JP2010503691A5 - - Google Patents
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- JP2010503691A5 JP2010503691A5 JP2009528374A JP2009528374A JP2010503691A5 JP 2010503691 A5 JP2010503691 A5 JP 2010503691A5 JP 2009528374 A JP2009528374 A JP 2009528374A JP 2009528374 A JP2009528374 A JP 2009528374A JP 2010503691 A5 JP2010503691 A5 JP 2010503691A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 17
- 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 108010077895 Sarcosine Proteins 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 3
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine zwitterion Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 3
- UCMIRNVEIXFBKS-UHFFFAOYSA-N β-Alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 3
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 2
- 208000009899 Burkitt Lymphoma Diseases 0.000 claims 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N GABA Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 229940043230 Sarcosine Drugs 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims 2
- 229960003692 aminobutyric acid Drugs 0.000 claims 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- -1 ethyl asparagine Chemical compound 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000003442 weekly Effects 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- HAWJUUUDZFZUKG-UHFFFAOYSA-N 2,2-diaminoheptanedioic acid Chemical compound OC(=O)C(N)(N)CCCCC(O)=O HAWJUUUDZFZUKG-UHFFFAOYSA-N 0.000 claims 1
- PECYZEOJVXMISF-REOHCLBHSA-N 2,3-Diaminopropionic acid Chemical compound [NH3+]C[C@H](N)C([O-])=O PECYZEOJVXMISF-REOHCLBHSA-N 0.000 claims 1
- RDFMDVXONNIGBC-UHFFFAOYSA-N 2-aminoheptanoic acid Chemical compound CCCCCC(N)C(O)=O RDFMDVXONNIGBC-UHFFFAOYSA-N 0.000 claims 1
- QCHPKSFMDHPSNR-UHFFFAOYSA-N 3-Aminoisobutyric acid Chemical compound NCC(C)C(O)=O QCHPKSFMDHPSNR-UHFFFAOYSA-N 0.000 claims 1
- XABCFXXGZPWJQP-UHFFFAOYSA-N 3-aminoadipic acid Chemical compound OC(=O)CC(N)CCC(O)=O XABCFXXGZPWJQP-UHFFFAOYSA-N 0.000 claims 1
- BJBUEDPLEOHJGE-BKLSDQPFSA-N 3-hydroxy-L-proline Chemical compound OC1CCN[C@@H]1C(O)=O BJBUEDPLEOHJGE-BKLSDQPFSA-N 0.000 claims 1
- 229940000687 6-Aminocaproic Acid Drugs 0.000 claims 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N Aminocaproic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 1
- 229960001230 Asparagine Drugs 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- VEVRNHHLCPGNDU-MUGJNUQGSA-O Desmosine Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(CC[C@H](N)C(O)=O)=C(CCC[C@H](N)C(O)=O)C(CC[C@H](N)C(O)=O)=C1 VEVRNHHLCPGNDU-MUGJNUQGSA-O 0.000 claims 1
- 229960002591 Hydroxyproline Drugs 0.000 claims 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-2-aminohexanoic acid zwitterion Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid zwitterion Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 1
- JUQLUIFNNFIIKC-YFKPBYRVSA-N L-2-aminopimelic acid Chemical compound OC(=O)[C@@H](N)CCCCC(O)=O JUQLUIFNNFIIKC-YFKPBYRVSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-UHNVWZDZSA-N L-allo-isoleucine Chemical compound CC[C@@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-UHNVWZDZSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- PQNASZJZHFPQLE-LURJTMIESA-N N(6)-methyl-L-lysine Chemical compound CNCCCC[C@H](N)C(O)=O PQNASZJZHFPQLE-LURJTMIESA-N 0.000 claims 1
- 108010065338 N-ethylglycine Proteins 0.000 claims 1
- YPIGGYHFMKJNKV-UHFFFAOYSA-N N-ethylglycine zwitterion Chemical compound CC[NH2+]CC([O-])=O YPIGGYHFMKJNKV-UHFFFAOYSA-N 0.000 claims 1
