JP2010516292A5 - - Google Patents
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- JP2010516292A5 JP2010516292A5 JP2009548313A JP2009548313A JP2010516292A5 JP 2010516292 A5 JP2010516292 A5 JP 2010516292A5 JP 2009548313 A JP2009548313 A JP 2009548313A JP 2009548313 A JP2009548313 A JP 2009548313A JP 2010516292 A5 JP2010516292 A5 JP 2010516292A5
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- Prior art keywords
- seq
- nucleotide sequence
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- metastasis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 41
- 206010027476 Metastases Diseases 0.000 claims description 40
- 230000009401 metastasis Effects 0.000 claims description 38
- 230000014509 gene expression Effects 0.000 claims description 35
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 19
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 206010006187 Breast cancer Diseases 0.000 claims description 11
- 208000026310 Breast neoplasm Diseases 0.000 claims description 11
- 230000003321 amplification Effects 0.000 claims description 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 9
- 239000013610 patient sample Substances 0.000 claims description 6
- 108020004999 messenger RNA Proteins 0.000 claims description 5
- 239000000523 sample Substances 0.000 claims description 4
- 238000010839 reverse transcription Methods 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims 56
- 125000003729 nucleotide group Chemical group 0.000 claims 56
- 102100022210 COX assembly mitochondrial protein 2 homolog Human genes 0.000 claims 8
- 108010076303 Centromere Protein A Proteins 0.000 claims 8
- 101000900446 Homo sapiens COX assembly mitochondrial protein 2 homolog Proteins 0.000 claims 8
- 101000687968 Homo sapiens Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Proteins 0.000 claims 8
- 101000896657 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Proteins 0.000 claims 8
- 101000593405 Homo sapiens Myb-related protein B Proteins 0.000 claims 8
- 101000721146 Homo sapiens Origin recognition complex subunit 6 Proteins 0.000 claims 8
- 101000619112 Homo sapiens Proline-rich protein 11 Proteins 0.000 claims 8
- 101000928406 Homo sapiens Protein diaphanous homolog 3 Proteins 0.000 claims 8
- 101001096541 Homo sapiens Rac GTPase-activating protein 1 Proteins 0.000 claims 8
- 101000582404 Homo sapiens Replication factor C subunit 4 Proteins 0.000 claims 8
- 101000837565 Homo sapiens Ubiquitin-conjugating enzyme E2 S Proteins 0.000 claims 8
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 claims 8
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 claims 8
- 102100024262 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Human genes 0.000 claims 8
- 102100021691 Mitotic checkpoint serine/threonine-protein kinase BUB1 Human genes 0.000 claims 8
- 102100034670 Myb-related protein B Human genes 0.000 claims 8
- 102100025201 Origin recognition complex subunit 6 Human genes 0.000 claims 8
- 102100022566 Proline-rich protein 11 Human genes 0.000 claims 8
- 102100036468 Protein diaphanous homolog 3 Human genes 0.000 claims 8
- 102100037414 Rac GTPase-activating protein 1 Human genes 0.000 claims 8
- 102100030542 Replication factor C subunit 4 Human genes 0.000 claims 8
- 102100028718 Ubiquitin-conjugating enzyme E2 S Human genes 0.000 claims 8
- 210000004881 tumor cell Anatomy 0.000 claims 8
- 101001046554 Dictyostelium discoideum Thymidine kinase 1 Proteins 0.000 claims 7
- 101000945477 Homo sapiens Thymidine kinase, cytosolic Proteins 0.000 claims 7
- 102000015694 estrogen receptors Human genes 0.000 claims 7
- 108010038795 estrogen receptors Proteins 0.000 claims 7
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 claims 5
- 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 claims 5
- 101000996563 Homo sapiens Nuclear pore complex protein Nup214 Proteins 0.000 claims 4
