JP2010516678A5 - - Google Patents
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- JP2010516678A5 JP2010516678A5 JP2009546423A JP2009546423A JP2010516678A5 JP 2010516678 A5 JP2010516678 A5 JP 2010516678A5 JP 2009546423 A JP2009546423 A JP 2009546423A JP 2009546423 A JP2009546423 A JP 2009546423A JP 2010516678 A5 JP2010516678 A5 JP 2010516678A5
- Authority
- JP
- Japan
- Prior art keywords
- trem
- subject
- spp1
- expression
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000018368 Triggering Receptor Expressed on Myeloid Cells-1 Human genes 0.000 claims 22
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 claims 22
- 102000004264 Osteopontin Human genes 0.000 claims 11
- 108010081689 Osteopontin Proteins 0.000 claims 11
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 6
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 6
- 101150069237 TYROBP gene Proteins 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 230000008859 change Effects 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 108091027967 Small hairpin RNA Proteins 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 230000006020 chronic inflammation Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002452 interceptive effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88080407P | 2007-01-16 | 2007-01-16 | |
| US90426407P | 2007-02-28 | 2007-02-28 | |
| US92313107P | 2007-04-11 | 2007-04-11 | |
| US168707P | 2007-11-02 | 2007-11-02 | |
| PCT/US2008/000629 WO2008088849A2 (en) | 2007-01-16 | 2008-01-16 | Inflammation treatment, detection and monitoring via trem-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516678A JP2010516678A (ja) | 2010-05-20 |
| JP2010516678A5 true JP2010516678A5 (show.php) | 2012-03-22 |
Family
ID=39560886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546423A Pending JP2010516678A (ja) | 2007-01-16 | 2008-01-16 | Ｔｒｅｍ−１による炎症治療、検出およびモニタリング |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080247955A1 (show.php) |
| EP (1) | EP2121750A2 (show.php) |
| JP (1) | JP2010516678A (show.php) |
| CN (1) | CN101687916A (show.php) |
| AU (1) | AU2008205538A1 (show.php) |
| BR (1) | BRPI0806680A2 (show.php) |
| CA (1) | CA2675583A1 (show.php) |
| MX (1) | MX2009007368A (show.php) |
| WO (1) | WO2008088849A2 (show.php) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060084082A1 (en) * | 1997-03-07 | 2006-04-20 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| JP2011093806A (ja) * | 2008-02-20 | 2011-05-12 | Tokyo Medical & Dental Univ | 膠原病の予防・治療剤 |
| US8513185B2 (en) | 2009-10-13 | 2013-08-20 | Alexander B. Sigalov | Inhibition of TREM receptor signaling with peptide variants |
| JP5499405B2 (ja) * | 2010-06-02 | 2014-05-21 | 学校法人 聖マリアンナ医科大学 | 再発性多発軟骨炎の検査方法およびそれに用いられる検査キット |
| US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
| ES2750209T3 (es) * | 2012-02-15 | 2020-03-25 | Novo Nordisk As | Anticuerpos que se unen a y bloquean al receptor desencadenante expresado en células mieloides-1 (TREM-1) |
| LT2814844T (lt) * | 2012-02-15 | 2017-10-25 | Novo Nordisk A/S | Antikūnai, kurie jungiasi ir blokuoja ekspresuotą ant mieloidinių ląstelių inicijuojantį receptorių 1 (trem-1) |
| SI2814842T1 (sl) | 2012-02-15 | 2018-10-30 | Novo Nordisk A/S | Protitelesa, ki vežejo peptidoglikal prepoznan protein 1 |
| CA2904099A1 (en) | 2013-03-15 | 2014-09-18 | The Broad Institute, Inc. | Dendritic cell response gene expression, compositions of matters and methods of use thereof |
| EP2835641A1 (en) * | 2013-08-09 | 2015-02-11 | Inotrem | Methods and kits for predicting the risk of having a cardiovascular disease or event |
| CA2939246A1 (en) * | 2014-03-27 | 2015-10-01 | Genentech, Inc. | Methods for diagnosing and treating inflammatory bowel disease |
| WO2016009086A1 (en) | 2014-07-17 | 2016-01-21 | Novo Nordisk A/S | Site directed mutagenesis of trem-1 antibodies for decreasing viscosity |
| US11213598B2 (en) | 2015-11-12 | 2022-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Labeled probe and methods of use |
