JP2010509204A5 - - Google Patents
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- Publication number
- JP2010509204A5 JP2010509204A5 JP2009535151A JP2009535151A JP2010509204A5 JP 2010509204 A5 JP2010509204 A5 JP 2010509204A5 JP 2009535151 A JP2009535151 A JP 2009535151A JP 2009535151 A JP2009535151 A JP 2009535151A JP 2010509204 A5 JP2010509204 A5 JP 2010509204A5
- Authority
- JP
- Japan
- Prior art keywords
- omega
- lipid composition
- eicosapentaen
- prodrug
- docosahexaen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims 106
- 150000002632 lipids Chemical class 0.000 claims 99
- 239000000651 prodrug Substances 0.000 claims 68
- 229940002612 prodrug Drugs 0.000 claims 68
- 150000001298 alcohols Chemical class 0.000 claims 48
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 13
- 235000015872 dietary supplement Nutrition 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 150000002148 esters Chemical class 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 150000007513 acids Chemical class 0.000 claims 4
- -1 omega-3 fatty acid ester Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 3
- 229910010082 LiAlH Inorganic materials 0.000 claims 3
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 3
- 229960003194 meglumine Drugs 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 229910052796 boron Inorganic materials 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 150000004678 hydrides Chemical class 0.000 claims 2
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 2
- 239000002994 raw material Substances 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010033307 Overweight Diseases 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000001258 dyslipidemic effect Effects 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- ZYYXPAPDNCOHOS-UHFFFAOYSA-N icosa-1,3,5,7,9-pentaen-1-ol Chemical compound CCCCCCCCCCC=CC=CC=CC=CC=CO ZYYXPAPDNCOHOS-UHFFFAOYSA-N 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 229940106134 krill oil Drugs 0.000 claims 1
- 239000012280 lithium aluminium hydride Substances 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 125000002640 tocopherol group Chemical group 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- MBBZMMPHUWSWHV-UHFFFAOYSA-N CNCC(C(C(C(CO)O)O)O)O Chemical compound CNCC(C(C(C(CO)O)O)O)O MBBZMMPHUWSWHV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85626706P | 2006-11-03 | 2006-11-03 | |
| US85626906P | 2006-11-03 | 2006-11-03 | |
| US85626806P | 2006-11-03 | 2006-11-03 | |
| SE0602352 | 2006-11-03 | ||
| PCT/IB2007/004590 WO2008139261A2 (en) | 2006-11-03 | 2007-11-02 | Omega-3 lipid compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010509204A JP2010509204A (ja) | 2010-03-25 |
| JP2010509204A5 true JP2010509204A5 (OSRAM) | 2010-12-24 |
Family
ID=39876685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535151A Pending JP2010509204A (ja) | 2006-11-03 | 2007-11-02 | 脂肪酸アルコール |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100266681A1 (OSRAM) |
| JP (1) | JP2010509204A (OSRAM) |
| KR (1) | KR20090077081A (OSRAM) |
| CN (1) | CN101646426A (OSRAM) |
| BR (1) | BRPI0718393A2 (OSRAM) |
| CA (1) | CA2667153A1 (OSRAM) |
| MX (1) | MX2009004339A (OSRAM) |
| NO (1) | NO20092131L (OSRAM) |
| RU (1) | RU2009121007A (OSRAM) |
| WO (1) | WO2008139261A2 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134147A1 (en) * | 2008-05-02 | 2009-11-05 | Pronova Biopharma Norge As | Lipid compositions containing derivatives of epa and dha an their use thereof |
