JP2010519183A5 - - Google Patents
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- Publication number
- JP2010519183A5 JP2010519183A5 JP2009549095A JP2009549095A JP2010519183A5 JP 2010519183 A5 JP2010519183 A5 JP 2010519183A5 JP 2009549095 A JP2009549095 A JP 2009549095A JP 2009549095 A JP2009549095 A JP 2009549095A JP 2010519183 A5 JP2010519183 A5 JP 2010519183A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- precursor
- precipitation
- aqueous
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims 16
- 239000002243 precursor Substances 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 238000001556 precipitation Methods 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 3
- 239000000017 hydrogel Substances 0.000 claims 3
- 238000006116 polymerization reaction Methods 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 230000000269 nucleophilic effect Effects 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920006037 cross link polymer Polymers 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 239000003505 polymerization initiator Substances 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000005185 salting out Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89989807P | 2007-02-06 | 2007-02-06 | |
| PCT/US2008/001577 WO2008097581A1 (en) | 2007-02-06 | 2008-02-06 | Polymerization with precipitation of proteins for elution in physiological solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010519183A JP2010519183A (ja) | 2010-06-03 |
| JP2010519183A5 true JP2010519183A5 (enExample) | 2011-03-24 |
Family
ID=39676361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549095A Abandoned JP2010519183A (ja) | 2007-02-06 | 2008-02-06 | 生理溶液の溶出のためのタンパク質の沈殿を用いる重合 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080187568A1 (enExample) |
| EP (1) | EP2121057A4 (enExample) |
| JP (1) | JP2010519183A (enExample) |
| AU (1) | AU2008214319A1 (enExample) |
| CA (1) | CA2677532A1 (enExample) |
| WO (1) | WO2008097581A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2459228B1 (en) | 2009-07-31 | 2020-03-04 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an insulin linker conjugate |
| NZ597964A (en) | 2009-07-31 | 2014-04-30 | Sanofi Aventis Deutschland | Long acting insulin composition |
| PL2459220T3 (pl) * | 2009-07-31 | 2021-03-08 | Ascendis Pharma A/S | Biodegradowalne nierozpuszczalne w wodzie hydrożele na bazie poli(glikolu etylenowego) |
| WO2011065916A1 (en) | 2009-11-24 | 2011-06-03 | Agency For Science, Technology And Research | Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel |
| EP3583960A1 (en) | 2009-12-15 | 2019-12-25 | Incept, LLC | Implants and biodegradable fiducial markers |
| EP2380920A1 (en) | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
| EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
| US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
| US8722254B2 (en) | 2011-05-09 | 2014-05-13 | Washington State University Research Foundation | Flexible solid state conductors including polymer mixed with protein |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| CN104349769B (zh) | 2011-12-05 | 2018-10-09 | 因赛普特有限责任公司 | 医用有机凝胶方法和组合物 |
| WO2014034884A1 (ja) * | 2012-08-31 | 2014-03-06 | 国立大学法人北陸先端科学技術大学院大学 | 凍結保存可能な細胞足場材料 |
| EP3131944B1 (en) * | 2014-04-17 | 2018-12-05 | The Corporation OF Mercer University | Vitamin e-based nanocarriers for drug delivery and methods of making and using the same |
| SG10201903210WA (en) | 2014-12-15 | 2019-05-30 | Univ Johns Hopkins | Sunitinib Formulations and Methods for Use Thereof in Treatment of Ocular Disorders |
| JP6712081B2 (ja) * | 2015-03-10 | 2020-06-17 | 国立大学法人 東京大学 | ゲル前駆体クラスターを用いた低濃度ゲルの製造方法、及び当該製造方法により得られるゲル |
| HK1257499A1 (zh) | 2015-11-12 | 2019-10-25 | Graybug Vision, Inc. | 用於治疗的聚集性微粒 |
| MX2019013363A (es) | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| EP3831871A4 (en) | 2018-07-31 | 2022-04-06 | The University of Tokyo | POLYMER GEL WITH SPONGE-LIKE POROUS STRUCTURE |
| JP2023510380A (ja) * | 2020-01-16 | 2023-03-13 | 香港科技大学 | 標的剤の放出制御のための組成物及び方法 |
| CN116507330A (zh) * | 2020-11-12 | 2023-07-28 | 普拉曼德有限责任公司 | 用于子宫内使用的原位形成的水凝胶和组合物设计 |
| US12343454B2 (en) * | 2020-11-12 | 2025-07-01 | Pramand LLC | Hydrogels formed in situ and composition design for intrauterine use |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3631018A (en) * | 1970-05-01 | 1971-12-28 | Baxter Laboratories Inc | Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate |
| US3790552A (en) * | 1972-03-16 | 1974-02-05 | Us Health | Method of removing hepatitis-associated antigen from a protein fraction using polyethylene glycol |
| US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| DE2512735A1 (de) * | 1975-03-22 | 1976-09-30 | Henkel & Cie Gmbh | Verfahren zur gewinnung von proteinen aus waessrigen protein- loesungen |
| DK144731C (da) * | 1976-07-30 | 1982-10-18 | Nordisk Insulinlab | Fremgangsmaade til isolering af proteinhormoner stammende fra humant hypofysevaev |
| US4693887A (en) * | 1983-09-15 | 1987-09-15 | The Kendall Company | Microphase separated hydrogels for controlled release of bioactive materials |
| FR2582515B1 (fr) * | 1985-05-30 | 1988-11-04 | Merieux Inst | Procede de preparation de gamma-gobulines administrables par voie intraveineuse et gamma-globulines obtenues |