| FR3044325B1 (fr) * | 2015-12-01 | 2019-05-03 | Biomerieux | Procede d'evaluation du risque de complications chez les patients qui presentent un syndrome de reponse inflammatoire systemique (sirs) |
| CN106053831A (zh) * | 2016-06-05 | 2016-10-26 | 潘时辉 | 一种用于自身免疫病检测的试剂盒 |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| BR112019022752A2 (pt) * | 2017-08-03 | 2020-05-19 | Alector Llc | anticorpos anti-trem2 e métodos de uso dos mesmos |
| WO2019087200A1 (en) * | 2017-11-06 | 2019-05-09 | Rambam Med-Tech Ltd. | Prognostic methods for anti-tnfa treatment |
| WO2019195126A1 (en) | 2018-04-02 | 2019-10-10 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| CN108752482B (zh) * | 2018-06-12 | 2019-04-30 | 南京卡提医学科技有限公司 | 携带截短或未截短的髓样细胞触发性受体信号结构的嵌合抗原受体及其应用 |
| EP3836951A1 (en) | 2018-08-13 | 2021-06-23 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| CN109833480B (zh) * | 2019-03-22 | 2021-09-07 | 中国科学院上海巴斯德研究所 | 靶向nk细胞免疫检查点治疗感染性疾病的方法 |
| EP3946349A4 (en) * | 2019-04-03 | 2023-05-24 | The Scripps Research Institute | METHOD OF INHIBITION OF TREM-1 |
| US20220372139A1 (en) * | 2019-07-15 | 2022-11-24 | Bristol-Myers Squibb Company | Anti-trem-1 antibodies and uses thereof |
| WO2021011681A1 (en) * | 2019-07-15 | 2021-01-21 | Bristol-Myers Squibb Company | Antibodies against human trem-1 and uses thereof |
| CN111157741B (zh) * | 2019-12-30 | 2022-08-16 | 广州市妇女儿童医疗中心 | 髓系细胞触发受体1在制备胃炎诊断或治疗试剂中的应用及试剂盒 |
| CN111437380A (zh) * | 2020-05-25 | 2020-07-24 | 南通大学 | Trem-2在监测血吸虫病肝纤维化进程的方法及应用 |
| CN112266956B (zh) * | 2020-11-12 | 2021-09-10 | 四川大学 | Map3k8检测试剂在制备牙髓炎筛查试剂盒及抑制剂在制备治疗牙髓炎的药物中的用途 |
| WO2022272018A1 (en) * | 2021-06-25 | 2022-12-29 | Amgen Inc. | Treatment of cardiovascular disease with trem-1 antigen binding proteins |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4034074A (en) * | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US4098876A (en) * | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4233402A (en) * | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5256775A (en) * | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5264564A (en) * | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5296347A (en) * | 1991-02-08 | 1994-03-22 | Ciba Corning Diagnostics Corp. | Bridge immunoassay |
| CA2431177C (en) * | 2000-12-08 | 2015-04-14 | Baylor College Of Medicine | Trem-1 splice variant for use in modifying immune responses |
| ES2593304T3 (es) * | 2002-05-02 | 2016-12-07 | Wyeth Holdings Llc | Conjugados de transportador derivado de caliqueamicina |
| WO2006031653A2 (en) * | 2004-09-10 | 2006-03-23 | Wyeth | Humanized anti-5t4 antibodies and anti-5t4 antibody / calicheamicin conjugates |
| NZ552065A (en) * | 2004-11-29 | 2008-04-30 | Bioxell Spa | Peptides derived from the TREM-1 protein that act as antagonists of the TREM-1 protein and have applications in the treatment of sepsis and septic shock |
| GB0426146D0 (en) * | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| TW200728718A (en) * | 2006-01-20 | 2007-08-01 | Nat Defense Medical Ct | Biomarkers for diagnosis of crescentic glomerulonephritis |
| US20070224638A1 (en) * | 2006-03-27 | 2007-09-27 | Institut Pasteur | Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections |
-
2008
- 2008-01-16 JP JP2009546423A patent/JP2010516678A/ja active Pending
- 2008-01-16 CN CN200880008378A patent/CN101687916A/zh active Pending
- 2008-01-16 CA CA002675583A patent/CA2675583A1/en not_active Abandoned
- 2008-01-16 EP EP08724590A patent/EP2121750A2/en not_active Withdrawn
- 2008-01-16 US US12/009,166 patent/US20080247955A1/en not_active Abandoned
- 2008-01-16 MX MX2009007368A patent/MX2009007368A/es not_active Application Discontinuation
- 2008-01-16 AU AU2008205538A patent/AU2008205538A1/en not_active Abandoned
- 2008-01-16 WO PCT/US2008/000629 patent/WO2008088849A2/en not_active Ceased
- 2008-01-16 BR BRPI0806680-9A patent/BRPI0806680A2/pt not_active IP Right Cessation
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