JP2010235612A5 - - Google Patents
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- Publication number
- JP2010235612A5 JP2010235612A5 JP2010109145A JP2010109145A JP2010235612A5 JP 2010235612 A5 JP2010235612 A5 JP 2010235612A5 JP 2010109145 A JP2010109145 A JP 2010109145A JP 2010109145 A JP2010109145 A JP 2010109145A JP 2010235612 A5 JP2010235612 A5 JP 2010235612A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- arylcarbonylamino
- alkoxy
- pharmaceutically acceptable
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NKJXMLIWSJATEE-UHFFFAOYSA-N Cc(cc1)ccc1C(NO)=N Chemical compound Cc(cc1)ccc1C(NO)=N NKJXMLIWSJATEE-UHFFFAOYSA-N 0.000 description 8
- 0 *[N+](c(cc1)cc2c1nc(-c1cc(-c3ccccc3)ccc1)[n]2O)[O-] Chemical compound *[N+](c(cc1)cc2c1nc(-c1cc(-c3ccccc3)ccc1)[n]2O)[O-] 0.000 description 7
- CUEKBBQYAWCAFY-UHFFFAOYSA-N Cc(cc1)c(C)cc1[NH+]([O-])O Chemical compound Cc(cc1)c(C)cc1[NH+]([O-])O CUEKBBQYAWCAFY-UHFFFAOYSA-N 0.000 description 7
- GKDIAVWPXOXCBW-UHFFFAOYSA-N Cc(cc1)ccc1C(NO)=C Chemical compound Cc(cc1)ccc1C(NO)=C GKDIAVWPXOXCBW-UHFFFAOYSA-N 0.000 description 2
- UNFAAXQGZJDPCX-UHFFFAOYSA-N NCc(cc1)ccc1C(NO)=N Chemical compound NCc(cc1)ccc1C(NO)=N UNFAAXQGZJDPCX-UHFFFAOYSA-N 0.000 description 2
- OPGWBTKZYLRPRW-UHFFFAOYSA-N Nc1cc(C(NO)=N)ccc1 Chemical compound Nc1cc(C(NO)=N)ccc1 OPGWBTKZYLRPRW-UHFFFAOYSA-N 0.000 description 2
- CPCBKIRIGJHCAX-UHFFFAOYSA-N C/[O]=C(/c1ncccc1)\Nc(cc1)ccc1-c1nc(ccc([N+]([O-])=O)c2)c2[n]1O Chemical compound C/[O]=C(/c1ncccc1)\Nc(cc1)ccc1-c1nc(ccc([N+]([O-])=O)c2)c2[n]1O CPCBKIRIGJHCAX-UHFFFAOYSA-N 0.000 description 1
- RHYIYQDBAQJCPY-UHFFFAOYSA-N CC(C)(C)C(Nc(cc1)ccc1-c([n](c1c2)O)nc1ccc2[N+]([O-])=O)=O Chemical compound CC(C)(C)C(Nc(cc1)ccc1-c([n](c1c2)O)nc1ccc2[N+]([O-])=O)=O RHYIYQDBAQJCPY-UHFFFAOYSA-N 0.000 description 1
- LZRKZIPAKYUIHX-UHFFFAOYSA-N CC(C)(C)OC(NCc(cc1)ccc1C(NO)=N)O Chemical compound CC(C)(C)OC(NCc(cc1)ccc1C(NO)=N)O LZRKZIPAKYUIHX-UHFFFAOYSA-N 0.000 description 1
- VIPMBJSGYWWHAO-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1C(N)=O Chemical compound CC(C)(C)c(cc1)ccc1C(N)=O VIPMBJSGYWWHAO-UHFFFAOYSA-N 0.000 description 1
- WZNUDZBRAFIOQX-UHFFFAOYSA-N CC(Nc(cccc1)c1-c1nc(ccc([N+]([O-])=O)c2)c2[n]1O)=O Chemical compound CC(Nc(cccc1)c1-c1nc(ccc([N+]([O-])=O)c2)c2[n]1O)=O WZNUDZBRAFIOQX-UHFFFAOYSA-N 0.000 description 1
- RMGFSSKOGFNSDW-UHFFFAOYSA-O CC(Nc1cc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)ccc1)=O Chemical compound CC(Nc1cc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)ccc1)=O RMGFSSKOGFNSDW-UHFFFAOYSA-O 0.000 description 1
- ZQPVJMLHNCFVNG-UHFFFAOYSA-N CC1(C)C(C)=CC([NH+]([O-])O)=CC1 Chemical compound CC1(C)C(C)=CC([NH+]([O-])O)=CC1 ZQPVJMLHNCFVNG-UHFFFAOYSA-N 0.000 description 1