| US5126141A (en) * | 1988-11-16 | 1992-06-30 | Mediventures Incorporated | Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides |
| US5800541A (en) * | 1988-11-21 | 1998-09-01 | Collagen Corporation | Collagen-synthetic polymer matrices prepared using a multiple step reaction |
| US5226877A (en) * | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
| DK469989D0 (da) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| US5468811A (en) * | 1989-11-02 | 1995-11-21 | National Patent Development Corporation | Hydrophilic composite polymer articles formed from a settable paste comprising a mixture of hydrophilic polymer and unsaturated monomer |
| US5135875A (en) * | 1990-08-15 | 1992-08-04 | Abbott Laboratories | Protein precipitation reagent |
| US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5330768A (en) * | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| US5525519A (en) * | 1992-01-07 | 1996-06-11 | Middlesex Sciences, Inc. | Method for isolating biomolecules from a biological sample with linear polymers |
| US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
| US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| US5266326A (en) * | 1992-06-30 | 1993-11-30 | Pfizer Hospital Products Group, Inc. | In situ modification of alginate |
| US5514379A (en) * | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
| US5395923A (en) * | 1993-02-23 | 1995-03-07 | Haemacure-Biotech, Inc. | Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out" |
| US5409703A (en) * | 1993-06-24 | 1995-04-25 | Carrington Laboratories, Inc. | Dried hydrogel from hydrophilic-hygroscopic polymer |
| US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
| US5900245A (en) * | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
| US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
| US6201065B1 (en) * | 1995-07-28 | 2001-03-13 | Focal, Inc. | Multiblock biodegradable hydrogels for drug delivery and tissue treatment |
| CA2239775C (en) * | 1995-12-18 | 2008-07-15 | Collagen Corporation | Crosslinked polymer compositions and methods for their use |
| US20090324721A1 (en) * | 1996-09-23 | 2009-12-31 | Jack Kennedy | Hydrogels Suitable For Use In Polyp Removal |
| US7009034B2 (en) * | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
| AU4648697A (en) * | 1996-09-23 | 1998-04-14 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US6416778B1 (en) * | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
| US6371975B2 (en) * | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
| US6150505A (en) * | 1997-09-19 | 2000-11-21 | Hadasit Medical Research Services & Development Ltd. | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII |
| IL135800A0 (en) * | 1997-10-27 | 2001-05-20 | Univ California | Methods and pharmaceutical compositions for the closure of retinal breaks |
| US6613358B2 (en) * | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
| US6152943A (en) * | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| US7335220B2 (en) * | 2004-11-05 | 2008-02-26 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
| US6632457B1 (en) * | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6514534B1 (en) * | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6605294B2 (en) * | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US7347850B2 (en) * | 1998-08-14 | 2008-03-25 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
| US6231889B1 (en) * | 1998-09-21 | 2001-05-15 | Chronorx, Llc | Unit dosage forms for the treatment of herpes simplex |
| JP2002531217A (ja) * | 1998-12-04 | 2002-09-24 | チャンドラシェカー ピー. パサック, | 生体適合性架橋ポリマー |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US6312725B1 (en) * | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| GB0102075D0 (en) * | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
| US20030091513A1 (en) * | 2001-10-03 | 2003-05-15 | Mohsen Nahed M. | Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media |
| ES2357889T3 (es) * | 2001-11-15 | 2011-05-03 | Piramal Healthcare (Canada) Limited | Composición y método para reticular o modificar homogéneamente quitosano en condiciones neutras. |
| WO2003089506A1 (en) * | 2002-04-22 | 2003-10-30 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
| US20040147016A1 (en) * | 2002-09-30 | 2004-07-29 | Rowley Jonathan A. | Programmable scaffold and methods for making and using the same |
| US7525570B2 (en) * | 2003-07-17 | 2009-04-28 | Igt | Security camera interface |
| WO2005120462A2 (en) * | 2004-06-07 | 2005-12-22 | Callisyn Pharmaceuticals, Inc. | Biodegradable and biocompatible crosslinked polymer hydrogel prepared from pva and/or peg macromer mixtures |
| US8795709B2 (en) * | 2006-03-29 | 2014-08-05 | Incept Llc | Superabsorbent, freeze dried hydrogels for medical applications |
-
2008
- 2008-02-06 EP EP08725234A patent/EP2121057A4/en not_active Withdrawn
- 2008-02-06 CA CA002677532A patent/CA2677532A1/en not_active Abandoned
- 2008-02-06 US US12/012,808 patent/US20080187568A1/en not_active Abandoned
- 2008-02-06 JP JP2009549095A patent/JP2010519183A/ja not_active Abandoned
- 2008-02-06 WO PCT/US2008/001577 patent/WO2008097581A1/en not_active Ceased
- 2008-02-06 AU AU2008214319A patent/AU2008214319A1/en not_active Abandoned
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