JP2010518946A5 - - Google Patents
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- Publication number
- JP2010518946A5 JP2010518946A5 JP2009550618A JP2009550618A JP2010518946A5 JP 2010518946 A5 JP2010518946 A5 JP 2010518946A5 JP 2009550618 A JP2009550618 A JP 2009550618A JP 2009550618 A JP2009550618 A JP 2009550618A JP 2010518946 A5 JP2010518946 A5 JP 2010518946A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- scaffold material
- osteonecrosis
- pdgf
- biocompatible matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 47
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 26
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 26
- 239000011159 matrix material Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 20
- 206010031264 Osteonecrosis Diseases 0.000 claims description 19
- 230000005855 radiation Effects 0.000 claims description 14
- 208000029985 osteonecrosis of the jaw Diseases 0.000 claims description 11
- 210000000988 bone and bone Anatomy 0.000 claims description 10
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 6
- 239000001506 calcium phosphate Substances 0.000 claims description 6
- 235000011010 calcium phosphates Nutrition 0.000 claims description 6
- 239000000872 buffer Substances 0.000 claims description 5
- 108010081589 Becaplermin Proteins 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 210000002805 bone matrix Anatomy 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims 5
- 241000186046 Actinomyces Species 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 230000001338 necrotic effect Effects 0.000 claims 2
- 230000035699 permeability Effects 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 239000008351 acetate buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89076307P | 2007-02-20 | 2007-02-20 | |
| PCT/US2008/054354 WO2008103690A2 (en) | 2007-02-20 | 2008-02-20 | Prevention and treatment for osteonecrosis and osteoradionecrosis of the jaw using pdgf and a bone matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518946A JP2010518946A (ja) | 2010-06-03 |
| JP2010518946A5 true JP2010518946A5 (cg-RX-API-DMAC7.html) | 2011-04-07 |
Family
ID=39710710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009550618A Pending JP2010518946A (ja) | 2007-02-20 | 2008-02-20 | 顎の骨壊死および顎の放射線骨壊死の予防および処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100151025A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2125000A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010518946A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008218763B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2678875A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008103690A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| EP2431060B1 (en) | 2005-11-17 | 2020-04-08 | BioMimetic Therapeutics, LLC | Maxillofacial bone augmentation using RHPDGF-BB and a biocompatible matrix |
| EP2311505B1 (en) | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| EP2049145B1 (en) * | 2006-06-30 | 2018-03-14 | BioMimetic Therapeutics, LLC | Pdgf-biomatrix compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| AU2007333425B2 (en) | 2006-11-03 | 2014-03-27 | Stryker Corporation | Compositions and methods for arthrodetic procedures |
| CN105854074B (zh) * | 2008-02-07 | 2019-10-15 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
| WO2012105223A1 (ja) * | 2011-01-31 | 2012-08-09 | オリンパス株式会社 | 免疫賦活剤 |
| CN107106492B (zh) | 2014-10-14 | 2022-07-05 | 塞缪尔·林奇 | 用于治疗伤口的组合物 |
| GB2549714A (en) * | 2016-04-25 | 2017-11-01 | Pharmaceutical Business Consultants Ltd | Vascularity affinity precursor structure for musculo-skeletal tissue healing |
| JP7117724B2 (ja) * | 2018-01-18 | 2022-08-15 | 新田ゼラチン株式会社 | 歯肉および歯槽粘膜の再生促進作用に基づく顎骨壊死、顎骨骨髄炎または抜歯後治癒不全の予防に用いる予防剤 |
