JP2019131548A - Composition - Google Patents

Abstract

To provide a stabilizing agent or a stabilization method for suppressing the deterioration of carotenoid such as astaxanthin which is known to be useful for anti-aging or the like and maintaining the effect over a long period of time and to provide a composition for suppressing the deterioration acceleration of carotenoid generated when nicotinic acid amide is incorporated into a composition containing carotenoid in order to obtain an excellent cosmetic or the like by anti-aging effects or the like and maintaining the effect over a long period of time.SOLUTION: The combination of carotenoid such as astaxanthin and an oil agent obtained from a specific plant exhibits a remarkable effect for preventing the discoloration of carotenoid such as astaxanthin or the like by light and stabilizing them and exhibits a remarkable suppressing effect in the deterioration acceleration of carotenoid generated when nicotinic acid amide is incorporated.SELECTED DRAWING: None

Description

  The present invention relates to a composition comprising a carotenoid, an oil obtained from a specific plant, and nicotinamide. The present invention also relates to a carotenoid stabilizer using an oil agent obtained from a specific plant and a carotenoid stabilization method.

  It is known that carotenoids such as astaxanthin have useful effects on the skin such as prevention of aging and prevention / improvement of spots. Carotenoids are naturally occurring yellow to red terpenoid pigments that can be found in plants, algae, and bacteria. Astaxanthins (including astaxanthin and esters thereof), which is a kind of carotenoid, are widely distributed in the animal and plant kingdoms in nature, and are mainly used as a color frying agent for farmed fish and chickens. In addition, astaxanthin is also known to have functions such as an antioxidant effect, an anti-inflammatory effect (see Patent Document 1 and Patent Document 2), and an anti-skin aging effect (see Patent Document 3). For this reason, it has been studied and implemented to add astaxanthins to foods, cosmetics, raw materials for pharmaceuticals and processed products thereof.

  Nicotinamide is a derivative of nicotinic acid, also called nicotinamide or niacinamide, and is used for prevention and treatment of nicotinic acid deficiency. Furthermore, skin roughness improvement, whitening effect, anti-aging effect and the like are known, and development of more excellent anti-aging cosmetics and the like is expected by combining nicotinamide and astaxanthins.

  On the other hand, carotenoids such as astaxanthin are structurally unstable, and it is known that deterioration is accelerated by heat, light, oxidation, etc., and it is difficult to stably contain them in a preparation. Therefore, in addition to the technology used in combination with ascorbic acid as a stabilizer and the inclusion such as inclusion with hard capsules (see Patent Document 4), specific oil-soluble plant extracts, alcohols, nut polyphenols and chelates In combination with an agent (see Patent Document 5), a method of adding an organic acid to a carotenoid-containing composition (see Patent Document 6), iron ion, iron chelating agent, dibromopyrene glycol, water-soluble antioxidant (See Patent Document 7), a method for stabilizing carotenoids such as astaxanthin by using a combination of red wine extract or collagen peptide (see Patent Document 8) is disclosed.

JP-A-2-49091 Japanese Patent Laid-Open No. 9-143063 Japanese Patent Application Laid-Open No. 5-15536 JP-A-1-215263 JP 2010-105988 A JP-A-6-264055 JP 2012-31067 A JP 2009-159929 A

  However, in any of these methods, the stabilizer is expensive, the effect of stabilization is not sufficient, or when the stabilizer is a water-soluble component, the oil component that dissolves carotenoids such as astaxanthin is dissolved. There was a problem that dispersion was difficult and sufficient effects could not be exhibited. Furthermore, it was not satisfactory from the viewpoint of enhancing the stability of carotenoids such as astaxanthin, which are known to have useful effects, and sustaining the effects over a long period of time.

  In addition, the inventors tried to contain nicotinamide in a composition containing carotenoids in order to obtain a composition excellent in improving skin roughness, whitening effect, anti-aging effect, etc. It was found that deterioration of carotenoids due to oxidation and the like was promoted.

  The problem to be solved by the present invention is to provide a stabilizer and a stabilization method for suppressing deterioration of carotenoids such as astaxanthin, which are known to be useful for preventing aging, and maintaining the effect for a long period of time. Is to provide. Furthermore, in order to obtain cosmetics and the like that are superior in anti-aging effects, etc., the carotenoid-containing composition contains nicotinic acid amide, which suppresses the promotion of carotenoid degradation and maintains its effect over a long period of time. Providing a composition;

  In view of such a situation, the present inventors have intensively studied to solve the above problems, and as a result, by combining a carotenoid such as astaxanthin and an oil obtained from a specific plant, prevention of fading due to light of the carotenoid such as astaxanthin, etc. It has been found that it exhibits a remarkable effect on stabilization of the present invention, and the present invention has been completed. It has also been found that a remarkable inhibitory effect is exerted in promoting the deterioration of carotenoids produced when nicotinamide is contained.

