JP2010518086A - スフェンタニルおよびナロキソンを含む経口腔投与製剤 - Google Patents

スフェンタニルおよびナロキソンを含む経口腔投与製剤 Download PDF

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Publication number
JP2010518086A
JP2010518086A JP2009549118A JP2009549118A JP2010518086A JP 2010518086 A JP2010518086 A JP 2010518086A JP 2009549118 A JP2009549118 A JP 2009549118A JP 2009549118 A JP2009549118 A JP 2009549118A JP 2010518086 A JP2010518086 A JP 2010518086A
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dosage formulation
oral dosage
administration
minutes
oral
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Japanese (ja)
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JP2010518086A5 (enExample
Inventor
イル ユム，スー
シャー，ジェイミン
ユン クォン，サン
ソン，シャオピン
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デュレクト コーポレーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009549118A 2007-02-09 2008-02-08 スフェンタニルおよびナロキソンを含む経口腔投与製剤 Pending JP2010518086A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90066107P 2007-02-09 2007-02-09
US90458507P 2007-03-02 2007-03-02
PCT/US2008/001711 WO2008100434A1 (en) 2007-02-09 2008-02-08 Transoral dosage forms comprising sufentanil and naloxone

Publications (2)

Publication Number Publication Date
JP2010518086A true JP2010518086A (ja) 2010-05-27
JP2010518086A5 JP2010518086A5 (enExample) 2011-03-31

Family

ID=39472527

Family Applications (1)

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JP2009549118A Pending JP2010518086A (ja) 2007-02-09 2008-02-08 スフェンタニルおよびナロキソンを含む経口腔投与製剤

Country Status (5)

Country Link
US (4) US20100010031A1 (enExample)
JP (1) JP2010518086A (enExample)
AU (1) AU2008216867B2 (enExample)
CA (1) CA2677281C (enExample)
WO (1) WO2008100434A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013510840A (ja) * 2009-11-12 2013-03-28 アカシア ファーマ リミテッド 口腔乾燥症の治療のためのベタネコールの使用
JP2018515580A (ja) * 2015-05-27 2018-06-14 マリンクロッド エルエルシー スフェンタニルクエン酸塩及びスフェンタニル塩の調合

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US20110033542A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
RU2504377C2 (ru) 2006-07-21 2014-01-20 БайоДеливери Сайенсиз Интэнэшнл, Инк. Способ трансмукозальной доставки лекарства, средство трансмукозальной доставки лекарства (варианты) и способ лечения боли
US20090246256A1 (en) * 2008-03-27 2009-10-01 Al-Ghananeem Abeer M Compositions and Methods for Transmucosal Delivery of Lofexidine
US8475832B2 (en) * 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
GB2476494A (en) * 2009-12-24 2011-06-29 Norwich Pharma Technologies Ltd Formulation for the sublingual delivery of sufentanil
WO2011137422A2 (en) 2010-04-30 2011-11-03 Apellis Pharmaceuticals, Inc. Methods and articles for preventing or reducing risk of developing a hyperallergenic immune system
DK2563316T3 (da) * 2010-04-30 2019-05-13 Allovate Llc Tandpasta til allergisk desensibilisering via mundslimhinder
GB201107533D0 (en) 2011-05-06 2011-06-22 Acacia Pharma Ltd Formulaiton
SG11201401446RA (en) * 2011-08-18 2014-09-26 Biodelivery Sciences Int Inc Abuse-resistant mucoadhesive devices for delivery of buprenorphine
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US9418672B2 (en) * 2012-06-05 2016-08-16 Apple Inc. Navigation application with adaptive instruction text
EP4100012A4 (en) * 2020-02-05 2024-02-07 Summit Biosciences Inc. MEDICINAL PRODUCTS INTENDED TO BE ADMINISTERED BY INTRANASAL ROUTE AND ASSOCIATED USES

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US4671953A (en) * 1985-05-01 1987-06-09 University Of Utah Research Foundation Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
WO1999024023A2 (de) * 1997-11-11 1999-05-20 Grünenthal GmbH FORMULIERUNG EINER KOMBINATION AUS OPIOID UND α-ADRENERGEM AGONISTEN UND DEREN VERWENDUNG
US20020160043A1 (en) * 2001-02-27 2002-10-31 Dennis Coleman Compositions and method of manufacture for oral dissolvable dosage forms
WO2006097361A1 (en) * 2005-03-18 2006-09-21 Ethypharm Sublingual coated tablet
JP2009519347A (ja) * 2005-12-13 2009-05-14 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド 乱用抵抗性経粘膜薬剤送達デバイス
JP2009536147A (ja) * 2006-01-06 2009-10-08 エーセルアールエックス ファーマシューティカルズ， インコーポレイテッド 経口経粘膜送達用の生体接着性薬調合物

