JP2010105988A - External preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external preparation for skin, which is excellent in stability, excellent in a chapped skin-improving effect and a wrinkle-preventing/improving effect as skin ageing-preventing effects, gives tension to the skin, prevents stains to brighten the skin, is well compatible with the skin, is free from stickiness and the like, and gives excellent senses of use. <P>SOLUTION: There is provided the external preparation for the skin, characterized by containing (a) an oil-soluble plant extract containing astaxanthin compounds and extracted from the flower petals of Adonis palaestina, Adonis microcarpa, Adonis annua or Adonis aestivalis, in genus Adonis of Ranunculaceae in an amount of 0.0001 to 0.2 mass%, on the basis of total amount of the composition, as an active ingredient of the astaxanthin compounds, (b) a 4 to 8C dihydric alcohol in an amount of 2 to 15 mass%, (c) a polyphenol in an amount of 0.0001 to 0.2 mass%, and (d) a chelate agent in an amount 0.1 to 2 mass%. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to external preparations such as skin lotions, emulsions, creams, ointments, packs, hair tonics, foundations and the like for cosmetics and pharmaceuticals for skin, and more specifically, has excellent stability and improves skin roughness as an effect of preventing skin aging. The present invention relates to an external preparation for skin which is excellent in effect and wrinkle prevention / improving effect, gives skin to the skin, prevents blotting, brightens the skin, has a good fit to the skin, has no stickiness, and has a good feeling of use.

Astaxanthin, known as a pigment for shellfish such as shrimp and salmon, and fish such as salmon, has been reported to have anti-aging effects such as antioxidant and anti-inflammatory effects, and is widely used in health foods and skin external preparations. It has become like this. For example, in Patent Document 1, astaxanthin or an ester thereof is proposed as a strong antioxidant or anti-inflammatory agent, and further, it is proposed as an effective composition for pharmaceuticals and cosmetics using the same. Moreover, in patent document 2, the composition suitable for the external use which combined astaxanthin and various medicinal components is proposed. However, these astaxanthins have a problem in stability to heat and light, and have a big problem that they are easily discolored with time when formulated as an external preparation for cosmetics and pharmaceuticals containing water. In addition, since a high concentration is required to exert an effect such as sufficient skin aging prevention in an external preparation, the color of astaxanthins remains on the skin, the conformability to the skin becomes poor, and the skin is sticky. There was also a problem in usability. In addition, the conventional techniques have not been able to fully exert the effect of giving skin or lightening the skin. In addition, astaxanthins that have been widely used in the past were obtained from extracts of green algae belonging to the genus Haematococcus described in Patent Document 3, or from yeast cells of Phaffia rhodozyma described in Patent Document 4. And those obtained from krill shells described in Patent Document 5 are the main ones.
Japanese Patent Laid-Open No. 02-049091 JP 09-143063 A JP 2004-331512 A JP-T-2003-53888 Japanese Patent Laid-Open No. 06-200909

  The present invention relates to external preparations such as skin lotions, emulsions, creams, ointments, packs, hair tonics, foundations and the like for cosmetics and pharmaceuticals for skin, and more specifically, has excellent stability and improves skin roughness as an effect of preventing skin aging. Providing skin external preparations with excellent effects, wrinkle prevention / improving effects, skin elasticity, prevention of blotches to brighten skin, good skin conformability, no stickiness, etc. That is.

When research was repeated in order to solve the said subject, in addition to the specific plant extract and specific polyhydric alcohol, it came to obtain the target skin external preparation by combining polyphenol and a chelating agent in a specific ratio.
That is, the present invention
Per total composition: a. Oil-soluble plant extract containing astaxanthins extracted from petals of Adonis palaestina, Adonis microcarpa, Adonis annua, and Adonis aestivalis As an effective component of astaxanthins, 0.0001 to 0.2% by mass, b. 2 to 15% by mass of a dihydric alcohol having 4 to 8 carbon atoms, c. 0.0001 to 0.2% by weight of polyphenol, d. Skin external preparation characterized by containing 0.1-2 mass% of chelating agents,
It is.

