JP2021161119A - Composition - Google Patents

Abstract

To provide a novel composition capable of suppressing the acceleration of the fading of carotenoids which is caused by the incorporation of nicotinic acid amide into a composition containing a carotenoid.SOLUTION: There is provided a composition comprising (A) a carotenoid, (B) nicotinic acid amide and (C) tranexamic acid. The carotenoid preferably includes astaxanthin or β-carotene, more preferably astaxanthin.SELECTED DRAWING: None

Description

The present invention relates to compositions. More specifically, it relates to an external skin preparation.

Carotenoids are known to have useful effects on the skin such as anti-aging and prevention / improvement of age spots. Carotenoids are naturally occurring pigments of yellow to red terpenoids that can be found in plants, algae, and bacteria. Carotenoids are widely distributed in the animal and plant kingdoms in nature, and have functions such as antioxidant effect, anti-inflammatory effect (for example, Patent Document 1 and Patent Document 2), and skin anti-aging effect (for example, Patent Document 3). Is also known. Therefore, it is being studied and implemented to add carotenoids to foods, cosmetics, raw materials for pharmaceuticals, processed products thereof, and the like.

In addition, nicotinamide is a derivative of nicotinic acid, also called nicotinamide or niacinamide, and is used for prevention and treatment of nicotinic acid deficiency. In addition, it is known to have rough skin improvement, whitening effect, anti-aging effect, etc., and it is expected to develop more excellent anti-aging cosmetics by combining nicotinamide and carotenoid.

On the other hand, carotenoids are structurally unstable, and it is known that deterioration is promoted by heat, light, oxidation, etc., and it is difficult to stably contain carotenoids in a pharmaceutical product. Therefore, in addition to devising measures such as inclusion with hard capsules (such as a technique for using ascorbic acid as a stabilizer) (for example, Patent Document 4), a specific oil-soluble plant extract, alcohol, and nuts have been devised. A method of combining a polyphenol and a chelating agent (for example, Patent Document 5), a method of adding an organic acid to a carotenoid-containing composition (for example, Patent Document 6), iron ions, an iron chelating agent, dibropyrene glycol, and water-soluble oxidation. A method for stabilizing a carotenoid is disclosed by using it in combination with an inhibitor (for example, Patent Document 7) or in combination with a red wine extract or a collagen peptide (for example, Patent Document 8).

Japanese Unexamined Patent Publication No. 2-49091 Japanese Unexamined Patent Publication No. 9-143063 Japanese Unexamined Patent Publication No. 5-155736 Japanese Unexamined Patent Publication No. 1-2152363 JP-A-2010-105988 Japanese Unexamined Patent Publication No. 6-264055 Japanese Unexamined Patent Publication No. 2012-31067 JP-A-2009-159929

However, in all of these methods, if the stabilizer is expensive, the stabilizing effect is not sufficient, or if the stabilizer is a water-soluble component, it is difficult to disperse the carotenoid into an oil-based component that dissolves the carotenoid. However, there was a problem that a sufficient effect could not be exhibited. Furthermore, it was not satisfactory from the viewpoint of enhancing the stability of carotenoids known to have useful effects and sustaining the effects for a long period of time.

In addition, the inventors tried to add nicotinamide to the composition containing carotenoid in order to obtain a composition excellent in skin roughness improvement, whitening effect, anti-aging effect, etc., but the carotenoid faded. Was found to be significantly promoted.

A main object of the present invention is to suppress the promotion of fading of carotenoids that occurs when a composition containing carotenoids contains nicotinamide.

In view of this situation, the present inventors have diligently studied to solve the above problems, and as a result, by adding tranexamic acid, the fading of the carotenoid that occurs when the composition containing the carotenoid contains nicotinamide is promoted. We have found that it can be remarkably suppressed, and have completed the present invention.

That is, the present invention
The following components (A) to (C);
It relates to a composition containing (A) carotenoid (B) nicotinamide (C) tranexamic acid.

The present invention relates to a composition in which the residual rate of absorbance of the carotenoid at 470 nm is 50% or more when exposed at 30 ° C. and 8900 lp for 14 days.

The present invention relates to a composition in which the content mass ratio (B) / (C) of the component (B) to the component (C) is 0.5 to 10.