- 101001091194 Homo sapiens Peptidyl-prolyl cis-trans isomerase G Proteins 0.000 claims 4
- 101000633869 Homo sapiens Pre-mRNA-splicing factor SLU7 Proteins 0.000 claims 4
- 102100033819 Nuclear pore complex protein Nup214 Human genes 0.000 claims 4
- 102100034850 Peptidyl-prolyl cis-trans isomerase G Human genes 0.000 claims 4
- 102100029252 Pre-mRNA-splicing factor SLU7 Human genes 0.000 claims 4
- 238000002493 microarray Methods 0.000 claims 4
- 102000011682 Centromere Protein A Human genes 0.000 claims 3
- 102100034838 Thymidine kinase, cytosolic Human genes 0.000 claims 3
- 238000012408 PCR amplification Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- -1 TKGA1 Proteins 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000010195 expression analysis Methods 0.000 description 2
- 238000001325 log-rank test Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89896307P | 2007-01-31 | 2007-01-31 | |
| US60/898,963 | 2007-01-31 | ||
| PCT/US2008/001339 WO2008094678A2 (en) | 2007-01-31 | 2008-01-31 | A molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013124548A Division JP2013176397A (ja) | 2007-01-31 | 2013-06-13 | 乳癌の遠隔転移を予測するための分子予後サインおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516292A JP2010516292A (ja) | 2010-05-20 |
| JP2010516292A5 true JP2010516292A5 (enExample) | 2015-02-26 |
| JP5913785B2 JP5913785B2 (ja) | 2016-05-25 |
Family
ID=39674722
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548313A Active JP5913785B2 (ja) | 2007-01-31 | 2008-01-31 | 乳癌の遠隔転移を予測するための分子予後サインおよびその使用 |
| JP2013124548A Withdrawn JP2013176397A (ja) | 2007-01-31 | 2013-06-13 | 乳癌の遠隔転移を予測するための分子予後サインおよびその使用 |
| JP2015237175A Withdrawn JP2016032480A (ja) | 2007-01-31 | 2015-12-04 | 乳癌の遠隔転移を予測するための分子予後サインおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013124548A Withdrawn JP2013176397A (ja) | 2007-01-31 | 2013-06-13 | 乳癌の遠隔転移を予測するための分子予後サインおよびその使用 |
| JP2015237175A Withdrawn JP2016032480A (ja) | 2007-01-31 | 2015-12-04 | 乳癌の遠隔転移を予測するための分子予後サインおよびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US7695915B2 (enExample) |
| EP (2) | EP2520668B1 (enExample) |
| JP (3) | JP5913785B2 (enExample) |
| CA (1) | CA2674907C (enExample) |
| WO (1) | WO2008094678A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080286273A1 (en) * | 2007-05-02 | 2008-11-20 | Siemens Medical Solutions Usa, Inc. | Knowledge-Based Proliferation Signatures and Methods of Use |
| US7960114B2 (en) | 2007-05-02 | 2011-06-14 | Siemens Medical Solutions Usa, Inc. | Gene signature of early hypoxia to predict patient survival |
| US20090203015A1 (en) * | 2008-02-13 | 2009-08-13 | Celera Corporation | Multiplex assays for hormonal and growth factor receptors, and uses thereof |
| EP2352847B1 (en) | 2008-11-10 | 2014-01-08 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Gene signature for predicting prognosis of patients with solid tumors |
| GB0821787D0 (en) * | 2008-12-01 | 2009-01-07 | Univ Ulster | A genomic-based method of stratifying breast cancer patients |
| WO2011039734A2 (en) * | 2009-10-02 | 2011-04-07 | Enzo Medico | Use of genes involved in anchorage independence for the optimization of diagnosis and treatment of human cancer |
| WO2011151061A1 (en) * | 2010-06-03 | 2011-12-08 | Ipsen Pharma S.A.S. | Al035301, a biomarker for breast cancer |
| WO2012009382A2 (en) * | 2010-07-12 | 2012-01-19 | The Regents Of The University Of Colorado | Molecular indicators of bladder cancer prognosis and prediction of treatment response |
| US8557525B1 (en) | 2011-02-25 | 2013-10-15 | Celera Corporation | Composite metastasis score with weighted coefficients for predicting breast cancer metastasis, and uses thereof |
| US10519505B2 (en) * | 2011-04-28 | 2019-12-31 | Harry Ostrer | Genomic signatures of metastasis in prostate cancer |
