JP2010273672A5

JP2010273672A5 -

Download PDF

Info

Publication number: JP2010273672A5
Authority: JP; Japan
Prior art keywords: cysteine; serine; amino acid; histidine; glutamine
Prior art date: 2010-04-14
Legal status : Pending

Application number

JP2010093307A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010273672A (ja

Filing date

2010-04-14

Publication date

2013-05-23

2010-04-14 Application filed filed Critical

2010-04-14 Priority to JP2010093307A priority Critical patent/JP2010273672A/ja

2010-04-14 Priority claimed from JP2010093307A external-priority patent/JP2010273672A/ja

2010-04-26 Priority to US13/266,525 priority patent/US8778650B2/en

2010-04-26 Priority to CN201080019156.4A priority patent/CN102421893B/zh

2010-04-26 Priority to EP16163320.1A priority patent/EP3061817B1/en

2010-04-26 Priority to PCT/JP2010/057838 priority patent/WO2010126156A2/en

2010-04-26 Priority to DK16163320.1T priority patent/DK3061817T3/en

2010-04-26 Priority to EP10719131A priority patent/EP2424981A2/en

2010-12-09 Publication of JP2010273672A publication Critical patent/JP2010273672A/ja

2013-05-23 Publication of JP2010273672A5 publication Critical patent/JP2010273672A5/ja

Status Pending legal-status Critical Current

Links

MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 18
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 15
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 15
235000018417 cysteine Nutrition 0.000 claims 15
229960002433 cysteine Drugs 0.000 claims 15
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 15
235000004400 serine Nutrition 0.000 claims 15
229960001153 serine Drugs 0.000 claims 15
239000004475 Arginine Substances 0.000 claims 12
108091005658 Basic proteases Proteins 0.000 claims 12
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 12
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 12
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 12
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 12
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 12
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 12
239000004472 Lysine Substances 0.000 claims 12
235000004279 alanine Nutrition 0.000 claims 12
229960003767 alanine Drugs 0.000 claims 12
235000009697 arginine Nutrition 0.000 claims 12
229960003121 arginine Drugs 0.000 claims 12
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 12
235000004554 glutamine Nutrition 0.000 claims 12
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 12
229960002743 glutamine Drugs 0.000 claims 12
235000014304 histidine Nutrition 0.000 claims 12
229960002885 histidine Drugs 0.000 claims 12
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 12
235000018977 lysine Nutrition 0.000 claims 12
229960003646 lysine Drugs 0.000 claims 12
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 9
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 9
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 9
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 9
239000004473 Threonine Substances 0.000 claims 9
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 9
235000006109 methionine Nutrition 0.000 claims 9
229930182817 methionine Natural products 0.000 claims 9
229960004452 methionine Drugs 0.000 claims 9
235000008521 threonine Nutrition 0.000 claims 9
229960002898 threonine Drugs 0.000 claims 9
235000014393 valine Nutrition 0.000 claims 9
229960004295 valine Drugs 0.000 claims 9
239000004474 valine Substances 0.000 claims 9
150000001413 amino acids Chemical group 0.000 claims 8
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
239000004471 Glycine Substances 0.000 claims 6
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 6
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 6
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 6
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 6
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 6
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 6
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 6
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 6
125000000539 amino acid group Chemical group 0.000 claims 6
235000013922 glutamic acid Nutrition 0.000 claims 6
229960002989 glutamic acid Drugs 0.000 claims 6
239000004220 glutamic acid Substances 0.000 claims 6
229960002449 glycine Drugs 0.000 claims 6
235000014705 isoleucine Nutrition 0.000 claims 6
229960000310 isoleucine Drugs 0.000 claims 6
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 6
235000005772 leucine Nutrition 0.000 claims 6
229960003136 leucine Drugs 0.000 claims 6
235000008729 phenylalanine Nutrition 0.000 claims 6
229960005190 phenylalanine Drugs 0.000 claims 6
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 6
229960004799 tryptophan Drugs 0.000 claims 6
235000002374 tyrosine Nutrition 0.000 claims 6
229960004441 tyrosine Drugs 0.000 claims 6
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 6
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 3
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
235000009582 asparagine Nutrition 0.000 claims 3
229960001230 asparagine Drugs 0.000 claims 3
235000003704 aspartic acid Nutrition 0.000 claims 3
229960005261 aspartic acid Drugs 0.000 claims 3
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
235000013930 proline Nutrition 0.000 claims 3
229960002429 proline Drugs 0.000 claims 3
239000003599 detergent Substances 0.000 claims 2
230000035772 mutation Effects 0.000 claims 2
108090000623 proteins and genes Proteins 0.000 claims 2
239000003945 anionic surfactant Substances 0.000 claims 1
238000004140 cleaning Methods 0.000 claims 1
238000012258 culturing Methods 0.000 claims 1
239000007788 liquid Substances 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
238000000034 method Methods 0.000 claims 1
244000005700 microbiome Species 0.000 claims 1

JP2010093307A 2009-04-30 2010-04-14 アルカリプロテアーゼ変異体 Pending JP2010273672A (ja)