JP2008120712A - Aqueous dispersion for cosmetic product, method for producing the same and cosmetic product - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an aqueous dispersion for cosmetic products having excellent stability and a method for producing the dispersion. <P>SOLUTION: The aqueous dispersion for cosmetic products contains a carotenoid essentially free from vitamin A activity and a ≥5C dihydric alcohol. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an aqueous dispersion for cosmetics excellent in stability, a method for producing the same, and a cosmetic containing the aqueous dispersion.

  It is known that carotenoids exhibit various physiological actions such as antioxidant action, immunostimulatory action, and anticarcinogenic action in vivo. For this reason, carotenoids are widely used as components of pharmaceuticals, health supplements, and cosmetics, and various base materials for formulating carotenoids as ingredients of foods and cosmetics have been developed.

  For example, Patent Document 1 discloses a method for preparing an aqueous liquid agent of a fat-soluble substance by stirring and mixing a fat-soluble substance such as vitamin A, an emulsifying material, a sugar alcohol such as sorbitol, and water, followed by high-pressure treatment. Is disclosed. Patent Document 2 discloses a method for producing a skin cosmetic base material by preparing an aqueous liposome solution using an oil-soluble component, phospholipids, polyhydric alcohol, and the like, and then freeze-drying the aqueous liposome solution. Is disclosed.

By the way, carotenoids having no vitamin A efficacy (for example, lutein, zeaxanthin, astaxanthin, canthaxanthin, lycopene) may have high physiological effects on the skin, such as skin aging, keratinization, and reduction of wrinkles. Are known. However, since these carotenoids are not substantially dissolved in water, when these carotenoids are blended in cosmetics mainly composed of water, they are not dispersed in water unless a large amount of surfactant is used. Is usually difficult to manufacture. Moreover, even if an aqueous dispersion can be produced, stability and homogeneity are low, such as precipitation occurring over time.
JP 2000-212066 A JP 2005-179313 A

  An object of the present invention is to provide a cosmetic aqueous dispersion excellent in dispersion stability and a method for producing the same, and to provide a cosmetic containing the aqueous dispersion.

The aqueous dispersion for cosmetics according to one aspect of the present invention is:
It contains a carotenoid substantially free of vitamin A potency and a dihydric alcohol having 5 or more carbon atoms.

  In the present invention, “a carotenoid having substantially no vitamin A potency” means that the biological potency as vitamin A is less than 1/24 of that of retinol. Α-carotene, β-carotene, cryptoxanthin Not included. That is, the vitamin A potency of carotenoids having substantially no vitamin A potency is less than that of α-carotene and β-cryptoxanthin (the vitamin A potency of α-carotene and β-cryptoxanthin is that of retinol. About 1/24 of the vitamin A potency).

  In the cosmetic aqueous dispersion, the carotenoid may be xanthophyll having substantially no vitamin A efficacy. In this case, the xanthophyll may be at least one selected from lutein, zeaxanthin, astaxanthin, and canthaxanthin.

  In the cosmetic aqueous dispersion, the carotenoid may be carotene having substantially no vitamin A potency. In this case, the carotene may be lycopene.

  In the cosmetic aqueous dispersion, the dihydric alcohol may be at least one selected from pentylene glycol, hexylene glycol, and dipropylene glycol.

  The cosmetic aqueous dispersion may further contain an emulsifying material. In this case, the emulsifier may be egg yolk phospholipid.

  The cosmetic according to one embodiment of the present invention is formulated with the cosmetic aqueous dispersion.

  The aqueous cosmetic composition according to one embodiment of the present invention is formulated with the cosmetic aqueous dispersion.

  The method for producing an aqueous dispersion for cosmetics according to one embodiment of the present invention comprises a step of preparing a dispersion by dispersing a carotenoid substantially free of vitamin A efficacy and a dihydric alcohol having 5 or more carbon atoms in water. And a step of high-pressure treatment of the dispersion.

