JP2010501252A - スペクトル情報を使用して、分析対象物の濃度を決定する、非侵襲的方法 - Google Patents
スペクトル情報を使用して、分析対象物の濃度を決定する、非侵襲的方法 Download PDFInfo
- Publication number
- JP2010501252A JP2010501252A JP2009525575A JP2009525575A JP2010501252A JP 2010501252 A JP2010501252 A JP 2010501252A JP 2009525575 A JP2009525575 A JP 2009525575A JP 2009525575 A JP2009525575 A JP 2009525575A JP 2010501252 A JP2010501252 A JP 2010501252A
- Authority
- JP
- Japan
- Prior art keywords
- skin tissue
- raman
- high intensity
- intensity light
- generating material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 411
- 239000012491 analyte Substances 0.000 title claims abstract description 137
- 230000003595 spectral effect Effects 0.000 title claims abstract description 54
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 213
- 239000000463 material Substances 0.000 claims abstract description 186
- 230000003287 optical effect Effects 0.000 claims description 67
- 238000010521 absorption reaction Methods 0.000 claims description 61
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 34
- 239000008103 glucose Substances 0.000 claims description 34
- 238000003745 diagnosis Methods 0.000 claims description 33
- 239000000126 substance Substances 0.000 claims description 17
- 239000000975 dye Substances 0.000 claims description 16
- 238000003384 imaging method Methods 0.000 claims description 16
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 8
- 239000007850 fluorescent dye Substances 0.000 claims description 7
- 239000002096 quantum dot Substances 0.000 claims description 6
- 239000004793 Polystyrene Substances 0.000 claims description 5
- 239000004417 polycarbonate Substances 0.000 claims description 5
- 229920000515 polycarbonate Polymers 0.000 claims description 5
- 229920002223 polystyrene Polymers 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 description 271
- 238000005259 measurement Methods 0.000 description 18
- 239000000523 sample Substances 0.000 description 9
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 238000012937 correction Methods 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 210000003722 extracellular fluid Anatomy 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 229920000995 Spectralon Polymers 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- 229910000530 Gallium indium arsenide Inorganic materials 0.000 description 2
- 102000007513 Hemoglobin A Human genes 0.000 description 2
- 108010085682 Hemoglobin A Proteins 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000002189 fluorescence spectrum Methods 0.000 description 2
- 229910052732 germanium Inorganic materials 0.000 description 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- XCAUINMIESBTBL-UHFFFAOYSA-N lead(ii) sulfide Chemical compound [Pb]=S XCAUINMIESBTBL-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002428 photodynamic therapy Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- GGYFMLJDMAMTAB-UHFFFAOYSA-N selanylidenelead Chemical compound [Pb]=[Se] GGYFMLJDMAMTAB-UHFFFAOYSA-N 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 0 *CC1CCCC1 Chemical compound *CC1CCCC1 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102100039250 Essential MCU regulator, mitochondrial Human genes 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 101000813097 Homo sapiens Essential MCU regulator, mitochondrial Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 238000001237 Raman spectrum Methods 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004190 glucose uptake Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008832 photodamage Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83929906P | 2006-08-22 | 2006-08-22 | |
| PCT/US2007/018310 WO2008024288A2 (en) | 2006-08-22 | 2007-08-17 | Non-invasive methods of using spectral information in determining analyte concentrations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010501252A true JP2010501252A (ja) | 2010-01-21 |
| JP2010501252A5 JP2010501252A5 (enrdf_load_stackoverflow) | 2010-10-07 |
Family
ID=39107321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525575A Withdrawn JP2010501252A (ja) | 2006-08-22 | 2007-08-17 | スペクトル情報を使用して、分析対象物の濃度を決定する、非侵襲的方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2056716A2 (enrdf_load_stackoverflow) |
| JP (1) | JP2010501252A (enrdf_load_stackoverflow) |
| CA (1) | CA2661952A1 (enrdf_load_stackoverflow) |
| TW (1) | TW200819732A (enrdf_load_stackoverflow) |
| WO (1) | WO2008024288A2 (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012140708A1 (ja) * | 2011-04-12 | 2012-10-18 | パナソニック株式会社 | 生体に含有される生体成分の濃度を測定する方法 |
| KR101207695B1 (ko) * | 2010-08-11 | 2012-12-03 | 서울대학교산학협력단 | 형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치 |
