JP2010502615A5 - - Google Patents
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- JP2010502615A5 JP2010502615A5 JP2009526695A JP2009526695A JP2010502615A5 JP 2010502615 A5 JP2010502615 A5 JP 2010502615A5 JP 2009526695 A JP2009526695 A JP 2009526695A JP 2009526695 A JP2009526695 A JP 2009526695A JP 2010502615 A5 JP2010502615 A5 JP 2010502615A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- group
- pyridin
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 92
- 125000000623 heterocyclic group Chemical group 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 32
- 125000001153 fluoro group Chemical group F* 0.000 claims 29
- -1 —OH Chemical group 0.000 claims 22
- 125000001424 substituent group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000005842 heteroatom Chemical group 0.000 claims 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- YQHDDFDDIDIOPD-UHFFFAOYSA-N 1-[3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]cyclopropan-1-amine Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(ON=2)C2(N)CC2)=C1 YQHDDFDDIDIOPD-UHFFFAOYSA-N 0.000 claims 1
- SLYFMDRPLJXHDY-UHFFFAOYSA-N 1-[3-[6-[3-methyl-2-[4-(1,3-thiazol-2-ylmethoxy)phenyl]butan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]cyclopropan-1-amine Chemical compound C=1C=C(C=2N=C(ON=2)C2(N)CC2)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1OCC1=NC=CS1 SLYFMDRPLJXHDY-UHFFFAOYSA-N 0.000 claims 1
- NHLWDQJAMPQLIM-UHFFFAOYSA-N 2-[2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl]-5-(2-methyltetrazol-5-yl)pyridine Chemical compound CN1N=NC(C=2C=NC(=CC=2)C(C=2C=CC(OCC=3N=CC=CC=3)=CC=2)C(C)(C)C)=N1 NHLWDQJAMPQLIM-UHFFFAOYSA-N 0.000 claims 1
- WJPCFBULFYVUGI-UHFFFAOYSA-N 2-[3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]propan-2-amine Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(ON=2)C(C)(C)N)=C1 WJPCFBULFYVUGI-UHFFFAOYSA-N 0.000 claims 1
- BSYBJXIZRGPSRI-UHFFFAOYSA-N 2-[3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(ON=2)C(C)(C)O)=C1 BSYBJXIZRGPSRI-UHFFFAOYSA-N 0.000 claims 1
- ZMDOMMHKYOCECR-UHFFFAOYSA-N 2-[3-[6-[3-methyl-2-[4-(1,3-thiazol-2-ylmethoxy)phenyl]butan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol Chemical compound C=1C=C(C=2N=C(ON=2)C(C)(C)O)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1OCC1=NC=CS1 ZMDOMMHKYOCECR-UHFFFAOYSA-N 0.000 claims 1
- MPSPSWMXIQJKDL-UHFFFAOYSA-N 2-[6-[2-[4-(2-aminopyrimidin-5-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]propan-2-ol Chemical compound C=1C=C(C(C)(C)O)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C1=CN=C(N)N=C1 MPSPSWMXIQJKDL-UHFFFAOYSA-N 0.000 claims 1
- BTBGEKULIKSEHL-UHFFFAOYSA-N 2-[6-[2-[4-(6-aminopyridazin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]propan-2-ol Chemical compound C=1C=C(C(C)(C)O)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C1=CC=C(N)N=N1 BTBGEKULIKSEHL-UHFFFAOYSA-N 0.000 claims 1
- SDTVHWGVLSAAOS-UHFFFAOYSA-N 2-[6-[6-[2-[4-[2-(2,5-dimethylpyrrol-1-yl)pyrimidin-5-yl]phenyl]-3-methylbutan-2-yl]pyridin-3-yl]pyridazin-3-yl]propan-2-ol Chemical compound C=1C=C(C=2N=NC(=CC=2)C(C)(C)O)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C(C=N1)=CN=C1N1C(C)=CC=C1C SDTVHWGVLSAAOS-UHFFFAOYSA-N 0.000 claims 1