- KSPIYJQBLVDRRI-UHFFFAOYSA-N N-methylisoleucine Chemical compound CCC(C)C(NC)C(O)=O KSPIYJQBLVDRRI-UHFFFAOYSA-N 0.000 claims 1
- AKCRVYNORCOYQT-UHFFFAOYSA-N N-methylvaline Chemical compound CNC(C(C)C)C(O)=O AKCRVYNORCOYQT-UHFFFAOYSA-N 0.000 claims 1
- 229960003104 Ornithine Drugs 0.000 claims 1
- KITHNHJPIHPBQH-UHFFFAOYSA-N [N+](=O)([O-])[SiH2]O[SiH2][N+](=O)[O-] Chemical compound [N+](=O)([O-])[SiH2]O[SiH2][N+](=O)[O-] KITHNHJPIHPBQH-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229960002684 aminocaproic acid Drugs 0.000 claims 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229940000635 beta-Alanine Drugs 0.000 claims 1
- 230000001588 bifunctional Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004405 heteroalkoxy group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- RGXCTRIQQODGIZ-UHFFFAOYSA-O isodesmosine Chemical compound OC(=O)C(N)CCCC[N+]1=CC(CCC(N)C(O)=O)=CC(CCC(N)C(O)=O)=C1CCCC(N)C(O)=O RGXCTRIQQODGIZ-UHFFFAOYSA-O 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N trans-L-hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 1
- OYIFNHCXNCRBQI-UHFFFAOYSA-N α-Aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 claims 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N α-Aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims 1
- FUOOLUPWFVMBKG-UHFFFAOYSA-N α-aminoisobutanoic acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84493806P | 2006-09-15 | 2006-09-15 | |
US86451606P | 2006-11-06 | 2006-11-06 | |
US11/704,607 US7462627B2 (en) | 2006-02-09 | 2007-02-09 | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
PCT/US2007/076241 WO2008033643A2 (en) | 2006-09-15 | 2007-08-17 | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010503691A JP2010503691A (ja) | 2010-02-04 |
JP2010503691A5 true JP2010503691A5 (US07462627-20081209-C00021.png) | 2011-05-06 |
Family
ID=39184444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009528374A Pending JP2010503691A (ja) | 2006-09-15 | 2007-08-17 | 7‐エチル‐10‐ヒドロキシカンプトセシンのマルチアームポリマー複合体を用いた非ホジキンリンパ腫の治療方法 |
Country Status (11)
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
AU2008213576B2 (en) * | 2007-02-09 | 2013-01-17 | Enzon Pharmaceuticals, Inc. | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
CA2732508C (en) | 2008-08-11 | 2016-03-15 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
HUE047352T2 (hu) | 2008-09-23 | 2020-04-28 | Nektar Therapeutics | Eljárás ütemezett beadásra kamptotecin elõgyógyszerekkel (például PEG-ironotekánnal) |
WO2010048018A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
KR20120094546A (ko) * | 2009-05-04 | 2012-08-24 | 인터자인 테크놀로지스, 인코포레이티드 | 종양 치료를 위한 sn―38을 함유하는 폴리머 미셀 |
BR112012001395A2 (pt) * | 2009-07-22 | 2019-09-24 | Enzon Pharmaceuticals Inc | metodo para tratar um câncer her2 positivo em um mamifero metodo para aumentar os efetivos de antagonistas do receptor her2 em um mamifero apresentando um cancêr her2 positivo metodo para inibir o crescimento ou proliferação de células her2 positivas em um mamifero |
PL2501413T3 (pl) * | 2009-11-18 | 2019-09-30 | Nektar Therapeutics | Formy koniugatów polimer-lek w postaci soli kwasowych |
WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
DK3052101T3 (da) | 2013-10-04 | 2019-12-16 | Prolynx Llc | Konjugater af sn-38 med langsom frigivelse |
CN104650342B (zh) * | 2013-11-18 | 2018-07-10 | 江苏豪森药业集团有限公司 | 多支链聚合药物前体及其应用 |
CN108727582B (zh) * | 2017-04-21 | 2021-11-05 | 博瑞生物医药(苏州)股份有限公司 | 靶向抗癌偶联物 |
KR20200109345A (ko) | 2018-01-12 | 2020-09-22 | 프로린크스 엘엘시 | 상승적 암 치료 |
CN110577550A (zh) * | 2018-06-08 | 2019-12-17 | 遵义医学院 | 喜树碱-甘氨酸-去甲斑蝥素结合物及其应用 |