- VVZYBQHJHUXXPG-UHFFFAOYSA-N CC1(C2=CC([N+](O)=O)=CC1)N=C(c1cc(C(F)(F)F)ccc1)N2O Chemical compound CC1(C2=CC([N+](O)=O)=CC1)N=C(c1cc(C(F)(F)F)ccc1)N2O VVZYBQHJHUXXPG-UHFFFAOYSA-N 0.000 description 1
- RIEAJIVEXCZCIX-UHFFFAOYSA-N CN(C)c(cc1)ccc1-c1nc(ccc([N+](O)=O)c2)c2[n]1O Chemical compound CN(C)c(cc1)ccc1-c1nc(ccc([N+](O)=O)c2)c2[n]1O RIEAJIVEXCZCIX-UHFFFAOYSA-N 0.000 description 1
- GEBBAUHUTGGURH-UHFFFAOYSA-N CN(C)c1cccc(-c([n](c2c3)O)nc2ccc3[N+]2([O-])OC2)c1 Chemical compound CN(C)c1cccc(-c([n](c2c3)O)nc2ccc3[N+]2([O-])OC2)c1 GEBBAUHUTGGURH-UHFFFAOYSA-N 0.000 description 1
- YSKSOUNHUMDIEN-UHFFFAOYSA-N CN(C1c(cccc2)c2OC)c(ccc([N+](O)=O)c2)c2N1O Chemical compound CN(C1c(cccc2)c2OC)c(ccc([N+](O)=O)c2)c2N1O YSKSOUNHUMDIEN-UHFFFAOYSA-N 0.000 description 1
- NZZZOYVRPOWZJQ-UHFFFAOYSA-N CNc1cccc(C(N)=O)c1 Chemical compound CNc1cccc(C(N)=O)c1 NZZZOYVRPOWZJQ-UHFFFAOYSA-N 0.000 description 1
- IQMOCCRAIJWKAG-UHFFFAOYSA-N CO[NH+](c(cc12)ccc1nc(-c1cc(N)ccc1)[n]2O)[O-] Chemical compound CO[NH+](c(cc12)ccc1nc(-c1cc(N)ccc1)[n]2O)[O-] IQMOCCRAIJWKAG-UHFFFAOYSA-N 0.000 description 1
- KPPMTHUVVOUFOC-UHFFFAOYSA-N COc(cc(cc1)-c([n](c2c3)O)nc2ccc3[NH+]([O-])O)c1O Chemical compound COc(cc(cc1)-c([n](c2c3)O)nc2ccc3[NH+]([O-])O)c1O KPPMTHUVVOUFOC-UHFFFAOYSA-N 0.000 description 1
- DPFLFJZJMBZUNI-UHFFFAOYSA-N COc(cc1)cc(OC)c1-c1nc(ccc([N+](O)=O)c2)c2[n]1O Chemical compound COc(cc1)cc(OC)c1-c1nc(ccc([N+](O)=O)c2)c2[n]1O DPFLFJZJMBZUNI-UHFFFAOYSA-N 0.000 description 1
- HOEJMWBAZBZFER-UHFFFAOYSA-N COc(cc1)ccc1-c1nc(ccc([N+](O)=O)c2)c2[n]1O Chemical compound COc(cc1)ccc1-c1nc(ccc([N+](O)=O)c2)c2[n]1O HOEJMWBAZBZFER-UHFFFAOYSA-N 0.000 description 1
- FGCLDLAXLPHEEW-UHFFFAOYSA-N COc(ccc(-c1nc(ccc([N+]([O-4])=O)c2)c2[n]1O)c1)c1OC Chemical compound COc(ccc(-c1nc(ccc([N+]([O-4])=O)c2)c2[n]1O)c1)c1OC FGCLDLAXLPHEEW-UHFFFAOYSA-N 0.000 description 1
- CKSUEGYEOOXEBA-UHFFFAOYSA-N COc1cc(-c([n](c2c3)O)nc2ccc3[N+]([O-])=O)ccc1 Chemical compound COc1cc(-c([n](c2c3)O)nc2ccc3[N+]([O-])=O)ccc1 CKSUEGYEOOXEBA-UHFFFAOYSA-N 0.000 description 1
- MKPKUFYFBXOKTE-UHFFFAOYSA-N COc1cc(-c2nc(ccc([NH+]([O-])O)c3)c3[n]2O)cc(OC)c1OC Chemical compound COc1cc(-c2nc(ccc([NH+]([O-])O)c3)c3[n]2O)cc(OC)c1OC MKPKUFYFBXOKTE-UHFFFAOYSA-N 0.000 description 1
- ZJFPNRIWCSCUFT-UHFFFAOYSA-N CSc1ccc(C(Nc(c2c3)ccc3[N+]([O-])=O)N2O)cc1 Chemical compound CSc1ccc(C(Nc(c2c3)ccc3[N+]([O-])=O)N2O)cc1 ZJFPNRIWCSCUFT-UHFFFAOYSA-N 0.000 description 1
- DZHMAZFAUFAUHA-UHFFFAOYSA-N Cc(c(C)c1)ccc1[N+](O)=O Chemical compound Cc(c(C)c1)ccc1[N+](O)=O DZHMAZFAUFAUHA-UHFFFAOYSA-N 0.000 description 1