That is, the present invention includes the following components (a) to (c);
(A) Carotenoid (b) Contains oil agent (c) nicotinic acid amide obtained from one or more plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simondiaceae, Acetaceae It is related with the composition to do.

The said component (a) is related with the said composition of astaxanthin.

The component (b) is the genus Gramineae, Gramineae Zuzudama, Lamiaceae Perilla, Sesame Sesame, Camellia Camellia, Asteraceae Safflower, Asteraceae Olive, Simmonidae Simmonia, Acatezaceae Arganoki It is related with the said composition which is an oil agent obtained from the 1 or more types of plant chosen from a genus.

Said component (b) is at least one selected from rice germ oil, rice bran oil, sesame oil, sesame seed oil, camellia seed oil, pearl barley oil, safflower oil, olive fruit oil, jojoba oil, argan oil It relates to the composition described.

The said composition is related with the said composition which is cosmetics or a skin external preparation.

The present invention relates to a carotenoid stabilizer comprising as an active ingredient an oil agent obtained from one or more plants selected from the family of Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simmondiaceae, and Acetaceae.

It is characterized by adding to the composition containing carotenoid an oil agent obtained from one or more kinds of plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simondiaceae, Acetaceae The present invention relates to a method for stabilizing carotenoids.

A carotenoid in which an oil agent obtained from one or more plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Asteraceae, Simondiaceae, Acatezaceae is added to a composition containing carotenoid and nicotinamide It relates to a stabilization method.

  The composition, stabilizer and stabilization method of the present invention can effectively exert the effects of carotenoids such as astaxanthins by suppressing the degradation of carotenoids such as astaxanthins.

  Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after.

  In the present invention, the carotenoid of component (a) includes any of plants, algae and bacteria. Moreover, it is not limited to the thing of natural origin, Any thing will be included by the carotenoid in this invention if it is obtained according to a conventional method.

  Examples of carotenoids include hydrocarbons (carotenes), oxidized alcohol derivatives thereof (xanthophylls), and esters thereof. In the present invention, these compounds are referred to as “carotenoid” unless otherwise specified. Examples of carotenoids include actinioerythrol, astaxanthin, bixin, canthaxanthin, capsanthin, capsorubin, β-8′-apo-carotenal (apocarotenal), β-12′-apo-carotenal, α-carotene, β-carotene , “Carotene” (a mixture of α- and β-carotenes), γ-carotene, δ-carotene, β-cryptoxanthine, echinone, palm oil carotene, lutein, lycopene, biorelythrin, zeaxanthin, fucoxanthin and among them hydroxyl Or ester of what contains carboxyl can be mentioned.

  The carotenoid used in the present invention is preferably liquid at room temperature. Particularly preferred examples are astaxanthins that have an antioxidant effect, an anti-inflammatory effect, a skin aging prevention effect, a whitening effect, and the like and are known as colorants in the yellow to red range.

Astaxanthin is a red pigment having an absorption maximum at 476 nm (ethanol) and 468 nm (hexane), and is classified into xanthophylls, and its chemical structure is 3,3′-dihydroxy-β, β-carotene-4, 4′-dione ( C ₄₀ H ₅₂ 0 ₄ , molecular weight 596.82). In the present invention, the term “astaxanthin” includes the above-mentioned derivatives such as astaxanthin and astaxanthin ester unless otherwise specified.

  Astaxanthins used in the present invention can be extracted from natural products such as krill, salmon, trout, cypress, red yeast, hematococcus algae or synthetic products, but extracted from hematococcus algae. A thing (henceforth Haematococcus alga extract) is especially preferable from the point of quality and productivity. The extraction solvent for obtaining astaxanthin from a natural product may be an aqueous solvent or an organic solvent. As the organic solvent, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, ethyl acetate, ether, hexane, or the like can be used. Also, carbon dioxide in a supercritical state can be used. These solvents may be used alone or in combination of two or more.

  Specific examples of the origin of the Haematococcus alga extract usable in the present invention include Haematococcus pluvialis, Haematococcus lacustris, Haematococcus capensis, Haematococcus capensis, Examples thereof include Haematococcus droebakensis and Haematococcus zimbabwiensis. Further, commercially available Haematococcus alga extract can be used, for example, ASTOTS-S, -5O, -10O, etc. manufactured by Fuji Film, Asteryl Oil 50F manufactured by Fuji Chemical Industry Co., Ltd. And 5F, Astaxanthin-5C manufactured by Oriza Oil Chemical Co., Ltd., 20C, Astaxanthin 5% oil manufactured by Bioactives Japan, Astabio (registered trademark) AR1, AR5 manufactured by Biogenic, and the like. Moreover, as Krill origin, Marin Daio company Astax-S etc. are mentioned.