| WO2025024276A1 (en) * | 2023-07-21 | 2025-01-30 | Mercury Bio, Inc. | Production and delivery of therapeutic nucleic acids packaged in yeast extracellular vesicles embedded in biocompatible implant matrices |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1260391A (en) * | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
| DE4120325A1 (de) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | Implantatwerkstoff |
| US5614206A (en) * | 1995-03-07 | 1997-03-25 | Wright Medical Technology, Inc. | Controlled dissolution pellet containing calcium sulfate |
| JP4809963B2 (ja) * | 1999-11-11 | 2011-11-09 | オリンパス株式会社 | 骨補填材 |
| JP2003019195A (ja) * | 2000-05-19 | 2003-01-21 | Mmt:Kk | 生体用部材 |
| AU2003210996A1 (en) * | 2002-02-11 | 2003-09-04 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
| WO2003094617A2 (en) * | 2002-05-06 | 2003-11-20 | Genentech, Inc. | Use of vegf for treating bone defects |
| ATE418619T1 (de) * | 2002-06-14 | 2009-01-15 | Pierce Biotechnology Inc | Homogenes assay zum nachweis von enzymaktivität |
| JP2004159971A (ja) * | 2002-11-14 | 2004-06-10 | Hideki Yoshikawa | 骨形成用部材およびその製造方法 |
| EP1433489A1 (en) * | 2002-12-23 | 2004-06-30 | Degradable Solutions AG | Biodegradable porous bone implant with a barrier membrane sealed thereto |
| JPWO2004105825A1 (ja) * | 2003-01-10 | 2006-07-20 | 多木化学株式会社 | 骨形成用生体材料、該材料を含む注入用製剤、及び該材料を調製するためのキット、並びにこれらを用いる骨形成方法 |
| DE60307683T2 (de) * | 2003-02-13 | 2008-05-15 | Synthes Gmbh | Injizierbare mischung zum ersatz von knochengewebe in situ |
| PL1641916T3 (pl) * | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| EP1661580B1 (en) * | 2003-07-25 | 2014-01-08 | Ono Pharmaceutical Co., Ltd. | Remedy for cartilage-related diseases |
| JP2005111130A (ja) * | 2003-10-10 | 2005-04-28 | Olympus Corp | 骨補填材の製造方法 |
| US20080200372A1 (en) * | 2004-01-16 | 2008-08-21 | Institute Of Nutraceutical Research Pty Ltd. | Glycosaminoglycan Peptides Derived From Connective Tissues And Use Thereof In The Prevention Of Arthritis And Other Degenerative Medical Conditions |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| JP2006320442A (ja) * | 2005-05-18 | 2006-11-30 | Toshiba Ceramics Co Ltd | リン酸カルシウム系骨補填材 |
| EP2431060B1 (en) * | 2005-11-17 | 2020-04-08 | BioMimetic Therapeutics, LLC | Maxillofacial bone augmentation using RHPDGF-BB and a biocompatible matrix |
| EP2311505B1 (en) * | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
| EP2049145B1 (en) * | 2006-06-30 | 2018-03-14 | BioMimetic Therapeutics, LLC | Pdgf-biomatrix compositions and methods for treating rotator cuff injuries |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| AU2007333425B2 (en) * | 2006-11-03 | 2014-03-27 | Stryker Corporation | Compositions and methods for arthrodetic procedures |
| WO2008100442A1 (en) * | 2007-02-09 | 2008-08-21 | Biomet Biologics, Inc. | Treatment of tissue defects with a therapeutic composition |
| CN104623669A (zh) * | 2007-08-22 | 2015-05-20 | 斯丹姆涅恩有限公司 | 含细胞因子溶液的新组合物 |
| CN105854074B (zh) * | 2008-02-07 | 2019-10-15 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
| CN102231992B (zh) * | 2008-09-09 | 2015-05-20 | 生物模拟治疗公司 | 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法 |
| KR20110100269A (ko) * | 2008-12-19 | 2011-09-09 | 바이오미메틱 세라퓨틱스, 인크. | 감소된 프로테아제 활성을 갖는 골 이식편 및 선택 방법 및 용도 |
| JP2012519556A (ja) * | 2009-03-05 | 2012-08-30 | バイオミメティック セラピューティクス， インコーポレイテッド | 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法 |
-
2008
- 2008-02-20 US US12/527,692 patent/US20100151025A1/en not_active Abandoned
- 2008-02-20 JP JP2009550618A patent/JP2010518946A/ja active Pending
- 2008-02-20 WO PCT/US2008/054354 patent/WO2008103690A2/en not_active Ceased
- 2008-02-20 AU AU2008218763A patent/AU2008218763B2/en not_active Ceased
- 2008-02-20 CA CA002678875A patent/CA2678875A1/en not_active Abandoned
- 2008-02-20 EP EP08743499A patent/EP2125000A2/en not_active Withdrawn
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