  The cosmetic aqueous dispersion and the method for producing the same are excellent in stability and homogeneity. In addition, since the carotenoid is uniformly dispersed and the stability is excellent because the cosmetic water-based dispersion is blended, the cosmetic can continuously exhibit an antioxidant effect. .

  Hereinafter, an aqueous dispersion for cosmetics according to an embodiment of the present invention, a method for producing the same, and a cosmetic containing the aqueous dispersion will be described in detail. In the present embodiment and examples described later, “%” means “mass%”.

1. Cosmetic aqueous dispersion The cosmetic aqueous dispersion according to the present embodiment has a carotenoid substantially free of vitamin A efficacy (hereinafter also referred to as “component (I)”) and a carbon number of 5 or more. It is a composition containing a dihydric alcohol (hereinafter also referred to as “component (II)”). The cosmetic aqueous dispersion according to this embodiment can be used as a cosmetic base material, that is, an intermediate raw material for blending into cosmetics, and can be diluted with an aqueous medium at the time of use as necessary. Good.

1.1. Ingredient (I)
Component (I) is a carotenoid that has substantially no vitamin A potency. Component (I) may be used alone or in combination of two or more.

  Carotenoids are classified into carotenes, which are hydrocarbons, and xanthophylls containing oxygen atoms. Vitamin A efficacy is an indicator of biological efficacy as vitamin A (retinol) in vivo.

  Carotenoids with vitamin A potency usually contain an unsubstituted β-ionone ring and a polyene chain having 11 or more carbon atoms. On the other hand, the carotenoid having substantially no vitamin A potency is a xanthophyll having a β-ionone ring substituted with at least one of an oxygen atom and an oxygen atom-containing group, or does not contain a β-ionone ring. Caroten. Examples of the β-ionone ring substituted with an oxygen atom include a β-ionone ring substituted with a carbonyl group, and the β-ionone ring substituted with an oxygen atom-containing group is a β-ionone ring substituted with a hydroxyl group. -The ionone ring is mentioned.

  Carotenoids having substantially no vitamin A efficacy are roughly classified into xanthophylls having substantially no vitamin A efficacy and carotenes having substantially no vitamin A efficacy. Each will be described below.

1.1.1. Xanthophyll Xanthophylls having substantially no vitamin A efficacy include, for example, lutein, zeaxanthin, astaxanthin, canthaxanthin, isazeaxanthin, 3'-hydroxyechinenone, 4'-hydroxyechinenone, phenicoxanthine, 2 -Hydroxycanthaxanthin, idoxanthin, cluster xanthine, adonixanthin, anteraxanthin, bixin, capsanthin, capsorubin, crocetin, β-apo-8'-carotenal, ethyl-β-apo-8'-carotenoic acid, fucoxanthin, Examples include violaxanthin. Among these, at least one selected from lutein, zeaxanthin, astaxanthin, and canthaxanthin is preferable. All of these xanthophylls have a biological potency as vitamin A that is less than 1/24 of retinol.

  Lutein and zeaxanthin are pigments contained in petals of green and yellow vegetables such as kale and spinach and plants such as marigold. Lutein and zeaxanthin have an antioxidant action, and have an action of reducing skin aging, keratinization, and wrinkle generation by protecting skin cells from active oxygen generated by ultraviolet rays or the like. Astaxanthin is a red pigment contained in crustaceans, crustaceans and algae, and lycopene is a pigment contained in tomatoes, cocoons, etc., and these also have an antioxidant effect.

  Xanthophyll, which has virtually no vitamin A potency, generally has a low affinity for water. Moreover, since xanthophyll which does not have vitamin A efficacy substantially has high polarity compared with carotenoid which has vitamin A efficacy, it is guessed that the affinity to oil is low. Thus, xanthophyll, which has virtually no vitamin A potency, has a low affinity for both water and oil.

