JP2010502739A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010502739A5 JP2010502739A5 JP2009527590A JP2009527590A JP2010502739A5 JP 2010502739 A5 JP2010502739 A5 JP 2010502739A5 JP 2009527590 A JP2009527590 A JP 2009527590A JP 2009527590 A JP2009527590 A JP 2009527590A JP 2010502739 A5 JP2010502739 A5 JP 2010502739A5
- Authority
- JP
- Japan
- Prior art keywords
- chor
- group
- het
- conr
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC1N=**(C2)N2N1 Chemical compound CC1N=**(C2)N2N1 0.000 description 12
- RXYPXQSKLGGKOL-UHFFFAOYSA-N CN1CCN(C)CC1 Chemical compound CN1CCN(C)CC1 RXYPXQSKLGGKOL-UHFFFAOYSA-N 0.000 description 3
- SHUFMYQIRSPTNO-HYXAFXHYSA-N C/C(/[IH-]=[N+]=O)=N/C Chemical compound C/C(/[IH-]=[N+]=O)=N/C SHUFMYQIRSPTNO-HYXAFXHYSA-N 0.000 description 1
- VPRMRWSVDQDYCR-UHFFFAOYSA-N C[N](C)(C)CCOc1ccc(CCCCNC(NC(c2nc(Cl)c(N)nc2N)=O)=N)cc1 Chemical compound C[N](C)(C)CCOc1ccc(CCCCNC(NC(c2nc(Cl)c(N)nc2N)=O)=N)cc1 VPRMRWSVDQDYCR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84266906P | 2006-09-07 | 2006-09-07 | |
| US84296306P | 2006-09-08 | 2006-09-08 | |
| PCT/US2007/077907 WO2008031048A2 (en) | 2006-09-07 | 2007-09-07 | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010502739A JP2010502739A (ja) | 2010-01-28 |
| JP2010502739A5 true JP2010502739A5 (enExample) | 2010-10-21 |
Family
ID=39158105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527590A Pending JP2010502739A (ja) | 2006-09-07 | 2007-09-07 | ナトリウムチャネル阻害剤及び浸透圧調節物質を用いた処置による粘膜水和及び粘液クリアランスの改善 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7981898B2 (enExample) |
| EP (1) | EP2059239A4 (enExample) |
| JP (1) | JP2010502739A (enExample) |
| AR (1) | AR062742A1 (enExample) |
| TW (1) | TW200819430A (enExample) |
| WO (1) | WO2008031048A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| PT1663235E (pt) * | 2003-08-18 | 2013-10-29 | Parion Sciences Inc | Novos bloqueadores dos canais do sódio de pirazinoílguanidina protegida |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| BRPI0716884A2 (pt) * | 2006-09-07 | 2013-10-15 | Parion Sciences Inc | Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos |
| EP2211956A4 (en) * | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA |
| KR101654549B1 (ko) * | 2008-02-26 | 2016-09-07 | 패리온 사이언스 인코퍼레이티드 | 다중방향족 나트륨 채널 차단제 |
| US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| US8778383B2 (en) | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| AR086745A1 (es) * | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| BR112013032771B1 (pt) | 2011-06-27 | 2021-01-12 | Parion Sciences, Inc. | dipeptídio quimicamente e metabolicamente estável possuindo potente atividade bloqueadora de canais de sódio |
| DK2855435T3 (en) | 2012-05-29 | 2018-07-16 | Parion Sciences Inc | DENDRIMER-LIKE AMINOAMIDES WITH SODIUM CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF DRY EYES AND OTHER MILK DISEASES |
| ES2674665T3 (es) * | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| BR112015014349A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente |
| US9029382B2 (en) | 2012-12-17 | 2015-05-12 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds |
| AU2014309251B2 (en) | 2013-08-23 | 2018-05-24 | Parion Sciences, Inc. | Dithiol mucolytic agents |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| CN112321472A (zh) | 2015-01-30 | 2021-02-05 | 帕里昂科学公司 | 新型单硫醇粘液溶解剂 |
| CN107708680A (zh) | 2015-04-30 | 2018-02-16 | 帕里昂科学公司 | 新的二硫醇粘液溶解剂的前药 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501729A (en) * | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| KR930701992A (ko) * | 1990-10-05 | 1993-09-08 | 웨인 알.조운즈 | 환자의 폐에 잔존하는 점액 분비물의 제거 방법 |
| AUPM411494A0 (en) * | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| US6264975B1 (en) * | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| US6926911B1 (en) * | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| JP2004513870A (ja) * | 1999-07-19 | 2004-05-13 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | ナトリウムチャネルブロッカーの結合物及びその使用法 |
| WO2001055390A1 (en) * | 2000-01-28 | 2001-08-02 | Human Genome Sciences, Inc. | Human serpin polynucleotides, polypeptides, and antibodies |
| US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| AU2004264441A1 (en) * | 2003-08-18 | 2005-02-24 | Parion Sciences, Inc. | Cyclic pyrazinoylguanidine sodium channel blockers |
| PT1663235E (pt) * | 2003-08-18 | 2013-10-29 | Parion Sciences Inc | Novos bloqueadores dos canais do sódio de pirazinoílguanidina protegida |
| AU2004271945A1 (en) * | 2003-08-18 | 2005-03-24 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) * | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| BRPI0716884A2 (pt) * | 2006-09-07 | 2013-10-15 | Parion Sciences Inc | Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos |
-
2007
- 2007-09-07 JP JP2009527590A patent/JP2010502739A/ja active Pending
- 2007-09-07 AR ARP070103972A patent/AR062742A1/es unknown
- 2007-09-07 EP EP07842074A patent/EP2059239A4/en not_active Ceased
- 2007-09-07 TW TW096133635A patent/TW200819430A/zh unknown
- 2007-09-07 US US11/852,003 patent/US7981898B2/en not_active Expired - Fee Related
- 2007-09-07 WO PCT/US2007/077907 patent/WO2008031048A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010502739A5 (enExample) | ||
| KR101654549B1 (ko) | 다중방향족 나트륨 채널 차단제 | |
| EP3490987B1 (en) | Novel therapeutic agents for the treatment of hbv infection | |
| AU2006276978B2 (en) | New capped pyrazinoylguanidine sodium channel blockers | |
| AU2004266704B2 (en) | Capped pyrazinoylguanidine sodium channel blockers | |
| CA2509981C (en) | Hetero substitued sodium channel blockers | |
| JP2009539882A5 (enExample) | ||
| WO2005016879A2 (en) | Cyclic pyrazinoylguanidine sodium channel blockers | |
| AU2004271945A1 (en) | Aliphatic pyrazinoylguanidine sodium channel blockers | |
| AU2003211135A1 (en) | Sodium channel blockers | |
| EP2059239A2 (en) | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes | |
| JP2010502738A5 (enExample) | ||
| KR20150095869A (ko) | 아릴알킬- 및 아릴옥시알킬-치환된 상피 나트륨 채널 차단 화합물 | |
| AU2012201188B2 (en) | New capped pyrazinoylguanidine sodium channel blockers | |
| HK1112853B (en) | New capped pyrazinoylguanidine sodium channel blockers | |
| HK40009256A (en) | Novel therapeutic agents for the treatment of hbv infection | |
| HK40009256B (en) | Novel therapeutic agents for the treatment of hbv infection | |
| AU2013200821A1 (en) | Heteroaromatic pyrazinoylguanidine sodium channel blockers | |
| HK1172333A (en) | Capped pyrazinoylguanidine sodium channel blockers |