JP2010504910A5 - - Google Patents

Info

Publication number

JP2010504910A5

JP2010504910A5 JP2009528741A JP2009528741A JP2010504910A5 JP 2010504910 A5 JP2010504910 A5 JP 2010504910A5 JP 2009528741 A JP2009528741 A JP 2009528741A JP 2009528741 A JP2009528741 A JP 2009528741A JP 2010504910 A5 JP2010504910 A5 JP 2010504910A5

Authority

JP

Japan

Prior art keywords

packing

satraplatin

day

pharmaceutical

orally

Prior art date

2007-09-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000012856 packing Methods 0.000 claims 33
• 190014017285 satraplatin Chemical compound 0.000 claims 29
• 229960005399 satraplatin Drugs 0.000 claims 29
• 239000003814 drug Substances 0.000 claims 24
• 239000003246 corticosteroid Substances 0.000 claims 14
• 238000002512 chemotherapy Methods 0.000 claims 8
• 206010062904 Hormone-refractory prostate cancer Diseases 0.000 claims 5
• 229940123237 Taxane Drugs 0.000 claims 5
• 230000003474 anti-emetic effect Effects 0.000 claims 5
• 239000002111 antiemetic agent Substances 0.000 claims 5
• 230000001394 metastastic effect Effects 0.000 claims 5
• 206010061289 metastatic neoplasm Diseases 0.000 claims 5
• 238000011393 cytotoxic chemotherapy Methods 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 3
• MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims 3
• 229960003727 granisetron Drugs 0.000 claims 3
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 3
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 229960001334 corticosteroids Drugs 0.000 claims 2
• 229960003668 docetaxel Drugs 0.000 claims 2
• 239000002895 emetic Substances 0.000 claims 2
• 229960001842 estramustine Drugs 0.000 claims 2
• FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 229940126601 medicinal product Drugs 0.000 claims 2
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 2
• 229960001156 mitoxantrone Drugs 0.000 claims 2
• 210000002784 stomach Anatomy 0.000 claims 2
• 229960003048 vinblastine Drugs 0.000 claims 2
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
• 206010006002 Bone pain Diseases 0.000 claims 1
• 206010061818 Disease progression Diseases 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 208000009956 adenocarcinoma Diseases 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 230000005750 disease progression Effects 0.000 claims 1
• 238000001794 hormone therapy Methods 0.000 claims 1
• 230000001926 lymphatic effect Effects 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
• 229960004618 prednisone Drugs 0.000 claims 1
• 210000002307 prostate Anatomy 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1