  Although content of the component (a) in this invention is not specifically limited, From a viewpoint of exhibiting a useful effect on skin, such as antioxidant, anti-aging, and the prevention and improvement of a spot, Preferably it is 0.000001-0. 0.1% by mass (hereinafter simply referred to as “%”), more preferably 0.00001 to 0.01%. When an extract is used, the concentration of the extract is not limited as long as the amount of solute is within the above range.

  The oil agent obtained from one or more kinds of plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Solanumaceae, Simondiaceae, Acatezidae of component (b) in the present invention includes It is an oily component obtained from the plant to which it belongs. A method for obtaining an oily component from a plant is not particularly limited, and a general method can be used. For example, a method of squeezing plant roots, rhizomes, stems, leaves, flowers, fruits, seeds, or the like, or a mixture thereof, or a method of extracting with a solvent can be used. Although it does not specifically limit as a solvent used for extraction, Methanol, ethanol, isopropanol, acetone, 1, 3- butylene glycol, ethylene glycol, propylene glycol, glycerol, ethyl acetate, ether, hexane, etc. can be used. Also, carbon dioxide in a supercritical state can be used. These solvents may be used alone or in combination of two or more. The extract by the solvent may be in any form such as liquid, paste, gel, solid, and powder. Further, the extract can be used as it is after preparation, but it may be concentrated, dried or spray-dried and dissolved again in oil or polar solvent. Although not particularly limited, it is particularly preferable to use a method of squeezing plant roots, rhizomes, stems, leaves, flowers, fruits, seeds, etc., or a mixture thereof from the viewpoint of obtaining more oily components. Furthermore, if necessary, it can be used after being subjected to treatments such as decolorization, deodorization, and desalting using filtration, activated carbon, ion exchange resin and the like within a range not affecting the effects of the present invention. In addition, it can be fractionated and used by methods such as ultrafiltration, ion exchange chromatography and gel filtration chromatography.

  The grass family plant includes the whole plant belonging to the grass family (Poaceae (Gramineae)). The Gramineae is a large family consisting of more than 9,500 species of about 600 genera. Most grasses are herbs with elongated leaves and stems.

  Major genera of the family Gramaceae (Phyllostachys), Rice genus (Oryza), Oatza (Avena), Sorghum (Sorghum), Saccharum (Coix), Sasa (genus Sasa), etc. However, any of these can be used, and the production area and collection time are not particularly limited. Specific plants include, but are not limited to, mushroom (Phyllostachys bambusoides Siebold et Zucc.), Rice (Oryza sativa L.), oat (Avena fatua L.), sorghum (Sorghumbicolar Moench var.bicolor), sugarcane (Saccharum spontaneum L.var.arenicola Ohwi), Kumazasa (Sasa veitchii Rehder), Juzdama (Coix lachrymal-jobi L.), pearl barley (Coix lachrymal-jobi L.) and the like. The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits and seeds, but it is particularly preferable to use seeds. Although it is not particularly limited, rice germ oil, rice bran oil, or barley oil obtained from the genus Oryza or Coix is used from the viewpoint of ensuring the stability of the composition such as odor and discoloration over time. It is particularly preferred. Commercially available products include Oriza Brown Rice Germ Oil-S (Orisa Oil Chemical Co., Ltd.), Rice Salad Oil (Tsukino) (Tsukino Food Industry Co., Ltd.), Orizatocotrienol (Orisa Oil Chemical Co., Ltd.), Yokuinin Oil (Chiba Flour Mills Co. 1 type or 2 types or more can be used.

  The Labiatae plant includes the whole plant belonging to Labiatae (Labiatae (Lamiaceae)). There are about 180 genera and 2500 species distributed almost all over the world, while Japan has 32 genera and 97 species native to Japan. Most Lamiaceae are vegetation with four-ridged stems, but rarely become shrubs, and in this case the stems are wide. The leaves are cruciform, there are no takuya leaves, and many plants contain essential oils. It becomes the fruit which put four seeds in the gargle.

  The major genera of the family Lamiaceae include Rosemaryus, Scutellaria, Chelonopsis, Lamium, Salvia, Mentha, Perilla ), Genus Isodon, genus Labandura, etc., but any of these can be used, and the production area and collection time are not particularly limited. Although it does not specifically limit as a specific plant, Rosemary (Rosmarinus officinalis L.), Scarella willow (Scutellaria baicalensis Georgi), Musk elephant (Chelonopsis moschata Miq.), Odorikosou (Lamium album L.), Sage (Salvia officinalis L.) ), Safflower salvia (Salvia coccinea L.), mint (Mentha arvensis L.), perilla (Perilla frutescens Britton), egoma (Perilla frutescens Britton), cassow (Isodn japonicus H Hara), lavender (Lavandula angustifolia) . The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use egoma oil obtained from Perilla from the viewpoint of ensuring the stability of the composition such as odor change and discoloration over time. Examples of commercially available products include sesame oil (manufactured by Maruzen Pharmaceutical Co., Ltd.), sesame oil (manufactured by Ota Oil & Fats Co., Ltd.), sesame oil (refined) (manufactured by Summit Oil Co., Ltd.), and the like, and one or more can be used. .

