JP2010500360A - 炎症性サイトカイン阻害剤による下気道炎症疾患の局所療法 - Google Patents
炎症性サイトカイン阻害剤による下気道炎症疾患の局所療法 Download PDFInfo
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9895444B2 (en) * | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
| GB0521621D0 (en) | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| US8940683B2 (en) | 2006-08-10 | 2015-01-27 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| MX2009013137A (es) | 2007-06-06 | 2010-04-30 | Domantis Ltd | Metodos para seleccionar polipeptidos resistentes a la proteasa. |
| US8551534B2 (en) * | 2007-10-10 | 2013-10-08 | Parion Sciences, Inc. | Inhaled hypertonic saline delivered by a heated nasal cannula |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| CN102089326B (zh) | 2008-05-13 | 2014-12-31 | 诺维莫尼公司 | 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法 |
| US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| CN102573790B (zh) | 2009-08-27 | 2017-03-22 | 拜欧米特生物制剂有限责任公司 | 用于产生白介素‑1受体拮抗剂的可植入装置 |
| US8778383B2 (en) | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| US20130281405A1 (en) * | 2012-04-02 | 2013-10-24 | Lenard M. Lichtenberger | Use of pc-nsaids to treat and/or prevent pulmonary inflammation |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| JP2016518388A (ja) | 2013-04-30 | 2016-06-23 | オティトピック インク． | 乾燥粉末配合および使用方法 |
| WO2015081253A1 (en) | 2013-11-26 | 2015-06-04 | Biomet Biologics, Llc | Methods of mediating macrophage phenotypes |
| WO2016044775A1 (en) * | 2014-09-19 | 2016-03-24 | Aerovu Technologies, Inc. | Spacer device with flow rate spirometer cross reference to related application (s) |
| US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
| US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| AU2017432640B2 (en) | 2017-09-22 | 2023-11-30 | Aspeya US Inc. | Dry powder compositions with magnesium stearate |
| US11918646B2 (en) | 2017-12-11 | 2024-03-05 | Board Of Regents, The University Of Texas System | Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration |
| WO2020021574A1 (en) * | 2018-07-27 | 2020-01-30 | Wockhardt Limited | Pharmaceutical compositions and methods |
| EA202091615A1 (ru) | 2018-12-21 | 2021-03-05 | Аегис Терапьютикс, Ллс | Интраназальные составы на основе эпинефрина и способы лечения заболевания |
| US20220409627A1 (en) * | 2019-12-02 | 2022-12-29 | Altavant Sciences Gmbh | Treatment of lower airways disorders |
| EP4153213A1 (en) * | 2020-05-21 | 2023-03-29 | Altavant Sciences GmbH | An inhaled il-1 blockade treatment for respiratory tract immunopathology |
| WO2022016068A1 (en) * | 2020-07-16 | 2022-01-20 | Tbd Pharma Llc | Dexamethasone solution for the treatment of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infections |
| WO2022051247A1 (en) * | 2020-09-01 | 2022-03-10 | Dianomi Therapeutics, Inc. | Methods for treating or preventing inflammatory events |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| JP2024517694A (ja) * | 2021-04-22 | 2024-04-23 | オンスピラ セラピューティクス インコーポレイテッド | インターロイキン－１受容体アンタゴニストの組成物 |
| EP4417215A1 (en) * | 2023-02-20 | 2024-08-21 | Sorbonne Universite | Interleukin-1 for the treatment and prevention of allergies |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004511515A (ja) * | 2000-10-16 | 2004-04-15 | デューク・ユニバーシティ | 嚢胞性繊維症におけるエアロゾル化されたｓ−ニトロソグルタチオンの治療的使用 |
| WO2006075776A1 (ja) * | 2005-01-13 | 2006-07-20 | Anges Mg, Inc. | 慢性閉塞性肺疾患(COPD)、嚢胞性線維症(Cystic Fibrosis)または肺高血圧症(pulmonary hypertension)治療剤 |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE448277B (sv) | 1985-04-12 | 1987-02-09 | Draco Ab | Indikeringsanordning vid en doseringsanordning for lekemedel |