The present invention relates to a composition in which the component (A) carotenoid is astaxanthin.

The present invention further relates to a composition further containing component (D) a nonionic surfactant.

The present invention relates to a cosmetic or a skin external preparation containing the above composition.

The present invention relates to a carotenoid fading inhibitor containing the component (C) tranexamic acid as an active ingredient.

The present invention relates to a method for suppressing fading of a carotenoid by mixing the component (C) tranexamic acid with a composition containing the component (A) carotenoid.

The present invention can provide a composition that suppresses the fading of a carotenoid, and a fading inhibitor or a method for suppressing fading in a composition containing a carotenoid and a nicotinamide.

Hereinafter, the present invention will be described in detail. In addition, in this specification, "~" means the range including the numerical values before and after it.

The carotenoid of the component (A) in the present invention includes any of plants, algae and bacteria. Further, the carotenoids in the present invention are not limited to those of natural origin, and any carotenoids obtained according to a conventional method are included.

Examples of carotenoids include hydrocarbons (carotenes), their oxidized alcohol derivatives (xanthophylls), and esters thereof. Unless otherwise specified in the present invention, these compounds are collectively referred to as "carotenoids". Examples of carotenoids are actinioerythrol, astaxanthin, bixin, cantaxanthin, capsantin, capsorbin, β-8'-apo-carotene (apocarotene), β-12'-apo-carotene, α-carotene, β-carotene. , "Carotene" (mixture of α- and β-carotene), γ-carotene, δ-carotene, β-cryptoxanthin, ekinenone, palm oil carotene, lutein, lycopene, biorelitrin, zeaxanthin, fucoxanthin and hydroxyl among them Alternatively, esters of those containing carboxyl can be mentioned.

The carotenoid used in the present invention is preferably astaxanthin or β-carotene, which has an antioxidant effect, an anti-inflammatory effect, a skin anti-aging effect, a whitening effect and the like, and is known as a colorant in the range of yellow to red. , More preferably astaxanthin.

Astaxanthin is a red dye with an absorption maximum at 476 nm (ethanol) and 468 nm (hexane), and has a chemical structure of 3,3'-dihydroxy-β, β-carotene-4,4'-dione (C ₄₀ H ₅₂ O). ₄ : The molecular weight is 596.82). In the present invention, unless otherwise specified, the above-mentioned derivatives such as astaxanthin and astaxanthin ester are collectively referred to as "astaxanthins".
Β-carotene is a red-orange dye having an absorption maximum at 453 nm (hexane), and has a chemical structure of β, β-carotene (C ₄₀ H ₅₆ : molecular weight 536.88).

Astaxanthin used in the present invention may be, for example, extracted from natural products such as oyster, salmon, trout, Fukujusou, red yeast, Haematococcus algae, or synthetic products, but extracted from Haematococcus algae. (Hereinafter, also referred to as Haematococcus algae extract) is particularly preferable from the viewpoint of quality and productivity. The extraction solvent for obtaining astaxanthin from a natural product may be an aqueous solvent or an organic solvent. As the organic solvent, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, ethyl acetate, ether, hexane and the like can be used. Further, carbon dioxide or the like in a supercritical state can also be used. These solvents may be used alone or in combination of two or more.

Specific sources of the Haematococcus algae extract that can be used in the present invention include Haematococcus pluvialis, Haematococcus lacustris, Haematococcus capensis, and Haematococcus capensis. Examples include Haematococcus droebakensis and Haematococcus zimbabwiensis. Further, a widely commercially available Haematococcus algae extract can be used. For example, ASTOTS-S, -5O, -10O, etc. manufactured by Fuji Film Co., Ltd., Astaxanthin oil 50F manufactured by Fuji Chemical Industry Co., Ltd., the same. 5F and the like, astaxanthin-5C and 20C manufactured by Oryza Oleochemical Co., Ltd., astaxanthin 5% oil manufactured by Bioactives Japan Co., Ltd., Astaxanthin (registered trademark) AR1 and AR5 manufactured by Biogenic Co., Ltd. can be mentioned. Examples of krill-derived materials include Astax-S manufactured by Marine Daio Co., Ltd.