  Sesame plant includes all plants belonging to Pedaliaceae. The sesame family known as sesame, a typical oil plant, is said to have a maximum of 20 genera and 80 species. The main genus of the sesame family includes Sesamum, Thunbergia, and Hygrophia, but any of these can be used, and the production area and collection time are not particularly limited. Specific examples of the plant include, but are not limited to, sesame (Sesamum indicum L.), Lorenka quail (Thunbergia laurifolia Lindl), and ogitsume (Hygrophila salicifolia Nees). The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use sesame seed oil obtained from Sesamum from the viewpoint of ensuring the stability of the composition such as odor and discoloration over time. Commercially available products include refined sesame oil (manufactured by Summit Oil Co., Ltd.), gold seal genuine sesame oil (manufactured by Kadoya Oil Co., Ltd.), genuine sesame oil (manufactured by Nisshin Oil Rio Co., Ltd.), organic sesame oil (manufactured by Koei Kogyo Co., Ltd.), etc. 1 type (s) or 2 or more types can be used.

  A camellia plant includes the whole plant which belongs to the camellia family (Theaceae). The camellia family has more than 600 species of about 28 genera. The main genus of Camellia is Camellia, and its production area and collection time are not particularly limited. Specific plants include, but are not limited to, camellia or camellia (Camellia japonica L.). The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use camellia seed oil obtained from Camellia from the viewpoint of ensuring the stability of the composition such as odor change and color change over time. Examples of commercially available products include camellia oil (manufactured by Oshima Coffee Co., Ltd.), refined camellia oil (manufactured by Yokoseki Oil & Fat Co., Ltd.), and the like, and one or more can be used.

  Asteraceae includes all plants belonging to the Asteraceae family. The Asteraceae is a large family that is classified into 1100-1200 genera and has more than 23,000 species. Most of the Asteraceae are perennials, but about 7% are annuals, about 3% are woody and some are full-fledged. The rough feature of the Asteraceae is a head flower composed of a large number of closely spaced florets and a total septum surrounding them. The main genus of the Asteraceae is Chrysanthemum, Echinacea, Achillea, Carthamus, Matricaria, Artemisia, Calendula, etc. However, any of these can be used, and the production area and collection time are not particularly limited. Although it does not specifically limit as a specific plant, Chrysanthemum morifolium Ramat, feverfew (Chrysanthemum Parthenium Pers.), Echinacea angustifolia (Echinacea angustifolia DC.), Achillea millefolium L. (Achillea millefolium L.), Carthamus tinctorius L.), chamomile (Matricaria chamomilla L.), mugwort (Artemisia princeps Pampan), eucalyptus (Calendula officinalis L.) and the like. The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use safflower oil obtained from the genus Carthamus from the viewpoint of ensuring the stability of the composition such as odor change and color change over time. Examples of commercially available products include Nissin Beni Flower Oil (Nisshin Oilio Co., Ltd.), Saflower Salad Oil (refined) (Summit Oil Co., Ltd.), Organic Saflower Oil (SNOI Co., Ltd.), and the like. The above can be used.

  The oleaceae plant includes all plants belonging to the oleaceae family (Oleaceae). There are about 30 genera and 600 species from the world tropical to temperate, and about 26 species of 7 genera are distributed in Japan. The oleaceae is a woody family that includes shrubs, tall trees that become timber, fruit trees such as olives, and shrubs used in perfumes such as jasmine. The main genus of the family Oxaceae includes the genus Olive (Olea), the genus Osmanthus, the genus Syringa, and the genus Buddleja. Is not particularly limited. Specific examples of the plant include, but are not limited to, olives (Olea europaea L.), betel oysters (Osmanthus fragrans Lour. Var. Aurantiacus Makino), and Fusafujitsugi (Buddeleja davidii Franch.). The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use olive fruit oil obtained from Olea, from the viewpoint of ensuring the stability of the composition such as odor change and color change over time. Examples of commercially available products include refined olive oil (manufactured by NOF Corporation), refined olive oil (produced by Summit Oil Co., Ltd.), and organic refined olive oil (produced by Koei Kogyo Co., Ltd.), and one or more kinds can be used.