  The external preparation for skin of the present invention is excellent in stability, as an anti-aging effect on skin, excellent in rough skin improvement effect, wrinkle prevention / improvement effect, gives skin flesh, prevents spots and brightens skin, and It is well-familiar with the skin, has no stickiness, and is easy to use.

  In the following, the invention will be described in more detail.

<A. Oil-soluble plant extract containing astaxanthins, hereinafter also referred to as component A>
The A component used in the present invention is characterized by having a red flower among the genus Fuchsiaceae, Adonis palaestina, Adonis microcarpa, Adonis annua, nuts An oil-soluble extract extracted from petals of Adonis aestivalis with various solvents and contains astaxanthins. Of these, oil-soluble extracts extracted with various solvents from petals of Adonis palaestina are preferred because of their effects, stability, and availability. The component A is prepared as follows, for example. That is, after freeze-drying the portion (flower part) containing the petals of Adonis palaestina, ethanol and an antioxidant are added and mixed under a nitrogen stream and left at room temperature for 24 hours. Then, after distilling off the solvent and washing with water, purified sunflower oil is added to prepare the astaxanthin to 5%. Here, the astaxanthin includes both astaxanthin and its derivatives. Astaxanthin has the following formula:

And astaxanthin derivatives include esters of astaxanthin. For example, amino acid esters such as glycine and alanine, carboxylic acid esters such as acetates and citrates and salts thereof, inorganic acid esters such as phosphates and sulfates and salts thereof, glycosides such as glucosides, or Monoesters selected from highly unsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, unsaturated fatty acids such as oleic acid and linoleic acid, saturated fatty acids such as palmitic acid and stearic acid, and the like Or a different type | mold diester body etc. are mentioned. A commercially available product is “Astarose” manufactured by Nippon Yakuhin Co., Ltd.

<B. C 4-8 dihydric alcohol Hereinafter also referred to as B component>
The dihydric alcohol of component B used in the present invention is a compound having two hydroxyl groups in one molecule and is generally called glycols. In the present invention, a dihydric alcohol having 4 to 8 carbon atoms is used among glycols. Specific examples include diethylene glycol, butylene glycol, isoprene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, heptylene glycol, octylene glycol and the like. Among them, from the viewpoint of antiseptic properties, feeling of use, etc. Are butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, octylene glycol, particularly preferred are 1,3-butylene glycol, 1,2-pentylene glycol, dipropylene glycol, 1,2 -Hexylene glycol, 1,2-octylene glycol.

<C. Polyphenol, hereinafter also referred to as C component>
The C component polyphenol used in the present invention is a compound having a plurality of phenolic hydroxyl groups (hydroxyl groups bonded to aromatic rings such as benzene ring and naphthalene ring) in the molecule, and includes flavonol, isoflavone, tannin, This is a general term for substances that can be produced when plants perform photosynthesis, such as catechin, quercetin, and anthocyanin. A part of the sugar content is changed, and it is contained as a component in the leaves, flowers, and bark of plants. It is a plant pigment and a bitter component, and is known to have a function to assist in the generation and activation of plant cells. It has become. Of these, nut polyphenols obtained from thin skins such as peanuts, walnuts, and pecan nuts, catechins, tannins, and anthocyanins are preferable, and nut polyphenols are more preferable.
In the present invention, it is possible to use polyphenols purified or synthesized from plant extracts, but plant extracts containing polyphenols may be used.

