JP2010505482A5 - - Google Patents
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- Publication number
- JP2010505482A5 JP2010505482A5 JP2009530811A JP2009530811A JP2010505482A5 JP 2010505482 A5 JP2010505482 A5 JP 2010505482A5 JP 2009530811 A JP2009530811 A JP 2009530811A JP 2009530811 A JP2009530811 A JP 2009530811A JP 2010505482 A5 JP2010505482 A5 JP 2010505482A5
- Authority
- JP
- Japan
- Prior art keywords
- spinal
- implant
- retention factor
- nucleus implant
- cartilage differentiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 14
- 210000000845 cartilage Anatomy 0.000 claims 8
- 230000004069 differentiation Effects 0.000 claims 8
- 230000014759 maintenance of location Effects 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102100022185 Melanoma-derived growth regulatory protein Human genes 0.000 claims 4
- 101710195116 Melanoma-derived growth regulatory protein Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 210000000278 spinal cord Anatomy 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 3
- 238000002513 implantation Methods 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 208000008765 Sciatica Diseases 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000008035 Back Pain Diseases 0.000 claims 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 claims 1
- 206010050296 Intervertebral disc protrusion Diseases 0.000 claims 1
- 206010028570 Myelopathy Diseases 0.000 claims 1
- 206010037779 Radiculopathy Diseases 0.000 claims 1
- 208000029033 Spinal Cord disease Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001195 anabolic effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000003848 cartilage regeneration Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 230000002648 chondrogenic effect Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 201000002972 idiopathic scoliosis Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000005198 spinal stenosis Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06021093.7 | 2006-10-06 | ||
| EP06021093 | 2006-10-06 | ||
| PCT/EP2007/008660 WO2008040557A1 (en) | 2006-10-06 | 2007-10-05 | A spinal nucleus pulposus implant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010505482A JP2010505482A (ja) | 2010-02-25 |
| JP2010505482A5 true JP2010505482A5 (https=) | 2010-11-25 |
| JP5484059B2 JP5484059B2 (ja) | 2014-05-07 |
Family
ID=38910893
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530811A Expired - Fee Related JP5484059B2 (ja) | 2006-10-06 | 2007-10-05 | 脊髄核インプラント |
| JP2009530810A Expired - Fee Related JP5404402B2 (ja) | 2006-10-06 | 2007-10-05 | 医薬適用のための乾燥した再構成したベシクル形成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530810A Expired - Fee Related JP5404402B2 (ja) | 2006-10-06 | 2007-10-05 | 医薬適用のための乾燥した再構成したベシクル形成 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20090297580A1 (https=) |
| EP (2) | EP2081551B1 (https=) |
| JP (2) | JP5484059B2 (https=) |
| KR (1) | KR101333279B1 (https=) |
| CN (3) | CN102940878A (https=) |
| CA (1) | CA2664637C (https=) |
| CY (1) | CY1113934T1 (https=) |
| DK (1) | DK2081551T3 (https=) |
| ES (2) | ES2400162T3 (https=) |
| HR (1) | HRP20130328T1 (https=) |
| PL (1) | PL2081551T3 (https=) |
| PT (1) | PT2081551E (https=) |
| RS (1) | RS52706B (https=) |
| RU (1) | RU2443412C2 (https=) |
| SI (1) | SI2081551T1 (https=) |
| TW (1) | TWI455731B (https=) |
| WO (2) | WO2008040557A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6907884B2 (en) | 2002-09-30 | 2005-06-21 | Depay Acromed, Inc. | Method of straddling an intraosseous nerve |
| US7258690B2 (en) | 2003-03-28 | 2007-08-21 | Relievant Medsystems, Inc. | Windowed thermal ablation probe |
| US8361067B2 (en) | 2002-09-30 | 2013-01-29 | Relievant Medsystems, Inc. | Methods of therapeutically heating a vertebral body to treat back pain |
| US7879103B2 (en) | 2005-04-15 | 2011-02-01 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
| US7959683B2 (en) | 2006-07-25 | 2011-06-14 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
| CA2957010C (en) | 2008-09-26 | 2017-07-04 | Relievant Medsystems, Inc. | Systems and methods for navigating an instrument through bone |