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US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
FI943042L (fi) * 1991-12-24 1994-06-23 Yamanouchi Pharma Co Ltd Suuontelossa hajoava valmiste ja sen valmistus
CA2251623C (en) * 1996-05-13 2006-12-19 Novartis Consumer Health S.A. Buccal delivery system
US6103257A (en) * 1998-07-17 2000-08-15 Num-Pop, Inc. System for delivering pharmaceuticals to the buccal mucosa
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
SE9803239D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab Composition for the treatment of acute pain
US6552024B1 (en) * 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US6394306B1 (en) * 2000-06-23 2002-05-28 Delsys Pharmaceutical Corp. Medication dispenser for dispensing flat dosage forms
US20050042281A1 (en) * 2003-08-21 2005-02-24 Singh Nikhilesh N. Compositions for delivering therapeutic agents across the oral mucosa
US20050065175A1 (en) * 2003-09-24 2005-03-24 Xanodyne Pharmacal, Inc. Oral transmucosal methadone
PT1708686E (pt) * 2003-12-31 2011-04-20 Cima Labs Inc Forma de dosagem de fentanil oral efervescente geralmente linear e métodos de administração
US20070104763A1 (en) * 2005-11-10 2007-05-10 Navinta Llc Composition of fentanyl citrate oral solid transmucosal dosage form, excipient and binding material therefore, and methods of making
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
JP5632284B2 (ja) 2007-08-07 2014-11-26 エーセルアールエックス ファーマシューティカルズ， インコーポレイテッド 経口経粘膜剤形を使用する処置時の鎮静および無痛のための組成物および方法
WO2009113798A2 (en) 2008-03-14 2009-09-17 Lg Electronics Inc. Scanning method in wireless system
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US4671953A (en) * 1985-05-01 1987-06-09 University Of Utah Research Foundation Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
WO1999024023A2 (de) * 1997-11-11 1999-05-20 Grünenthal GmbH FORMULIERUNG EINER KOMBINATION AUS OPIOID UND α-ADRENERGEM AGONISTEN UND DEREN VERWENDUNG
US20020160043A1 (en) * 2001-02-27 2002-10-31 Dennis Coleman Compositions and method of manufacture for oral dissolvable dosage forms
WO2006097361A1 (en) * 2005-03-18 2006-09-21 Ethypharm Sublingual coated tablet
JP2009519347A (ja) * 2005-12-13 2009-05-14 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド 乱用抵抗性経粘膜薬剤送達デバイス
JP2009536147A (ja) * 2006-01-06 2009-10-08 エーセルアールエックス ファーマシューティカルズ， インコーポレイテッド 経口経粘膜送達用の生体接着性薬調合物

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JPN5010002226; ＫＵＮＺ，Ｋ．　Ｍ．，ＥＴ　ＡＬ．: '"Ｓｅｖｅｒｅ　Ｅｐｉｓｏｄｉｃ　Ｐａｉｎ：　Ｍａｎａｇｅｍｅｎｔ　ｗｉｔｈ　Ｓｕｂｌｉｎｇｕａｌ　Ｓｕｆｅｎｔａｎｉｌ"' ＪＯＵＲＮＡＬ　ＯＦ　ＰＡＩＮ　ＡＮＤ　ＳＹＭＰＴＯＭ　ＭＡＮＡＧＥＭＥＮＴ ＶＯＬ．８，ＮＯ．４, 199305, ＰＰ．１８９-１９０ *
JPN5010002227; ＳＴＡＮＬＥＹ，Ｔ．　Ｈ．，ＥＴ　ＡＬ．: '"Ｎｏｖｅｌ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍｓ：　Ｏｒａｌ　Ｔｒａｎｓｍｕｃｏｓａｌ　ａｎｄ　Ｉｎｔｒａｎａｓａｌ　Ｔｒａｎｓｍｕｃｏｓａｌ"' ＪＯＵＲＮＡＬ　ＯＦ　ＰＡＩＮ　ＡＮＤ　ＳＹＭＰＴＯＭ　ＭＡＮＡＧＥＭＥＮＴ ＶＯＬ．７，ＮＯ．３, 199204, ＰＰ．１６３-１７１ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013510840A (ja) * 2009-11-12 2013-03-28 アカシア ファーマ リミテッド 口腔乾燥症の治療のためのベタネコールの使用
JP2018515580A (ja) * 2015-05-27 2018-06-14 マリンクロッド エルエルシー スフェンタニルクエン酸塩及びスフェンタニル塩の調合

Also Published As

Publication number Publication date
US20200281915A1 (en) 2020-09-10
AU2008216867A1 (en) 2008-08-21
US20100010031A1 (en) 2010-01-14
US20180228792A1 (en) 2018-08-16
US20160158215A1 (en) 2016-06-09
CA2677281C (en) 2019-10-29
AU2008216867B2 (en) 2014-01-30
CA2677281A1 (en) 2008-08-21
US10603312B2 (en) 2020-03-31
WO2008100434A1 (en) 2008-08-21

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