| US5851526A (en) | 1985-04-19 | 1998-12-22 | Ludwig Institute For Cancer Research | Methods of treating colon cancer utilizing tumor-specific antibodies |
| US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| JP2647427B2 (ja) | 1987-04-24 | 1997-08-27 | 帝人株式会社 | 被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット |
| US5306620A (en) | 1987-07-08 | 1994-04-26 | The Scripps Research Institute | Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation |
| US5149780A (en) | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
| CA2000048A1 (en) | 1988-10-03 | 1990-04-03 | Edward F. Plow | Peptides and antibodies that inhibit integrin-ligand bindin g |
| US5360716A (en) | 1988-10-24 | 1994-11-01 | Otsuka Pharmaceutical Co., Ltd. | Human tumor necrosis factor αspecific monoclonal antibody and method for detecting human tumor necrosis factor α |
| US5223395A (en) | 1988-12-01 | 1993-06-29 | Centocor, Inc. | Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples |
| US5147638A (en) | 1988-12-30 | 1992-09-15 | Oklahoma Medical Research Foundation | Inhibition of tumor growth by blockade of the protein C system |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5498694A (en) | 1989-05-25 | 1996-03-12 | La Jolla Cancer Research Foundation | Peptides of the cytoplasmic domain of integrin |
| US5644034A (en) | 1989-08-07 | 1997-07-01 | Peptide Technology Ltd. | Tumour necrosis factor binding ligands |
| DE69027121T3 (de) | 1989-08-07 | 2001-08-30 | Peptech Ltd., Dee Why | Bindeligande für tumornekrosisfaktor |
| US5959087A (en) | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
| DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
| US5262520A (en) | 1989-12-01 | 1993-11-16 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
| US5196511A (en) | 1989-12-01 | 1993-03-23 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
| US5136021A (en) | 1990-02-27 | 1992-08-04 | Health Research, Inc. | TNF-inhibitory protein and a method of production |
| DE4006269A1 (de) | 1990-02-28 | 1991-08-29 | Max Planck Gesellschaft | Antikoerper gegen den tumor-nekrosefaktor-rezeptor |
| GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
| US5830678A (en) | 1990-10-30 | 1998-11-03 | Fred Hutchinson Cancer Research Center | Method for identifying a target peptide that modulates the binding of epinectin ligand to integrin receptors |
| US5994510A (en) | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
| GB9028123D0 (en) | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
| AU1235392A (en) | 1991-01-14 | 1992-08-17 | New York University | Cytokine-induced protein, tsg-14, dna coding therefor and uses thereof |
| ES2103834T3 (es) | 1991-01-15 | 1997-10-01 | Bayer Ag | Complementacion de receptores de la superficie celular. |
| US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| US5698195A (en) | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
| US5310874A (en) | 1991-05-03 | 1994-05-10 | The Scripps Research Institute | Integrin α subunit cytoplasmic domain polypeptides and antibodies |
| KR100246082B1 (ko) | 1991-07-02 | 2000-04-01 | 인헤일, 인코오포레이티드 | 에어로졸화된약제를전달하는방법및장치 |
| US5334380A (en) | 1991-09-27 | 1994-08-02 | Board Of Regents, The University Of Texas System | Anti-endotoxin, interleukin-1 receptor antagonist and anti-tumor necrosis factor antibody with arginine-free formulations for the treatment of hypotension |
| US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| CA2132091C (en) | 1992-04-03 | 2008-09-16 | Kyung J. Kim | Antibodies to alphavbeta3 integrin |