| ITPD20110201A1 (it) * | 2011-06-16 | 2012-12-17 | Univ Degli Studi Trieste | Metodo per la prognosi di tumori al seno basata sull'espressione dell'enzima prolil isomerarasi pin1 in combinazione con mutazioni del gene tp53 |
| GB201116131D0 (en) * | 2011-09-19 | 2011-11-02 | Epistem Ltd | Probe |
| US20140315844A1 (en) * | 2012-11-30 | 2014-10-23 | Celera Corporation | Multi-gene signatures for predicting response to chemotherapy or risk of metastasis for breast cancer |
| KR101672531B1 (ko) * | 2013-04-18 | 2016-11-17 | 주식회사 젠큐릭스 | 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도 |
| AU2015300970A1 (en) | 2014-08-07 | 2017-03-30 | Curelator, Inc. | Chronic disease discovery and management system |
| TWI582240B (zh) * | 2015-05-19 | 2017-05-11 | 鄭鴻鈞 | 以基因體預後評估試劑組預測乳癌患者局部區域復發風險及放射治療有效性的方法、用途及裝置 |
| WO2017047102A1 (en) * | 2015-09-16 | 2017-03-23 | Riken | Biomarker for cancer and use thereof |
| CN108647493B (zh) * | 2018-05-09 | 2022-01-18 | 中国科学院昆明动物研究所 | 一种肾透明细胞癌个性化预后评估方法 |
| CN108470111B (zh) * | 2018-05-09 | 2022-01-18 | 中国科学院昆明动物研究所 | 一种基于多基因表达特征谱的胃癌个性化预后评估方法 |
| WO2021205828A1 (ja) * | 2020-04-10 | 2021-10-14 | 国立大学法人 東京大学 | 予後予測装置、及びプログラム |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| FR2540122B1 (fr) | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5004565A (en) | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US5856522A (en) | 1995-05-04 | 1999-01-05 | Tropix, Inc. | Method of using synthesis of 1,2-dioxetanes and kits therefore |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5994073A (en) | 1990-08-30 | 1999-11-30 | Tropix, Inc. | Enhancement of chemiluminescent assays |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6027923A (en) | 1993-07-23 | 2000-02-22 | Bio-Rad Laboratories, Inc. | Linked linear amplification of nucleic acids |
| AU8126694A (en) | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5705333A (en) | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
| US5773628A (en) | 1994-11-14 | 1998-06-30 | Tropix, Inc. | 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use |
| US5591591A (en) | 1995-02-09 | 1997-01-07 | Tropix, Inc. | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore |
| US5801115A (en) | 1995-09-05 | 1998-09-01 | Kataleuna Gmbh | Catalyst composition and methods for using and preparing same |
| US5679803A (en) | 1995-10-25 | 1997-10-21 | Tropix, Inc. | 1,2 chemiluminescent dioxetanes of improved performance |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
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| WO2002072889A2 (en) | 2001-01-12 | 2002-09-19 | Applera Corporation | Methods and compositions for microarray control |
| US7306910B2 (en) * | 2003-04-24 | 2007-12-11 | Veridex, Llc | Breast cancer prognostics |
| US20050221398A1 (en) | 2004-01-16 | 2005-10-06 | Ipsogen, Sas, A Corporation Of France | Protein expression profiling and breast cancer prognosis |
| KR101515821B1 (ko) * | 2005-09-01 | 2015-04-30 | 오스다이어그나스틱스 피티와이 엘티디. | 핵산의 증폭, 정량분석 및 동정 방법 |
-
2008
- 2008-01-31 EP EP12169115.8A patent/EP2520668B1/en active Active
- 2008-01-31 WO PCT/US2008/001339 patent/WO2008094678A2/en not_active Ceased
- 2008-01-31 JP JP2009548313A patent/JP5913785B2/ja active Active
- 2008-01-31 EP EP08725050A patent/EP2129789B1/en active Active
- 2008-01-31 US US12/012,530 patent/US7695915B2/en active Active
- 2008-01-31 CA CA2674907A patent/CA2674907C/en active Active
-
2009
- 2009-12-15 US US12/638,040 patent/US8614058B2/en active Active
-
2013
- 2013-06-13 JP JP2013124548A patent/JP2013176397A/ja not_active Withdrawn
- 2013-11-19 US US14/083,755 patent/US20140179548A1/en not_active Abandoned
-
2015
- 2015-12-04 JP JP2015237175A patent/JP2016032480A/ja not_active Withdrawn
-
2016
- 2016-02-03 US US15/014,294 patent/US20160289766A1/en not_active Abandoned
-
2018
- 2018-06-08 US US16/003,682 patent/US11028445B2/en active Active
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