<D. Chelating agent Hereinafter also referred to as component D>
The D component chelating agent used in the present invention is a sequestering agent that catches heavy metal ions and alkaline earth metal ions in water, and generally includes organic chelating agents and inorganic chelating agents. Typical examples of organic chelating agents are aminocarboxylic acid chelating agents, such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), hydroxyethyliminodiacetic acid (HIDA), hydroxyethylethylenediaminetriacetic acid ( EHDTA), diethylenetriaminepentaacetic acid (DTPA), triethylenetetraaminehexaacetic acid (TTHA), dicarboxymethylglutamic acid (GLDA), dihydroxyethylglycine (DHEG), 1,3-propanediaminetetraacetic acid (PDTA), 1,3 -Diamino-2-hydroxypropanetetraacetic acid (DPTA-OH) and their salts. Examples of other chelating agents include hydroxyethane diphosphonic acid (HEDP), nitrilotrismethylene phosphonic acid (NTMP), phosphonobutane tricarboxylic acid (PBTC), citric acid, ascorbic acid, and salts thereof. Among them, preferred in terms of stability, safety, feeling in use, etc. are ethylenediaminetetraacetic acid (EDTA), 1,3-propanediaminetetraacetic acid (PDTA), 1,3-diamino-2-hydroxypropanetetraacetic acid (DPTA). -OH), hydroxyethanediphosphonic acid (HEDP), citric acid, ascorbic acid and their salts, particularly preferred are ethylenediaminetetraacetic acid (EDTA), hydroxyethanediphosphonic acid (HEDP), citric acid, Ascorbic acid and their salts.

(Skin external preparation)
The amount of component A in the external preparation for skin of the present invention is 0.0001 to 0.2% by weight, preferably 0.0005 to 0.1% by weight, more preferably 0 as astaxanthins in the total amount of the composition. .0005 to 0.05% by weight. If it is less than 0.0001% by weight, it is not possible to obtain a sufficient rough skin improvement effect, wrinkle prevention / improvement effect, or an effect to give the skin to the skin. This is disadvantageous in terms of cost.

  The amount of component B in the external preparation for skin of the present invention is 2 to 15% by weight, preferably 2 to 12% by weight, more preferably 2 to 10% by weight, based on the total amount of the composition. If it is less than 2% by weight, the conformability to the skin and the effect of improving skin roughness are weakened, and if it exceeds 15% by weight, the effect of sticking to the skin is weakened.

  The amount of component C in the external preparation for skin of the present invention is 0.0001 to 0.2% by weight, preferably 0.0005 to 0.2% by weight, more preferably 0.0005 to the total amount of the composition. 0.1% by weight. If it is less than 0.0001% by weight, it may cause problems with rough skin, wrinkle prevention / improvement effect, stain prevention, and stability, while if it exceeds 0.2% by weight, it may cause problems with lightening and stability and cost. Disadvantageous.

  The amount of component D in the external preparation for skin of the present invention is 0.1 to 2% by weight, preferably 0.1 to 1.8% by weight, more preferably 0.15 to 1.5% by weight in the total amount of the composition. %. If it is less than 0.1% by weight, problems in stability occur and the effect of imparting transparency and brightness to the skin is weakened. If it exceeds 2% by weight, conformability to the skin is deteriorated and stickiness may be caused.

In addition, it is also possible to mix | blend the additive normally used for cosmetics and a pharmaceutical with the skin external preparation of this invention in the range which does not impair the performance of the skin external preparation of this invention. For example, lower alcohols such as ethanol and isopropyl alcohol, polyhydric alcohols other than the components of the present invention such as propylene glycol, polyethylene glycol, glycerin, sorbitol, maltitol and isomaltitol, saccharides such as lactose, fructose and sucrose, fluid Hydrocarbon oils such as paraffin, liquid isoparaffin, squalane, petrolatum, solid paraffin, natural fats such as beef tallow, lard, fish oil, fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, tri Synthetic triglycerides such as glyceryl 2-ethylhexanoate, isopropyl myristate, isopropyl palmitate, cetyl palmitate, ethyl oleate, oleyl oleate, octyldodecyl myristate, beeswax, carnauba wax Waxes, highly polymerized dimethylpolysiloxane, polyether-modified dimethylpolysiloxane, amino-modified dimethylpolysiloxane and other silicone derivatives, ceramide, cholesterol, protein derivatives, lanolin, lanolin derivatives, lecithin and other oily bases, soap, acylmethyl Anionic surfactant such as taurine salt, amide ether sulfate ester salt, amide amino acid salt, amphoteric surfactant such as amidopropyldimethylaminoacetic acid betaine, polyoxyethylene alkyl ether, fatty acid ester of polyethylene glycol, sorbitan fatty acid ester, Polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, glycerin mono fatty acid ester, Non-ionic surfactants such as alkyl polyglucoside and alkanolamide, cationic surfactants such as alkyltrimethylammonium chloride, semipolar surfactants such as alkyldimethylamine oxide, organic compounds such as pyrrolidone carboxylate and sodium chloride Inorganic salts, acids and alkalis as pH adjusters, bactericides, antioxidants, blood circulation promoters, UV absorbers, UV scattering agents, natural extracts derived from animals and plants, vitamins, amino acids, photosensitizers, dyes, pigments and A fragrance etc. can be mix | blended.