- VORFXHLULHFGLK-UHFFFAOYSA-N 2-[6-[6-[3-methyl-2-[4-(pyridin-2-ylmethoxy)phenyl]butan-2-yl]pyridin-3-yl]pyridazin-3-yl]propan-2-ol Chemical compound C=1C=C(C=2N=NC(=CC=2)C(C)(C)O)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1OCC1=CC=CC=N1 VORFXHLULHFGLK-UHFFFAOYSA-N 0.000 claims 1
- VGRHLVFNTXNBSY-UHFFFAOYSA-N 3-[6-[2-[4-(5-ethoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-6-(trifluoromethyl)pyridazine Chemical compound CCOC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=NC(=CC=2)C(F)(F)F)=C1 VGRHLVFNTXNBSY-UHFFFAOYSA-N 0.000 claims 1
- VPRXUEULTKRBLF-UHFFFAOYSA-N 3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-5-(piperidin-1-ylmethyl)-1,2,4-oxadiazole Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(CN3CCCCC3)ON=2)=C1 VPRXUEULTKRBLF-UHFFFAOYSA-N 0.000 claims 1
- URMZYSAQPRHSID-UHFFFAOYSA-N 3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-5-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazole Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(CN3CCCC3)ON=2)=C1 URMZYSAQPRHSID-UHFFFAOYSA-N 0.000 claims 1
- BNVQOOQPYYTKGR-UHFFFAOYSA-N 3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-6-(trifluoromethyl)pyridazine Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=NC(=CC=2)C(F)(F)F)=C1 BNVQOOQPYYTKGR-UHFFFAOYSA-N 0.000 claims 1
- LZMOGQRSNOCFBL-UHFFFAOYSA-N 3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-6-methylpyridazine Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=NC(C)=CC=2)=C1 LZMOGQRSNOCFBL-UHFFFAOYSA-N 0.000 claims 1
- WCYXSZFONNYHAH-UHFFFAOYSA-N 3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-6-methylsulfonylpyridazine Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=NC(=CC=2)S(C)(=O)=O)=C1 WCYXSZFONNYHAH-UHFFFAOYSA-N 0.000 claims 1
- VRSASRAFWHZJHN-UHFFFAOYSA-N 3-[6-[2-[4-[5-(difluoromethoxy)pyridin-3-yl]phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-6-(trifluoromethyl)pyridazine Chemical compound C=1C=C(C=2N=NC(=CC=2)C(F)(F)F)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C1=CN=CC(OC(F)F)=C1 VRSASRAFWHZJHN-UHFFFAOYSA-N 0.000 claims 1
- UHEXALWTJKOQSE-UHFFFAOYSA-N 3-[6-[2-[4-[5-(fluoromethoxy)pyridin-3-yl]phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-6-(trifluoromethyl)pyridazine Chemical compound C=1C=C(C=2N=NC(=CC=2)C(F)(F)F)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C1=CN=CC(OCF)=C1 UHEXALWTJKOQSE-UHFFFAOYSA-N 0.000 claims 1
- XYNGRXGJSXCIJI-UHFFFAOYSA-N 3-[6-[3-methyl-2-[4-(5-phenylmethoxypyridin-3-yl)phenyl]butan-2-yl]pyridin-3-yl]-6-(trifluoromethyl)pyridazine Chemical compound C=1C=C(C=2N=NC(=CC=2)C(F)(F)F)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C(C=1)=CN=CC=1OCC1=CC=CC=C1 XYNGRXGJSXCIJI-UHFFFAOYSA-N 0.000 claims 1
- RJZADSBVMKIPAS-UHFFFAOYSA-N 3-chloro-6-[6-[3-methyl-2-[4-(pyridin-2-ylmethoxy)phenyl]butan-2-yl]pyridin-3-yl]pyridazine Chemical compound C=1C=C(C=2N=NC(Cl)=CC=2)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1OCC1=CC=CC=N1 RJZADSBVMKIPAS-UHFFFAOYSA-N 0.000 claims 1
- PTQBCWMMHIBZTA-UHFFFAOYSA-N 4-[[3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]methyl]morpholine Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(CN3CCOCC3)ON=2)=C1 PTQBCWMMHIBZTA-UHFFFAOYSA-N 0.000 claims 1
- PEUGVPRFQHBGGK-UHFFFAOYSA-N 4-[[3-[6-[3-methyl-2-[4-(pyridin-2-ylmethoxy)phenyl]butan-2-yl]pyridin-3-yl]-1,2,4-oxadiazol-5-yl]methyl]morpholine Chemical compound C=1C=C(C=2N=C(CN3CCOCC3)ON=2)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1OCC1=CC=CC=N1 PEUGVPRFQHBGGK-UHFFFAOYSA-N 0.000 claims 1