| GB201009368D0 (en) * | 2010-06-04 | 2010-07-21 | Sana Pharma As | Dietary formulations |
| US8691297B2 (en) * | 2010-09-01 | 2014-04-08 | Nippon Suisan Kaisha, Ltd. | Alcoholic injury mitigating agent |
| CA2876177C (en) * | 2012-06-11 | 2022-06-14 | The Cleveland Clinic Foundation | Treatment and prevention of cardiovascular disease and thrombosis |
| CN102860506A (zh) * | 2012-08-08 | 2013-01-09 | 辽宁省大连海洋渔业集团公司 | 磷虾油微囊粉及其制备方法 |
| EP2961727B1 (en) * | 2013-02-28 | 2016-12-28 | Pronova BioPharma Norge AS | Method of preparing 2-((5z,8z,11z,14z,17z)-icosa-5,8,11,14,17-pentaenyloxy)butanoic acid |
| EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
| BR112017005388B1 (pt) | 2014-10-02 | 2022-09-13 | Evonik Operations Gmbh | Alimento para animais contendo biomassa de aurantiochytrium |
| CN106793803B (zh) | 2014-10-02 | 2021-03-09 | 赢创运营有限公司 | 通过挤压含pufa的生物质来制备含pufa的饲料的方法 |
| CN118813731A (zh) | 2014-10-02 | 2024-10-22 | 赢创运营有限公司 | 用于制备具有高细胞稳定性的含pufa生物质的方法 |
| CA2958439C (en) | 2014-10-02 | 2022-09-20 | Evonik Industries Ag | Feedstuff of high abrasion resistance and good stability in water, containing pufas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01207224A (ja) * | 1988-02-10 | 1989-08-21 | Nonogawa Shoji:Kk | 頭髪用化粧料及び養毛剤 |
| GB8819110D0 (en) * | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| ES2298197T3 (es) * | 2000-01-31 | 2008-05-16 | Harting S.A. | Composiciones que contienen esteres de acidos grasos de fitosterol y de policosanol para reducir el colesterol y los trigliceridos de la sangre. |
| WO2002024180A2 (en) * | 2000-09-21 | 2002-03-28 | Nutrition 21, Inc. | Chromium containing compositions for the treatment of diabetes, the reduction of body fat, improvement of insulin sensitivity and reduction of hyperglycemia and hypercholesteremia |
| CN1516592A (zh) * | 2001-06-18 | 2004-07-28 | �����Ǽ���&������Դ����˾ | 用于预防和/或治疗心血管疾病、关节炎、皮肤癌、糖尿病、经前综合症和透皮转运的磷虾和/或海产提取物 |
| ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| BR0309740A (pt) * | 2002-05-03 | 2005-02-22 | Pronova Biocare As | Uso de ácido eicosapentaenóico (epa), ácido docosaexaenóico (dha) ou de uma mistura de epa e dha ou de um sal ou derivado farmaceuticamente aceitáveis dos mesmos |
| CN1309813C (zh) * | 2002-08-07 | 2007-04-11 | 花王株式会社 | 油脂组合物 |
| US8017651B2 (en) * | 2002-11-22 | 2011-09-13 | Bionexus, Ltd. | Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia |
| CA2515328A1 (en) * | 2003-03-05 | 2004-09-16 | Solvay Pharmaceuticals Gmbh | Use of omega-3-fatty acids in the treatment of diabetic patients |
| SE0303513D0 (sv) * | 2003-12-19 | 2003-12-19 | Pronova Biocare As | Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof |
-
2007
- 2007-11-02 CA CA002667153A patent/CA2667153A1/en not_active Abandoned
- 2007-11-02 BR BRPI0718393-3A patent/BRPI0718393A2/pt not_active IP Right Cessation
- 2007-11-02 WO PCT/IB2007/004590 patent/WO2008139261A2/en not_active Ceased
- 2007-11-02 CN CN200780040625A patent/CN101646426A/zh active Pending
- 2007-11-02 RU RU2009121007/04A patent/RU2009121007A/ru not_active Application Discontinuation
- 2007-11-02 MX MX2009004339A patent/MX2009004339A/es not_active Application Discontinuation
- 2007-11-02 JP JP2009535151A patent/JP2010509204A/ja active Pending
- 2007-11-02 US US12/447,971 patent/US20100266681A1/en not_active Abandoned
- 2007-11-02 KR KR1020097011471A patent/KR20090077081A/ko not_active Ceased
-
2009
- 2009-06-02 NO NO20092131A patent/NO20092131L/no not_active Application Discontinuation
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