  Simmondiaceae plants include all plants belonging to the Simmondsiaceae family. Simmondiaceae is a woody family consisting of only one species of Simmondsia kinesis, belonging to the genus Simmonia. Simmondsia chinensis is also called jojoba. Even tall ones are only 3 meters, but some individuals have survived for over 200 years. Seeds contain oil (liquid wax). There are no particular restrictions on the production area or the collection time, and the use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use jojoba oil obtained from the genus Simmonia from the viewpoint of ensuring the stability of the composition such as odor change and color change over time. Examples of commercially available products include refined jojoba oil (manufactured by Koei Kogyo Co., Ltd.), organic refined jojoba oil (manufactured by Koei Kogyo Co., Ltd.), jojoba oil (refined) (manufactured by Summit Oil Co., Ltd.), and the like. Can be used.

  The Acateaceae plant includes all plants belonging to the Sacateaceae family. The Acatezaceae is a large family consisting of more than 1,100 species of 53 genera. Trees of the Acatezaceae range from a huge tropical rainforest that is as high as 40 meters to a small tree that forms the bottom of the forest, as well as species of thorny shrubs that grow in dry areas. The main genera of the Acetaceae family include the genus Arganania and the genus Vitellaria, but any of these can be used, and the production area and collection time are not particularly limited. Specific plants include, but are not limited to, Argania spinosa, Vitellaria paradoxa, and the like. The use site is not particularly limited, such as roots, rhizomes, stems, leaves, flowers, fruits, and seeds, but it is particularly preferable to use seeds. Although not particularly limited, it is particularly preferable to use an argan oil obtained from the genus Argania from the viewpoint of ensuring the stability of the composition such as odor change and color change over time. Examples of commercially available products include argan oil (manufactured by Nutrition Act), argan oil (manufactured by BASF), and ARGAN OIL (manufactured by DSM), and one or more of them can be used.

  The content of the component (b) in the present invention is not particularly limited, and is preferably 0.0001 to 70%, more preferably from the viewpoint that the stabilizing effect of the component (a) can be exhibited. It is 0.0005-50%, More preferably, it is 0.001-10%.

  Further, the content mass ratio of the component (a) and the component (b) is not particularly limited, but (b) / (a) = 0.01 to 500,000 from the viewpoint that the effect of stabilizing the component (a) is excellent. It is preferable that it is 0.1-300,000, and it is especially preferable that it is 0.1-200000.

  The nicotinic acid amide of component (c) in the present invention is an amide compound of nicotinic acid (also called vitamin B3 or niacin), and is a derivative of nicotinic acid also called nicotinamide or niacinamide. Nicotinamide is a water-soluble vitamin and is a known substance that is one of the vitamin B groups, and can be extracted from a natural product (rice bran or the like) or synthesized by a known method. Specifically, those listed in the 15th revision Japanese Pharmacopoeia 2008 can be used.

  The content of the component (c) in the present invention is not particularly limited, and is preferably 0.01 to 10%, more preferably 0.5 to 8% from the viewpoint of excellent anti-aging action. 1 to 6% is particularly preferable.

  Moreover, although the content mass ratio of a component (b) and a component (c) is not specifically limited, From the viewpoint that it is excellent in the stabilization effect of a component (a) and can suppress the stickiness originating in a component (c), (B) / (c) = 0.00001 to 1000 is preferable, 0.0005 to 500 is more preferable, and 0.0001 to 100 is particularly preferable.

  The content mass ratio of the component (a) and the component (c) is not particularly limited, but is preferably (c) / (a) = 1 to 500,000 from the viewpoint of being excellent in the stabilizing effect of the component (a). 10 to 300,000 is more preferable, and 100 to 200,000 is particularly preferable.

  Further, in the present invention, it is more preferable to add an alcohol as the component (d) because the dispersibility of the component (c) in the components (a) and (b) is excellent. Alcohols are not particularly limited as long as they are used in cosmetics, external preparations for skin, foods, inks, detergents, softeners for clothing, fragrances, deodorants, fabrics, and the like. it can. For example, lower alcohols such as ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, 1,2-pentanediol, ethylene glycol, Examples thereof include polyhydric alcohols such as polyethylene glycol, and one or more of these can be used. Among these, from the viewpoint of excellent dispersibility of the component (c) in the components (a) and (b), it is preferable to use a lower alcohol, and it is particularly preferable to use ethanol.

  Although content of the component (d) in this invention is not specifically limited, From a viewpoint of being excellent by the dispersibility to the component (a) and (b) of a component (c), it is 0.1 to 50%. It is preferably 1 to 40%, particularly preferably 5 to 30%.

  Further, the content mass ratio of the component (c) and the component (d) is not particularly limited, but from the viewpoint of being excellent in dispersibility of the component (c) in the components (a) and (b), (d) / (C) is preferably 0.1 to 100, more preferably 0.5 to 60, and particularly preferably 1 to 45.