- XFSLNFPBOVDKGL-UHFFFAOYSA-N 5-[(4-fluoropiperidin-1-yl)methyl]-3-[6-[2-[4-(5-methoxypyridin-3-yl)phenyl]-3-methylbutan-2-yl]pyridin-3-yl]-1,2,4-oxadiazole Chemical compound COC1=CN=CC(C=2C=CC(=CC=2)C(C)(C(C)C)C=2N=CC(=CC=2)C=2N=C(CN3CCC(F)CC3)ON=2)=C1 XFSLNFPBOVDKGL-UHFFFAOYSA-N 0.000 claims 1
- LCIRNMSVGFMZDL-UHFFFAOYSA-N 5-[6-[2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl]pyridin-3-yl]-1,3,4-oxadiazol-2-amine Chemical compound C=1C=C(C=2OC(N)=NN=2)C=NC=1C(C(C)(C)C)C(C=C1)=CC=C1OCC1=CC=CC=N1 LCIRNMSVGFMZDL-UHFFFAOYSA-N 0.000 claims 1
- CMROPCOVGFVSQU-UHFFFAOYSA-N 6-[2-[4-(2-aminopyrimidin-5-yl)phenyl]-3-methylbutan-2-yl]pyridine-3-carbonitrile Chemical compound C=1C=C(C#N)C=NC=1C(C)(C(C)C)C(C=C1)=CC=C1C1=CN=C(N)N=C1 CMROPCOVGFVSQU-UHFFFAOYSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000003460 beta-lactamyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002792 delta-lactamyl group Chemical group 0.000 claims 1
- 125000001965 gamma-lactamyl group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 0 C*(C)c1n[n]cc1 Chemical compound C*(C)c1n[n]cc1 0.000 description 2
- ZYMHCFYHVYGFMS-UHFFFAOYSA-N Cc1cnc[o]1 Chemical compound Cc1cnc[o]1 ZYMHCFYHVYGFMS-UHFFFAOYSA-N 0.000 description 1
- GVSNQMFKEPBIOY-UHFFFAOYSA-N Cc1n[nH]nc1 Chemical compound Cc1n[nH]nc1 GVSNQMFKEPBIOY-UHFFFAOYSA-N 0.000 description 1
- XZGLNCKSNVGDNX-UHFFFAOYSA-N Cc1n[nH]nn1 Chemical compound Cc1n[nH]nn1 XZGLNCKSNVGDNX-UHFFFAOYSA-N 0.000 description 1
- CUMCMYMKECWGHO-UHFFFAOYSA-N Cc1n[o]cc1 Chemical compound Cc1n[o]cc1 CUMCMYMKECWGHO-UHFFFAOYSA-N 0.000 description 1
- FZAXBPZVVJOFKX-UHFFFAOYSA-N Cc1n[o]cn1 Chemical compound Cc1n[o]cn1 FZAXBPZVVJOFKX-UHFFFAOYSA-N 0.000 description 1
- WOTIUKDGJBXFLG-UHFFFAOYSA-N Cc1n[s]cc1 Chemical compound Cc1n[s]cc1 WOTIUKDGJBXFLG-UHFFFAOYSA-N 0.000 description 1
- ZMSIFDIKIXVLDF-UHFFFAOYSA-N Cc1nnc[o]1 Chemical compound Cc1nnc[o]1 ZMSIFDIKIXVLDF-UHFFFAOYSA-N 0.000 description 1
- RQSCFNPNNLWQBJ-UHFFFAOYSA-N Cc1nnc[s]1 Chemical compound Cc1nnc[s]1 RQSCFNPNNLWQBJ-UHFFFAOYSA-N 0.000 description 1
- YHYAXSUALJGNIS-UHFFFAOYSA-N Ic1ccn[o]1 Chemical compound Ic1ccn[o]1 YHYAXSUALJGNIS-UHFFFAOYSA-N 0.000 description 1
- IENVYPZXMHMGLD-UHFFFAOYSA-N Ic1ccn[s]1 Chemical compound Ic1ccn[s]1 IENVYPZXMHMGLD-UHFFFAOYSA-N 0.000 description 1
- KSCNOSBFEDSBOM-UHFFFAOYSA-N Ic1n[nH]cn1 Chemical compound Ic1n[nH]cn1 KSCNOSBFEDSBOM-UHFFFAOYSA-N 0.000 description 1
- FODCOTDONXWBIG-UHFFFAOYSA-N Ic1n[s]cn1 Chemical compound Ic1n[s]cn1 FODCOTDONXWBIG-UHFFFAOYSA-N 0.000 description 1
- VAQSRTGFMKWNIH-UHFFFAOYSA-N Ic1ncc[s]1 Chemical compound Ic1ncc[s]1 VAQSRTGFMKWNIH-UHFFFAOYSA-N 0.000 description 1
- ZTLJPKSDOIYBHM-UHFFFAOYSA-N Ic1nnn[nH]1 Chemical compound Ic1nnn[nH]1 ZTLJPKSDOIYBHM-UHFFFAOYSA-N 0.000 description 1
- ACTKAGSPIFDCMF-UHFFFAOYSA-N Nc1ncc[o]1 Chemical compound Nc1ncc[o]1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84175806P | 2006-09-01 | 2006-09-01 | |
| US93388607P | 2007-06-08 | 2007-06-08 | |
| US96159807P | 2007-07-23 | 2007-07-23 | |
| PCT/US2007/018991 WO2008030369A1 (en) | 2006-09-01 | 2007-08-29 | Inhibitors of 5 -lipoxygenase activating protein ( flap) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010502615A JP2010502615A (ja) | 2010-01-28 |
| JP2010502615A5 true JP2010502615A5 (https=) | 2010-09-16 |