WO2022035843A1 (en) * | 2020-08-12 | 2022-02-17 | Nanomedicine Innovation Center, Llc | Topoisomerase inhibitors |
CN116406301A (zh) | 2020-09-28 | 2023-07-07 | 生物医药研究基金会机构(Irb巴塞罗那) | 可用于治疗癌症的sn38肽缀合物 |
WO2023095741A1 (ja) * | 2021-11-25 | 2023-06-01 | 日油株式会社 | 医療用4分岐型水溶性ポリマー |
WO2023186822A1 (en) | 2022-03-28 | 2023-10-05 | Hospital Sant Joan De Deu | Peptidic water-soluble delivery system of anticancer drugs |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
US4943579A (en) | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
AU4406793A (en) * | 1992-06-04 | 1993-12-30 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5605976A (en) * | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
US5730990A (en) * | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
US5736156A (en) | 1995-03-22 | 1998-04-07 | The Ohio State University | Liposomal anf micellular stabilization of camptothecin drugs |
TW438775B (en) * | 1995-04-07 | 2001-06-07 | Pharmacia & Upjohn Co Llc | Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
JPH10168373A (ja) * | 1996-12-12 | 1998-06-23 | Fuji Xerox Co Ltd | インクジェット記録用インク及びそれを用いる記録方法 |
JP3855344B2 (ja) * | 1997-02-19 | 2006-12-06 | 日本油脂株式会社 | ポリオキシアルキレンカルボン酸の製造方法 |
US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
US6111107A (en) * | 1997-11-20 | 2000-08-29 | Enzon, Inc. | High yield method for stereoselective acylation of tertiary alcohols |
US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
WO2000021370A1 (en) | 1998-10-14 | 2000-04-20 | University Of Kentucky Research Foundation | Oligonucleotide delivery systems for camptothecins |
WO2000040755A2 (en) | 1999-01-06 | 2000-07-13 | Cornell Research Foundation, Inc. | Method for accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
WO2000064486A2 (en) | 1999-04-28 | 2000-11-02 | Vectramed, Inc. | Enzymatically activated polymeric drug conjugates |
AU4564200A (en) * | 1999-04-29 | 2000-11-17 | Aventis Pharma S.A. | Method for treating cancer using camptothecin derivatives and 5-fluorouracil |
HUP0203123A3 (en) | 1999-10-12 | 2004-12-28 | Cell Therapeutics Inc Seattle | Process for preparation of polyglutamate-therapeutic agent conjugates |
CA2394980C (en) * | 1999-12-22 | 2008-05-13 | Shearwater Corporation | Sterically hindered derivatives of water soluble polymers |
US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
AU2001230864A1 (en) | 2000-01-12 | 2001-07-24 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2001257577A1 (en) * | 2000-02-28 | 2001-09-03 | Shearwater Corporation | Water-soluble polymer conjugates of artelinic acid |
CA2402643A1 (en) | 2000-03-17 | 2001-09-27 | Cell Therapeutics, Inc. | Polyglutamic acid-camptothecin conjugates and methods of preparation |
US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
US6629995B1 (en) | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
US6756037B2 (en) * | 2000-03-31 | 2004-06-29 | Enzon, Inc. | Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups |
AU2002217981A1 (en) * | 2000-11-30 | 2002-06-11 | Cornerstone Pharmaceuticals, Inc. | Water-soluble polymer conjugates of triazine derivatives |
US20020123401A1 (en) | 2001-03-02 | 2002-09-05 | Henry Rassem Ragheb | Combination starter-generator |
US20020182272A1 (en) * | 2001-05-30 | 2002-12-05 | Bruce Halstead | Methods of treatment of HIV-associated conditions |
JP4123856B2 (ja) * | 2001-07-31 | 2008-07-23 | 日油株式会社 | 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法 |
WO2003033525A1 (en) | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
WO2003037384A2 (en) | 2001-10-29 | 2003-05-08 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase c inhibitors |