- UHBGYFCCKRAEHA-UHFFFAOYSA-N Cc(cc1)ccc1C(N)=O Chemical compound Cc(cc1)ccc1C(N)=O UHBGYFCCKRAEHA-UHFFFAOYSA-N 0.000 description 1
- KJMNPGUHEUTHMR-UHFFFAOYSA-N Cc1cccc(C(NO)=N)c1 Chemical compound Cc1cccc(C(NO)=N)c1 KJMNPGUHEUTHMR-UHFFFAOYSA-N 0.000 description 1
- UAKAWWHOQNNATR-UHFFFAOYSA-N Cc1ccccc1C(NO)=N Chemical compound Cc1ccccc1C(NO)=N UAKAWWHOQNNATR-UHFFFAOYSA-N 0.000 description 1
- UACPBQAEDQTXMM-UHFFFAOYSA-N N=C(c(cc1)ccc1NCc1ccccc1)NO Chemical compound N=C(c(cc1)ccc1NCc1ccccc1)NO UACPBQAEDQTXMM-UHFFFAOYSA-N 0.000 description 1
- CLPULQLDSKYGSQ-UHFFFAOYSA-N N=C(c(cc1)ccc1NS(=O)=O)NO Chemical compound N=C(c(cc1)ccc1NS(=O)=O)NO CLPULQLDSKYGSQ-UHFFFAOYSA-N 0.000 description 1
- TUHCVZPTDBUXMQ-UHFFFAOYSA-N N=C(c(cc1)ccc1Oc1ccccc1)NO Chemical compound N=C(c(cc1)ccc1Oc1ccccc1)NO TUHCVZPTDBUXMQ-UHFFFAOYSA-N 0.000 description 1
- FJNGCQFGXMNISZ-UHFFFAOYSA-N N=C(c1ccc(CNC(c2ccccc2)=O)cc1)NO Chemical compound N=C(c1ccc(CNC(c2ccccc2)=O)cc1)NO FJNGCQFGXMNISZ-UHFFFAOYSA-N 0.000 description 1
- CLAHOZSYMRNIPY-UHFFFAOYSA-N NC(NCCO)=O Chemical compound NC(NCCO)=O CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 description 1
- BLNVISNJTIRAHF-UHFFFAOYSA-N NC(c(cc1)ccc1Cl)=O Chemical compound NC(c(cc1)ccc1Cl)=O BLNVISNJTIRAHF-UHFFFAOYSA-N 0.000 description 1
- MJTGQALMWUUPQM-UHFFFAOYSA-N NC(c1cc(Cl)ccc1)=O Chemical compound NC(c1cc(Cl)ccc1)=O MJTGQALMWUUPQM-UHFFFAOYSA-N 0.000 description 1
- SXLQKSLYHNACFX-UHFFFAOYSA-N NC(c1cccc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)c1)=N Chemical compound NC(c1cccc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)c1)=N SXLQKSLYHNACFX-UHFFFAOYSA-N 0.000 description 1
- KGPOBHINXYYIPO-UHFFFAOYSA-O NC(c1cccc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)c1)=O Chemical compound NC(c1cccc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)c1)=O KGPOBHINXYYIPO-UHFFFAOYSA-O 0.000 description 1
- PHBWXPZUQTVKQT-UHFFFAOYSA-N Nc(cc1)ccc1-c([n](c1c2)O)nc1ccc2[N+](O)=O Chemical compound Nc(cc1)ccc1-c([n](c1c2)O)nc1ccc2[N+](O)=O PHBWXPZUQTVKQT-UHFFFAOYSA-N 0.000 description 1
- OZHAUABVHPMKOM-UHFFFAOYSA-N Nc(cccc1)c1-c([n](c1c2)O)nc1ccc2[N+]([O-])=O Chemical compound Nc(cccc1)c1-c([n](c1c2)O)nc1ccc2[N+]([O-])=O OZHAUABVHPMKOM-UHFFFAOYSA-N 0.000 description 1
- CFZHYRNQLHEHJS-UHFFFAOYSA-N Nc(cccc1)c1C(NO)=N Chemical compound Nc(cccc1)c1C(NO)=N CFZHYRNQLHEHJS-UHFFFAOYSA-N 0.000 description 1
- PKSNJHUPPDGFEC-UHFFFAOYSA-O OC(c1cccc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)c1)=O Chemical compound OC(c1cccc(-c([n](c2c3)O)nc2ccc3[N+](O)=O)c1)=O PKSNJHUPPDGFEC-UHFFFAOYSA-O 0.000 description 1
