JP2010505482A5 - - Google Patents
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- Publication number
- JP2010505482A5 JP2010505482A5 JP2009530811A JP2009530811A JP2010505482A5 JP 2010505482 A5 JP2010505482 A5 JP 2010505482A5 JP 2009530811 A JP2009530811 A JP 2009530811A JP 2009530811 A JP2009530811 A JP 2009530811A JP 2010505482 A5 JP2010505482 A5 JP 2010505482A5
- Authority
- JP
- Japan
- Prior art keywords
- spinal
- implant
- retention factor
- nucleus implant
- cartilage differentiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 14
- 210000000845 cartilage Anatomy 0.000 claims 8
- 230000004069 differentiation Effects 0.000 claims 8
- 230000014759 maintenance of location Effects 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 102100022185 Melanoma-derived growth regulatory protein Human genes 0.000 claims 4
- 101710195116 Melanoma-derived growth regulatory protein Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 210000000278 spinal cord Anatomy 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 3
- 238000002513 implantation Methods 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 208000008765 Sciatica Diseases 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 208000008035 Back Pain Diseases 0.000 claims 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 claims 1
- 206010050296 Intervertebral disc protrusion Diseases 0.000 claims 1
- 206010028570 Myelopathy Diseases 0.000 claims 1
- 206010037779 Radiculopathy Diseases 0.000 claims 1
- 208000029033 Spinal Cord disease Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001195 anabolic effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000003848 cartilage regeneration Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001612 chondrocyte Anatomy 0.000 claims 1
- 230000002648 chondrogenic effect Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 201000002972 idiopathic scoliosis Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000005198 spinal stenosis Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06021093.7 | 2006-10-06 | ||
| EP06021093 | 2006-10-06 | ||
| PCT/EP2007/008660 WO2008040557A1 (en) | 2006-10-06 | 2007-10-05 | A spinal nucleus pulposus implant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010505482A JP2010505482A (ja) | 2010-02-25 |
| JP2010505482A5 true JP2010505482A5 (enExample) | 2010-11-25 |
| JP5484059B2 JP5484059B2 (ja) | 2014-05-07 |
Family
ID=38910893
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530810A Expired - Fee Related JP5404402B2 (ja) | 2006-10-06 | 2007-10-05 | 医薬適用のための乾燥した再構成したベシクル形成 |
| JP2009530811A Expired - Fee Related JP5484059B2 (ja) | 2006-10-06 | 2007-10-05 | 脊髄核インプラント |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530810A Expired - Fee Related JP5404402B2 (ja) | 2006-10-06 | 2007-10-05 | 医薬適用のための乾燥した再構成したベシクル形成 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9526761B2 (enExample) |
| EP (2) | EP2081551B1 (enExample) |
| JP (2) | JP5404402B2 (enExample) |
| KR (1) | KR101333279B1 (enExample) |
| CN (3) | CN101605534A (enExample) |
| CA (1) | CA2664637C (enExample) |
| CY (1) | CY1113934T1 (enExample) |
| DK (1) | DK2081551T3 (enExample) |
| ES (2) | ES2400162T3 (enExample) |
| HR (1) | HRP20130328T1 (enExample) |
| PL (1) | PL2081551T3 (enExample) |
| PT (1) | PT2081551E (enExample) |
| RS (1) | RS52706B (enExample) |
| RU (1) | RU2443412C2 (enExample) |
| SI (1) | SI2081551T1 (enExample) |
| TW (1) | TWI455731B (enExample) |
| WO (2) | WO2008040556A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6907884B2 (en) | 2002-09-30 | 2005-06-21 | Depay Acromed, Inc. | Method of straddling an intraosseous nerve |
| US8361067B2 (en) | 2002-09-30 | 2013-01-29 | Relievant Medsystems, Inc. | Methods of therapeutically heating a vertebral body to treat back pain |
| US7258690B2 (en) | 2003-03-28 | 2007-08-21 | Relievant Medsystems, Inc. | Windowed thermal ablation probe |
| CA2604622A1 (en) | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
| US7959683B2 (en) | 2006-07-25 | 2011-06-14 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
| US10028753B2 (en) | 2008-09-26 | 2018-07-24 | Relievant Medsystems, Inc. | Spine treatment kits |