  According to the cosmetic aqueous dispersion according to the present embodiment, the vitamin A potency is substantially obtained by containing xanthophyll having substantially no vitamin A potency and a dihydric alcohol having 5 or more carbon atoms described later. Since the affinity of xanthophyll, which is not inherently present, to both water and oil can be increased, the stability of the dispersed state is excellent.

1.1.2. Carotene Examples of carotenes having substantially no vitamin A potency include lycopene, 3,4-dehydrolycopene, 1,2-dihydro-3,4-dehydrolycopene, 1,2-dihydrolycopene, 1,1 ′ , 2,2′-tetrahydrolycopene, 7,8,11,12-tetrahydrolycopene, 7,7 ′, 8,8′-tetrahydrolycopene, phytofluene, phytoene, among which lycopene is preferred. All of these carotenes have a biological potency as vitamin A of less than 1/24 of retinol.

  According to the cosmetic aqueous dispersion according to the present embodiment, the vitamin A potency is substantially increased by containing a carotene that has substantially no vitamin A potency and a dihydric alcohol having 5 or more carbon atoms, which will be described later. Therefore, it is possible to increase the affinity of the carotene, which is not included in the water and oil, to be excellent in dispersion stability.

1.1.3. Blending amount The concentration of the component (I) is preferably 0.001 to 1%, and preferably 0.01 to 0.1% with respect to the total amount of the cosmetic aqueous dispersion according to this embodiment. Is more preferable. When the concentration of the component (I) is less than 0.001%, the effect of the component (I) is hardly exhibited, while when it exceeds 1%, precipitation or separation may occur.

  The concentration of component (I) is preferably 0.002 to 50, more preferably 0.05 to 5, when the concentration of component (II) is 100 parts by mass.

1.2. Ingredient (II)
Component (II) is a dihydric alcohol having 5 or more carbon atoms. Component (II) may be used alone or in combination of two or more.

  Component (II) preferably has 5 to 8 carbon atoms, more preferably 5 to 7 carbon atoms. Moreover, it is preferable that component (II) has a secondary hydroxyl group.

  Examples of the component (II) include pentylene glycol, hexylene glycol, dipropylene glycol, isopentyldiol, 1,2-hexanediol, and 1,2-octanediol. Among these, pentyleneglycol and hexylene It is preferably at least one selected from glycol and dipropylene glycol. By using the dihydric alcohol as component (II), the stability of the aqueous dispersion according to this embodiment can be further improved.

  The amount of component (II) is preferably 2 to 50000 parts by mass, more preferably 200 to 2000 parts by mass, per 1 part by mass of component (I).

  Moreover, it is preferable that it is 1 to 50% with respect to the total amount of the aqueous dispersion for cosmetics which concerns on this embodiment, and, as for the density | concentration of component (II), it is more preferable that it is 5 to 20%.

1.3. Emulsifying Material The cosmetic aqueous dispersion according to one embodiment of the present invention may further contain an emulsifying material.

  As the emulsifying material, egg yolk phospholipid is preferable from the viewpoint of excellent moisture retention. Here, “egg yolk phospholipid” is a generic name for phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and their lyso form, which are constituent lipids of egg yolk, and refers to a lipid composition mainly composed of these. The phospholipid content in egg yolk phospholipids depends on the degree of purification, but when used as a cosmetic, it is preferably 70% or more, more preferably 90% or more. The phospholipid composition in egg yolk phospholipids is derived from egg yolk as a raw material, but specific phospholipids can be removed or enhanced by purification. Moreover, the lysolysis rate of an egg yolk phospholipid can be adjusted by making phospholipase A etc. act on an egg yolk phospholipid.

  Moreover, when blended in a cosmetic, egg yolk phospholipid is preferably hydrogenated in that it is stable against oxidation.

  In the cosmetic aqueous dispersion according to this embodiment, when egg yolk phospholipid is used as an emulsifying agent, the blending amount of egg yolk phospholipid is 1-1000 parts by mass with respect to 1 part by mass of component (I). Preferably, it is 5-100 mass parts.