- SFVUPDINIWVHFW-UHFFFAOYSA-N O[n](c1c2)c(-c(cc3)cc4c3OCO4)nc1ccc2[N+](O)=O Chemical compound O[n](c1c2)c(-c(cc3)cc4c3OCO4)nc1ccc2[N+](O)=O SFVUPDINIWVHFW-UHFFFAOYSA-N 0.000 description 1
- RXBPQXKJPKUQCN-UHFFFAOYSA-O O[n](c1c2)c(-c(cc3)ccc3NC(c3ccccc3)=O)nc1ccc2[N+](O)=O Chemical compound O[n](c1c2)c(-c(cc3)ccc3NC(c3ccccc3)=O)nc1ccc2[N+](O)=O RXBPQXKJPKUQCN-UHFFFAOYSA-O 0.000 description 1
- VPJPTIGPSYBTPQ-UHFFFAOYSA-O O[n](c1c2)c(-c(cc3)ccc3NC(c3cnccc3)=O)nc1ccc2[N+](O)=O Chemical compound O[n](c1c2)c(-c(cc3)ccc3NC(c3cnccc3)=O)nc1ccc2[N+](O)=O VPJPTIGPSYBTPQ-UHFFFAOYSA-O 0.000 description 1
- WGUJGAHMTSMEGO-UHFFFAOYSA-N O[n](c1c2)c(-c3cc(OC(F)(F)F)ccc3)nc1ccc2[N+](O)=O Chemical compound O[n](c1c2)c(-c3cc(OC(F)(F)F)ccc3)nc1ccc2[N+](O)=O WGUJGAHMTSMEGO-UHFFFAOYSA-N 0.000 description 1
- WAFBZWKGUZVAOG-UHFFFAOYSA-N O[n]1c(-c2cc(-[n]3cccc3)ccc2)nc(cc2)c1cc2[N+](O)=O Chemical compound O[n]1c(-c2cc(-[n]3cccc3)ccc2)nc(cc2)c1cc2[N+](O)=O WAFBZWKGUZVAOG-UHFFFAOYSA-N 0.000 description 1
- QXZHGVLHHAUZOD-UHFFFAOYSA-N O[n]1c(-c2cc(Br)ccc2)nc(cc2)c1cc2[N+](O)=O Chemical compound O[n]1c(-c2cc(Br)ccc2)nc(cc2)c1cc2[N+](O)=O QXZHGVLHHAUZOD-UHFFFAOYSA-N 0.000 description 1
- XEFRWYWCTGFUNI-UHFFFAOYSA-O Oc(cc1)ccc1-c([n](c1c2)O)nc1ccc2[N+](O)=O Chemical compound Oc(cc1)ccc1-c([n](c1c2)O)nc1ccc2[N+](O)=O XEFRWYWCTGFUNI-UHFFFAOYSA-O 0.000 description 1
- QMOBWYOTYUWHPA-UHFFFAOYSA-N [O-2][N+](C(C=C12)=CC(C3)C13N=C(c(cccc1)c1Br)N2O)=O Chemical compound [O-2][N+](C(C=C12)=CC(C3)C13N=C(c(cccc1)c1Br)N2O)=O QMOBWYOTYUWHPA-UHFFFAOYSA-N 0.000 description 1
- IVSJJXWLAXDQQT-UHFFFAOYSA-N [O-4][N+](c(cc12)ccc1nc(-c(cc1)ccc1NCCO)[n]2O)=O Chemical compound [O-4][N+](c(cc12)ccc1nc(-c(cc1)ccc1NCCO)[n]2O)=O IVSJJXWLAXDQQT-UHFFFAOYSA-N 0.000 description 1
- FOYREYGSLHFBRV-UHFFFAOYSA-N [O-][N+](c(cc12)ccc1nc(-c(cc1)ccc1NC(C1CCCCC1)=O)[n]2O)=O Chemical compound [O-][N+](c(cc12)ccc1nc(-c(cc1)ccc1NC(C1CCCCC1)=O)[n]2O)=O FOYREYGSLHFBRV-UHFFFAOYSA-N 0.000 description 1
- LSCZBBHTIUCHRK-UHFFFAOYSA-N [O-][N+](c(cc12)ccc1nc(-c(cccc1)c1NC(c1ccc[o]1)=O)[n]2O)=O Chemical compound [O-][N+](c(cc12)ccc1nc(-c(cccc1)c1NC(c1ccc[o]1)=O)[n]2O)=O LSCZBBHTIUCHRK-UHFFFAOYSA-N 0.000 description 1
- PAAAOMDCHZADHV-UHFFFAOYSA-N [O-][N+](c(cc12)ccc1nc(-c1cc(NC(c3ccc[o]3)=O)ccc1)[n]2O)=O Chemical compound [O-][N+](c(cc12)ccc1nc(-c1cc(NC(c3ccc[o]3)=O)ccc1)[n]2O)=O PAAAOMDCHZADHV-UHFFFAOYSA-N 0.000 description 1
- ZHRJLSAZMWHPNS-UHFFFAOYSA-N [O-][N+](c(cc12)ccc1nc(-c1cc(NC(c3ccccc3)=O)ccc1)[n]2O)=O Chemical compound [O-][N+](c(cc12)ccc1nc(-c1cc(NC(c3ccccc3)=O)ccc1)[n]2O)=O ZHRJLSAZMWHPNS-UHFFFAOYSA-N 0.000 description 1
