|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4997913A
(en)
*
|
1986-06-30 |
1991-03-05 |
Oncogen |
pH-sensitive immunoconjugates and methods for their use in tumor therapy
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
WO1992003918A1
(en)
|
1990-08-29 |
1992-03-19 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE278019T1
(de)
|
1991-06-21 |
2004-10-15 |
Inst Medical W & E Hall |
Neuartige rezeptor-typ tyrosinkinase und deren verwendung
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
NO175798C
(no)
|
1992-07-22 |
1994-12-07 |
Sinvent As |
Fremgangsmåte og anordning til aktiv stöydemping i et lokalt område
|
|
US5885573A
(en)
|
1993-06-01 |
1999-03-23 |
Arch Development Corporation |
Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5811097A
(en)
*
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5770380A
(en)
|
1996-09-13 |
1998-06-23 |
University Of Pittsburgh |
Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6342220B1
(en)
*
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6864227B1
(en)
*
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
DK2180007T4
(da)
|
1998-04-20 |
2017-11-27 |
Roche Glycart Ag |
Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
SI1135153T1
(show.php)
|
1998-11-20 |
2005-08-31 |
Genentech Inc |
|
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
PL220113B1
(pl)
|
1999-01-15 |
2015-08-31 |
Genentech Inc |
Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc
|
|
CA2367212A1
(en)
|
1999-04-01 |
2000-10-12 |
Innogenetics N.V. |
A polypeptide structure for use as a scaffold
|
|
ES2571230T3
(es)
|
1999-04-09 |
2016-05-24 |
Kyowa Hakko Kirin Co Ltd |
Procedimiento para controlar la actividad de una molécula inmunofuncional
|
|
EP1094110A1
(en)
|
1999-10-21 |
2001-04-25 |
Leadd B.V. |
Apoptosis inducing proteinaceous substance
|
|
KR100787073B1
(ko)
|
2000-06-28 |
2007-12-21 |
글리코파이, 인크. |
변형된 당단백질의 제조방법
|
|
AU9419801A
(en)
|
2000-10-06 |
2002-04-22 |
Kyowa Hakko Kogyo Kk |
Cells producing antibody compositions
|
|
WO2002030954A1
(en)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Method of purifying antibody
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
ES2727425T3
(es)
|
2000-12-12 |
2019-10-16 |
Medimmune Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
|
US7041302B2
(en)
*
|
2001-01-09 |
2006-05-09 |
Biother Corporation |
Therapeutic modulation of the tumor inflammatory response
|
|
US6652853B2
(en)
*
|
2001-03-08 |
2003-11-25 |
Ludwig Institute For Cancer Research |
Method for treating cancer using A33 specific antibodies and chemotherapeutic agents
|
|
AU2002252456A1
(en)
*
|
2001-03-23 |
2002-10-08 |
Aphton Corporation |
Combination treatment of pancreatic cancer
|
|
US20050049194A1
(en)
*
|
2001-11-09 |
2005-03-03 |
Jonas Frisen |
Use of ephrins and related molecules to regulate cellular proliferation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
CA2478297C
(en)
|
2002-03-19 |
2013-05-14 |
Plant Research International B.V. |
Optimizing glycan processing in plants
|
|
WO2003102144A2
(en)
|
2002-05-29 |
2003-12-11 |
Curagen Corporation |
Compositions and methods of use for an ephrin rreceptor
|
|
EP1553963A4
(en)
*
|
2002-09-24 |
2006-05-03 |
Burnham Inst |
NEW MEANS FOR MODULATING EPH RECEPTOR ACTIVITY
|
|
DK2364996T3
(en)
|
2002-09-27 |
2017-02-06 |
Xencor Inc |
Optimized Fc variants and methods for their formation
|
|
AU2003900541A0
(en)
|
2003-02-07 |
2003-02-20 |
Ludwig Institute For Cancer Research |
Modulation of cell adhesion and tumour cell metastasis
|
|
WO2005021710A2
(en)
*
|
2003-06-02 |
2005-03-10 |
University Of Miami |
Chimeric molecules and methods of use
|
|
WO2005069970A2
(en)
*
|
2004-01-20 |
2005-08-04 |
Kalobios, Inc. |
Antibody specificity transfer using minimal essential binding determinants
|
|
WO2006023420A2
(en)
*
|
2004-08-16 |
2006-03-02 |
Medimmune, Inc. |
Integrin antagonists with enhanced antibody dependent cell-mediated cytotoxicity activity
|
|
WO2006052409A2
(en)
|
2004-10-23 |
2006-05-18 |
Case Western Reserve University |
Peptide and small molecule agonists of epha and their uses
|
|
EP2422811A2
(en)
*
|
2004-10-27 |
2012-02-29 |
MedImmune, LLC |
Modulation of antibody specificity by tailoring the affinity to cognate antigens
|
|
PT2343380T
(pt)
|
2004-11-16 |
2019-09-18 |
Humanigen Inc |
Permuta de cassetes da região variável de imunoglobulina
|
|
WO2007084926A2
(en)
|
2006-01-17 |
2007-07-26 |
Biolex Therapeutics, Inc. |
Compositions and methods for humanization and optimization of n-glycans in plants
|
|
US7846724B2
(en)
|
2006-04-11 |
2010-12-07 |
Hoffmann-La Roche Inc. |
Method for selecting CHO cell for production of glycosylated antibodies
|