  In addition, instead of egg yolk phospholipid or together with egg yolk phospholipid, what is generally used as a surfactant can be used as an emulsifying material. Examples of such emulsifiers include polyglycerin fatty acid esters, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyoxyethylene alkyl ethers, lauryl Examples include sodium sulfate, polyoxyethylene hydrogenated castor oil, sodium alkylbenzene sulfonate, and polyoxyethylene stearyl ether.

1.4. Aqueous medium In the aqueous dispersion for cosmetics according to the present embodiment, the aqueous medium for dispersing the above components is preferably a mixed medium with water or a solvent miscible with water. As the water-soluble medium, known alcohols that can be used as cosmetic ingredients can be used.

2. Cosmetics A cosmetic according to one embodiment of the present invention is formulated with the aqueous dispersion for cosmetics according to the above embodiment.

  Although the aspect of the cosmetic is not particularly limited, cosmetics applied to the skin (including the scalp), hair, and nails are preferable. For example, cleaning agents, lotions, shampoos, rinses, hair tonics, hair nourishing agents, Cleansing, shaving lotion, after shave lotion, after sun lotion, deodorant lotion, body lotion (including hand care lotion and foot care lotion), permanent solution, coloring solution, body shampoo, liquid bath preparation, cream (eg, vanishing cream, cold) Cream), milky lotion, serum, pack, lip balm, lip gloss, nail treatment, hair treatment, hair conditioner, hair styling, hair pack, body oil, etc. Aqueous cosmetic preparation of the essence and the like are more preferable.

3. Method for Producing Cosmetic Aqueous Dispersion A method for producing a cosmetic aqueous dispersion according to an embodiment of the present invention includes a carotenoid substantially free of vitamin A efficacy and a dihydric alcohol having 5 or more carbon atoms. And a step of preparing a crude dispersion by dispersing the mixture in a high pressure and a step of subjecting the coarse dispersion to high pressure.

  For example, the aqueous dispersion for cosmetics according to the present embodiment can be produced by the following method. In addition, the manufacturing method of the cosmetics aqueous dispersion which concerns on this embodiment is not limited to the following method, The cosmetics aqueous dispersion which concerns on this embodiment can be prepared with various methods.

  First, component (I), an emulsifying material, and a preservative are mixed and dispersed in component (II), and heated to 0 to 90 ° C. (preferably 50 to 75 ° C.) to be dissolved. Water is gradually added to this mixture to prepare a coarse dispersion. Next, the obtained coarse dispersion is subjected to high-pressure treatment at a pressure of 100 to 250 MPa (preferably 150 to 250 MPa) using a high-pressure emulsifier, so that the coarse dispersion is homogenized and the makeup according to the present embodiment. Aqueous dispersions can be produced.

  Examples of the high pressure emulsifier include a Menton-Gorin type high pressure homogenizer, a jet water flow reversal type high pressure emulsifier, a microfluidizer (manufactured by Microfull Disc), a nanomizer (manufactured by Nanomizer), and an optimizer (manufactured by Sugino Machine). Can be used.

4). EXAMPLES Next, the present invention will be described in more detail based on the following examples and test examples. The present invention is not limited to these.

4.1. Test example 1
The aqueous dispersions of Examples 1 to 3 and Comparative Examples 1 and 2 were prepared by the following method. In this test example, lutein was used as component (I), and dihydric alcohols shown in Table 1 were used as component (II). Lutein was blended as an oil containing 20% lutein (trade name “Flora GLO Lutein 20% Suspension”). This lutein-containing oil usually contains about 1% zeaxanthin. Moreover, hydrogenated egg yolk phospholipid (lecithin) (trade name “yolk lecithin PL-100P”, manufactured by QP Corporation) was used as an emulsifying material.