- VEDKLSAVOFGKEE-UHFFFAOYSA-N [O-][N+]1(c(cc23)ccc2nc(-c(cccc2)c2NC(c2c[o]cc2)=O)[n]3O)OC1 Chemical compound [O-][N+]1(c(cc23)ccc2nc(-c(cccc2)c2NC(c2c[o]cc2)=O)[n]3O)OC1 VEDKLSAVOFGKEE-UHFFFAOYSA-N 0.000 description 1
- CPIFHUDZTIOEGM-UHFFFAOYSA-N [O-][NH+](c(cc12)ccc1nc(-c(cc1)ccc1NC(c1ccc[o]1)=O)[n]2O)[O-] Chemical compound [O-][NH+](c(cc12)ccc1nc(-c(cc1)ccc1NC(c1ccc[o]1)=O)[n]2O)[O-] CPIFHUDZTIOEGM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42331902P | 2002-11-01 | 2002-11-01 | |
| US60/423,319 | 2002-11-01 | ||
| US42591602P | 2002-11-13 | 2002-11-13 | |
| US60/425,916 | 2002-11-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550495A Division JP2006513162A (ja) | 2002-11-01 | 2003-11-03 | 転写因子調節化合物およびその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012039805A Division JP2012131813A (ja) | 2002-11-01 | 2012-02-27 | 転写因子調節化合物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010235612A JP2010235612A (ja) | 2010-10-21 |
| JP2010235612A5 true JP2010235612A5 (sr) | 2012-04-12 |
| JP5175316B2 JP5175316B2 (ja) | 2013-04-03 |
Family
ID=32314482
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550495A Pending JP2006513162A (ja) | 2002-11-01 | 2003-11-03 | 転写因子調節化合物およびその使用方法 |
| JP2010109145A Expired - Fee Related JP5175316B2 (ja) | 2002-11-01 | 2010-05-11 | 転写因子調節化合物およびその使用方法 |
| JP2012039805A Pending JP2012131813A (ja) | 2002-11-01 | 2012-02-27 | 転写因子調節化合物およびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550495A Pending JP2006513162A (ja) | 2002-11-01 | 2003-11-03 | 転写因子調節化合物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012039805A Pending JP2012131813A (ja) | 2002-11-01 | 2012-02-27 | 転写因子調節化合物およびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1558341A4 (sr) |
| JP (3) | JP2006513162A (sr) |
| AU (1) | AU2003291226B2 (sr) |
| CA (1) | CA2504448C (sr) |
| WO (1) | WO2004041209A2 (sr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1462105A1 (en) * | 2003-03-28 | 2004-09-29 | Procorde GmbH | Activation specific inhibitors of NF-kB and method of treating inflammatory processes in cardio-vascular diseases |
| ATE363905T1 (de) | 2003-04-17 | 2007-06-15 | Janssen Pharmaceutica Nv | 2-phenyl-benzimidazol und 2-phenyl-imidazo-4,5)- pyridin-derivate als checkpoint-kinase-cds1 (chk2)-hemmer zur behandlung von krebs |
| JP2008504233A (ja) * | 2004-04-23 | 2008-02-14 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用法 |
| WO2007016292A2 (en) * | 2005-07-27 | 2007-02-08 | Vertex Pharmaceuticals Incorporated | Heterocyclic amides as biofilm modulators |
| JP5390186B2 (ja) | 2005-08-12 | 2014-01-15 | ユナイテッド ステイツ ガバメント アズ レプリゼンティッド バイ ザ セクレタリー オブ ザ ユナイテッド ステイツ アーミー アンド ザ ユーエス アーミー メディカル リサーチ アンド マティリ | 広い抗菌スペクトルを有する抗菌性化合物 |
