JP2010508306A5 - - Google Patents
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- Publication number
- JP2010508306A5 JP2010508306A5 JP2009534946A JP2009534946A JP2010508306A5 JP 2010508306 A5 JP2010508306 A5 JP 2010508306A5 JP 2009534946 A JP2009534946 A JP 2009534946A JP 2009534946 A JP2009534946 A JP 2009534946A JP 2010508306 A5 JP2010508306 A5 JP 2010508306A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pai
- agent
- weight
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 33
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 claims description 22
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 14
- 208000010412 Glaucoma Diseases 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- -1 WAY-140312 Chemical compound 0.000 claims description 8
- 229940122072 Carbonic anhydrase inhibitor Drugs 0.000 claims description 4
- ODXQFEWQSHNQNI-UHFFFAOYSA-N Tiplasinin Chemical compound C12=CC=C(C=3C=CC(OC(F)(F)F)=CC=3)C=C2C(C(=O)C(=O)O)=CN1CC1=CC=CC=C1 ODXQFEWQSHNQNI-UHFFFAOYSA-N 0.000 claims description 4
- 102100035140 Vitronectin Human genes 0.000 claims description 4
- 108010031318 Vitronectin Proteins 0.000 claims description 4
- 239000000556 agonist Substances 0.000 claims description 4
- 239000002585 base Substances 0.000 claims description 4
- 239000002876 beta blocker Substances 0.000 claims description 4
- 229940097320 beta blocking agent Drugs 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims description 4
- 239000003623 enhancer Substances 0.000 claims description 4
- 239000003349 gelling agent Substances 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 239000003604 miotic agent Substances 0.000 claims description 4
- 239000004090 neuroprotective agent Substances 0.000 claims description 4
- 239000003961 penetration enhancing agent Substances 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 150000003180 prostaglandins Chemical class 0.000 claims description 4
- 239000003590 rho kinase inhibitor Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 239000003981 vehicle Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 206010030043 Ocular hypertension Diseases 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 210000001585 trabecular meshwork Anatomy 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 15
- 208000030533 eye disease Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86371506P | 2006-10-31 | 2006-10-31 | |
| PCT/US2007/083170 WO2008055205A2 (en) | 2006-10-31 | 2007-10-31 | Pai-1 binding modulators for the treatment of ocular disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508306A JP2010508306A (ja) | 2010-03-18 |
| JP2010508306A5 true JP2010508306A5 (https=) | 2011-06-30 |
Family
ID=39345074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534946A Pending JP2010508306A (ja) | 2006-10-31 | 2007-10-31 | 眼障害を治療するためのｐａｉ−１結合調節因子 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20080107644A1 (https=) |
| EP (1) | EP2077829A2 (https=) |
| JP (1) | JP2010508306A (https=) |
| KR (1) | KR20090082401A (https=) |
| CN (1) | CN101588798A (https=) |
| AU (1) | AU2007313684A1 (https=) |
| CA (1) | CA2666316A1 (https=) |
| MX (1) | MX2009004792A (https=) |
| RU (1) | RU2465898C2 (https=) |
| WO (1) | WO2008055205A2 (https=) |
| ZA (1) | ZA200902453B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100158897A1 (en) * | 2006-10-31 | 2010-06-24 | Alcon Research, Ltd. | Pai-1 modulators for the treatment of ocular disorders |
| US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
| CN103959068B (zh) * | 2011-11-15 | 2016-04-06 | 国立大学法人浜松医科大学 | 基于纤溶酶原激活物抑制剂－1的流产、早产治疗药 |
| US10946076B2 (en) | 2013-02-13 | 2021-03-16 | The Research Foundation For The State University Of New York | Glaucoma treatment |
| US9820954B2 (en) * | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0642789B1 (en) * | 1992-05-22 | 1999-09-29 | Senju Pharmaceutical Co., Ltd. | Remedy for glaucoma |
| AR002194A1 (es) * | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| IL143687A0 (en) * | 1998-12-11 | 2002-04-21 | Khamar Bakulesh Mafatlal | The process for manufacturing formulation of topical beta blockers with improved efficacy |
| AU771635B2 (en) * | 1999-01-05 | 2004-04-01 | American National Red Cross, The | Methods for treating conditions associated with the accumulation of excess extracellular matrix |
| WO2003071267A1 (en) * | 2002-02-19 | 2003-08-28 | Vanderbilt University | Therapeutic methods employing pai-1 inhibitors and transgenic non-human animal for screening candidate pai-1 inhibitors |
| US7351407B2 (en) * | 2002-04-30 | 2008-04-01 | Alcon, Inc. | Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
-
2007
- 2007-10-31 WO PCT/US2007/083170 patent/WO2008055205A2/en not_active Ceased
- 2007-10-31 US US11/931,393 patent/US20080107644A1/en not_active Abandoned
- 2007-10-31 MX MX2009004792A patent/MX2009004792A/es not_active Application Discontinuation
- 2007-10-31 RU RU2009120545/15A patent/RU2465898C2/ru not_active IP Right Cessation
- 2007-10-31 JP JP2009534946A patent/JP2010508306A/ja active Pending
- 2007-10-31 CN CNA2007800407976A patent/CN101588798A/zh active Pending
- 2007-10-31 AU AU2007313684A patent/AU2007313684A1/en not_active Abandoned
- 2007-10-31 ZA ZA200902453A patent/ZA200902453B/xx unknown
- 2007-10-31 CA CA002666316A patent/CA2666316A1/en not_active Abandoned
- 2007-10-31 KR KR1020097010021A patent/KR20090082401A/ko not_active Withdrawn
- 2007-10-31 EP EP07868631A patent/EP2077829A2/en not_active Withdrawn
-
2010
- 2010-06-25 US US12/823,773 patent/US20100260784A1/en not_active Abandoned
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