| US8509868B2 (en) | 2011-04-12 | 2013-08-13 | Panasonic Corporation | Method for measuring a concentration of a biogenic substance contained in a living body |
| JP2015010938A (ja) * | 2013-06-28 | 2015-01-19 | 株式会社バイオマーカーサイエンス | 糖尿病の検出方法 |
| JP2016147042A (ja) * | 2015-02-12 | 2016-08-18 | コリア フォトニクス テクノロジー インスティテュート | 光干渉断層撮影を用いた色素性病変の定量化システム及び方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0606891D0 (en) | 2006-04-05 | 2006-05-17 | Council Cent Lab Res Councils | Raman Analysis Of Pharmaceutical Tablets |
| US9662047B2 (en) * | 2010-08-05 | 2017-05-30 | Massachusetts Institute Of Technology | Portable raman diagnostic system |
| CN103529013A (zh) * | 2013-10-18 | 2014-01-22 | 福建师范大学 | 一种基于dcdr光谱技术的精浆果糖快速检测的方法 |
| CN114295522B (zh) * | 2021-12-28 | 2024-03-29 | 华东理工大学 | 基于振动光谱成像的渗透深度及空间浓度分布的分析方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6070093A (en) * | 1997-12-02 | 2000-05-30 | Abbott Laboratories | Multiplex sensor and method of use |
| US6975891B2 (en) * | 2001-12-21 | 2005-12-13 | Nir Diagnostics Inc. | Raman spectroscopic system with integrating cavity |
| WO2006127766A1 (en) * | 2005-05-25 | 2006-11-30 | Bayer Healthcare Llc | Methods of using raman spectral information in determining analyte concentrations |
-
2007
- 2007-08-17 EP EP07837020A patent/EP2056716A2/en not_active Withdrawn
- 2007-08-17 JP JP2009525575A patent/JP2010501252A/ja not_active Withdrawn
- 2007-08-17 WO PCT/US2007/018310 patent/WO2008024288A2/en active Application Filing
- 2007-08-17 CA CA002661952A patent/CA2661952A1/en not_active Abandoned
- 2007-08-22 TW TW96131095A patent/TW200819732A/zh unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101207695B1 (ko) * | 2010-08-11 | 2012-12-03 | 서울대학교산학협력단 | 형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치 |
| WO2012140708A1 (ja) * | 2011-04-12 | 2012-10-18 | パナソニック株式会社 | 生体に含有される生体成分の濃度を測定する方法 |
| JP5076035B1 (ja) * | 2011-04-12 | 2012-11-21 | パナソニック株式会社 | 生体に含有される生体成分の濃度を測定する方法 |
| US8509868B2 (en) | 2011-04-12 | 2013-08-13 | Panasonic Corporation | Method for measuring a concentration of a biogenic substance contained in a living body |
| JP2015010938A (ja) * | 2013-06-28 | 2015-01-19 | 株式会社バイオマーカーサイエンス | 糖尿病の検出方法 |
| JP2016147042A (ja) * | 2015-02-12 | 2016-08-18 | コリア フォトニクス テクノロジー インスティテュート | 光干渉断層撮影を用いた色素性病変の定量化システム及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008024288A3 (en) | 2008-11-13 |
| TW200819732A (en) | 2008-05-01 |
| EP2056716A2 (en) | 2009-05-13 |
| WO2008024288A2 (en) | 2008-02-28 |
| CA2661952A1 (en) | 2008-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7603151B2 (en) | Non-invasive methods of using spectral information in determining analyte concentrations | |
| JP2010501252A (ja) | スペクトル情報を使用して、分析対象物の濃度を決定する、非侵襲的方法 | |
| US8452365B2 (en) | Methods of using Raman spectral information in determining analyte concentrations | |
| CN102697510B (zh) | 使用组织荧光确定某一糖化终产物或疾病状态 | |
| Ge et al. | Identification of colonic dysplasia and neoplasia by diffuse reflectance spectroscopy and pattern recognition techniques | |
| US7952692B2 (en) | Method and apparatus for determination of analyte concentration | |
| CN100998499B (zh) | 使用组织荧光确定某一糖化终产物或疾病状态 | |
| JP2013511341A (ja) | 冠動脈石灰化又は冠動脈疾患を検出する方法及び装置 | |
| W Huck et al. | Critical review upon the role and potential of fluorescence and near-infrared imaging and absorption spectroscopy in cancer related cells, serum, saliva, urine and tissue analysis | |
| JPH0749309A (ja) | 光散乱式成分濃度測定装置および方法 | |
| JP2011523059A (ja) | 生物組織中のカロテノイドの非侵襲的測定 | |
| JP4361822B2 (ja) | 目的物の成分濃度測定方法及び装置 | |
| Durkin et al. | Comparison of methods to determine chromophore concentrations from fluorescence spectra of turbid samples | |
| JP2013138720A (ja) | 測定装置および測定方法 | |
| JP2010501252A5 (enrdf_load_stackoverflow) | ||
| JP4618341B2 (ja) | コヒーレントアンチストークスラマン散乱光を利用した生体内物質量測定方法 | |
| JP2009539459A (ja) | 専用特殊照明分光法 | |
| KR100634498B1 (ko) | 체내성분 측정장치 및 방법 | |
| WO2011046005A1 (ja) | 分子組成測定方法及び装置 | |
| KR100794555B1 (ko) | 다중 파장 광원 장치 및 이를 이용한 생체 조직의 광학특성 분석 시스템 | |
| US9392943B2 (en) | System for glycated protein detection | |
| Lykina et al. | Analysis of albumin Raman scattering registration efficiency from different volume and shape cuvette | |
| WO2010002278A1 (en) | System for glycated protein detection | |
| KR20090025958A (ko) | 체액 성분 측정용 비침습 프로브, 이를 포함하는 비침습적체액 성분 측정 시스템, 및 비침습적 체액 성분 측정 방법 | |
| KR20230126508A (ko) | 분광 원리 기반 비침습적 농도 측정 방법 및 이를 수행하는 시스템 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100817 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100817 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20120322 |