JP2010107519A - 多重スペクトルコード化を用いる共焦点顕微鏡法並びに分光法コード化共焦点顕微鏡法のためのシステム及び装置 - Google Patents
多重スペクトルコード化を用いる共焦点顕微鏡法並びに分光法コード化共焦点顕微鏡法のためのシステム及び装置 Download PDFInfo
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Abstract
【解決手段】光ファイバ9の末端に接続された可撓性プローブによる内視鏡法に特に有用な走査型共焦点顕微鏡法システム及び装置。プローブは、対象物のある領域にわたって1次元に延びるスペクトル成分を有する多重スペクトル光のビームを送出し、別の次元での走査のために動かされる、回折格子12及びレンズ14を有する。上記領域の画像を提供するために、反射共焦点スペクトルが測定される。
【選択図】図1
Description
エム・ラヤディヤクシャ(M. Rajadhyaksha)等,「ヒトの皮膚の生体内共焦点走査型レーザ顕微鏡法:メラニンが強く対抗する(In vivo confocal scanning laser microscopy of human skin: Melanin provides strong contest)」,J. Invest. Derm.,1995年,第104巻,p.946,
ビー・アール・マスターズ(B. R. Masters)編,「眼科学における非侵襲性診断法(Noninvasive diagnostic techniques in ophthalmology)」,(米国ニューヨーク),スプリンガー−バーラグ(Springer-Verlag),1990年に収録されている、アール・エイチ・ウエッブ(R. H. Webb),「走査型レーザ検眼鏡(Scanning Laser opthalmoscope)」,及び
ジー・ジェイ・ターネイ(G. J. Tearney)、アール・エイチ・ウエッブ及びビー・イー・ブーマ(B. E. Bouma),「スペクトルコード化共焦点顕微鏡法(Spectrally encoded confocal microscopy)」,Optics Letters,1998年,第23巻,第15号,p.1152−1154。
9 光ファイバ
9a レンズ
10 多色入力ビーム
12 回折格子
14 対物レンズ
16 試料
Claims (19)
- 注目する人体領域に移動させることができる、共焦点顕微鏡システムと共に使うことができる装置であって、当該装置が、
光の放射軸に対し実質的に横断方向の1次元に延びる共焦点光スペクトルにより前記領域を照明するために回折スペクトルを分離する第1の手段及び、
少なくとも1つのレンズ手段とグレーティング手段とを有してなる第2の手段であって、当該少なくとも1つのレンズ手段とグレーティング手段を使って、前記共焦点光スペクトルを、前記実質的に横断方向の1次元に平行でない軸の周りに回転させて、前記領域の画像に関係する情報を得るものを有してなることを特徴とする装置。 - 組織に関連のある共焦点画像を提供する装置であって、当該装置が、
共焦点光スペクトルを提供するように構成された光を分散する第1の手段、
少なくとも1つのレンズ手段とグレーティング手段とを有してなる第2の手段であって、前記組織に前記共焦点光スペクトルの焦点を合わせるように構成され、前記光スペクトルが、前記光の放射軸に対し実質的に横断方向の1次元に延びているものであり、前記少なくとも1つのレンズ手段とグレーティング手段を使って、前記実質的に横断方向の1次元に平行でない軸の周りに前記共焦点光スペクトルを回転するもの、及び
前記組織に関連のある画像を提供するために前記共焦点光スペクトルの戻ってきたものに従って前記組織から戻ってきた光を検出するように構成された第3の手段を有してなることを特徴とする装置。 - 前記第1の手段が、さらに、光ファイバを経由して光を受けるように構成されていることを特徴とする請求項2に記載の装置。
- 前記第1の手段が、前記共焦点光スペクトルを前記横断方向の1次元に偏向するように構成された光偏向ユニットを有してなることを特徴とする請求項2に記載の装置。
- 前記第2の手段が、プリズム及び二重プリズム回折格子の内の少なくとも1つを含むことを特徴とする請求項4に記載の装置。
- 前記第2の手段が、更に、ホログラム回折格子を含むことを特徴とする請求項5に記載の装置。
- 前記第2の手段が、更に、前記プリズムの傾斜面に固定されている回折格子を含むことを特徴とする請求項5に記載の装置。
- 前記プリズムが反射型プリズムであることを特徴とする請求項5に記載の装置。
- 前記組織における前記共焦点光スペクトルを調節するように構成された第4の手段を更に含むことを特徴とする請求項2記載の装置。
- 前記第4の手段が、更に、別の方向の1次元に沿った方向に前記共焦点光スペクトルを動かすように構成されていることを特徴とする請求項9に記載の装置。
- 前記第4の手段が、更に、前記第2の手段を調節するように構成されていることを特徴とする請求項9に記載の装置。
- 前記第4の手段が、バルーンを有することを特徴とする請求項11に記載の装置。
- 光源からの光を入力するための手段を更に含み、前記第4の手段が、前記光を入力するための手段を調節するように構成されていることを特徴とする請求項9に記載の装置。
- 前記光を入力するための手段が、ファイバ/コリメータ集成体を含むことを特徴とする請求項13に記載の装置。
- 前記第4の手段が、前記ファイバ/コリメータ集成体を動かすために、回転カム機構、回転レバー機構および環状圧電バイモルフの内の少なくとも1つを含むことを特徴とする請求項14に記載の装置。
- 前記第4の手段が、縦方向の1次元とは別の方向の1次元に延びる軸の周りで、前記共焦点光スペクトルを移動させることを特徴とする請求項9に記載の装置。
- 前記第1の手段に送られる光を生成するように構成された光源を含むことを特徴とする請求項2に記載の装置。
- 注目する人体領域に移動させることができるプローブを有する共焦点顕微鏡システムにおいて、前記プローブが、光の放射軸に対し実質的に横断方向の1次元に延びる共焦点光スペクトルにより前記領域を照射するように構成された回折スペクトルを分離する第1の手段、及び、少なくとも1つのレンズ手段とグレーティング手段とを有してなる第2の手段であって、当該少なくとも1つのレンズ手段とグレーティング手段を使って、前記共焦点光スペクトルを前記実質的に横断方向の1次元に平行でない軸の周りに回転させて、反射された前記共焦点スペクトルを測定することにより、前記領域の画像を得る第2の手段を有してなることを特徴とする共焦点顕微鏡システム。
- 注目する人体領域に移動させることができる第1の手段であって、前記人体領域の軸上深さ次元に平行でない1次元に延びる共焦点光スペクトルにより前記領域を照明するもの及び、
前記共焦点光スペクトルを別の次元に沿って移動させ、反射された前記共焦点光スペクトルを測定することにより前記人体領域の画像を得るように構成された第2の手段を有してなる共焦点顕微鏡システムであって、
前記第2の手段が、(i)グリズム、(ii) 圧電変換器、(iii)複数のプリズム又はビーム偏向器、(iv)2重プリズムグレーティング及び(v)バルーンのうちの少なくとも一つからなることを特徴とするシステム。
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EP1461654A4 (en) | 2013-10-02 |
WO2003046636A9 (en) | 2004-02-26 |
JP2013056165A (ja) | 2013-03-28 |
JP2015157073A (ja) | 2015-09-03 |
AU2002351184A1 (en) | 2003-06-10 |
JP2005510323A (ja) | 2005-04-21 |
JP6098953B2 (ja) | 2017-03-22 |
EP1461654A1 (en) | 2004-09-29 |
WO2003046636A1 (en) | 2003-06-05 |
US20020122246A1 (en) | 2002-09-05 |
US6831781B2 (en) | 2004-12-14 |
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