  Hereinafter, the present invention will be described in more detail with reference to examples. In addition,% in a table | surface represents the mass%.

(Examples 1 to 3 and Comparative Examples 1 and 2)
A skin external preparation which is a skin lotion shown in Table 1 was prepared, and 7 items were evaluated according to the following evaluation criteria. The results are shown in Table 1.
<Evaluation items and evaluation criteria>
(1) Skin familiarity 20 females (28 to 61 years old) are panelists and the skin feel is determined as follows after washing the face, and the average of 20 persons is obtained. An average value of 1.5 points or more was evaluated as a skin external preparation having a good feel during use.
2 points: When you feel familiar with the skin during use.
1 point: If you feel a little familiar to the skin during use.
0 points: When the user feels that familiarity with the skin is bad.

(2) Stickiness after use 20 women (28 to 61 years old) are panelists, and after washing their face, the skin feel after 10 minutes using skin external preparations is determined as follows. An average value was obtained, and an average value of 1.5 points or more was evaluated as a skin external preparation having no stickiness after use.
2 points: When there is no stickiness.
1 point: When the skin feels somewhat sticky.
0 points: When the skin feels very sticky.

(3) Skin roughening effect 10 panelists (32 to 50 years old) with rough skin are used as panelists, and the skin condition when the topical skin preparation is used twice a day for 2 consecutive days is used as a sensory test. And it determined as follows, calculated | required the average value of 10 persons, and evaluated that the average value of 1.5 points or more is a skin external preparation with a rough skin improvement effect.
2 points: When it is felt that rough skin has been cured.
1 point: When it feels that the rough skin has been cured somewhat.
0 point: When it feels that the rough skin improvement effect is not seen at all.

(4) Wrinkle prevention / improvement effect About the condition of skin when 20 females (28 to 61 years old) with rough skin are used as panelists and the topical skin preparation is used twice a day for up to 4 weeks. A sensory test was performed and the following determination was made. The average value of 20 persons was obtained, and an average value of 1.5 points or more was evaluated as a skin external preparation having an effect of improving skin roughness.
2 points: When wrinkles are clearly reduced.
1 point: When wrinkles are felt to be slightly reduced.
0 points: When wrinkles are not reduced or increased.

(5) Skin tension 20 females (28 to 61 years old) are panelists, and the skin condition when the topical skin preparation is used twice a day for 2 consecutive days is subjected to a sensory test. The average value of 20 persons was determined, and an average value of 1.5 points or more was evaluated as a skin external preparation having an effect of giving a skin feel and transparency.
2 points: When the skin is clearly felt.
1 point: When it feels that the skin has a little bit.
0 points: When the skin feels non-sticky.

(6) Transparency and brightness of the skin 20 females (28 to 61 years old) are panelists, and the skin condition when using a topical skin preparation twice a day for 4 consecutive days is subjected to a sensory test. The average value of 20 persons was determined as follows, and an average value of 1.5 points or more was evaluated as a skin external preparation having an effect of imparting transparency to the skin and brightening it.
2 points: When the skin is clearly transparent and feels brighter.
1 point: When the skin is slightly transparent and feels brighter.
0 point: When it is felt that there is no change in the transparency and brightness of the skin.