  The constituent components of the A phase and the constituent components of the B phase shown in Table 1 below were separately mixed and heated to 70 ° C. to obtain the A phase and the B phase. When the constituents of phase A were dissolved, a coarse dispersion was made by adding phase B. The coarse dispersion was homogenized at a pressure of 150 to 250 MPa using a high-pressure emulsifier (jet water flow reversal type high-pressure emulsifier) to prepare an aqueous dispersion.

  The obtained aqueous dispersion was divided into three parts, stored at 4 ° C., 40 ° C., and room temperature, and the state after 7 days was observed. The stability was determined according to the following criteria.

  S: Neither separation nor precipitation was observed in any temperature range.

  B: At any temperature range, at least one of separation and precipitation was observed.

  In Examples 1 and 2, when the state after 30 days was observed, neither separation nor precipitation was observed in any temperature range. In Example 1, when the state after 60 days was observed, neither separation nor precipitation was observed.

4.2. Test example 2
In the same manner as in Test Example 1, aqueous dispersions of Examples 4 to 6 and Comparative Examples 3 and 4 were prepared. The lycopene was blended as an extract containing 15% lycopene (trade name “Lyc-O-Mato 15% oleoresin”). Moreover, the hydrogenated egg yolk phospholipid (lecithin) used in Test Example 1 was used as the emulsifying material.

  The obtained aqueous dispersion was divided into three parts, stored at 4 ° C., 40 ° C., and room temperature, and the state after 7 days was observed and judged according to the following criteria.

  S: Neither separation nor precipitation was observed in any temperature range.

  B: At any temperature range, at least one of separation and precipitation was observed.

4.3. Test example 3
In the same manner as in Test Example 1, aqueous dispersions of Examples 6 to 8 were prepared. In addition, the lutein used the lutein containing oil used in Test Example 1. Moreover, hydrogenated egg yolk phospholipid (lecithin) (trade name “yolk lecithin PL-100P”, QP Corporation) was used as an emulsifying material. Furthermore, polyglycerin fatty acid esters and sucrose fatty acid esters having an HLB of 8 to 16 (polyglycerin fatty acid ester (trade name “NIKKOL Decaglyn”, Nikko Chemicals Co., Ltd.), sucrose fatty acid ester (trade name “Ryoto Sugar” Ester ", Mitsubishi Chemical Foods Co., Ltd.)).

  The obtained aqueous dispersion was divided into three parts, stored at 4 ° C., 40 ° C., and room temperature, and the state after 7 days was observed. The stability was determined according to the following criteria.

  S: Neither separation nor precipitation was observed in any temperature range.

  A: Neither separation nor precipitation was observed in any temperature range, but the viscosity increased.

4.4. Test example 4
In this test example, lotion was prepared using the aqueous dispersion of Example 1 according to the following formulation. Specifically, after the raw materials other than the aqueous dispersion of Example 1 were dissolved in purified water, this was mixed with the aqueous dispersion of Example 1 to prepare a lotion for this test example.

<< Prescription >> Aqueous Dispersion of Example 1 20.0 (%)
1,3-butylene glycol 5.0 (%)
Glycerin 5.0 (%)
Sodium hyaluronate 0.01 (%)
Chamomile extract 0.01 (%)
Methylparaben 0.1 (%)
Purified water 69.88 (%)
――――――――――――――――――――――――――
Total 100.00 (%)
The lotion obtained in this test example was excellent in feeling of use and moisture retention, and was stable with no precipitation over a long period of time.

4.5. Test Example 5
In this test example, a cosmetic liquid was prepared using the aqueous dispersion of Example 2 according to the following formulation. Specifically, after the raw materials other than the aqueous dispersion of Example 2 were dissolved in purified water, this was mixed with the aqueous dispersion of Example 2 to prepare the cosmetic liquid of this test example.