It is known that β-carotene used in the present invention is substantially insoluble in water and practically insoluble in organic solvents such as ethanol, cyclohexane, and ether. Furthermore, it is sensitive to light and heat and may be easily decomposed by contact with oxygen in the air. There are many commercially available products, such as β-carotene manufactured by Tokyo Chemical Industry Co., Ltd. and β-carotene manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.

The content of the component (A) in the composition of the present invention is not particularly limited, but is preferably 0. It is 0.0001 to 0.1% by mass (hereinafter simply referred to as “%”), and more preferably 0.00001 to 0.01%. When an extract is used, the concentration of the extract is not limited as long as the amount of the solute is within the above range.

The nicotinamide of the component (B) in the present invention is an amide compound of nicotinic acid (vitamin B3, also called niacin), and is a derivative of nicotinamide, also called nicotinamide or niacinamide. Nicotinamide is a water-soluble vitamin, which is a known substance that is one of the B vitamins, and can be extracted from natural products (rice bran, etc.) or synthesized by a known method. Specifically, those listed in the 15th revised Japanese Pharmacopoeia 2008 can be used.

The content of the component (B) in the composition of the present invention is not particularly limited, but is preferably 0.001 to 10%, preferably 0.5 to 8%, from the viewpoint of excellent anti-aging effect. It is more preferable, and it is particularly preferable that it is 3 to 6%.

The component (C) tranexamic acid used in the composition of the present invention is a kind of amino acid represented by the chemical name: trans-4- (aminomethyl) cyclohexane-1-carboxylic acid, and is used for the skin as described above. In addition to being known as an ingredient with whitening and anti-inflammatory effects, it may also be used as a hemostatic agent.

The content of the component (C) in the composition of the present invention is not particularly limited, but is preferably 0.1 to 5% from the viewpoint of the carotenoid fading inhibitory effect in the composition containing carotenoid and nicotinamide. ~ 2% is more preferable.

The mass ratio (B) / (C) of the component (B) to the component (C) is not particularly limited, but is preferably 100 or less, preferably 10 or less, from the viewpoint of the carotenoid fading suppressing effect. Is more preferable, and 4 or less is particularly preferable. Further, the lower limit is preferably 0.002 or more, and more preferably 0.5 or more.

The composition of the present invention can further contain the component (D) nonionic surfactant. Ingredient (D) The nonionic surfactant is not particularly limited, and is, for example, sucrose fatty acid ester, polyglyceryl oleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, and polyoxyethylene hydrogenated castor oil. , Polyoxyethylene hydrogenated castor oil isostearate, polyoxyethylene polyoxypropylene decyltetradecyl ether, and the like. Among these, from the viewpoint of the fading inhibitory effect of carotenoids, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil isostearate, and polyoxyethylene polyoxy Polyoxyethylene-based nonionic surfactants to which ethylene oxide is added, such as propylene decyl tetradecyl ether, are preferable, and polyoxyethylene hydrogenated castor oil isostearate and polyoxyethylene polyoxypropylene decyl tetradecyl ether are more preferable.
The content of the component (D) in the composition of the present invention is not particularly limited, but is preferably 0.01 to 1%, more preferably 0.03 to 0.5%, from the viewpoint of the carotenoid fading inhibitory effect.

Examples of the aqueous component used in the present invention include so-called water such as deionized water, distilled water, purified water, hot spring water, and plant-derived steam distilled water such as rose water and lavender water. The content of the aqueous component in the composition of the present invention is not particularly limited, but is preferably 40 to 90%.

In addition to the above-mentioned components, the composition of the present invention includes cosmetics, external skin preparations, foods, inks, detergents, soft finishing agents for clothing, fragrances, as long as the effects of the present invention are not impaired. Ingredients used in formulations such as deodorants and textiles, that is, oily ingredients, surfactants other than ingredient (D), metal salts, gelling agents, powders, water-soluble polymers, film-forming agents, resins, UV protection agents, inclusion compounds, antibacterial agents, preservatives, fragrances, deodorants, salts, pH regulators, antioxidants, refreshing agents, animal / microorganism-derived extracts, plant extracts, blood circulation promoters, astringents , Anti-fat leak agent, whitening agent, anti-inflammatory agent, active oxygen scavenger, cell activator, moisturizer, chelating agent, keratolytic agent, enzyme, hormones, ingredient (A), vitamins other than ingredient (B) Etc. can be added.

