JP2010520884A5 - - Google Patents
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- Publication number
- JP2010520884A5 JP2010520884A5 JP2009552912A JP2009552912A JP2010520884A5 JP 2010520884 A5 JP2010520884 A5 JP 2010520884A5 JP 2009552912 A JP2009552912 A JP 2009552912A JP 2009552912 A JP2009552912 A JP 2009552912A JP 2010520884 A5 JP2010520884 A5 JP 2010520884A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- independently
- alkyl
- hydrogen
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims description 388
- 229910052739 hydrogen Inorganic materials 0.000 claims description 322
- 239000001257 hydrogen Substances 0.000 claims description 322
- 150000002431 hydrogen Chemical class 0.000 claims description 264
- 125000001188 haloalkyl group Chemical group 0.000 claims description 232
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 156
- 125000003107 substituted aryl group Chemical group 0.000 claims description 156
- 125000001072 heteroaryl group Chemical group 0.000 claims description 146
- 125000001475 halogen functional group Chemical group 0.000 claims description 140
- 150000001875 compounds Chemical class 0.000 claims description 118
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 92
- 125000002947 alkylene group Chemical group 0.000 claims description 92
- 125000003342 alkenyl group Chemical group 0.000 claims description 82
- 125000000304 alkynyl group Chemical group 0.000 claims description 82
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 82
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 82
- 125000000623 heterocyclic group Chemical group 0.000 claims description 82
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 82
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 82
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 58
- 125000000262 haloalkenyl group Chemical group 0.000 claims description 32
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 32
- -1 (2-fluorodibenzo [b, d] thiophene-4,6-diyl) bis (methylene) Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 239000012453 solvate Substances 0.000 claims description 16
- 239000000651 prodrug Substances 0.000 claims description 14
- 229940002612 prodrug Drugs 0.000 claims description 14
- 241000124008 Mammalia Species 0.000 claims description 12
- YEQUTLMSIJSBHR-UHFFFAOYSA-N carbamimidoylsulfanylmethyl carbamimidothioate Chemical compound NC(=N)SCSC(N)=N YEQUTLMSIJSBHR-UHFFFAOYSA-N 0.000 claims description 10
- 208000016286 Iron metabolism disease Diseases 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- RICFBYYSLVWNTQ-UHFFFAOYSA-N [2,7-ditert-butyl-5-(carbamimidoylsulfanylmethyl)-9,9-dimethylxanthen-4-yl]methyl carbamimidothioate Chemical compound C1=C(C(C)(C)C)C=C2C(C)(C)C3=CC(C(C)(C)C)=CC(CSC(N)=N)=C3OC2=C1CSC(N)=N RICFBYYSLVWNTQ-UHFFFAOYSA-N 0.000 claims description 2
- RYBBRMHNTXACFN-UHFFFAOYSA-N [4,5,8-tris(carbamimidoylsulfanylmethyl)biphenylen-1-yl]methyl carbamimidothioate Chemical compound NC(=N)SCC1=CC=C(CSC(N)=N)C2=C1C1=C2C(CSC(=N)N)=CC=C1CSC(N)=N RYBBRMHNTXACFN-UHFFFAOYSA-N 0.000 claims description 2
- DXUPGDWGOABSDH-UHFFFAOYSA-N [5-(carbamimidoylsulfanylmethyl)acridin-4-yl]methyl carbamimidothioate Chemical compound C1=CC(CSC(N)=N)=C2N=C3C(CSC(=N)N)=CC=CC3=CC2=C1 DXUPGDWGOABSDH-UHFFFAOYSA-N 0.000 claims description 2
- YPBKXBQJGRXXJQ-UHFFFAOYSA-N [6-(carbamimidoylsulfanylmethyl)phenoxathiin-4-yl]methyl carbamimidothioate Chemical compound S1C2=CC=CC(CSC(N)=N)=C2OC2=C1C=CC=C2CSC(=N)N YPBKXBQJGRXXJQ-UHFFFAOYSA-N 0.000 claims description 2
- KZPZQJQJVUEFJN-UHFFFAOYSA-N [8-(carbamimidoylsulfanylmethyl)-9-oxofluoren-1-yl]methyl carbamimidothioate Chemical compound C12=CC=CC(CSC(N)=N)=C2C(=O)C2=C1C=CC=C2CSC(=N)N KZPZQJQJVUEFJN-UHFFFAOYSA-N 0.000 claims description 2
- PGLQOIXGWNOUFX-UHFFFAOYSA-N [8-(carbamimidoylsulfanylmethyl)anthracen-1-yl]methyl carbamimidothioate Chemical compound C1=CC(CSC(N)=N)=C2C=C3C(CSC(=N)N)=CC=CC3=CC2=C1 PGLQOIXGWNOUFX-UHFFFAOYSA-N 0.000 claims description 2
- AVVNVDBKYFRSIR-UHFFFAOYSA-N [8-(carbamimidoylsulfanylmethyl)biphenylen-1-yl]methyl carbamimidothioate Chemical compound C12=CC=CC(CSC(N)=N)=C2C2=C1C=CC=C2CSC(=N)N AVVNVDBKYFRSIR-UHFFFAOYSA-N 0.000 claims description 2