<< Prescription >> Aqueous dispersion 50.0 (%) in Example 2
Glycerin 20.0 (%)
1,3-butylene glycol 10.0 (%)
Xanthan gum 1.5 (%)
Sodium hyaluronate 0.1 (%)
Hydrolyzed eggshell membrane 0.1 (%)
Methylparaben 0.1 (%)
Perfume
Purified water 18.2 (%)
―――――――――――――――――――――――――――
Total 100.0 (%)
The cosmetic liquid obtained in this test example was excellent in feeling of use and moisture retention, and was stable with no precipitates formed over a long period of time.

4.6. Test Example 6
In this test example, a shampoo was prepared using the aqueous dispersion of Example 1 according to the following formulation. Specifically, purified water is heated to 70 ° C., raw materials other than the purified water and the aqueous dispersion are mixed with the purified water, and the liquid obtained by cooling is mixed with the aqueous dispersion of Example 1. Then, the shampoo of this test example was prepared.

<< Prescription >> Aqueous Dispersion of Example 1 20.0 (%)
Polyoxyethylene (3) lauryl sulfate
Triethanolamine (40%) 30.0 (%)
Sodium lauryl sulfate (30%) 15.0 (%)
Lauroyl diethanolamide 3.0 (%)
Polyethylene glycol distearate 2.0 (%)
Dimethicone polyol 0.2 (%)
EDTA-2Na 0.1 (%)
Citric acid 0.1 (%)
Methylparaben 0.1 (%)
Perfume
Purified water 29.5 (%)
―――――――――――――――――――――――――――
Total 100.0 (%)
The shampoo obtained in this test example was excellent in the feeling of use, and was stable with no precipitation over a long period of time.

4.7. Test Example 7
In this test example, a hair set lotion was prepared using the aqueous dispersion of Example 1 according to the following formulation. Specifically, the aqueous dispersion of Example 1 is mixed with purified water, and raw materials other than the purified water and the aqueous dispersion of Example 1 are dissolved in ethanol, and then the purified water and the ethanol are gradually added. The hair set lotion of this test example was prepared by mixing.

<< Prescription >> Aqueous dispersion 10.0 (%) of Example 1
Polyvinylpyrrolidone 3.0 (%)
Polyoxyethylene (20) oleyl ether 0.1 (%)
1,3-butylene glycol 1.0 (%)
Methyl polysiloxane 0.5 (%)
Ethyl alcohol 20.0 (%)
Perfume
Purified water 65.4 (%)
―――――――――――――――――――――――――――
Total 100.0 (%)
The hair set lotion obtained in this test example was excellent in the feeling of use and was stable with no precipitation over a long period of time.

Claims (11)

  An aqueous dispersion for cosmetics containing a carotenoid substantially free of vitamin A efficacy and a dihydric alcohol having 5 or more carbon atoms.   The cosmetic aqueous dispersion according to claim 1, wherein the carotenoid is xanthophyll having substantially no vitamin A efficacy.   The cosmetic aqueous dispersion according to claim 2, wherein the xanthophyll is at least one selected from lutein, zeaxanthin, astaxanthin, and canthaxanthin.   The cosmetic aqueous dispersion according to claim 1, wherein the carotenoid is carotene having substantially no vitamin A efficacy.   The cosmetic aqueous dispersion according to claim 4, wherein the carotene is lycopene.   The cosmetic aqueous dispersion according to any one of claims 1 to 5, wherein the dihydric alcohol is at least one selected from pentylene glycol, hexylene glycol, and dipropylene glycol.   The aqueous dispersion for cosmetics according to any one of claims 1 to 6, further comprising an emulsifying material.   The cosmetic aqueous dispersion according to claim 7, wherein the emulsifying material is egg yolk phospholipid.   A cosmetic comprising the cosmetic aqueous dispersion according to any one of claims 1 to 8.   An aqueous cosmetic containing the aqueous dispersion for cosmetics according to any one of claims 1 to 8.   A cosmetic aqueous system comprising a step of dispersing a carotenoid substantially free of vitamin A potency and a dihydric alcohol having 5 or more carbon atoms in water to prepare a dispersion, and a step of subjecting the dispersion to high-pressure treatment. A method for producing a dispersion.