| WO2007053945A1 (en) * | 2005-11-09 | 2007-05-18 | Kane Biotech Inc. | Oral anti-microbial composition comprising competence-stimulating peptide |
| AU2007351886A1 (en) * | 2006-06-23 | 2008-10-30 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| EP2099466B1 (en) * | 2006-12-01 | 2015-06-03 | Laclede, Inc. | Use of hydrolytic and oxidative enzymes to dissolve biofilm in ears |
| CA2681813A1 (en) * | 2007-03-27 | 2009-01-08 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| EP2000140A1 (en) | 2007-06-05 | 2008-12-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of derivatives of 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine or of 3-oxo-2,3-dihydro-5H-imidazolo[3,2-a]pyrimidine for the preparation of pharmaceutical compositions intended for the treatment of cancer |
| US8618300B2 (en) * | 2008-09-04 | 2013-12-31 | Boehringer Ingelheim International Gmbh | Indolizine inhibitors of leukotriene production |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| WO2010124097A2 (en) * | 2009-04-22 | 2010-10-28 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| WO2011151620A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| HUE028746T2 (en) * | 2010-06-01 | 2016-12-28 | Summit Therapeutics Plc | Compounds for the treatment of a disease associated with Clostridium difficile |
| WO2011151618A2 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| WO2011151617A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151619A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| US9382226B2 (en) * | 2010-07-21 | 2016-07-05 | Merck Sharp & Dohme Corp. | Aldosterone synthase inhibitors |
| CN103402988B (zh) | 2010-10-25 | 2015-11-25 | 范德比尔特大学 | 用于抑制昆虫宿主感觉的组合物 |
| CA2834817C (en) * | 2011-05-02 | 2019-01-15 | Lapenna, Jose Carlos | Fixative solution, for fixation and preservation of biological samples |
| US9578881B2 (en) | 2011-05-06 | 2017-02-28 | Vanderbilt University | Compositions for inhibition of insect sensing |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| ITMI20132192A1 (it) * | 2013-12-23 | 2015-06-24 | Purisa S R L | Composti antimicrobici |
| US20180000793A1 (en) | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
| US10791739B2 (en) | 2015-03-25 | 2020-10-06 | Vanderbilt University | Binary compositions as disruptors of orco-mediated odorant sensing |
| US10472687B2 (en) | 2016-01-08 | 2019-11-12 | Institute For Systems Biology | Methods to identify antituberculosis compounds |
| MA50256A (fr) | 2017-09-15 | 2020-07-22 | Aduro Biotech Inc | Composés de pyrazolopyrimidinone et leurs utilisations |
| KR20220024617A (ko) | 2019-07-17 | 2022-03-03 | 서밋 (옥스포드) 리미티드 | 리디닐라졸 및 이의 결정 형태의 제조방법 |
