JP2010510238A - γ線被曝に対する放射線防護および治療の方法 - Google Patents
γ線被曝に対する放射線防護および治療の方法 Download PDFInfo
- Publication number
- JP2010510238A JP2010510238A JP2009537375A JP2009537375A JP2010510238A JP 2010510238 A JP2010510238 A JP 2010510238A JP 2009537375 A JP2009537375 A JP 2009537375A JP 2009537375 A JP2009537375 A JP 2009537375A JP 2010510238 A JP2010510238 A JP 2010510238A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- branched
- linear
- lpa
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measurement Of Radiation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86587106P | 2006-11-15 | 2006-11-15 | |
| PCT/US2007/084875 WO2008140574A2 (en) | 2006-11-15 | 2007-11-15 | Radiation protection and treatment for exposure to gamma-radiation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010510238A true JP2010510238A (ja) | 2010-04-02 |
| JP2010510238A5 JP2010510238A5 (https=) | 2011-01-06 |
Family
ID=40002804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537375A Pending JP2010510238A (ja) | 2006-11-15 | 2007-11-15 | γ線被曝に対する放射線防護および治療の方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2099469A4 (https=) |
| JP (1) | JP2010510238A (https=) |
| AU (1) | AU2007353320B2 (https=) |
| CA (1) | CA2705612A1 (https=) |
| IL (1) | IL198789A0 (https=) |
| WO (1) | WO2008140574A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018016523A1 (ja) * | 2016-07-20 | 2018-01-25 | 国立大学法人 長崎大学 | 新規放射線防護剤 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2935677C (en) * | 2013-12-30 | 2022-07-26 | Rama Krishna Reddy SINGIDI | Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate |
| WO2017011457A1 (en) * | 2015-07-12 | 2017-01-19 | The University Of Tennessee Research Foundation | Compositions and methods for protecting colonic epithelial barrier function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005032494A2 (en) * | 2003-10-09 | 2005-04-14 | University Of Tennessee Research Foundation | Lpa receptor agonists and antagonists and methods of use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070078111A1 (en) * | 2005-07-19 | 2007-04-05 | Gabor Tigyi | LPA2 receptor agonist inhibitors of CFTR |
-
2007
- 2007-11-15 JP JP2009537375A patent/JP2010510238A/ja active Pending
- 2007-11-15 EP EP07874288A patent/EP2099469A4/en not_active Withdrawn
- 2007-11-15 AU AU2007353320A patent/AU2007353320B2/en not_active Ceased
- 2007-11-15 CA CA2705612A patent/CA2705612A1/en not_active Abandoned
- 2007-11-15 WO PCT/US2007/084875 patent/WO2008140574A2/en not_active Ceased
-
2009
- 2009-05-17 IL IL198789A patent/IL198789A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005032494A2 (en) * | 2003-10-09 | 2005-04-14 | University Of Tennessee Research Foundation | Lpa receptor agonists and antagonists and methods of use |
Non-Patent Citations (8)
| Title |
|---|
| JPN6012056407; DENG,W. et al: 'Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemother' Gastroenterology Vol.123, No.1, 2002, p.206-16 * |
| JPN6012056410; 産科と婦人科 Vol.47,No.4, 1980, p.704-706 * |
| JPN6013029603; メルクマニュアル第17版日本語版 , 1999, p.2437-2441 * |
| JPN6013029607; CUI,Y.F. et al: 'Apoptosis of circulating lymphocytes induced by whole body gamma-irradiation and its mechanism' J Environ Pathol Toxicol Oncol Vol.18, No.3, 1999, p.185-9 * |
| JPN7012004419; DENG,W. et al: 'LPA protects intestinal epithelial cells from apoptosis by inhibiting the mitochondrial pathway' Am J Physiol Gastrointest Liver Physiol Vol.284, No.5, 2003, p.G821-9 * |
| JPN7013002285; GOETZL,E.J. et al: 'Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in associatio' J Immunol Vol.162, No.4, 1999, p.2049-56 * |
| JPN7013002286; HU,X. et al: 'Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis throu' J Biol Chem Vol.280, No.10, 2005, p.9498-508 * |
| JPN7013002287; PRZEMECK,S.M. et al: 'Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by' Am J Physiol Gastrointest Liver Physiol Vol.292, No.2, 200610, p.G620-7 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018016523A1 (ja) * | 2016-07-20 | 2018-01-25 | 国立大学法人 長崎大学 | 新規放射線防護剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL198789A0 (en) | 2011-08-01 |
| CA2705612A1 (en) | 2008-11-20 |
| AU2007353320B2 (en) | 2014-01-23 |
| EP2099469A4 (en) | 2013-02-27 |
| WO2008140574A3 (en) | 2009-01-15 |
| WO2008140574A2 (en) | 2008-11-20 |
| AU2007353320A1 (en) | 2008-11-20 |
| EP2099469A2 (en) | 2009-09-16 |
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