JP2011523059A - 生物組織中のカロテノイドの非侵襲的測定 - Google Patents
生物組織中のカロテノイドの非侵襲的測定 Download PDFInfo
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Abstract
Description
本願は、米国特許出願第12/134,667号(2008年6月6日提出)に基づき優先権を主張し、この参照によりその内容全体を本願明細書に引用したものとする。
1.D. S. Michaud, D. D. Ffeskanich, E. B. Rimm, et al. "Intake of specific carotenoids and risk of lung cancer in 2 prospective UScohorts", Am. J. Clin. Nutr. 92, 990-997 (2000).
2.L. N. Kolonel, J. H. Hankin, A. S. Whittemore, et al., "Vegetables, fruits, legumes, and prostate cancer: a multiethnic case-control study", Cancer Epidemiol. Biomarkers Prev. 9, 795-804 (2000).
3.S. Liu, J. E. Manson, I. M. Lee, et al., " Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study", Am. J. Clin. Nutr. 72, 922-928 (2000).
4.Age-Related Eye Disease Study Group, "The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in case-control study", ARES Rep. No. 22, Arch. Ophthalmol. (Chicago) 125, 1225-1232 (2007).
5.W. Gellermann, R. W. McClane, N. B. Katz, and P. S. Bernstein, "Method and Apparatus For Noninvasive Measurement Of Carotenoids And Related Chemical Substances in Biological Tissue", U.S.Patent 6,205,354 Bl (March 2001).
6.T. R. Hata, T. A. Scholz, I. V. Ermakov, et al., "Noninvasive Raman spectroscopic detection of carotenoids in human skin", J. Invest. Dermatol. 115, 441-448 (2000).
7.I. V. Ermakov, M. R. Ermakova, R. W. McClane, W. Gellermann, "Resonance Raman Detection of Carotenoid Antioxidants in Living Human Tissues", Opt. Lett. 26, 1179-1181 (2001).
8.I. V. Ermakov, M. R. Ermakova, W. Gellermann, and J. Lademann, "Noninvasive selective detection of lycopene and beta-carotene in human skin using Raman spectroscopy", J. Biomed. Opt. 9, 332-338 (2004).
9.W. Gellermann, J. A. Zidichouski, C. R. Smidt, and P. S. Bernstein, "Raman detection of carotenoids in human tissue", in Carotenoids and Retinoids: Molecular Aspects and Health Issues, L. Packer, K. Kraemer, U. Obermueller-Jervic, and H. Sies, Eds., Chapter 6, pp. 86-114, AOCS Press, Champain, Illinois (2005).
10.S. Mayne et al., manuscript in preparation.
11.J. van de Kraats, D. van Norren, T T.J.M Berendschot, U.S.patent application US2007/0252950.
12.W. Stahl, U. Heinrich, H. Jungmann, J. von Laar, M. Schietzel, H. Sies, and H. Tronnier, "Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting betatene", J. Nutr. 128, 903 (1998).
13.W. Stahl, U. Heinrich, H. Jungmann, H. Tronnier, and H. Sies, "Carotenoids in Human Skin: Noninvasive Measurement and Identification of Dermal Carotenoids and Carotenol Esters", Methods in Enzymology 319, 494-502 (2000).
14.F. Niedorf, H. Jungmann, and M. Kietzmann, "Noninvasive reflection spectra provide quantitative information about the spatial distribution of skin chromophores", Med. Phys. 32, 1297-1307 (2005).
15.S. Alaluf, U. Heinrich, W. Stahl, H. Tronnier, and S. Wiseman, "Dietary Carotenoids Contribute to Normal Human Skin Color and UV Photosensitivity", J. of Nutrition 132, 399-403 (2002).
