JP2010507580A5 - - Google Patents
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- Publication number
- JP2010507580A5 JP2010507580A5 JP2009533551A JP2009533551A JP2010507580A5 JP 2010507580 A5 JP2010507580 A5 JP 2010507580A5 JP 2009533551 A JP2009533551 A JP 2009533551A JP 2009533551 A JP2009533551 A JP 2009533551A JP 2010507580 A5 JP2010507580 A5 JP 2010507580A5
- Authority
- JP
- Japan
- Prior art keywords
- dops
- long chain
- dppc
- composition
- prosaposin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- 238000000034 method Methods 0.000 claims 20
- 150000003904 phospholipids Chemical class 0.000 claims 20
- WTBFLCSPLLEDEM-JIDRGYQWSA-N 1,2-dioleoyl-sn-glycero-3-phospho-L-serine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC WTBFLCSPLLEDEM-JIDRGYQWSA-N 0.000 claims 16
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 12
- 150000002632 lipids Chemical class 0.000 claims 12
- 102100036197 Prosaposin Human genes 0.000 claims 9
- 101710152403 Prosaposin Proteins 0.000 claims 9
- 125000000129 anionic group Chemical group 0.000 claims 8
- 102100031242 Deoxyhypusine synthase Human genes 0.000 claims 6
- 101000844963 Homo sapiens Deoxyhypusine synthase Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000017852 Saposin Human genes 0.000 claims 5
- 108050007079 Saposin Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- DSNRWDQKZIEDDB-GCMPNPAFSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(z)-octadec-9-enoyl]oxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-GCMPNPAFSA-N 0.000 claims 4
- 239000002356 single layer Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 239000002691 unilamellar liposome Substances 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 230000002902 bimodal effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86231206P | 2006-10-20 | 2006-10-20 | |
| US60/862,312 | 2006-10-20 | ||
| PCT/US2007/081880 WO2008051818A2 (en) | 2006-10-20 | 2007-10-19 | Spontaneously forming ellipsoidal phospholipid unilamellar vesicles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507580A JP2010507580A (ja) | 2010-03-11 |
| JP2010507580A5 true JP2010507580A5 (cg-RX-API-DMAC7.html) | 2010-12-02 |
| JP5253402B2 JP5253402B2 (ja) | 2013-07-31 |
Family
ID=39325270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533551A Expired - Fee Related JP5253402B2 (ja) | 2006-10-20 | 2007-10-19 | 自発的に形成する楕円体の単層リン脂質小胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100311844A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2081552A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5253402B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101541307A (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0717475A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2666953A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008051818A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834147B2 (en) | 2003-04-28 | 2010-11-16 | Childrens Hospital Medical Center | Saposin C-DOPS: a novel anti-tumor agent |
| EP2020988B1 (en) | 2006-04-28 | 2017-08-16 | Children's Hospital Medical Center | Compositions comprising fusogenic proteins or polypeptides derived from prosaposin for application in transmembrane drug delivery systems |
| AU2008363813A1 (en) * | 2008-11-07 | 2010-05-14 | Children's Hospital Medical Center | Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems |
| CN108926535B (zh) * | 2011-02-01 | 2020-12-29 | 常州长吉生物技术开发有限公司 | SapC-磷脂纳米囊泡冻干制剂、 其制备方法及用途 |
| DK2745834T3 (en) | 2012-12-18 | 2017-01-16 | Salipro Biotech Ag | Salipro particles |
| LT3043814T (lt) | 2013-09-13 | 2021-02-25 | Salipro Biotech AB | Antigenas ir jo gamybos būdas |
| JP7081865B2 (ja) | 2018-03-23 | 2022-06-07 | ベキシオン ファーマシューティカルズ インコーポレイテッド | サポシンｃ薬学的組成物および癌を治療する方法 |
| EP4125816A4 (en) * | 2020-04-01 | 2024-01-10 | University of Cincinnati | MATERIALS AND METHODS FOR IMMUNOSUPRESSIVE TUMOR MICRO-TARGETED CANCER THERAPY |
| US11833254B2 (en) * | 2020-05-27 | 2023-12-05 | University Of Connecticut | Discoidal nano universal platform for efficient delivery of PNAs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921706A (en) * | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
| US6433040B1 (en) * | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| WO2000012553A1 (en) * | 1998-08-28 | 2000-03-09 | Myelos Corporation | Cyclic prosaposin-derived peptides and uses thereof |
| US6872406B2 (en) * | 2000-02-11 | 2005-03-29 | Children's Hospital Research Foundation | Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems |
| US7834147B2 (en) * | 2003-04-28 | 2010-11-16 | Childrens Hospital Medical Center | Saposin C-DOPS: a novel anti-tumor agent |
| EP2020988B1 (en) * | 2006-04-28 | 2017-08-16 | Children's Hospital Medical Center | Compositions comprising fusogenic proteins or polypeptides derived from prosaposin for application in transmembrane drug delivery systems |
| AU2008363813A1 (en) * | 2008-11-07 | 2010-05-14 | Children's Hospital Medical Center | Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems |
-
2007
- 2007-10-19 CA CA002666953A patent/CA2666953A1/en not_active Abandoned
- 2007-10-19 EP EP07854199A patent/EP2081552A2/en not_active Withdrawn
- 2007-10-19 CN CNA2007800438762A patent/CN101541307A/zh active Pending
- 2007-10-19 WO PCT/US2007/081880 patent/WO2008051818A2/en not_active Ceased
- 2007-10-19 BR BRPI0717475-6A patent/BRPI0717475A2/pt not_active IP Right Cessation
- 2007-10-19 US US12/445,707 patent/US20100311844A1/en not_active Abandoned
- 2007-10-19 JP JP2009533551A patent/JP5253402B2/ja not_active Expired - Fee Related
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