| JP5688022B2 (ja) | 2008-09-26 | 2015-03-25 | リリーバント メドシステムズ、インコーポレイテッド | 骨の内部を通って器具を誘導するためのシステムおよび方法 |
| AR080219A1 (es) | 2010-02-18 | 2012-03-21 | Osiris Therapeutics Inc | Productos de membranas corionicas inmunocompatibles |
| RU2588658C2 (ru) * | 2010-04-27 | 2016-07-10 | ЭсСиАйЭл Текнолоджи ГмбХ | Стабильные водные композиции белка mia/cd-rap |
| US10390877B2 (en) | 2011-12-30 | 2019-08-27 | Relievant Medsystems, Inc. | Systems and methods for treating back pain |
| US20130202682A1 (en) * | 2012-01-24 | 2013-08-08 | The Trustees Of Columbia University In The City Of New York | Synthetic matrix vesicles for biomimetic mineralization |
| HRP20230655T1 (hr) * | 2012-07-05 | 2023-10-13 | Taiwan Liposome Company, Ltd. | Metode liječenja artritisa |
| US10588691B2 (en) | 2012-09-12 | 2020-03-17 | Relievant Medsystems, Inc. | Radiofrequency ablation of tissue within a vertebral body |
| AU2013337680B2 (en) | 2012-11-05 | 2019-04-18 | Relievant Medsystems, Inc. | Systems and methods for creating curved paths through bone and modulating nerves within the bone |
| US9724151B2 (en) | 2013-08-08 | 2017-08-08 | Relievant Medsystems, Inc. | Modulating nerves within bone using bone fasteners |
| US10159646B2 (en) * | 2013-08-12 | 2018-12-25 | Altum-Avro Pharma Partnership | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| US8986732B2 (en) | 2013-08-12 | 2015-03-24 | Helix Biopharma Corporation | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| DK3233136T3 (da) * | 2014-12-18 | 2019-05-20 | Bracco Suisse Sa | Formulering med målrettede gasfyldte mikrovesikler |
| MX381655B (es) | 2015-05-04 | 2025-03-13 | Versantis AG | Metodo para preparar vesiculas con gradiente de ph de transmembrana. |
| US10660852B2 (en) | 2015-09-18 | 2020-05-26 | Bionet Pharma Gmbh | Expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein |
| EP3439691A4 (en) * | 2016-04-04 | 2020-05-13 | GU Ventures AB | METHODS AND COMPOSITIONS FOR TREATING INTERVERTEBRAL DISC HERNIA |
| AU2018258070A1 (en) * | 2017-04-25 | 2019-10-24 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| MX393126B (es) * | 2017-08-28 | 2025-03-24 | Tlc Biopharmaceuticals Inc | Composiciones anestesicas de liberacion sostenida, y metodos de preparacion de las mismas |
| CN111356448A (zh) * | 2017-09-18 | 2020-06-30 | 北卡罗莱纳州立大学 | 人工β细胞及其使用方法 |
| KR102649069B1 (ko) | 2018-05-31 | 2024-03-19 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물 |
| WO2020027466A1 (ko) | 2018-07-28 | 2020-02-06 | 주식회사 엑소코바이오 | 엑소좀의 동결건조 방법 |
| KR102163806B1 (ko) * | 2018-07-30 | 2020-10-07 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물 |
| CN113166783B (zh) * | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| WO2021050767A1 (en) | 2019-09-12 | 2021-03-18 | Relievant Medsystems, Inc. | Systems and methods for tissue modulation |
| AU2021306313A1 (en) | 2020-07-10 | 2023-03-02 | Relievant Medsystems, Inc. | Vertebral denervation in conjunction with vertebral fusion |
| US12082876B1 (en) | 2020-09-28 | 2024-09-10 | Relievant Medsystems, Inc. | Introducer drill |
| EP4268150A4 (en) | 2020-12-22 | 2024-12-18 | Relievant Medsystems, Inc. | PREDICTION OF CANDIDATES FOR SPINAL CORD NEUROMODULATION |
| CN113995852B (zh) * | 2021-11-08 | 2024-01-30 | 河北大学 | Arg-脂质体微囊、微囊包封的鱼精蛋白-siRNA复合体及其制备方法和应用 |
| US12433668B1 (en) | 2021-11-08 | 2025-10-07 | Relievant Medsystems, Inc. | Impedance stoppage mitigation during radiofrequency tissue ablation procedures |
| CN221431621U (zh) * | 2023-07-10 | 2024-07-30 | 常州富谦生物科技有限公司 | 一种多层膜结构 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH621479A5 (enExample) * | 1977-08-05 | 1981-02-13 | Battelle Memorial Institute | |
| FR2416008A1 (fr) * | 1978-02-02 | 1979-08-31 | Oreal | Lyophilisats de liposomes |
| IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
| FR2591105B1 (fr) * | 1985-12-11 | 1989-03-24 | Moet Hennessy Rech | Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide. |
| US4897353A (en) * | 1986-03-13 | 1990-01-30 | University Of Southwestern Louisiana | Cryogenic protection of phosphofructokinase using amino acids and zinc ions |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| CA2088975A1 (en) | 1990-08-08 | 1992-02-09 | Anthony H. Huang | Stable doxorubicin/liposome composition |