  In the composition of the present invention, in addition to the above components, cosmetics, external preparations for skin, foods, inks, detergents, softeners for clothing, fragrance, Ingredients used in preparations such as deodorants and fabrics, that is, water (purified water, hot spring water, deep water, etc.), oil agents, surfactants, metal soaps, gelling agents, powders, water-soluble polymers, Film-forming agents, resins, UV protection agents, inclusion compounds, antibacterial agents, fragrances, deodorants, salts, pH adjusters, refreshing agents, animal / microbe-derived extracts, plant extracts, blood circulation promoters, astringents, Antiseborrheic agents, whitening agents, anti-inflammatory agents, active oxygen scavengers, cell activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like can be added.

  The manufacturing method of the composition of this invention is not specifically limited, It prepares by a conventional method. For example, the said components (a)-(d) Furthermore, the method of preparing by adding the said arbitrary component as needed and mixing this is mentioned.

  The composition of the present invention can be implemented in various forms such as liquid, gel, cream, solid, mousse, etc., and is stored in a sprayable container and sprayed in a mist. May be used. The dosage form of the product of the present invention is not particularly limited, such as a solubilizing type, an oil-in-water type, a water-in-oil type, an oily type, a water-in-oil-in-water type, an oil-in-water-in-oil type, and a multilayer type.

  There is no restriction | limiting in particular regarding the use of the composition of this invention, It uses as a composition for various uses, such as cosmetics, an external preparation for skin, foodstuffs, ink, detergent, the softening finishing agent for clothes, a fragrance | flavor, a deodorant, and a textile. be able to. The composition of the present invention is preferably used as a cosmetic or a skin external preparation from the viewpoint of excellent anti-aging effect and the like.

  Examples of the food (including animal feed) of the present invention include frozen food, powdered food, sheet food, bottled food, canned food, retort food, capsule food, tablet food, etc. It may be in any form, such as natural liquid foods containing sugars, fats, trace elements, vitamins, emulsifiers, fragrances, etc., processed forms such as semi-digested nutrient foods and component nutrient foods, and drinks.

  Examples of the cosmetics of the present invention are not particularly limited. For example, skin care cosmetics such as milky lotion, cream, lotion, cosmetic liquid, pack, foundation, blusher, lipstick, eye color, mascara, eyeliner, nail polish, etc. It may be in any form of makeup cosmetics, hair nourishing agents, hair tonics, shampoos, rinses, hair waxes and other cosmetics for hair, and facial cleansers.

  Examples of the external preparation for skin of the present invention are not particularly limited, and may be any form such as an external gel, cream, ointment, liquid, liniment, and haptic.

  Moreover, although carotenoids such as astaxanthin have a useful effect as described above, it is difficult to obtain the expected effect due to structural instability, and it is difficult to maintain the effect over a long period of time. However, as shown in the Examples below, the carotenoid-containing composition is composed of one or more plants selected from the Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Asteraceae, Simondiaceae, Acateaceae. By containing the obtained oil agent, the carotenoid in the composition can be stabilized.

  By utilizing an oil agent obtained from one or more kinds of plants selected from the aforementioned Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Compositaeaceae, Spiraceae, Simondiaceae, and Acetaceae of the present invention, the stability of carotenoids is improved. It is possible to improve the efficiency of carotenoids. For example, the oil agent obtained from one or more plants selected from the Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Moleaceae, Simondiaceae, and Acetaceae is used to prevent carotenoids from fading and photodegradation. It is possible to exert a remarkable effect on suppression. And carotenoids are useful for preventing and improving rough skin and wrinkles, preventing and improving stains, and also useful for preventing aging and whitening, so the gramineae, perilla, sesame, camellia, asteraceae, Oils obtained from one or more kinds of plants selected from the family Moleaceae, Simondiaceae, and Acanthaceae can dramatically enhance these effects (for example, anti-aging effect and whitening effect) possessed by carotenoids. Maintaining the effects of carotenoids over a longer period by using an oil agent obtained from one or more plants selected from the grass family, Lamiaceae, sesame family, camellia family, asteraceae family, oleaceae family, Simondiaceae family, Acetaceae family Even if the carotenoid content is reduced, the same or higher effect can be expected.

  Therefore, the oil agent obtained from one or more kinds of plants selected from the Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Asteraceae, Simondiaceae, Acetaceae of the present invention has a carotenoid stabilizing effect. Therefore, it is used as a carotenoid stabilizer comprising as an active ingredient an oil agent obtained from one or more kinds of plants selected from the aforementioned gramineae, persimmonaceae, sesameaceae, camelliaceae, asteraceae, oleaceae, simoniaceae, and acetaceae. It is possible. The oil of the present invention obtained from one or more plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Oxaliaceae, Simondiaceae and Acetaceae is used for stabilizing carotenoids. It can also be used in various formulations intended for carotenoid stabilization and can be used to produce these various formulations. Therefore, the oil agent obtained from one or more plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simondiaceae, Acetaceae of the present invention is for stabilizing carotenoids. It can be contained in external preparations for skin, cosmetics, pharmaceuticals, quasi drugs, foods and drinks, and functional foods (for example, foods for specified health use, supplements, etc.). The amount of the oil agent obtained from one or more kinds of plants selected from the Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Compositaeaceae, Oleaceae, Simondiaceae, and Acetaceae of the present invention is not particularly limited, but carotenoid Preferably it is 1-50 million mass parts with respect to 1 mass part, More preferably, it is 1-3000 mass parts, Most preferably, it is 1-2 million.

