JP2010520280A5 - - Google Patents
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- Publication number
- JP2010520280A5 JP2010520280A5 JP2009552676A JP2009552676A JP2010520280A5 JP 2010520280 A5 JP2010520280 A5 JP 2010520280A5 JP 2009552676 A JP2009552676 A JP 2009552676A JP 2009552676 A JP2009552676 A JP 2009552676A JP 2010520280 A5 JP2010520280 A5 JP 2010520280A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- notch2
- notch1
- numb1
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims description 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 208000030808 Clear cell renal carcinoma Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 6
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 6
- 206010073251 clear cell renal cell carcinoma Diseases 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 201000007270 liver cancer Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
- 201000011330 nonpapillary renal cell carcinoma Diseases 0.000 claims description 6
- 201000002528 pancreatic cancer Diseases 0.000 claims description 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 230000003053 immunization Effects 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90499407P | 2007-03-05 | 2007-03-05 | |
| US96104607P | 2007-07-18 | 2007-07-18 | |
| US95994607P | 2007-07-18 | 2007-07-18 | |
| US95997107P | 2007-07-18 | 2007-07-18 | |
| PCT/US2008/001694 WO2008108910A2 (en) | 2007-03-05 | 2008-02-08 | Negative genetic regulation of cancer cell renewal in synergy with notch- or numb-specific immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520280A JP2010520280A (ja) | 2010-06-10 |
| JP2010520280A5 true JP2010520280A5 (enExample) | 2012-04-12 |
Family
ID=39539638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552676A Withdrawn JP2010520280A (ja) | 2007-03-05 | 2008-02-08 | ＮｏｔｃｈまたはＮｕｍｂ特異的免疫療法との相乗効果を有する、癌細胞の再生のネガティブな遺伝的制御 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100062012A1 (enExample) |
| EP (1) | EP2134356A2 (enExample) |
| JP (1) | JP2010520280A (enExample) |
| WO (1) | WO2008108910A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| JP2009539403A (ja) | 2006-06-13 | 2009-11-19 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌を診断および処置するための組成物および方法 |
| CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| BRPI0914007A2 (pt) | 2008-07-08 | 2015-11-17 | Oncomed Pharm Inc | anatagonistas e agentes de ligação de notch e métodos para uso dos mesmos |
| AU2010261364B2 (en) | 2009-06-18 | 2015-05-07 | Pfizer Inc. | Anti Notch-1 antibodies |
| AU2010300747A1 (en) * | 2009-09-30 | 2012-04-26 | Genentech, Inc. | Treating Notch1-antagonist-resistant cancer (s) using Notch3 antagonists |
| ES2561102T3 (es) | 2010-01-13 | 2016-02-24 | Oncomed Pharmaceuticals, Inc. | Agentes de unión a Notch1 y procedimientos de uso de los mismos |
| WO2012080926A2 (en) | 2010-12-15 | 2012-06-21 | Wyeth Llc | Anti-notch1 antibodies |
| KR101535219B1 (ko) * | 2011-11-18 | 2015-07-09 | 한국생명공학연구원 | Ｎｏｔｃｈ３에 대한 인간 단일클론항체 |
| US9944700B2 (en) | 2013-03-13 | 2018-04-17 | Novartis Ag | Notch2 binding molecules for treating respiratory diseases |
| CN109467598B (zh) * | 2018-11-28 | 2021-11-09 | 生命谷（海南）生物科技股份有限公司 | 肿瘤相关基因notch1突变短肽及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998057621A1 (en) * | 1997-06-18 | 1998-12-23 | The Trustees Of Columbia University In The City Ofnew York | Angiogenic modulation by notch signal transduction |
| GB9927328D0 (en) * | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
| US20040126762A1 (en) * | 2002-12-17 | 2004-07-01 | Morris David W. | Novel compositions and methods in cancer |
| CA2546017A1 (en) * | 2003-11-26 | 2005-06-16 | Health Research, Inc. | Use of notch pathway interfering agents for treatment of plasma cell disorders |
| GB0421838D0 (en) * | 2004-09-30 | 2004-11-03 | Congenia S R L | Cancer markers |
-
2008
- 2008-02-08 EP EP08725340A patent/EP2134356A2/en not_active Withdrawn
- 2008-02-08 US US12/529,759 patent/US20100062012A1/en not_active Abandoned
- 2008-02-08 JP JP2009552676A patent/JP2010520280A/ja not_active Withdrawn
- 2008-02-08 WO PCT/US2008/001694 patent/WO2008108910A2/en not_active Ceased