The surfactant is not particularly limited, and examples thereof include an anionic surfactant, a cationic surfactant, and an amphoteric surfactant.

The oily component is not particularly limited, but regardless of the origin of animal oils, vegetable oils, synthetic oils, etc., and the properties of solid oils, semi-solid oils, liquid oils, volatile oils, etc., hydrocarbons, fats and oils, waxes, etc. Examples include hydrogenated oils, ester oils, fatty acids, higher alcohols, silicone oils, fluorine-based oils, lanolin derivatives, oil-based gelling agents and the like. The content of the oily component in the composition of the present invention is not particularly limited, but when it is less than 10%, the fading suppressing effect of astaxanthin can be remarkably evaluated.

Moisturizers include, for example, proteins, mucopolysaccharides, collagen, elastin, keratin, polyhydric alcohols, etc., antioxidants include, for example, tocopherol, ascorbic acid, etc., and preservatives include, for example, paraoxybenzoic acid ester, phenoxyethanol, etc. Can be mentioned.

The method for producing the composition of the present invention is not particularly limited, and the composition is prepared by a conventional method. For example, the above-mentioned components (A) to (C) may be further prepared by adding the above-mentioned optional components as necessary and mixing them.

The composition of the present invention can be carried out in various forms such as liquid, gel, cream, solid, and mousse, and is contained in a container that can be sprayed into a mist and sprayed into a mist. May be used. The dosage form of the product of the present invention is not particularly limited, such as a solubilized type, an oil-in-water type, a water-in-oil type, an oil-based type, a water-in-oil-in-water type, an oil-in-oil-in-oil type, and a multilayer type.

The use of the composition of the present invention is not particularly limited, and it is used as a composition for various purposes such as cosmetics, external skin preparations, foods, inks, detergents, soft finishes for clothing, air fresheners, deodorants, and textiles. be able to. The composition of the present invention is preferably used as a cosmetic or a skin external preparation from the viewpoint of being excellent in anti-aging effect and the like.

Examples of foods (including animal feeds) of the present invention include frozen foods, powdered foods, sheet foods, bottled foods, canned foods, retort foods, capsule foods, tablet foods, and the like, as well as proteins, for example. It may be in any form such as a naturally liquid food containing sugars, fats, trace elements, vitamins, emulsifiers, fragrances and the like, a semi-digested nutritional food and a component nutritional food, and a processed form such as a drink.

Examples of the cosmetics of the present invention are not particularly limited, and for example, skin care cosmetics such as milky lotions, creams, lotions, beauty liquids, packs, foundations, cheeks, lipsticks, eye colors, mascara, eyeliners, manicures, etc. It may be in any form such as make-up cosmetics, hair nourishing agents, hair tonics, shampoos, rinses, hair cosmetics such as hair wax, and cleaning agents such as washing pigments.

The example of the external skin preparation of the present invention is not particularly limited, and may be in any form of, for example, an external gel, a cream, an ointment, a liquid, a liniment, a happ, a sheet, or the like.

Hereinafter, the present invention will be described in more detail with reference to examples. It should be noted that these do not limit the present invention in any way.

<Test of carotenoid fading inhibitory effect when nicotinamide is contained>

Example 1: When the carotenoid is particularly astaxanthin (Products 1 and 2 of the present invention)

The present inventor has found that the combination of astaxanthin and nicotinamide promotes the fading of astaxanthin by light, and that the fading promotion can be suppressed in tranexamic acid. The results are shown in Table 1.

After preparing each sample solution shown in Table 1, they were transferred to a standard bottle (No. 5 standard bottle, Kawaguchi Yakuhin Kagaku) and stored under exposure conditions (30 ° C., 8900 lp) for 14 days.

Changes in the astaxanthin residual rate in each sample solution were observed by absorbance measurement. 100 μl was dispensed into a 96-well plate (manufactured by Falcon) and measured with a microplate reader (manufactured by Biotech).