| US10028753B2 (en) | 2008-09-26 | 2018-07-24 | Relievant Medsystems, Inc. | Spine treatment kits |
| CA2790436A1 (en) | 2010-02-18 | 2011-08-25 | Osiris Therapeutics, Inc. | Immunocompatible chorionic membrane products |
| SG10201502398RA (en) * | 2010-04-27 | 2015-05-28 | Scil Technology Gmbh | Stable MIA/CD-RAP formulations |
| WO2013101772A1 (en) | 2011-12-30 | 2013-07-04 | Relievant Medsystems, Inc. | Systems and methods for treating back pain |
| US20130202682A1 (en) * | 2012-01-24 | 2013-08-08 | The Trustees Of Columbia University In The City Of New York | Synthetic matrix vesicles for biomimetic mineralization |
| SI2854769T1 (sl) * | 2012-07-05 | 2023-09-29 | Taiwan Liposome Company, Ltd. | Postopki za zdravljenje artritisa |
| US10588691B2 (en) | 2012-09-12 | 2020-03-17 | Relievant Medsystems, Inc. | Radiofrequency ablation of tissue within a vertebral body |
| CA2889478C (en) | 2012-11-05 | 2020-11-24 | Relievant Medsystems, Inc. | Systems and methods for creating curved paths through bone and modulating nerves within the bone |
| US9724151B2 (en) | 2013-08-08 | 2017-08-08 | Relievant Medsystems, Inc. | Modulating nerves within bone using bone fasteners |
| US10159646B2 (en) * | 2013-08-12 | 2018-12-25 | Altum-Avro Pharma Partnership | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| US8986732B2 (en) | 2013-08-12 | 2015-03-24 | Helix Biopharma Corporation | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| KR102190157B1 (ko) * | 2014-12-18 | 2020-12-14 | 브라코 스위스 에스.에이. | 표적화된 기체-충전 미세소포 제형 |
| AU2016256979B2 (en) | 2015-05-04 | 2021-01-28 | Genfit | Method for preparing transmembrane pH-gradient vesicles |
| CA2998665A1 (en) * | 2015-09-18 | 2017-03-23 | Bionet Pharma Gmbh | Improvement of expression and folding in the manufacturing process of cd-rap by using a cd-rap precursor protein |
| US20190111178A1 (en) * | 2016-04-04 | 2019-04-18 | Gu Ventures Ab | Methods and compositions for the treatment of intervertebral disc herniation |
| CA3061205A1 (en) * | 2017-04-25 | 2018-11-01 | Memorial Sloan Kettering Cancer Center | Triterpene saponin analogues |
| CN111182889A (zh) | 2017-08-28 | 2020-05-19 | 美商Tlc生物医药公司 | 缓释麻醉剂组成物及其制备方法 |
| WO2019055901A1 (en) | 2017-09-18 | 2019-03-21 | North Carolina State University | ARTIFICIAL β CELLS AND METHODS OF USE |
| KR102646145B1 (ko) | 2018-05-31 | 2024-03-11 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| KR102058961B1 (ko) | 2018-07-28 | 2019-12-24 | 주식회사 엑소코바이오 | 엑소좀의 동결건조 방법 |
| KR102163806B1 (ko) * | 2018-07-30 | 2020-10-07 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물 |
| HRP20240586T1 (hr) * | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| EP4027912B1 (en) | 2019-09-12 | 2024-12-18 | Relievant Medsystems, Inc. | Systems for tissue modulation |
| WO2022011115A1 (en) | 2020-07-10 | 2022-01-13 | Relievant Medsystems, Inc. | Vertebral denervation in conjunction with vertebral fusion |
| US12082876B1 (en) | 2020-09-28 | 2024-09-10 | Relievant Medsystems, Inc. | Introducer drill |
| AU2021409967A1 (en) | 2020-12-22 | 2023-08-03 | Relievant Medsystems, Inc. | Prediction of candidates for spinal neuromodulation |
| US12433668B1 (en) | 2021-11-08 | 2025-10-07 | Relievant Medsystems, Inc. | Impedance stoppage mitigation during radiofrequency tissue ablation procedures |
| CN113995852B (zh) * | 2021-11-08 | 2024-01-30 | 河北大学 | Arg-脂质体微囊、微囊包封的鱼精蛋白-siRNA复合体及其制备方法和应用 |
| CN221431621U (zh) * | 2023-07-10 | 2024-07-30 | 常州富谦生物科技有限公司 | 一种多层膜结构 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH621479A5 (https=) * | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
| FR2416008A1 (fr) * | 1978-02-02 | 1979-08-31 | Oreal | Lyophilisats de liposomes |
| IL79114A (en) | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
| FR2591105B1 (fr) * | 1985-12-11 | 1989-03-24 | Moet Hennessy Rech | Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide. |
| US4897353A (en) * | 1986-03-13 | 1990-01-30 | University Of Southwestern Louisiana | Cryogenic protection of phosphofructokinase using amino acids and zinc ions |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| WO1992002208A1 (en) | 1990-08-08 | 1992-02-20 | Liposome Technology, Inc. | Stable doxorubicin/liposome composition |