Claims (20)
- 可視及び青色スペクトル領域におけるカロテノイドの吸収帯と重なる光で組織の局所領域を照射するステップと、
前記局所領域中の血液発色団のレベルを低減させるように、所定時間、前記局所領域に圧力を加えるステップと、
前記局所領域中のカロテノイドレベルを反射ラマン分光法で調べるステップとを含む、生物組織中のカロテノイドレベルを非侵襲的に測定する方法。 - 前記圧力は、前記組織に約5〜20秒間加えられる請求項1に記載の方法。
- 前記カロテノイドレベルは、カロテノイドの全見掛け吸光度と、前記局所領域に圧力を加える間に残余している発色団全てによるバックグラウンド吸光度との間の差として選択される請求項1に記載の方法。
- 前記カロテノイドレベルは、478nm又は約478nmにおける全見掛け吸光度と、前記局所領域に圧力を加える間に残余している発色団全てによるバックグラウンド吸光度との間の差として選択される請求項1に記載の方法。
- 前記局所領域への血流を制限するステップを更に含む請求項1に記載の方法。
- 前記光は、約350〜900nmのスペクトル範囲に実質的にわたる白色光である請求項1に記載の方法。
- 前記光は、一方が480nm又は約480nm、他方が620nm又は約620nmである別々の光源から得られる請求項1に記載の方法。
- 前記カロテノイドレベルを、正常な生物組織と比較して、悪性疾患又は他の病状のリスク又は存在を評価するステップを更に含む請求項1に記載の方法。
- 前記組織は、ヒト皮膚である請求項1に記載の方法。
- 前記皮膚は、指先又は手の他の部分の皮膚である請求項11に記載の方法。
- 可視及び青色スペクトル領域におけるカロテノイドの吸収帯と重なる光で組織の局所領域を照射する光源と、
前記局所領域における血液発色団のレベルを低減させるように、所定期間、前記局所領域に圧力を加える装置と、
前記局所領域におけるカロテノイドレベルを反射分光法で調べるラマン分光器とを備える生物組織中のカロテノイドレベルを非侵襲的に測定するシステム。 - 前記圧力は、前記組織に約5〜20秒間加えられる請求項13に記載のシステム。
- 前記圧力を加える装置は、光及び反射スペクトルが通過する光透過性部材である請求項13に記載のシステム。
- 前記圧力を加える装置は、光及び反射スペクトルが通過するレンズである請求項13に記載のシステム。
- 前記局所領域への血流を制限するカフ又は他の装置を更に備える請求項13に記載のシステム。
- 前記光源は、約350〜900nmのスペクトル範囲に実質的にわたる白色光源である請求項13に記載のシステム。
- 前記光源は、一方が480nm又は約480nm、他方が620nm又は約620nmである別々の光源を備える請求項13に記載のシステム。
- 前記局所領域に所定期間前記圧力を加える装置がプローブ体に含まれており、
前記光源からの光は、第1の光ファイバーを介して前記プローブまで送られ、
反射スペクトルは、第2の光ファイバーを介して前記プローブ体から前記ラマン分光器まで運ばれる請求項13に記載のシステム。
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US12/134,667 US8260402B2 (en) | 2008-06-06 | 2008-06-06 | Noninvasive measurement of carotenoids in biological tissue |
US12/134,667 | 2008-06-06 | ||
PCT/US2009/046272 WO2009149266A2 (en) | 2008-06-06 | 2009-06-04 | Noninvasive measurement of carotenoids in biological tissue |
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JP2011523059A5 JP2011523059A5 (ja) | 2012-07-19 |
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AU (1) | AU2009256144B2 (ja) |
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Also Published As
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CA2726975A1 (en) | 2009-12-10 |
WO2009149266A2 (en) | 2009-12-10 |
US20090306521A1 (en) | 2009-12-10 |
KR20110038020A (ko) | 2011-04-13 |
WO2009149266A3 (en) | 2010-04-29 |
US20120330164A1 (en) | 2012-12-27 |
JP5574246B2 (ja) | 2014-08-20 |
AU2009256144A1 (en) | 2009-12-10 |
EP2294385A2 (en) | 2011-03-16 |
EP2294385A4 (en) | 2013-04-03 |
AU2009256144B2 (en) | 2014-06-26 |
US8260402B2 (en) | 2012-09-04 |
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