| US5478725A (en) | 1992-06-12 | 1995-12-26 | University Of Pennsylvania | αv β3 integrin as a predictor of endometriosis |
| WO1994006498A1 (en) | 1992-09-23 | 1994-03-31 | Fisons Plc | Inhalation device |
| JP3616091B2 (ja) | 1992-10-08 | 2005-02-02 | ザ ケネディー インスティチュート オブ リューマトロジー | 自己免疫疾患および炎症性疾患の治療 |
| EP0665759B1 (en) | 1992-10-19 | 1998-12-23 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US5705481A (en) | 1992-11-06 | 1998-01-06 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Cyclopeptides |
| DK0680451T3 (da) | 1993-01-19 | 1999-07-19 | Glaxo Group Ltd | Aerosoldispenser samt fremgangsmåde ved dens fremstilling |
| DE4310643A1 (de) | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| US5579578A (en) | 1993-10-27 | 1996-12-03 | Hayes Wheels International, Inc. | Method for producing a rim for a vechicle wheel |
| IT1273790B (it) | 1994-02-18 | 1997-07-10 | Guidotti & C Spa Labor | Derivati eterociclici diazotati aventi attivita' aii antagonista |
| US5523209A (en) | 1994-03-14 | 1996-06-04 | The Scripps Research Institute | Methods for identifying inhibitors of integrin activation |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| US5770565A (en) | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
| DE4415310A1 (de) | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
| EP0766564A4 (en) | 1994-06-24 | 1998-09-23 | Immunex Corp | SLOW RELEASE POLYPEPTIDES COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL CONDITIONS |
| US5579758A (en) | 1994-07-13 | 1996-12-03 | Century; Theodore J. | Sub-miniature aerosolizer with helical flow path formed by threaded insert |
| DE69531187T2 (de) | 1994-12-20 | 2004-04-22 | Merck Patent Gmbh | Monoklonaler Antikörper gegen das Alpha-V-Integrin |
| US5513630A (en) | 1995-03-08 | 1996-05-07 | Century; Theodore J. | Powder dispenser |
| US5780426A (en) | 1995-06-07 | 1998-07-14 | Ixsys, Incorporated | Fivemer cyclic peptide inhibitors of diseases involving αv β3 |
| US5767071A (en) | 1995-06-07 | 1998-06-16 | Ixsys Incorporated | Sevenmer cyclic peptide inhibitors of diseases involving αv β3 |
| ZA967182B (en) | 1995-08-24 | 1998-05-25 | Magainin Pharma | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders. |
| US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
| GB9526100D0 (en) | 1995-12-20 | 1996-02-21 | Intersurgical Ltd | Nebulizer |
| ATE209053T1 (de) | 1996-01-03 | 2001-12-15 | Glaxo Group Ltd | Inhaliervorrichtung |
| US5817457A (en) | 1996-02-07 | 1998-10-06 | Ma Bioservices, Inc. | Methods and kits for detecting viral reverse transcriptase activity in a sample using an acidic pH or an elevated temperature |
| AU5362998A (en) | 1996-11-27 | 1998-06-22 | Du Pont Pharmaceuticals Company | Novel integrin receptor antagonists |
| US5863769A (en) * | 1997-01-28 | 1999-01-26 | Smithkline Beecham Corporation | DNA encoding interleukin-1 receptor antagonist (IL-1raβ) |
| US6590079B2 (en) | 1997-01-30 | 2003-07-08 | Ixsys, Incorporated | Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same |
| US5921447A (en) | 1997-02-13 | 1999-07-13 | Glaxo Wellcome Inc. | Flow-through metered aerosol dispensing apparatus and method of use thereof |
| JP2002508656A (ja) | 1997-03-12 | 2002-03-19 | スミスクライン・ビーチャム・コーポレイション | 抗−アルファベータ３ヒト化モノクローナル抗体 |
| ES2187954T3 (es) | 1997-04-11 | 2003-06-16 | Searle & Co | Anticuerpos anti-integrina avb3 antagonistas. |
| US5968741A (en) | 1997-04-11 | 1999-10-19 | Cedars-Sinai Medical Center | Methods of diagnosing a medically resistant clinical subtype of ulcerative colitis |
| US6171787B1 (en) | 1997-06-26 | 2001-01-09 | Abbott Laboratories | Member of the TNF family useful for treatment and diagnosis of disease |