(7) Stability over time The cosmetic was sealed in a transparent glass container and stored at 0 ° C., 25 ° C. and 40 ° C. for 3 months. The appearance was observed and evaluated in the following three stages.
○: Good stability (no change in appearance at any temperature)
Δ: Slightly poor (slightly at any temperature, causing precipitation or slight discoloration)
×: Stability failure (at any temperature, precipitation occurs or separates, or discoloration is significant)

  From Examples 1 to 3, the lotion using the ingredients of the present invention is excellent in rough skin improvement effect, wrinkle prevention / improvement effect, gives skin flesh, prevents spots and brightens the skin, and to the skin. It was easy to use, had no stickiness, and had excellent usability and stability. On the other hand, in Comparative Examples 1 and 2, sufficient performance was not obtained. That is, since the A component is not blended in Comparative Example 1, the effect of improving skin roughness, the effect of preventing wrinkle prevention / improvement, and the effect of giving the skin become weak and the transparency and brightness of the skin are not sufficient, and Comparative Example In No. 2, since the C component is not blended, the effect of improving rough skin, the effect of preventing and improving wrinkles, the transparency and brightness of the skin are weakened, and the stability is also problematic.

(Examples 4 to 6, Comparative Examples 3 and 4)
The skin external preparation which is an oil-in-water emulsion shown in Table 2 was prepared and evaluated by the same method as in Examples 1 to 3. The results are shown in Table 2.

  From Examples 4 to 6, the emulsions using the ingredients of the present invention are all excellent in improving rough skin, preventing wrinkles, and improving skin, giving skin flaking, preventing stains and brightening the skin, It was well-familiar, had no stickiness, excellent usability, and excellent stability. On the other hand, in Comparative Examples 3 and 4, sufficient performance is not obtained. That is, in Comparative Example 3, since the B component is not blended, the familiarity with the skin, the stickiness, and the rough skin improvement effect are deteriorated. Moreover, since d component is not mix | blended in the comparative example 4, the effect which provides a transparent feeling and brightness to skin becomes weak, and the problem is also produced in stability.

(Examples 7 and 8)
A skin external preparation which is an oil-in-water cream shown in Table 3 was prepared. Evaluation items (1) to (6) were prepared in the same manner as in Examples 1 to 3, and the stability over time was as described in (8) Evaluation was performed by the sex method. However, 10 components shown in Table 4 were used as common additive components.
The results are shown in Table 3.

(8) Stability over time The state when the cosmetic was sealed in a transparent glass container and stored at −5 ° C., 25 ° C., and 45 ° C. for 1 month was evaluated and evaluated in the following three stages.
○: Stability is good (no change in appearance at any temperature and no flickering etc.)
Δ: Slightly poor (slight precipitation or slight separation at any temperature, or slight lumps and lumps)
X: Poor stability (clearly precipitates or separates at any temperature.

  From Examples 7 and 8, the creams of the present invention are all excellent in improving rough skin, preventing wrinkles and improving, giving skin elasticity, preventing blotting and brightening the skin, and having good compatibility with the skin. In addition, there was no stickiness and the like, and the usability was excellent and the stability was also excellent.

(Examples 9 and 10)
The skin external preparation which is a water-in-oil cream shown in Table 5 was prepared and evaluated by the evaluation methods shown in Examples 7 and 8. However, 10 components shown in Table 6 were used as common additive components.

  From Examples 9 and 10, each of the creams of the present invention is excellent in rough skin improvement effect, wrinkle prevention / improvement effect, gives skin flesh, prevents blotting, brightens skin, and conformability to skin. In addition, it was not sticky and excellent in feeling of use, and also excellent in stability.

Claims (1)

Per total composition: a. Oil-soluble plant extract containing astaxanthins extracted from the petals of Adonis palaestina, Adonis microcarpa, Adonis annua, and Adonis aestivalis As an effective component of astaxanthins, 0.0001 to 0.2% by mass, b. 2 to 15% by mass of a dihydric alcohol having 4 to 8 carbon atoms, c. 0.0001 to 0.2% by weight of polyphenol, d. An external preparation for skin containing 0.1 to 2% by mass of a chelating agent.