CA2464346A1 (en) | 2001-10-30 | 2003-05-08 | Nektar Therapeutics Al, Corporation | Water-soluble polymer conjugates of retinoic acid |
US6608076B1 (en) * | 2002-05-16 | 2003-08-19 | Enzon, Inc. | Camptothecin derivatives and polymeric conjugates thereof |
BR0311627A (pt) * | 2002-06-06 | 2005-08-30 | Univ Washington | Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização |
PT1534340E (pt) * | 2002-09-06 | 2012-03-13 | Cerulean Pharma Inc | Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente |
US6649778B1 (en) * | 2002-09-20 | 2003-11-18 | Enzon, Inc. | Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same |
US7879868B2 (en) | 2002-10-11 | 2011-02-01 | Novartis Ag | Use of imatinib (glivec,sti-571) to inhibit breast cancer resistance protein (BCRP)-mediated resistance to therapeutic agents |
AU2003301021C1 (en) | 2002-12-16 | 2010-02-18 | Globelmmune, Inc. | Yeast-based vaccines as immunotherapy |
WO2004060967A1 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof |
US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
US7744861B2 (en) * | 2003-09-17 | 2010-06-29 | Nektar Therapeutics | Multi-arm polymer prodrugs |
US20050214250A1 (en) | 2003-11-06 | 2005-09-29 | Harris J M | Method of preparing carboxylic acid functionalized polymers |
MXPA06010505A (es) * | 2004-03-15 | 2006-12-19 | Nektar Therapeutics Al Corp | Composiciones y conjugados, basados en polimeros, de inhibidores de ingreso de vih. |
JP2007530954A (ja) | 2004-03-26 | 2007-11-01 | ブリストル−マイヤーズ スクイブ カンパニー | 非小細胞肺癌において上皮細胞増殖因子レセプターモジュレーターに対する感受性を決定するためのバイオマーカーおよび方法 |
WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
US7989554B2 (en) | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
ES2436109T3 (es) * | 2006-02-09 | 2013-12-27 | Belrose Pharma Inc. | Conjugados poliméricos de múltiples brazos de 7-etil-10-hidroxicamptotecina para el tratamiento del cáncer de mama, del cáncer colorrectal, del cáncer de páncreas, de ovario y de pulmón |
US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
AU2008213576B2 (en) * | 2007-02-09 | 2013-01-17 | Enzon Pharmaceuticals, Inc. | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
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2007
- 2007-02-09 US US11/704,607 patent/US7462627B2/en not_active Expired - Fee Related
- 2007-08-17 MX MX2009002853A patent/MX2009002853A/es not_active Application Discontinuation
- 2007-08-17 JP JP2009528374A patent/JP2010503691A/ja active Pending
- 2007-08-17 EP EP07814225A patent/EP2073809A4/en not_active Withdrawn
- 2007-08-17 CN CN2007800343014A patent/CN101707888B/zh not_active Expired - Fee Related
- 2007-08-17 WO PCT/US2007/076241 patent/WO2008033643A2/en active Application Filing
- 2007-08-17 KR KR1020147035602A patent/KR20150005721A/ko not_active Application Discontinuation
- 2007-08-17 KR KR1020097005140A patent/KR20090059117A/ko not_active Application Discontinuation
- 2007-08-17 CA CA002662920A patent/CA2662920A1/en not_active Abandoned
- 2007-08-17 BR BRPI0716807-1A patent/BRPI0716807A2/pt not_active IP Right Cessation
- 2007-08-17 AU AU2007297042A patent/AU2007297042B2/en not_active Ceased
-
2008
- 2008-11-20 US US12/274,474 patent/US7723351B2/en not_active Expired - Fee Related
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2009
- 2009-02-19 IL IL197122A patent/IL197122A0/en unknown
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2010
- 2010-04-19 US US12/762,434 patent/US8299089B2/en not_active Expired - Fee Related
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