  Hereinafter, the present invention will be described more specifically with reference to examples, but the scope of the present invention is not limited thereto.

<Photostabilization test of astaxanthin>

Astaxanthin has light absorption peculiar to a wavelength of 470 nm, and when the degradation of astaxanthin occurs, the residual ratio of astaxanthin was calculated according to the following procedure using the property that light absorption at a wavelength of 470 nm decreases. . The results are shown in Table 1.
200 μl of each sample solution shown in Table 1 was dispensed into a 96-well plate and irradiated with ultraviolet rays (UVB exposure: 1.65 J / cm 2).

The astaxanthin residual rate was calculated by measuring the absorbance at 470 nm of each sample solution and using the following formula (1). Here, the astaxanthin-containing system refers to Examples, Reference Examples and Comparative Examples containing astaxanthin, and the astaxanthin-free system refers to an astaxanthin 5% solution (astaxanthin − in each of Examples, Reference Examples and Comparative Examples). 5C (manufactured by Oriza Oil Chemical Co., Ltd.)) is referred to instead of tri (capryl / capric acid) glyceryl.

Astaxanthin residual rate (%) = ((A−B) / (C−D)) × 100 (1)

A = absorbance of an astaxanthin-containing system irradiated with ultraviolet light B = absorbance of an astaxanthin-free system irradiated with ultraviolet C = absorbance of an astaxanthin-containing system not irradiated with ultraviolet light D = absorbance of an astaxanthin-free system not irradiated with ultraviolet light

  From the results in Table 1, Reference Examples 1 to 8 were compared to Reference Example 9 using tri (capryl / capric acid) glyceryl (M Fine Oil CCT-1: manufactured by Miyoshi Oil & Fats Co., Ltd.) instead of component (b). All of them were excellent in the photostabilization effect of astaxanthin.

<Astaxanthin light stabilization effect test when nicotinamide is contained>

  By combining carotenoids such as astaxanthin with nicotinic acid amide, the present inventors can promote the fading of carotenoids such as astaxanthin by light (Comparative Example 1), and further the fading promotion is an oil agent obtained from a specific plant. It was found that it can be suppressed. The results are shown in Table 2.

  200 μl of each sample solution shown in Table 2 was dispensed into a 96-well plate and irradiated with ultraviolet rays (UVB exposure: 1.65 J / cm 2). In addition, the astaxanthin residual rate was measured by the method similar to Examples 1-8.

From the results of Table 2, surprisingly, the discoloration of astaxanthin is promoted more in Comparative Example 1 containing component (c) than in Reference Example 9 not containing component (c), and component (c) It is suggested that there is an effect on the stability of astaxanthin by.
On the other hand, in Examples 1 to 10, no significant discoloration of astaxanthin was observed while compounding component (c), and instead of component (b), tri (capryl / capric acid) glyceryl (M fine oil CCT- 1: Compared to Comparative Example 1 using Miyoshi Oil & Fats Co., Ltd., all of the results of Reference Examples 1 to 8 in Table 1 were excellent in the light stabilization effect of astaxanthin.

Example 11 [skin lotion]
(Ingredient) (%)
1. Glycerin 5.0
2. 1,3-butylene glycol 5.0
3. Lactic acid 0.05
4. Nicotinamide (Note 13) 2.5
5). Sodium lactate 0.1
6). Polyoxyethylene monooleate (20 mol) sorbitan 1.2
7). Ethanol 8.0
8). Rice germ oil (Note 2) 0.1
9. Astaxanthin 5% solution (Note 14) 0.001
10. Methyl paraoxybenzoate 0.1
11. Fragrance 0.05
12 Purified water remaining amount (Note 14) Astax-S (manufactured by Marine Daio)

(Production method)
A: Components (6) to (11) are mixed and dissolved.
B: Components (1) to (5) and (12) are mixed and dissolved.
C: A was added to B and mixed to obtain a skin lotion.

  The lotion of Example 11 was excellent in the stabilization effect of astaxanthins.