The astaxanthin residual ratio was calculated by measuring the absorbance of each sample solution at 470 nm and using the following formula (1). Here, the astaxanthin-containing system refers to the astaxanthin-containing product of the present invention and the comparative product, and the astaxanthin-free system refers to the astaxanthin 5% solution (astaxanthin-5C (oriza oil) in each of the present invention product and the comparative product. (Manufactured by Kasha)), which is prepared in place of tri (capril capric acid) glyceryl.

Astaxanthin residual rate (%) = ((AB) / (CD)) × 100 ... (1)

A = Absorbance of UV-irradiated astaxanthin-containing system B = Absorbance of UV-irradiated astaxanthin-free system C = Absorbance of UV-unirradiated astaxanthin-containing system D = Absorbance of UV-unirradiated astaxanthin-free system

From the results in Table 1, the fading of astaxanthin was promoted in the comparative products 1 and 2 containing the component (B) as compared with the comparative product 3 not containing the component (B), and the astaxanthin due to the component (B) was transferred to astaxanthin. We were able to confirm the effect on the stability of.
On the other hand, in the products 1 to 5 of the present invention in which the component (C) was blended in addition to the component (B), no remarkable fading of astaxanthin was observed, and the astaxanthin had an excellent fading suppressing effect.

Example 2: When the carotenoid is particularly β-carotene (Products 1 to 3 of the present invention)

The present inventor has found that the combination of β-carotene and nicotinamide promotes the fading of β-carotene by light, and that the fading promotion can be suppressed in tranexamic acid. The results are shown in Table 2.

After preparing each sample solution shown in Table 2, the sample solution was transferred to a standard bottle (No. 5 standard bottle, Kawaguchi Yakuhin Kagaku) and stored under exposure conditions (30 ° C., 8900 lp) for 8 hours.

Changes in the β-carotene residual ratio in each sample solution were observed by absorbance measurement. 200 μl was dispensed into a 96-well plate (manufactured by Falcon) and measured with a microplate reader (manufactured by Biotech).

The β-carotene residual ratio was calculated by measuring the absorbance of each sample solution at 455 nm and using the following formula (1). Here, the β-carotene-containing system refers to the product of the present invention and the comparative product containing β-carotene, and the β-carotene-free system refers to 5% of β-carotene in the respective product of the present invention and the comparative product. A solution (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) prepared in place of tri (capril capric acid) glyceryl.

β-carotene residual rate (%) = ((AB) / (CD)) × 100 ... (1)

A = Absorbance of UV-irradiated β-carotene-containing system B = Absorbance of UV-irradiated β-carotene-free system C = Absorbance of UV-unirradiated β-carotene-containing system D = Absorbance of UV-non-irradiated β-carotene-free system

From the results in Table 2, the fading of β-carotene was promoted in the comparative product 1 containing the component (B) as compared with the comparative product 2 not containing the component (B), and the β-carotene due to the component (B) was promoted. We were able to confirm the effect on stability on carotene.
On the other hand, the products 1 to 3 of the present invention in which the component (C) was blended in addition to the component (B) were excellent in the effect of suppressing the fading of β-carotene without observing remarkable fading of β-carotene.

Example 3 [Toner]
(Ingredient) (%)
1. 1. Ethanol 4.88
2. PEG-50 hydrogenated castor oil isostearate (Note 4) 0.3
3. 3. Methylparaben 0.1
4. Astaxanthin 5% solution (Note 1) 0.02
5.1,3-butylene glycol 0.5
6. Citric acid 0.03
7. Sodium citrate 0.1
8. Residual amount of purified water 9. Tranexamic acid (Note 3) 1.0
10. Nicotinamide (Note 2) 4.0

(Production method)
A: Ingredients (1) to (4) are mixed.
B: Ingredients (5) to (10) are mixed.
A was added to B and stirred to obtain a lotion.

The lotion of Example 3 was excellent in the fading-suppressing effect of astaxanthin.

