JP2010510769A - 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 - Google Patents

食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 Download PDF

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JP2010510769A
JP2010510769A JP2009537466A JP2009537466A JP2010510769A JP 2010510769 A JP2010510769 A JP 2010510769A JP 2009537466 A JP2009537466 A JP 2009537466A JP 2009537466 A JP2009537466 A JP 2009537466A JP 2010510769 A JP2010510769 A JP 2010510769A
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mirna
level
mir
hsa
esophageal cancer
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ヨン グオ,
ツァオリ チェン,
ジン チェン,
ジエ ヘ,
キース ミッチェルソン,
リァン ツァン,
シン メン,
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CapitalBio Corp
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CapitalBio Corp
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
JP2009537466A 2006-11-28 2006-11-28 食道癌の診断ならびに患者の生存の予後および改善のための方法および組成物 Withdrawn JP2010510769A (ja)

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PCT/CN2006/003195 WO2008064519A1 (fr) 2006-11-28 2006-11-28 Méthodes et compositions permettant de diagnostiquer un cancer de l'oesophage, d'établir un pronostic et d'améliorer la survie des patients

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JP (1) JP2010510769A (fr)
CN (1) CN101316935B (fr)
WO (1) WO2008064519A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015194627A1 (fr) * 2014-06-18 2015-12-23 東レ株式会社 Kit ou dispositif de détection du cancer de l'œsophage, et méthode de détection de celui-ci

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2633754C (fr) 2006-01-05 2013-06-18 The Ohio State University Research Foundation Procedes et compositions faisant intervenir des micro-arn pour le diagnostic et le traitement des cancers solides
EP2371971B1 (fr) 2006-03-20 2013-11-27 The Ohio State University Research Foundation Empreintes digitales micro-ARN pendant une mégacaryocytopoïese
EP2173908B1 (fr) 2007-08-03 2016-01-06 The Ohio State University Research Foundation Régions ultra-conservées codant pour des arnnc
CA2702241A1 (fr) * 2007-10-11 2009-04-16 The Ohio State University Research Foundation Procedes et compositions destines au diagnostic et au traitement de l'adenocarcinome de l'oesophage
US8916533B2 (en) 2009-11-23 2014-12-23 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
CN101851682B (zh) * 2010-06-25 2013-08-28 中国人民解放军南京军区南京总医院 一种用于检测食管鳞状细胞癌的微小核糖核酸组合及其应用
GB201014049D0 (en) * 2010-08-23 2010-10-06 Sistemic Uk Cell characterisation
WO2012065049A1 (fr) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Matériaux et procédés relatifs aux microarn-21, réparation de désappariement et cancer colorectal
CN103313706A (zh) 2010-11-15 2013-09-18 俄亥俄州立大学研究基金会 控制释放粘膜粘合系统
US20140031258A1 (en) * 2011-03-28 2014-01-30 The Johns Hopkins University Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac)
EP2766500A4 (fr) 2011-10-14 2015-10-14 Univ Ohio State Méthodes et matériaux relatifs au cancer des ovaires
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
EP2804960A4 (fr) 2012-01-20 2015-08-19 Univ Ohio State Signatures de marqueurs biologiques du cancer du sein concernant le pouvoir envahissant et le pronostic
CN103243161B (zh) * 2013-05-07 2015-02-25 中国医学科学院肿瘤医院 一种辅助预测食管鳞癌患者术后生存时间长短的产品
CN104034902B (zh) * 2014-05-09 2015-11-25 赤峰学院 利用4个蛋白联合预测食道癌患者预后的试剂盒
CN104774929B (zh) * 2015-03-18 2017-06-30 中山大学肿瘤防治中心 miR‑455‑3p在食管鳞状细胞癌中的诊断、治疗和预后的应用
EP3494230A4 (fr) * 2016-08-04 2020-07-29 Baylor Research Institute Méthodes de diagnostic et de traitement du cancer de l'oesophage
CN109652545A (zh) * 2019-01-11 2019-04-19 山西医科大学 Znf750在筛选用于治疗食管鳞癌靶向药物中的用途
CN112826504B (zh) * 2021-01-07 2024-03-26 中新国际联合研究院 一种游戏化的帕金森症状等级评估方法及装置
CN113430123A (zh) * 2021-06-28 2021-09-24 福建医科大学 一种与食管鳞癌发病相关的真菌菌群及其筛选方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1150317C (zh) * 1999-08-10 2004-05-19 中国医学科学院肿瘤医院肿瘤研究所 一种食管癌相关新基因
CN1223677C (zh) * 1999-08-10 2005-10-19 中国医学科学院肿瘤医院肿瘤研究所 一种食管癌相关基因
WO2005078139A2 (fr) * 2004-02-09 2005-08-25 Thomas Jefferson University Diagnostic et traitement de cancers a l'aide de microarn present dans ou au voisinage de caracteristiques chromosomiennes liees aux cancers

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015194627A1 (fr) * 2014-06-18 2015-12-23 東レ株式会社 Kit ou dispositif de détection du cancer de l'œsophage, et méthode de détection de celui-ci
JPWO2015194627A1 (ja) * 2014-06-18 2017-04-20 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
US10619212B2 (en) 2014-06-18 2020-04-14 Toray Industries, Inc. Esophageal cancer detection kit or device, and detection method
JP2021100411A (ja) * 2014-06-18 2021-07-08 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
JP7090851B2 (ja) 2014-06-18 2022-06-27 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
JP7153283B2 (ja) 2014-06-18 2022-10-14 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法
US11542558B2 (en) 2014-06-18 2023-01-03 Toray Industries, Inc. Esophageal cancer detection kit or device, and detection method
JP7436995B2 (ja) 2014-06-18 2024-02-22 東レ株式会社 食道がんの検出キット又はデバイス及び検出方法

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CN101316935A (zh) 2008-12-03
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