Example 12 [Emulsion]
(Ingredient) (%)
1. Polyoxyethylene monostearate (20 mol) sorbitan 1.0
2. Polyoxyethylene trioleate (20 mol) sorbitan 0.5
3. Glyceryl monostearate 1.0
4). Rice bran oil (Note 3) 1.0
5). Stearic acid 0.5
6). Behenyl alcohol 0.5
7). Squalane 4.0
8). Carboxyvinyl polymer 0.1
9. Methyl paraoxybenzoate 0.1
10. Sodium hydroxide 0.05
11. Nicotinamide (Note 13) 5.0
12 Purified water remaining amount 13. Ethanol 5.0
14 Astaxanthin 5% solution (Note 1) 0.01
15. Fragrance 0.05

(Production method)
A: Components (1) to (7) are uniformly mixed at 70 ° C.
B: Components (8) to (12) are uniformly mixed at 70 ° C.
C: A is added to B to emulsify, and cooled to room temperature.
D: (13) to (15) were added and mixed uniformly to obtain an emulsion.

  The emulsion of Example 12 was excellent in the stabilization effect of astaxanthins.

Example 13 [sunscreen cosmetic (water-in-oil cream)]
(Ingredient) (%)
1. Polyoxyethylene monolaurate (20 mol) sorbitan 0.2
2. Polyoxyethylene (60 mol) hydrogenated castor oil 0.1
3. Residual amount of purified water 4. Dipropylene glycol 10.0
5). Magnesium sulfate 0.5
6). Ascorbic acid glucoside 2.0
7). Nicotinamide (Note 13) 4.0
8). Silicone compound (Note 15) 3.0
9. Decamethylcyclopentasiloxane 20.0
10. Isotridecyl isononanoate 5.0
11. 2-Ethylhexyl paramethoxycinnamate 8.0
12 Olive fruit oil (Note 7) 3.0
13. Astaxanthin 5% solution (Note 16) 0.01
14 Dimethylstearyl ammonium hectorite 1.2
(Note 15) KF-6028 (Shin-Etsu Chemical Co., Ltd.)
(Note 16) Astaxanthin 5% oil (manufactured by Bioactives Japan)

(Production method)
A: Components (1) to (7) are uniformly dispersed.
B: Components (8) to (14) are uniformly dispersed.
C: While stirring B, A was gradually added to emulsify to obtain a water-in-oil cream sunscreen cosmetic.

  The sunscreen cosmetic of Example 13 (water-in-oil cream) was excellent in the astaxanthin stabilizing effect.

Example 14 [Ointment]
(Ingredient) (%)
1. Triethanolamine 2.0
2. Glycerin 5.0
3. Dipotassium glycyrrhizinate 0.5
4). 4. Purified water balance Nicotinamide (Note 13) 6.0
6). Stearic acid 18.0
7). Cetanol 4.0
8). Jojoba oil (Note 8) 0.5
9. Astaxanthin 5% solution (Note 1) 0.01
10. Dl-α-tocopherol acetate 0.2
11. Methyl paraoxybenzoate 0.1

(Production method)
A. Ingredients (1) to (5) are uniformly dissolved and kept at 75 ° C.
B. Ingredients (6) to (11) are heated and mixed and maintained at 75 ° C.
C. B was gradually added to A to obtain an ointment.

The ointment of Example 14 was excellent in the stabilization effect of astaxanthins.

  The method for stabilizing carotenoids such as astaxanthins of the present invention can be blended in foods and drinks and compositions, and is useful for exerting skin effects such as anti-aging, prevention of wrinkles and wrinkles. It is.

Claims (8)

The following components (a) to (c);
(A) Carotenoid (b) Contains oil agent (c) nicotinic acid amide obtained from one or more plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simondiaceae, Acetaceae Composition. The composition according to claim 1, wherein the component (a) is an astaxanthin. The component (b) is the genus Gramineae, Gramineae Zuzudama, Lamiaceae Perilla, Sesame Sesame, Camellia Camellia, Asteraceae Safflower, Asteraceae Olive, Simmonidae Simmonia, Acatezaceae Arganoki The composition according to claim 1 or 2, wherein the composition is an oil obtained from one or more plants selected from the genus. The component (b) is at least one selected from rice germ oil, rice bran oil, sesame oil, sesame seed oil, camellia seed oil, pearl barley oil, safflower oil, olive fruit oil, jojoba oil, and argan oil. Item 4. The composition according to any one of Items 1 to 3. The composition according to any one of claims 1 to 4, wherein the composition is a cosmetic or an external preparation for skin. A carotenoid stabilizer comprising, as an active ingredient, an oil agent obtained from one or more plants selected from the family of Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simondiaceae, and Acetaceae. It is characterized by adding to the composition containing carotenoid an oil agent obtained from one or more kinds of plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Spiraceae, Simondiaceae, Acetaceae To stabilize carotenoids. A carotenoid in which an oil agent obtained from one or more plants selected from the family Gramineae, Lamiaceae, Sesameaceae, Camelliaaceae, Asteraceae, Asteraceae, Simondiaceae, Acatezaceae is added to a composition containing carotenoid and nicotinamide Stabilization method.