Example 4 [Toner]
(Ingredient) (%)
1. 1. Ethanol 4.88
2. PEG-50 hydrogenated castor oil isostearate (Note 4) 0.3
3. 3. Methylparaben 0.1
4. β-carotene 5% solution (Note 5) 0.02
5.1,3-butylene glycol 0.5
6. Citric acid 0.03
7. Sodium citrate 0.1
8. Residual amount of purified water 9. Tranexamic acid (Note 3) 1.0
10. Nicotinamide (Note 2) 4.0

(Production method)
A: Ingredients (1) to (4) are mixed.
B: Ingredients (5) to (10) are mixed.
Add A to B and stir to obtain a lotion.

The lotion of Example 4 was excellent in the fading-suppressing effect of β-carotene.

Example 5 [milky lotion]
(Ingredient) (%)
1. 1. Polyoxyethylene monostearate (20 mol) sorbitan 1.0
2. Polyoxyethylene trioleate (20 mol) sorbitan 0.5
3. 3. Glyceryl monostearate 1.0
4. Stearic acid 0.5
5. Behenyl alcohol 0.5
6. Squalene 4.0
7. Carboxyvinyl polymer 0.1
8. Methyl paraoxybenzoate 0.1
9. Sodium hydroxide 0.05
10. Tranexamic acid (Note 3) 1.0
11. Nicotinamide (Note 2) 4.0
12. Residual amount of purified water 13. Ethanol 5.0
14. Astaxanthin 5% solution (Note 1) 0.01
15. Fragrance 0.05

(Production method)
A: Ingredients (1) to (6) are uniformly mixed at 70 ° C.
B: Ingredients (7) to (12) are uniformly mixed at 70 ° C.
C: Add A to B to emulsify and cool to room temperature.
D: (13) to (15) were added and mixed uniformly to obtain a milky lotion.

The milky lotion of Example 5 was excellent in the fading-suppressing effect of astaxanthin.

Example 6 [Cream]
(Ingredient) (%)
1. 1. Hydrogenated soybean lysophospholipid 1.0
2. Cholesterol complex hydrogenated soybean phospholipid (Note 6) 1.0
3. 3. Squalene 5.0
4. Heavy Liquid Isoparaffin 2.0
5. Neopentyl glycol dicaprate 5.0
6. Glyceryl tri2-ethylhexanoate 5.0
7. Phytosteryl oleate 1.0
8. Shea butter 1.0
9. Ceramide-2 0.01
10. Setostearyl alcohol 3.0
11. Behenyl alcohol 2.0
12. Astaxanthin 5% solution (Note 1) 0.01
13. Dipropylene glycol 20.0
14. Polyoxyethylene sorbitan monooleate 0.5
15. Sorbitan sesquioleate 0.5
16. Polyoxypropylene (10P.O.) Methylglucoside 5.0
17. Sodium metabisulfite 0.01
18. Sodium monohydrogen phosphate 0.1
19. Sodium dihydrogen phosphate 0.1
20. Preservatives Appropriate amount 21. Acrylic acid / acroyldimethyltaurine sodium copolymer 1
22. Hydroxypropyl Methyl Cellulose 0.1
23. Nicotinamide (Note 2) 4.0
24. Tranexamic acid (Note 3) 1.0
25. Remaining amount of purified water (Note 6) Contains 80% by mass of hydrogenated soybean phospholipids

(Production method)
A: Ingredients (1) to (15) are heated and dissolved at 70 ° C.
B: The component (25) is heated to 70 ° C., added to A and emulsified.
C: B was cooled, and the components (16) to (24) were added and mixed to obtain a cream.

The cream of Example 6 was excellent in the fading-suppressing effect of astaxanthin.

Example 7 [Sunscreen cosmetics (water-in-oil cream)]
(Ingredient) (%)
1. 1. Polyoxyethylene monolaurate (20 mol) sorbitan 0.2
2. Polyoxyethylene (60 mol) hardened castor oil 0.1
3. 3. Residual amount of purified water 4. Dipropylene glycol 10.0
5. Magnesium sulfate 0.5
6. Ascorbic acid glucoside 2.0
7. Nicotinamide (Note 2) 4.0
8. Tranexamic acid (Note 3) 1.0
9. Decamethylcyclopentasiloxane 20.0
10. Isotridecyl isononanoate 5.0
11. 2-Ethylhexyl paramethoxycinnamate 8.0
12. Dimethicone 3.0
13. Astaxanthin 5% solution (Note 1) 0.01
14. Dimethylstearylammonium hectorite 1.2

(Production method)
A: The components (1) to (8) are uniformly dispersed.
B: The components (9) to (14) are uniformly dispersed.
C: While stirring B, A was gradually added and emulsified to obtain a water-in-oil creamy sunscreen cosmetic.