| US6096707A (en) | 1997-07-11 | 2000-08-01 | Biotie Therapies Ltd. | Integrin binding peptide and use thereof |
| US6016800A (en) | 1997-10-24 | 2000-01-25 | Century; Theodore J. | Intrapulmonary aerosolizer |
| WO1999027086A1 (en) * | 1997-11-25 | 1999-06-03 | Brax Group Limited | Chimeric antisense oligonucleotides against tnf-alpha and their uses |
| JP2001524481A (ja) | 1997-11-26 | 2001-12-04 | デュポン ファーマシューティカルズ カンパニー | αＶβ３アンタゴニストとしての１，３，４−チアジアゾール類および１，３，４−オキサジアゾール類 |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6746839B1 (en) * | 1998-01-12 | 2004-06-08 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for an obstructive airway disease |
| EP1067940A4 (en) | 1998-03-03 | 2003-01-02 | Genaera Corp | FACTORS ASSOCIATED WITH ASTHMA AS TARGETS FOR THE TREATMENT OF ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS |
| US6294655B1 (en) * | 1998-04-03 | 2001-09-25 | Hyseq, Inc. | Anti-interleukin-1 receptor antagonist antibodies and uses thereof |
| US6541623B1 (en) * | 1998-04-03 | 2003-04-01 | Hyseq, Inc. | Interleukin—1 receptor antagonist and uses thereof |
| EP1105389A4 (en) | 1998-08-13 | 2001-10-17 | Merck & Co Inc | INTEGRIN RECEPTOR ANTAGONISTS |
| US6160099A (en) | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
| US6114517A (en) | 1998-12-10 | 2000-09-05 | Isis Pharmaceuticals Inc. | Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules |
| US6982089B2 (en) * | 1999-02-24 | 2006-01-03 | Tact Ip, Llc | Cytokine antagonists for neurological and neuropsychiatric disorders |
| WO2000062736A2 (en) * | 1999-04-06 | 2000-10-26 | East Carolina University | Low adenosine anti-sense oligonucleotide, compositions, kit and method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) and surfactant depletion |
| ES2300266T3 (es) * | 1999-05-20 | 2008-06-16 | Nuvelo, Inc. | Interleuquina-1 hy2, materiales y metodos. |
| US6531580B1 (en) | 1999-06-24 | 2003-03-11 | Ixsys, Inc. | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
| US20020068279A1 (en) * | 1999-12-06 | 2002-06-06 | Curagen Corporation | Novel Proteins and nucleic acids encoding the same |
| DK1255544T3 (da) | 2000-01-31 | 2007-09-17 | Genaera Corp | Mucin-syntese-inhibitorer |
| AU2002224408B2 (en) * | 2000-10-18 | 2007-08-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| US20020156009A1 (en) * | 2000-11-02 | 2002-10-24 | Dennis Ballinger | Novel interleukin - 1 Hy2 materials and methods |
| US20020128179A1 (en) * | 2000-12-01 | 2002-09-12 | Tacon William C. | Shaped microparticles for pulmonary drug delivery |
| WO2002098917A2 (en) * | 2001-02-12 | 2002-12-12 | Curagen Corporation | Human proteins and nucleic acids encoding same |
| WO2002070007A1 (en) | 2001-03-02 | 2002-09-12 | Medimmune, Inc. | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
| US20070021360A1 (en) * | 2001-04-24 | 2007-01-25 | Nyce Jonathan W | Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase |
| AUPR527801A0 (en) * | 2001-05-25 | 2001-06-21 | University Of Sydney, The | Animal husbandry iii |
| US20030099650A1 (en) * | 2001-07-25 | 2003-05-29 | Ho Alice Suk-Yue | Treatment of immune disorders and B cell disorders |
| EP1585477A4 (en) | 2001-11-30 | 2007-06-27 | Centocor Inc | ANTI-TNF ANTIBODIES, COMPOSITIONS, METHODS AND USES |
| AU2003213647A1 (en) | 2002-02-27 | 2003-09-09 | Emory University | Multimeric binding complexes |
| JP4133017B2 (ja) | 2002-06-20 | 2008-08-13 | 株式会社資生堂 | 毛髪処理用組成物 |
| US7572770B2 (en) | 2002-06-27 | 2009-08-11 | University Of Zurich | Use of an interleukin 1 receptor antagonist and/or pyrrolidinedithiocarbamate for the treatment or prophylaxis of type 2 diabetes |
