JP2010510238A - γ線被曝に対する放射線防護および治療の方法 - Google Patents

γ線被曝に対する放射線防護および治療の方法 Download PDF

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Publication number
JP2010510238A
JP2010510238A JP2009537375A JP2009537375A JP2010510238A JP 2010510238 A JP2010510238 A JP 2010510238A JP 2009537375 A JP2009537375 A JP 2009537375A JP 2009537375 A JP2009537375 A JP 2009537375A JP 2010510238 A JP2010510238 A JP 2010510238A
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alkyl
branched
linear
lpa
aromatic
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JP2010510238A5 (https=
Inventor
ウェンリン デング
ベーリサ グドゥドゥル
ガンガドハー ダーガム
ガボア ティジー
デュエイン ミラー
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University of Tennessee Research Foundation
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University of Tennessee Research Foundation
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measurement Of Radiation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009537375A 2006-11-15 2007-11-15 γ線被曝に対する放射線防護および治療の方法 Pending JP2010510238A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86587106P 2006-11-15 2006-11-15
PCT/US2007/084875 WO2008140574A2 (en) 2006-11-15 2007-11-15 Radiation protection and treatment for exposure to gamma-radiation

Publications (2)

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JP2010510238A true JP2010510238A (ja) 2010-04-02
JP2010510238A5 JP2010510238A5 (https=) 2011-01-06

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JP2009537375A Pending JP2010510238A (ja) 2006-11-15 2007-11-15 γ線被曝に対する放射線防護および治療の方法

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EP (1) EP2099469A4 (https=)
JP (1) JP2010510238A (https=)
AU (1) AU2007353320B2 (https=)
CA (1) CA2705612A1 (https=)
IL (1) IL198789A0 (https=)
WO (1) WO2008140574A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018016523A1 (ja) * 2016-07-20 2018-01-25 国立大学法人 長崎大学 新規放射線防護剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2935677C (en) * 2013-12-30 2022-07-26 Rama Krishna Reddy SINGIDI Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate
WO2017011457A1 (en) * 2015-07-12 2017-01-19 The University Of Tennessee Research Foundation Compositions and methods for protecting colonic epithelial barrier function

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032494A2 (en) * 2003-10-09 2005-04-14 University Of Tennessee Research Foundation Lpa receptor agonists and antagonists and methods of use

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US20070078111A1 (en) * 2005-07-19 2007-04-05 Gabor Tigyi LPA2 receptor agonist inhibitors of CFTR

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032494A2 (en) * 2003-10-09 2005-04-14 University Of Tennessee Research Foundation Lpa receptor agonists and antagonists and methods of use

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JPN6012056407; DENG,W. et al: 'Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemother' Gastroenterology Vol.123, No.1, 2002, p.206-16 *
JPN6012056410; 産科と婦人科 Vol.47,No.4, 1980, p.704-706 *
JPN6013029603; メルクマニュアル第17版日本語版 , 1999, p.2437-2441 *
JPN6013029607; CUI,Y.F. et al: 'Apoptosis of circulating lymphocytes induced by whole body gamma-irradiation and its mechanism' J Environ Pathol Toxicol Oncol Vol.18, No.3, 1999, p.185-9 *
JPN7012004419; DENG,W. et al: 'LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway' Am J Physiol Gastrointest Liver Physiol Vol.284, No.5, 2003, p.G821-9 *
JPN7013002285; GOETZL,E.J. et al: 'Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in associatio' J Immunol Vol.162, No.4, 1999, p.2049-56 *
JPN7013002286; HU,X. et al: 'Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis throu' J Biol Chem Vol.280, No.10, 2005, p.9498-508 *
JPN7013002287; PRZEMECK,S.M. et al: 'Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by' Am J Physiol Gastrointest Liver Physiol Vol.292, No.2, 200610, p.G620-7 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018016523A1 (ja) * 2016-07-20 2018-01-25 国立大学法人 長崎大学 新規放射線防護剤

Also Published As

Publication number Publication date
IL198789A0 (en) 2011-08-01
CA2705612A1 (en) 2008-11-20
AU2007353320B2 (en) 2014-01-23
EP2099469A4 (en) 2013-02-27
WO2008140574A3 (en) 2009-01-15
WO2008140574A2 (en) 2008-11-20
AU2007353320A1 (en) 2008-11-20
EP2099469A2 (en) 2009-09-16

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