20 | 2015-01-15 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 満腹応答を誘導するためのペットフード組成物 |
WO2024105922A1 (ja) * | 2022-11-18 | 2024-05-23 | プレミアアンチエイジング株式会社 | 抗肥満用、体脂肪減少用又は脂肪代謝促進用組成物 |
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CA2710211C (en) * | 2007-12-21 | 2013-09-10 | Hill's Pet Nutrition, Inc. | Pet food composition |
CA2767910C (en) * | 2009-07-21 | 2014-07-08 | Hill's Pet Nutrition, Inc. | Companion animal nutrition system |
AU2011203616B2 (en) * | 2010-01-06 | 2013-06-06 | Hill's Pet Nutrition, Inc. | Method of managing a weight condition in an animal |
JP6114695B2 (ja) | 2010-12-20 | 2017-04-12 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 満腹応答を誘導するためのペットフード組成物 |
AU2011345226B2 (en) | 2010-12-23 | 2014-11-13 | Hill's Pet Nutrition, Inc. | Pet food compositions and methods for treating arthritis and inflammation associated with arthritis |
DK2654453T3 (da) | 2010-12-23 | 2016-08-29 | Hills Pet Nutrition Inc | Kæledyrsfodersammensætninger og fremgangsmåder til vægttab og vægtvedligeholdelse |
EP2790529B1 (en) * | 2011-12-15 | 2015-12-09 | Hill's Pet Nutrition, Inc. | Pet food composition with a soft texture |
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WO2017161379A1 (en) * | 2016-03-18 | 2017-09-21 | 4Life Patents, Llc | Methods and compositions for weight control |
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2007
- 2007-02-23 AU AU2007347423A patent/AU2007347423B2/en not_active Ceased
- 2007-02-23 EP EP07757409A patent/EP2124614A1/en not_active Withdrawn
- 2007-02-23 CA CA2678808A patent/CA2678808C/en not_active Expired - Fee Related
- 2007-02-23 JP JP2009550863A patent/JP2010521422A/ja active Pending
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- 2007-02-23 CN CN200780052684A patent/CN101662948A/zh active Pending
- 2007-02-23 WO PCT/US2007/062714 patent/WO2008103180A1/en active Application Filing
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Cited By (2)
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JP2015006200A (ja) * | 2010-12-20 | 2015-01-15 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 満腹応答を誘導するためのペットフード組成物 |
WO2024105922A1 (ja) * | 2022-11-18 | 2024-05-23 | プレミアアンチエイジング株式会社 | 抗肥満用、体脂肪減少用又は脂肪代謝促進用組成物 |
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WO2008103180A1 (en) | 2008-08-28 |
BRPI0721349A2 (pt) | 2013-01-08 |
US20100048723A1 (en) | 2010-02-25 |
AU2007347423A1 (en) | 2008-08-28 |
CA2678808A1 (en) | 2008-08-28 |
CA2678808C (en) | 2012-07-10 |
EP2124614A1 (en) | 2009-12-02 |
ZA200906541B (en) | 2014-08-27 |
CN101662948A (zh) | 2010-03-03 |
AU2007347423B2 (en) | 2011-12-22 |
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