| GB0300427D0 (en) * | 2003-01-09 | 2003-02-05 | Univ Strathclyde | Pharmaceutical composition |
| WO2004098596A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising roflumilast and il-1 trap |
| US7507745B2 (en) * | 2004-02-20 | 2009-03-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins |
| US20050186175A1 (en) * | 2004-02-20 | 2005-08-25 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on benzilic acid esters and soluble TNF receptor fusion proteins |
| MX2007006593A (es) * | 2004-12-02 | 2008-03-04 | Domantis Ltd | Anticuerpos de dominio simple anti-il 1r1 y sus usos terapeuticos. |
| GB0426609D0 (en) | 2004-12-03 | 2005-01-05 | Ic Innovations Ltd | Analysis |
| ES2335232T3 (es) * | 2005-06-21 | 2010-03-23 | Xoma Technology Ltd. | Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta. |
| US20070005651A1 (en) * | 2005-07-01 | 2007-01-04 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Restoring modified assets |
| TW200745003A (en) * | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| PE20070823A1 (es) * | 2005-11-15 | 2007-08-09 | Glaxo Group Ltd | Sal tosilato de 8-(2,6-difluorofenil)-4-(4-fluoro-2-metilfenil)-2-{[2-hidroxi-1-(hidroximetil)etil]amino}pirido[2,3-]pirimidin-7(8h)-ona |
| WO2007063311A2 (en) * | 2005-12-01 | 2007-06-07 | Domantis Limited | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
| ES2389231T3 (es) * | 2005-12-21 | 2012-10-24 | Meda Pharma Gmbh & Co. Kg | Combinación de anticolinérgicos, glucocorticoides y agonistas de beta2 para el tratamiento de enfermedades inflamatorias |
| US7504106B2 (en) * | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
| CA2657581A1 (en) * | 2006-07-11 | 2008-01-17 | Roy C. Levitt | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
| US8940683B2 (en) | 2006-08-10 | 2015-01-27 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| CN102740877B (zh) * | 2009-09-06 | 2015-01-14 | 普罗塔布有限公司 | 对源自hsp65的肽-6有特异性的人源化抗体及其方法和用途 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004511515A (ja) * | 2000-10-16 | 2004-04-15 | デューク・ユニバーシティ | 嚢胞性繊維症におけるエアロゾル化されたｓ−ニトロソグルタチオンの治療的使用 |
| WO2006075776A1 (ja) * | 2005-01-13 | 2006-07-20 | Anges Mg, Inc. | 慢性閉塞性肺疾患(COPD)、嚢胞性線維症(Cystic Fibrosis)または肺高血圧症(pulmonary hypertension)治療剤 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6012046127; ＤＲＵＧ ＤＩＳＣＯＶＥＲＹ ＴＯＤＡＹ ＶＯＬ．１０， ＮＯ．２, 2005, Ｐ．９３-１０６ * |
| JPN6012046131; ＡＭ．Ｊ．ＲＥＳＰＩＲ．ＣＲＩＴ．ＣＡＲＥ ＭＥＤ． ＶＯＬ．１７２, 2005, Ｐ．４６５-４６９ * |
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| Publication number | Publication date |
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| EP3669878A1 (en) | 2020-06-24 |
| PT2068889T (pt) | 2020-01-30 |
| SI2068889T1 (sl) | 2020-03-31 |
| US10550389B2 (en) | 2020-02-04 |
| US20150232855A1 (en) | 2015-08-20 |
| US11718853B2 (en) | 2023-08-08 |
| ES2766770T3 (es) | 2020-06-15 |
| EP2068889B1 (en) | 2019-10-23 |
| EP2068889A1 (en) | 2009-06-17 |
| US20100209357A1 (en) | 2010-08-19 |
| US20200362351A1 (en) | 2020-11-19 |
| WO2008021237A1 (en) | 2008-02-21 |
| US8940683B2 (en) | 2015-01-27 |
| AU2007284690A1 (en) | 2008-02-21 |
| CA2660519A1 (en) | 2008-02-21 |
| CY1122533T1 (el) | 2021-01-27 |
| CA3177366A1 (en) | 2008-02-21 |
| DK2068889T3 (da) | 2020-02-03 |
| US11091763B2 (en) | 2021-08-17 |
| HUE048024T2 (hu) | 2020-05-28 |
| US20210395748A1 (en) | 2021-12-23 |
| EP2068889A4 (en) | 2012-07-11 |
| PL2068889T3 (pl) | 2020-06-29 |
| LT2068889T (lt) | 2020-02-10 |
| US20240084306A1 (en) | 2024-03-14 |
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