JP2010513229A5 - - Google Patents
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- Publication number
- JP2010513229A5 JP2010513229A5 JP2009540327A JP2009540327A JP2010513229A5 JP 2010513229 A5 JP2010513229 A5 JP 2010513229A5 JP 2009540327 A JP2009540327 A JP 2009540327A JP 2009540327 A JP2009540327 A JP 2009540327A JP 2010513229 A5 JP2010513229 A5 JP 2010513229A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- acetaminophen
- acetylcysteine
- blockers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 13
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 12
- 229960005489 paracetamol Drugs 0.000 claims 6
- 206010019851 Hepatotoxicity Diseases 0.000 claims 4
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 4
- 229960004308 acetylcysteine Drugs 0.000 claims 4
- 231100000304 hepatotoxicity Toxicity 0.000 claims 3
- 230000007686 hepatotoxicity Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 230000003474 anti-emetic effect Effects 0.000 claims 2
- 239000002111 antiemetic agent Substances 0.000 claims 2
- -1 5-HT3 blockers Substances 0.000 claims 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 claims 1
- 206010067125 Liver injury Diseases 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 231100000234 hepatic damage Toxicity 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 231100000334 hepatotoxic Toxicity 0.000 claims 1
- 230000003082 hepatotoxic effect Effects 0.000 claims 1
- 230000002427 irreversible effect Effects 0.000 claims 1
- 239000008141 laxative Substances 0.000 claims 1
- 229940125722 laxative agent Drugs 0.000 claims 1
- 230000008818 liver damage Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940035363 muscle relaxants Drugs 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 235000019645 odor Nutrition 0.000 claims 1
- 229940126409 proton pump inhibitor Drugs 0.000 claims 1
- 239000000612 proton pump inhibitor Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000000021 stimulant Substances 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87374306P | 2006-12-09 | 2006-12-09 | |
| US11/952,556 US20080139654A1 (en) | 2006-12-09 | 2007-12-07 | Acetaminophen compositions having minimized side effects including reduced hepatotoxicity |
| PCT/US2007/025167 WO2008073344A1 (en) | 2006-12-09 | 2007-12-08 | Acetaminophen compositions having minimized side effects including reduced hepatotoxicity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010513229A JP2010513229A (ja) | 2010-04-30 |
| JP2010513229A5 true JP2010513229A5 (enExample) | 2010-06-17 |
Family
ID=39498949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540327A Withdrawn JP2010513229A (ja) | 2006-12-09 | 2007-12-08 | 軽減された肝毒性を含む最小限に抑制された副作用を有するアセトアミノフェン組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080139654A1 (enExample) |
| EP (1) | EP2094253A4 (enExample) |
| JP (1) | JP2010513229A (enExample) |
| KR (1) | KR20090089867A (enExample) |
| CN (1) | CN101588797A (enExample) |
| AU (1) | AU2007332812A1 (enExample) |
| BR (1) | BRPI0721216A2 (enExample) |
| CA (1) | CA2671490A1 (enExample) |
| EA (1) | EA200970449A1 (enExample) |
| IL (1) | IL199056A0 (enExample) |
| MX (1) | MX2009006177A (enExample) |
| WO (1) | WO2008073344A1 (enExample) |
| ZA (1) | ZA200904764B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20080187A1 (it) * | 2008-02-07 | 2009-08-08 | Velleja Res Srl | Formulazioni di amminoacidi per la prevenzione del danno epatico da paracetamolo |
| US20110014285A1 (en) * | 2009-07-15 | 2011-01-20 | Herzenberg Leonore A | N-acetyl cysteine compositions and methods to improve the therapeutic efficacy of acetaminophen |
| TR201007652A2 (tr) * | 2010-09-20 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Sinerjik etki. |
| WO2013044085A1 (en) * | 2011-09-23 | 2013-03-28 | Subramanian Veerappan Sellappan | A solid, edible, chewable laxative composition |
| WO2014159994A1 (en) * | 2013-03-13 | 2014-10-02 | Nbip, Llc | Compositions and methods for removing the odor from glutathione when mixed in an aqueous system |
| US10104882B2 (en) * | 2013-04-29 | 2018-10-23 | Montefiore Medical Center | Methods and compositions for preventing and treating electrophile-mediated toxicities |
| ITMI20130874A1 (it) * | 2013-05-29 | 2014-11-30 | Zambon Spa | Compresse deglutibili di n-acetilcisteina |
| AU2017208123B2 (en) * | 2016-01-11 | 2022-04-21 | Egetis Therapeutics Ab | Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions |
| KR101962518B1 (ko) | 2016-09-13 | 2019-03-26 | 울산대학교 산학협력단 | 일산화탄소 또는 일산화탄소 공급체를 유효성분으로 함유하는 아세트아미노펜 유도 간 독성 예방 또는 치료용 조성물 |
| WO2018089400A1 (en) * | 2016-11-09 | 2018-05-17 | The Feinstein Institute For Medical Research | Iguratimod as an mif inhibitor |
| KR102813413B1 (ko) | 2019-08-27 | 2025-05-27 | 주식회사 엘지에너지솔루션 | 단위셀의 두께측정장치 및 두께측정방법 |
| US11590090B2 (en) * | 2019-09-14 | 2023-02-28 | Anzen Pharmaceuticals, LLC | Acetaminophen formulation with protection against toxic effects of overdose |
| EP4238559A1 (en) | 2022-03-04 | 2023-09-06 | Centre Hospitalier Universitaire de Caen Normandie | Combinations of acetaminophen and n-acetyl cysteine for the treatment of pain and fever |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474757A (en) * | 1992-10-16 | 1995-12-12 | Rutgers University | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
| GR1002731B (el) * | 1996-10-21 | 1997-07-04 | Uni-Pharma ����� ������ �.�.�.�. ������������ ���������� | Φαρμακευτικα ενεσιμα διαλυματα περιεχοντα συνδυασμους παρακεταμολης με αλλες δραστικες ουσιες. |
| DE19651551C2 (de) * | 1996-12-11 | 2000-02-03 | Klinge Co Chem Pharm Fab | Opioidantagonisthaltige galenische Formulierung |
| US6566401B2 (en) * | 2001-03-30 | 2003-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity |
| US6863901B2 (en) * | 2001-11-30 | 2005-03-08 | Collegium Pharmaceutical, Inc. | Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration |
-
2007
- 2007-12-07 US US11/952,556 patent/US20080139654A1/en not_active Abandoned
- 2007-12-08 WO PCT/US2007/025167 patent/WO2008073344A1/en not_active Ceased
- 2007-12-08 BR BRPI0721216-0A2A patent/BRPI0721216A2/pt not_active Application Discontinuation
- 2007-12-08 EA EA200970449A patent/EA200970449A1/ru unknown
- 2007-12-08 KR KR1020097011839A patent/KR20090089867A/ko not_active Withdrawn
- 2007-12-08 CA CA002671490A patent/CA2671490A1/en not_active Abandoned
- 2007-12-08 EP EP07853309A patent/EP2094253A4/en not_active Withdrawn
- 2007-12-08 AU AU2007332812A patent/AU2007332812A1/en not_active Abandoned
- 2007-12-08 CN CNA2007800389520A patent/CN101588797A/zh active Pending
- 2007-12-08 JP JP2009540327A patent/JP2010513229A/ja not_active Withdrawn
- 2007-12-08 MX MX2009006177A patent/MX2009006177A/es not_active Application Discontinuation
-
2009
- 2009-06-01 IL IL199056A patent/IL199056A0/en unknown
- 2009-07-07 ZA ZA2009/04764A patent/ZA200904764B/en unknown
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