JP2010510238A5 - - Google Patents
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- Publication number
- JP2010510238A5 JP2010510238A5 JP2009537375A JP2009537375A JP2010510238A5 JP 2010510238 A5 JP2010510238 A5 JP 2010510238A5 JP 2009537375 A JP2009537375 A JP 2009537375A JP 2009537375 A JP2009537375 A JP 2009537375A JP 2010510238 A5 JP2010510238 A5 JP 2010510238A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- branched
- linear
- aromatic
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 51
- 125000003118 aryl group Chemical group 0.000 claims description 40
- 125000001072 heteroaryl group Chemical group 0.000 claims description 40
- 125000000923 (C1-C30) alkyl group Chemical group 0.000 claims description 28
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 22
- 125000000739 C2-C30 alkenyl group Chemical group 0.000 claims description 20
- 125000002252 acyl group Chemical group 0.000 claims description 20
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 230000005855 radiation Effects 0.000 claims description 14
- 238000006467 substitution reaction Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- DSGBMMNDXFQXBM-UHFFFAOYSA-N dihydroxy-octadec-9-enoxy-sulfanylidene-lambda5-phosphane Chemical compound CCCCCCCCC=CCCCCCCCCOP(O)(O)=S DSGBMMNDXFQXBM-UHFFFAOYSA-N 0.000 claims description 6
- 206010025482 malaise Diseases 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 5
- 238000007918 intramuscular administration Methods 0.000 claims description 5
- 238000007920 subcutaneous administration Methods 0.000 claims description 5
- 230000004083 survival effect Effects 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 230000003394 haemopoietic effect Effects 0.000 claims description 3
- 238000007912 intraperitoneal administration Methods 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 210000002429 large intestine Anatomy 0.000 claims description 2
- 210000000813 small intestine Anatomy 0.000 claims description 2
- 210000005095 gastrointestinal system Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- -1 alkyl compound Chemical class 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 210000000777 hematopoietic system Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
- 0 CC1=NC(*)C(*)N1 Chemical compound CC1=NC(*)C(*)N1 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86587106P | 2006-11-15 | 2006-11-15 | |
| PCT/US2007/084875 WO2008140574A2 (en) | 2006-11-15 | 2007-11-15 | Radiation protection and treatment for exposure to gamma-radiation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010510238A JP2010510238A (ja) | 2010-04-02 |
| JP2010510238A5 true JP2010510238A5 (https=) | 2011-01-06 |
Family
ID=40002804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537375A Pending JP2010510238A (ja) | 2006-11-15 | 2007-11-15 | γ線被曝に対する放射線防護および治療の方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2099469A4 (https=) |
| JP (1) | JP2010510238A (https=) |
| AU (1) | AU2007353320B2 (https=) |
| CA (1) | CA2705612A1 (https=) |
| IL (1) | IL198789A0 (https=) |
| WO (1) | WO2008140574A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2935677C (en) * | 2013-12-30 | 2022-07-26 | Rama Krishna Reddy SINGIDI | Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate |
| WO2017011457A1 (en) * | 2015-07-12 | 2017-01-19 | The University Of Tennessee Research Foundation | Compositions and methods for protecting colonic epithelial barrier function |
| JPWO2018016523A1 (ja) * | 2016-07-20 | 2019-05-09 | 国立大学法人 長崎大学 | 新規放射線防護剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2433946B1 (en) * | 2003-10-09 | 2016-04-20 | University of Tennessee Research Foundation | LPA receptor agonists and antagonists and methods of use |
| US20070078111A1 (en) * | 2005-07-19 | 2007-04-05 | Gabor Tigyi | LPA2 receptor agonist inhibitors of CFTR |
-
2007
- 2007-11-15 JP JP2009537375A patent/JP2010510238A/ja active Pending
- 2007-11-15 EP EP07874288A patent/EP2099469A4/en not_active Withdrawn
- 2007-11-15 AU AU2007353320A patent/AU2007353320B2/en not_active Ceased
- 2007-11-15 CA CA2705612A patent/CA2705612A1/en not_active Abandoned
- 2007-11-15 WO PCT/US2007/084875 patent/WO2008140574A2/en not_active Ceased
-
2009
- 2009-05-17 IL IL198789A patent/IL198789A0/en unknown
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