| CA2120197A1 (en) * | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| GB9320668D0 (en) | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| US6066331A (en) * | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| IL115199A (en) * | 1995-09-07 | 2005-05-17 | Opperbas Holding Bv | Composition comprising a polynucleic acid molecule in a liposome and method using said composition |
| US6287590B1 (en) * | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
| AU5702099A (en) * | 1998-09-01 | 2000-03-21 | Millennium Pharmaceuticals, Inc. | A novel protein related to melanoma-inhibiting protein and uses thereof |
| EP1025871A1 (en) * | 1999-01-28 | 2000-08-09 | F. Hoffmann-La Roche Ag | Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair |
| US7435260B2 (en) * | 1999-08-13 | 2008-10-14 | Ferree Bret A | Use of morphogenetic proteins to treat human disc disease |
| ES2278648T3 (es) * | 1999-12-06 | 2007-08-16 | Warsaw Orthopedic, Inc. | Dispositivo para tratar un disco intervertebral. |
| AU2002331481B2 (en) * | 2001-10-03 | 2008-04-24 | Celator Pharmaceuticals, Inc. | Liposome loading with metal ions |
| JP2006518701A (ja) * | 2002-05-24 | 2006-08-17 | ネオファーム、インコーポレイティッド | カルジオリピン組成物、その製造方法及び使用 |
| US7169405B2 (en) * | 2003-08-06 | 2007-01-30 | Warsaw Orthopedic, Inc. | Methods and devices for the treatment of intervertebral discs |
| BRPI0509365B8 (pt) * | 2004-03-30 | 2021-05-25 | Ilypsa Inc | composição farmacêutica, kit farmacêutico, e, uso da referida composição |
| EP1778309B1 (en) * | 2004-05-21 | 2010-11-17 | Synthes GmbH | Replacement of nucleus pulposus using a hydrogel |
| CA2567405A1 (en) * | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
| EP1604693A1 (en) * | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | In situ forming scaffold, its manufacturing and use |
| WO2006050327A2 (en) * | 2004-10-28 | 2006-05-11 | Alza Corporation | Lyophilized liposome formulations and method |
| US20110071056A1 (en) * | 2009-09-24 | 2011-03-24 | Rajesh K Saini | Degradable Surfactants, Including Degradable Gemini Surfactants, and Associated Methods |
-
2007
- 2007-10-05 JP JP2009530811A patent/JP5484059B2/ja not_active Expired - Fee Related
- 2007-10-05 WO PCT/EP2007/008660 patent/WO2008040557A1/en not_active Ceased
- 2007-10-05 JP JP2009530810A patent/JP5404402B2/ja not_active Expired - Fee Related
- 2007-10-05 HR HRP20130328TT patent/HRP20130328T1/hr unknown
- 2007-10-05 CN CN2012104557068A patent/CN102940878A/zh active Pending
- 2007-10-05 RS RS20130131A patent/RS52706B/sr unknown
- 2007-10-05 EP EP07818735A patent/EP2081551B1/en active Active
- 2007-10-05 CA CA2664637A patent/CA2664637C/en not_active Expired - Fee Related
- 2007-10-05 CN CN2007800397245A patent/CN101528197B/zh not_active Expired - Fee Related
- 2007-10-05 ES ES07818735T patent/ES2400162T3/es active Active
- 2007-10-05 DK DK07818735.8T patent/DK2081551T3/da active
- 2007-10-05 SI SI200731193T patent/SI2081551T1/sl unknown
- 2007-10-05 ES ES07818736T patent/ES2708851T3/es active Active
- 2007-10-05 WO PCT/EP2007/008659 patent/WO2008040556A1/en not_active Ceased
- 2007-10-05 KR KR1020097009193A patent/KR101333279B1/ko not_active Expired - Fee Related
- 2007-10-05 PT PT78187358T patent/PT2081551E/pt unknown
- 2007-10-05 CN CNA2007800422016A patent/CN101605534A/zh active Pending
- 2007-10-05 RU RU2009117170/15A patent/RU2443412C2/ru not_active IP Right Cessation
- 2007-10-05 EP EP07818736.6A patent/EP2086507B1/en not_active Not-in-force
- 2007-10-05 PL PL07818735T patent/PL2081551T3/pl unknown
- 2007-10-05 TW TW096137658A patent/TWI455731B/zh not_active IP Right Cessation
-
2009
- 2009-04-06 US US12/419,131 patent/US20090297580A1/en not_active Abandoned
- 2009-04-06 US US12/419,167 patent/US9526761B2/en not_active Expired - Fee Related
-
2013
- 2013-04-18 CY CY20131100316T patent/CY1113934T1/el unknown
-
2016
- 2016-03-08 US US15/064,444 patent/US20160220638A1/en not_active Abandoned
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