The sunscreen cosmetic (water-in-oil cream) of Example 7 had an excellent stabilizing effect on astaxanthin.

Example 8 [Ointment]
(Ingredient) (%)
1. 1. Triethanolamine 2.0
2. Glycerin 5.0
3. 3. Dipotassium glycyrrhizinate 0.5
4. Residual amount of purified water 5. Nicotinamide (Note 2) 5.0
6. Tranexamic acid (Note 3) 1.5
7. Stearic acid 18.0
8. Cetanol 4.0
9. β-carotene 5% solution (Note 5) 0.02
10. Dl-α-tocopherol acetate 0.2
11. Methyl paraoxybenzoate 0.1

(Production method)
A. Ingredients (1) to (6) are uniformly dissolved and kept at 75 ° C.
B. Ingredients (7) to (11) are heated and mixed and kept at 75 ° C.
C. B was gradually added to A to obtain an ointment.

The ointment of Example 8 was excellent in the fading-suppressing effect of β-carotene.

Example 9 [Liquid foundation (oil-in-water cream)]
(Ingredient) (%)
1.1,3 Butylene glycol 5.0
2. Hydrogenated soybean phospholipid 0.5
3. 3. Titanium oxide 5.0
4. Bengala 0.1
5. Yellow iron oxide 1.0
6. Black iron oxide 0.05
7. Acrylic acid / alkyl methacrylate copolymer 0.5
8. Triethanolamine 1.5
9. Residual amount of purified water 10. Glycerin 5.0
11. Ethyl paraoxybenzoate 0.1
12. Nicotinamide (Note 2) 4.0
13. Tranexamic acid (Note 3) 1.0
14. Stearic acid 0.9
15. Glycerin monostearate 0.3
16. Setostearyl alcohol 0.4
17. Polyoxyethylene monooleate (20 mol) sorbitan 0.2
18. Polyoxyethylene trioleate (20 mol) sorbitan 0.2
19. Paramethoxycinnamate 2-ethylhexyl 5.0
20. Isododecane 2.0
21. Astaxanthin 5% solution (Note 1) 0.04
22. Ascorbyl tetrahexyl decanoate 0.05
23. α-tocopherol 0.01
24. Fragrance 0.02

(Production method)
A: Disperse components (1) to (6).
B: Add components (7) to (13) to A and mix uniformly at 70 ° C.
C: Ingredients (12) to (23) are uniformly mixed at 70 ° C.
D: Add B to C, emulsify, and cool to room temperature.
The component (24) was added to E: D to obtain an oil-in-water creamy liquid foundation.

The liquid foundation (oil-in-water cream type) of Example 9 had an excellent effect of suppressing fading of astaxanthin.

The method for stabilizing carotenoids such as astaxanthin and β-carotene of the present invention can be applied to foods and drinks and compositions, and the composition obtained by the stabilizing method is used for anti-aging, prevention of stains and wrinkles. It is useful for exerting effects on the skin such as improvement.

Claims (8)

The following components (A) to (C);
A composition containing (A) carotenoid (B) nicotinamide (C) tranexamic acid. The composition according to claim 1, wherein the residual ratio of the absorbance of the carotenoid at 470 nm is 50% or more when exposed at 30 ° C. and 8900 lp for 14 days. The composition according to claim 1 or 2, wherein the content mass ratio (B) / (C) of the component (B) to the component (C) is 0.5 to 10. The composition according to any one of claims 1 to 3, wherein the component (A) carotenoid is astaxanthin. The composition according to any one of claims 1 to 4, further containing the component (D) nonionic surfactant. A cosmetic or skin external preparation containing the composition according to any one of claims 1 to 5. Ingredient (C) A carotenoid fading inhibitor containing tranexamic acid as an active ingredient. A method for suppressing fading of a carotenoid, in which the component (C) tranexamic acid is mixed with a composition containing the component (A) carotenoid.