- DVMHUQSGVOMRKB-UHFFFAOYSA-N [9-(carbamimidoylsulfanylmethyl)dibenzothiophen-1-yl]methyl carbamimidothioate Chemical compound S1C2=CC=CC(CSC(N)=N)=C2C2=C1C=CC=C2CSC(=N)N DVMHUQSGVOMRKB-UHFFFAOYSA-N 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 *c1ccc(*)c(*2)c1*c1c2c(*)ccc1* Chemical compound *c1ccc(*)c(*2)c1*c1c2c(*)ccc1* 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89358507P | 2007-03-07 | 2007-03-07 | |
| PCT/US2008/056250 WO2008109840A1 (en) | 2007-03-07 | 2008-03-07 | Tricyclic compounds useful in treating iron disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520884A JP2010520884A (ja) | 2010-06-17 |
| JP2010520884A5 true JP2010520884A5 (https=) | 2012-07-05 |
Family
ID=39512833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552912A Withdrawn JP2010520884A (ja) | 2007-03-07 | 2008-03-07 | 鉄障害を処置するために有用な三環系化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090069408A1 (https=) |
| EP (1) | EP2061755A1 (https=) |
| JP (1) | JP2010520884A (https=) |
| CN (1) | CN101616892A (https=) |
| AR (1) | AR065628A1 (https=) |
| AU (1) | AU2008222666A1 (https=) |
| BR (1) | BRPI0808043A2 (https=) |
| CA (1) | CA2678895A1 (https=) |
| CL (1) | CL2008000666A1 (https=) |
| MX (1) | MX2009009466A (https=) |
| RU (1) | RU2009136996A (https=) |
| TW (1) | TW200845961A (https=) |
| WO (1) | WO2008109840A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2068855A2 (en) * | 2007-06-05 | 2009-06-17 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
| AR077892A1 (es) | 2009-08-20 | 2011-09-28 | Vifor Int Ag | Quinolinas antagonistas de la hepcidina |
| AR077958A1 (es) | 2009-08-27 | 2011-10-05 | Vifor Int Ag | Quinoxalinonas antagonistas de la hepcidina |
| AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
| JP2013503835A (ja) | 2009-09-07 | 2013-02-04 | ヴィフォール （インターナショナル） アクチェンゲゼルシャフト | 新規なエタンジアミン系ヘプシジン拮抗薬 |
| TW201111379A (en) | 2009-09-09 | 2011-04-01 | Vifor Int Ag | Novel thiazole-and oxazole-hepcidine-antagonists |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| CA3002416C (en) | 2015-10-23 | 2023-10-24 | Vifor (International) Ag | Benzimidazolyl derivatives for use as ferroportin inhibitors |
| JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
| TW202102478A (zh) | 2019-04-01 | 2021-01-16 | 瑞士商威佛（國際）股份有限公司 | 新穎的鐵螯合物 |
| CN114163417B (zh) * | 2021-12-06 | 2023-08-04 | 郑州海阔光电材料有限公司 | 一种3-溴硫芴的合成方法 |
| JP7817887B2 (ja) * | 2022-06-02 | 2026-02-19 | 旭化成株式会社 | ルテニウム錯体の製造方法、並びにルテニウム錯体及びこれを用いたジアミンの製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) * | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| WO1994006802A1 (fr) * | 1992-09-18 | 1994-03-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienodiazepine et son utilisation medicinale |
| US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
| US6080587A (en) * | 1998-01-23 | 2000-06-27 | Eli Lilly And Company | Method for preparing and selecting pharmaceutically useful sulfur-bridged bi- and triaromatic ring compounds from a structurally diverse universal library |
| GB9815880D0 (en) * | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
| US20060269498A1 (en) * | 2005-05-17 | 2006-11-30 | Gerard Malle | Hair shaping composition comprising at least one polyguanidine other than hydroxide |
| EP2068855A2 (en) * | 2007-06-05 | 2009-06-17 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
-
2008
- 2008-03-06 AR ARP080100936A patent/AR065628A1/es not_active Application Discontinuation
- 2008-03-06 CL CL200800666A patent/CL2008000666A1/es unknown
- 2008-03-07 CN CN200880005559A patent/CN101616892A/zh active Pending
- 2008-03-07 WO PCT/US2008/056250 patent/WO2008109840A1/en not_active Ceased
- 2008-03-07 TW TW097108246A patent/TW200845961A/zh unknown
- 2008-03-07 BR BRPI0808043-7A2A patent/BRPI0808043A2/pt not_active IP Right Cessation
- 2008-03-07 EP EP08754872A patent/EP2061755A1/en not_active Withdrawn
- 2008-03-07 JP JP2009552912A patent/JP2010520884A/ja not_active Withdrawn
- 2008-03-07 RU RU2009136996/04A patent/RU2009136996A/ru not_active Application Discontinuation
- 2008-03-07 US US12/044,731 patent/US20090069408A1/en not_active Abandoned
- 2008-03-07 CA CA002678895A patent/CA2678895A1/en not_active Abandoned
- 2008-03-07 AU AU2008222666A patent/AU2008222666A1/en not_active Abandoned
- 2008-03-07 MX MX2009009466A patent/MX2009009466A/es not_active Application Discontinuation
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