| JP7458622B2 (ja) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | 抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法 |
| CN110840897B (zh) * | 2019-11-28 | 2023-08-08 | 河北旺发生物科技有限公司 | 金属β-内酰胺酶抑制剂 |
| CN111166743B (zh) * | 2020-01-02 | 2022-03-22 | 中国医学科学院医药生物技术研究所 | 一类含噻唑结构化合物的抗感染用途 |
| GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
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| US3300505A (en) * | 1964-12-07 | 1967-01-24 | Ciba Geigy Corp | Ether-2-r-substituted benzimidazoles and derivatives and acid addition salts thereof |
| US3429890A (en) * | 1964-12-31 | 1969-02-25 | Merck & Co Inc | Certain 2-thiazolylbenzimidazole-1-oxy derivatives |
| US3325356A (en) * | 1965-08-20 | 1967-06-13 | Merck & Co Inc | Compositions and method for treating helminthiasis |
| GB1141936A (en) * | 1966-03-26 | 1969-02-05 | Shionogi & Co | Improvements in or relating to benzimidazole derivatives |
| DE1923481A1 (de) * | 1969-05-08 | 1970-11-12 | Hoechst Ag | Verfahren zur Herstellung von Amiden und Estern der 1-Hydroxy-benzimidazol-2-carbonsaeure |
| US3686110A (en) * | 1970-02-27 | 1972-08-22 | Meuch & Co Inc | 1-oxybenzimidazoles |
| US3646049A (en) * | 1970-03-05 | 1972-02-29 | Merck & Co Inc | Acylaminobenzimidazole derivatives |
| US3873558A (en) * | 1970-03-05 | 1975-03-25 | Merck & Co Inc | Process for preparing 1,5-substituted or 1,6-substituted benzimidazoles |
| CH556868A (de) * | 1970-03-05 | 1974-12-13 | Merck & Co Inc | Verfahren zur herstellung von 1-hydroxy-5-(oder 6-)-carbonyl-amino-2-(4'-thiazolyl)-benzimidazolen. |
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| CA2002859C (en) * | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
| AU4988997A (en) * | 1996-10-23 | 1998-05-15 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
| EP1109555A4 (en) * | 1998-08-31 | 2001-11-21 | Merck & Co Inc | NEW ANGIOGENIC INHIBITORS |
| JP4933730B2 (ja) * | 2001-05-04 | 2012-05-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用法 |
-
2003
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- 2003-11-03 WO PCT/US2003/035205 patent/WO2004041209A2/en active Application Filing
- 2003-11-03 CA CA2504448A patent/CA2504448C/en not_active Expired - Fee Related
- 2003-11-03 EP EP03783155A patent/EP1558341A4/en not_active Withdrawn
- 2003-11-03 AU AU2003291226A patent/AU2003291226B2/en not_active Ceased
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2010
- 2010-05-11 JP JP2010109145A patent/JP5175316B2/ja not_active Expired - Fee Related
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2012
- 2012-02-27 JP JP2012039805A patent/JP2012131813A/ja active Pending
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