Family
ID=38925607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009526695A Withdrawn JP2010502615A (ja) | 2006-09-01 | 2007-08-29 | ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）の阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8440672B2 (https=) |
| EP (1) | EP2064204B1 (https=) |
| JP (1) | JP2010502615A (https=) |
| AT (1) | ATE543810T1 (https=) |
| AU (1) | AU2007293373A1 (https=) |
| CA (1) | CA2666686A1 (https=) |
| WO (1) | WO2008030369A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007120574A2 (en) | 2006-04-11 | 2007-10-25 | Merck & Co., Inc. | Diaryl substituted alkanes |
| ATE543810T1 (de) | 2006-09-01 | 2012-02-15 | Merck Sharp & Dohme | Hemmer des 5-lipoxygenase aktivierenden proteins (flap) |
| EP2546232A1 (en) * | 2007-06-20 | 2013-01-16 | Merck Sharp & Dohme Corp. | Diphenyl Substituted Alkanes |
| WO2010027762A1 (en) | 2008-09-04 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Indolizine inhibitors of leukotriene production |
| WO2010032874A1 (ja) * | 2008-09-19 | 2010-03-25 | 住友化学株式会社 | 農業用組成物 |
| JP5690839B2 (ja) | 2009-12-04 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のベンゾイミダゾール阻害薬 |
| CA2797719C (en) | 2010-04-30 | 2019-11-26 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of usp1 deubiquitinating enzyme activity |
| MX2013001872A (es) * | 2010-08-16 | 2013-09-02 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrieno. |
| US8580829B2 (en) | 2010-08-26 | 2013-11-12 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| PH12013500545A1 (en) * | 2010-09-23 | 2013-05-06 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| WO2012040137A1 (en) * | 2010-09-23 | 2012-03-29 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| EP2632915B1 (en) | 2010-10-29 | 2015-08-12 | Boehringer Ingelheim International GmbH | Benzimidazole inhibitors of leukotriene production |
| JP5789888B2 (ja) | 2010-11-01 | 2015-10-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のベンゾイミダゾールインヒビター |
| US9073895B2 (en) | 2010-12-16 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| WO2013116182A1 (en) * | 2012-01-31 | 2013-08-08 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as inhibitors of leukotriene production |
| AR089853A1 (es) | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
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| HU186654B (en) | 1982-12-28 | 1985-09-30 | Richter Gedeon Vegyeszet | Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them |
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| DE10112401A1 (de) | 2001-03-13 | 2002-09-19 | Degussa | Alkohol-Dehydrogenase und deren Verwendung |
| CN1500239A (zh) | 2001-03-26 | 2004-05-26 | ��ʽ������Ϣ���� | 多媒体日历系统 |
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-
2007
- 2007-08-29 AT AT07837478T patent/ATE543810T1/de active
- 2007-08-29 US US12/377,136 patent/US8440672B2/en not_active Expired - Fee Related
- 2007-08-29 JP JP2009526695A patent/JP2010502615A/ja not_active Withdrawn
- 2007-08-29 AU AU2007293373A patent/AU2007293373A1/en not_active Abandoned
- 2007-08-29 WO PCT/US2007/018991 patent/WO2008030369A1/en not_active Ceased
- 2007-08-29 EP EP07837478A patent/EP2064204B1/en not_active Not-in-force
- 2007-08-29 CA CA002666686A patent/CA2666686A1/en not_active Abandoned
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