| CA2120197A1 (en) * | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| GB9320668D0 (en) * | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| US6066331A (en) * | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| IL115199A (en) | 1995-09-07 | 2005-05-17 | Opperbas Holding Bv | Composition comprising a polynucleic acid molecule in a liposome and method using said composition |
| US6287590B1 (en) * | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
| WO2000012762A1 (en) * | 1998-09-01 | 2000-03-09 | Millennium Pharmaceuticals, Inc. | A novel protein related to melanoma-inhibiting protein and uses thereof |
| EP1025871A1 (en) * | 1999-01-28 | 2000-08-09 | F. Hoffmann-La Roche Ag | Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair |
| US7435260B2 (en) * | 1999-08-13 | 2008-10-14 | Ferree Bret A | Use of morphogenetic proteins to treat human disc disease |
| JP4672947B2 (ja) * | 1999-12-06 | 2011-04-20 | ウォーソー・オーソペディック・インコーポレーテッド | 椎間板の治療装置及び方法 |
| JP4822666B2 (ja) * | 2001-10-03 | 2011-11-24 | セレーター ファーマシューティカルズ インコーポレイテッド | 金属イオンをローディングするリポソーム |
| EP1513853A2 (en) * | 2002-05-24 | 2005-03-16 | Neopharm, Inc. | Cardiolipin compositions, methods of preparation and use |
| US7169405B2 (en) * | 2003-08-06 | 2007-01-30 | Warsaw Orthopedic, Inc. | Methods and devices for the treatment of intervertebral discs |
| CA2557999C (en) * | 2004-03-30 | 2013-11-12 | Ilypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| AU2005245017A1 (en) * | 2004-05-21 | 2005-12-01 | Synthes Gmbh | Replacement of nucleus pulposus using a hydrogel |
| ES2369629T3 (es) * | 2004-05-25 | 2011-12-02 | Stryker Corporation | Uso de op-1 para tratar defectos del cartílago. |
| EP1604693A1 (en) * | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | In situ forming scaffold, its manufacturing and use |
| EP1809254A2 (en) * | 2004-10-28 | 2007-07-25 | Alza Corporation | Lyophilized liposome formulations and method |
| US20110071056A1 (en) * | 2009-09-24 | 2011-03-24 | Rajesh K Saini | Degradable Surfactants, Including Degradable Gemini Surfactants, and Associated Methods |
-
2007
- 2007-10-05 KR KR1020097009193A patent/KR101333279B1/ko not_active Expired - Fee Related
- 2007-10-05 EP EP07818735A patent/EP2081551B1/en active Active
- 2007-10-05 EP EP07818736.6A patent/EP2086507B1/en not_active Not-in-force
- 2007-10-05 JP JP2009530810A patent/JP5404402B2/ja not_active Expired - Fee Related
- 2007-10-05 TW TW096137658A patent/TWI455731B/zh not_active IP Right Cessation
- 2007-10-05 DK DK07818735.8T patent/DK2081551T3/da active
- 2007-10-05 HR HRP20130328TT patent/HRP20130328T1/hr unknown
- 2007-10-05 CA CA2664637A patent/CA2664637C/en not_active Expired - Fee Related
- 2007-10-05 SI SI200731193T patent/SI2081551T1/sl unknown
- 2007-10-05 CN CNA2007800422016A patent/CN101605534A/zh active Pending
- 2007-10-05 JP JP2009530811A patent/JP5484059B2/ja not_active Expired - Fee Related
- 2007-10-05 RU RU2009117170/15A patent/RU2443412C2/ru not_active IP Right Cessation
- 2007-10-05 PT PT78187358T patent/PT2081551E/pt unknown
- 2007-10-05 CN CN2007800397245A patent/CN101528197B/zh not_active Expired - Fee Related
- 2007-10-05 ES ES07818735T patent/ES2400162T3/es active Active
- 2007-10-05 WO PCT/EP2007/008659 patent/WO2008040556A1/en not_active Ceased
- 2007-10-05 PL PL07818735T patent/PL2081551T3/pl unknown
- 2007-10-05 CN CN2012104557068A patent/CN102940878A/zh active Pending
- 2007-10-05 WO PCT/EP2007/008660 patent/WO2008040557A1/en not_active Ceased
- 2007-10-05 ES ES07818736T patent/ES2708851T3/es active Active
- 2007-10-05 RS RS20130131A patent/RS52706B/sr unknown
-
2009
- 2009-04-06 US US12/419,167 patent/US9526761B2/en not_active Expired - Fee Related
- 2009-04-06 US US12/419,131 patent/US20090297580A1/en not_active Abandoned
-
2013
- 2013-04-18 CY CY20131100316T patent/CY1113934T1/el unknown
-
2016
- 2016-03-08 US US15/064,444 patent/US20160220638A1/en not_active Abandoned
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